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41. 发明授权

US07520866B2 Device and method for treatment of wounds with nitric oxide 有权
标题翻译：用一氧化氮治疗伤口的装置和方法
公开(公告)号：US07520866B2
公开(公告)日：2009-04-21
申请号：US11487600
申请日：2006-07-13
申请人： Alex Stenzler , Chris C Miller
发明人： Alex Stenzler , Chris C Miller
IPC分类号： A61M37/00 , A61M1/00 , A01N59/02
CPC分类号： A61M35/00 , A61B90/40 , A61H33/14 , A61K33/00 , A61L2/0094 , A61L15/18 , A61L15/44 , A61L2300/114 , A61L2300/602 , A61M1/0031 , A61M1/0088 , A61M13/003 , A61M13/006 , A61M2202/0275 , A61M2205/3334 , A61K2300/00
摘要： Topical exposure of nitric oxide gas to wounds such as chronic non-healing wounds may be beneficial in promoting healing of the wound and in preparing the wound bed for further treatment and recovery. Nitric oxide gas may be used, for example, to reduce the microbial infection and burden on these wounds, manage exudate secretion by reducing inflammation, upregulate expression of endogenous collagenase to locally debride the wound, and regulate the formation of collagen. High concentration of nitric oxide ranging from about 160 to 400 ppm may be used without inducing toxicity in the healthy cells around a wound site. Additionally, exposure to the high concentration for a first treatment period reduces the microbial burden and inflammation at the wound site and increase collagenase expression to debride necrotic tissue at the wound site. After a first treatment period with high concentration of nitric oxide, a second treatment period at a lower concentration of nitric oxide preferably ranging from about 5-20 ppm may to provided to restore the balance of nitric oxide and induce collagen expression to aid in the closure of the wound.
摘要翻译：一氧化氮气体局部暴露于伤口如慢性非愈合伤口可能有益于促进伤口愈合和制备伤口床进一步治疗和恢复。例如，可以使用一氧化氮气体来减少这些伤口的微生物感染和负担，通过减少炎症，上调内源性胶原酶的表达来局部清创伤口并调节胶原的形成来控制渗出物分泌。可以使用约160至400ppm范围内的高浓度一氧化氮，而不会在伤口部位周围的健康细胞中引起毒性。此外，在第一次治疗期间暴露于高浓度可减少伤口部位的微生物负担和炎症，并增加胶原酶表达以清除伤口部位的坏死组织。在具有高浓度一氧化氮的第一次治疗期后，可提供较低浓度的一氧化氮优选约5-20ppm的第二治疗期以恢复一氧化氮的平衡并诱导胶原表达以帮助闭合的伤口。

42. 发明申请

US20070144515A1 Intermittent dosing of nitric oxide gas 有权
标题翻译：间歇给药一氧化氮气体
公开(公告)号：US20070144515A1
公开(公告)日：2007-06-28
申请号：US11598221
申请日：2006-11-10
申请人： Alex Stenzler , Chris Miller , Bevin McMullin
发明人： Alex Stenzler , Chris Miller , Bevin McMullin
IPC分类号： A61M15/00 , A61M16/00
CPC分类号： A61M16/122 , A61H33/14 , A61K33/00 , A61M16/0003 , A61M16/0051 , A61M16/024 , A61M16/04 , A61M16/0666 , A61M16/0833 , A61M16/12 , A61M16/201 , A61M16/202 , A61M16/204 , A61M2016/003 , A61M2016/102 , A61M2202/0275 , A61M2205/3327 , A61M2205/3334
摘要： A method and corresponding device are described for combating microbes and infections by delivering intermittent high doses of nitric oxide to a mammal for a period of time and which cycles between high and low concentration of nitric oxide gas. The high concentration of nitric oxide is preferably delivered intermittently for brief periods of time that are interspersed with periods of time with either no nitric oxide delivery or lower concentrations of nitric oxide. The method is advantageous because at higher concentration, nitric oxide gas overwhelms the defense mechanism of pathogens that use the mammalian body to replenish their thiol defense system. A lower dose or concentration of nitric oxide gas delivered in between the bursts of high concentration nitric oxide maintains nitrosative stress pressure on the pathogens and also reduces the risk of toxicity of nitric oxide gas.
摘要翻译：描述了一种方法和相应的装置，用于通过向哺乳动物递送间歇性高剂量的一氧化氮一段时间并在高浓度和低浓度的一氧化氮气体之间循环来对抗微生物和感染。高浓度的一氧化氮优选间歇地递送短暂的时间段，其间隔着不含一氧化氮递送或较低浓度的一氧化氮的时间段。该方法是有利的，因为在较高的浓度下，一氧化氮气体压倒了使用哺乳动物身体补充其硫醇防御系统的病原体的防御机制。在高浓度一氧化氮脉冲之间输送的一氧化氮气体的较低剂量或浓度保持对病原体的亚硝化应激压力，并降低一氧化氮气体毒性的风险。

43. 发明授权

US07122018B2 Device and method for treatment of wounds with nitric oxide 有权
标题翻译：用一氧化氮治疗伤口的装置和方法
公开(公告)号：US07122018B2
公开(公告)日：2006-10-17
申请号：US11021109
申请日：2004-12-23
申请人： Alex Stenzler , Chris C Miller
发明人： Alex Stenzler , Chris C Miller
IPC分类号： A61M37/00 , A61M1/00 , A01N59/02
CPC分类号： A61M35/00 , A61B90/40 , A61H33/14 , A61K33/00 , A61L2/0094 , A61L15/18 , A61L15/44 , A61L2300/114 , A61L2300/602 , A61M1/0031 , A61M1/0088 , A61M13/003 , A61M13/006 , A61M2202/0275 , A61M2205/3334 , A61K2300/00
摘要： Topical exposure of nitric oxide gas to wounds such as chronic non-healing wounds may be beneficial in promoting healing and preparing the wound bed for further treatment and recovery. Nitric oxide gas may be used to reduce the microbial infection, manage exudates secretion by reducing inflammation, upregulate expression of endogenous collagenase to locally debride the wound, and regulate the formation of collagen. High concentration of nitric oxide ranging from 160–400 ppm may be used without inducing toxicity in the healthy cells around a wound site. Exposure to the high concentration for a first treatment period reduces the microbial burden and inflammation, and increases collagenase expression to debride necrotic tissue at the wound site. After a first treatment period, a second treatment period at a lower concentration of nitric oxide, preferably ranging from 5–20 ppm may be used to restore the balance of nitric oxide and induce collagen expression aiding in the wound closure.
摘要翻译：一氧化氮气体局部暴露于伤口如慢性非愈合伤口可能有益于促进愈合和制备伤口床进一步治疗和恢复。可以使用一氧化氮气体来减少微生物感染，通过减少炎症，上调内源性胶原酶的表达来局部清创伤口，调节胶原蛋白的形成来控制渗出物的分泌。可以使用160-400ppm范围内的高浓度一氧化氮，而不会在伤口部位周围的健康细胞中引起毒性。在第一次治疗期间暴露于高浓度会降低微生物负担和炎症，并增加胶原酶表达以清除伤口部位的坏死组织。在第一次治疗期后，可以使用较低浓度的一氧化氮，优选5-20ppm的第二治疗期，以恢复一氧化氮的平衡并诱导帮助伤口闭合的胶原表达。

44. 发明申请

US20050137521A1 Device and method for treatment of surface infections with nitric oxide 有权
标题翻译：用一氧化氮治疗表面感染的装置和方法
公开(公告)号：US20050137521A1
公开(公告)日：2005-06-23
申请号：US10944479
申请日：2004-09-17
申请人： Alex Stenzler
发明人： Alex Stenzler
IPC分类号： A61M13/00 , A61B19/00 , A61H33/14 , A61M1/00 , A61M27/00 , A61M35/00 , A61M37/00
CPC分类号： A61M1/0088 , A61B90/40 , A61H33/14 , A61M1/0031 , A61M13/003 , A61M13/006 , A61M27/00 , A61M35/00 , A61M2202/0275 , A61M2205/3334
摘要： A device for the topical delivery of nitric oxide gas to an infected area of skin includes a source of nitric oxide gas, a bathing unit, a flow control valve, and a vacuum unit. The bathing unit is adapted to surround the area of the infected skin and form a substantially air-tight seal with the skin surface. The bathing unit is also in fluidic communication with the source of nitric oxide. The flow control valve is position downstream of the source of nitric oxide and upstream of the bathing unit. The flow control valve controls the amount of nitric oxide gas that is delivered to the bathing unit. The vacuum unit is positioned downstream of the bathing unit and is used to withdraw gas from the bathing unit. Application of nitric oxide gas to the infected area of skin reduces levels of bacteria in the infected area and promotes the healing process.
摘要翻译：用于将一氧化氮气体局部递送到皮肤感染区域的装置包括一氧化氮气体源，洗澡单元，流量控制阀和真空单元。洗澡单元适于包围被感染皮肤的区域并与皮肤表面形成基本上气密的密封。洗澡单元也与一氧化氮来源流体连通。流量控制阀位于一氧化氮源和洗澡单元上游的下游。流量控制阀控制输送到洗澡单元的一氧化氮气体的量。真空单元位于洗澡单元的下游，用于从洗澡单元中抽出气体。一氧化氮气体在感染皮肤区域的应用可以减少感染区域的细菌数量，促进愈合过程。

45. 发明授权

US06793644B2 Device and method for treatment of surface infections with nitric oxide 有权
标题翻译：用一氧化氮治疗表面感染的装置和方法
公开(公告)号：US06793644B2
公开(公告)日：2004-09-21
申请号：US10172270
申请日：2002-06-14
申请人： Alex Stenzler
发明人： Alex Stenzler
IPC分类号： A61M3700
CPC分类号： A61M1/0088 , A61B90/40 , A61H33/14 , A61M1/0031 , A61M13/003 , A61M13/006 , A61M27/00 , A61M35/00 , A61M2202/0275 , A61M2205/3334
摘要： A method of treating infected tissue with topical nitric oxide exposure includes the steps of providing a source of nitric oxide containing gas and delivering the nitric oxide containing gas to a skin surface containing infected tissue so as to bathe the infected tissue with nitric oxide.
摘要翻译：用局部一氧化氮暴露处理感染组织的方法包括提供含一氧化氮的气体源并将含有一氧化氮的气体输送到含有感染组织的皮肤表面以便用一氧化氮洗涤感染组织的步骤。

46. 发明授权

US06612308B2 Portable isocapnia circuit and isocapnia method 有权
标题翻译：便携式isocapnia电路和isocapnia方法
公开(公告)号：US06612308B2
公开(公告)日：2003-09-02
申请号：US10093797
申请日：2002-03-08
申请人： Joseph Fisher , Alex Vesely , Hiroshi Sasano , Steve Iscoe , Alex Stenzler
发明人： Joseph Fisher , Alex Vesely , Hiroshi Sasano , Steve Iscoe , Alex Stenzler
IPC分类号： A62B700
CPC分类号： A61M16/12 , A61M16/0045 , A61M16/08
摘要： A portable isocapnia circuit and an isocapnia method. A breathing port of the circuit allows a subject to inhale and exhale. Connected to the breathing port, a bifurcate conduit has a first conduit branch and a second conduit branch. The first conduit branch has an atmospheric air inlet, from which the atmospheric air is provided for inhalation, an inspiratory check valve to allow a one-way flow of the atmospheric air, and an atmospheric air aspirator. The second conduit branch has a one-way expiratory check valve and a expiratory gas reservoir. A one-way check valve is used to interconnect the first and second conduit branch, from which the expiratory gas stored in the expiratory gas reservoir flows to the first conduit branch to mix with the atmospheric air when the minute ventilation exceeds the atmospheric air.
摘要翻译：便携式异卡路里电路和异味法。电路的呼吸口允许受试者吸入并呼气。连接到呼吸端口，分叉导管具有第一导管支路和第二导管支路。第一管道分支具有大气空气入口，大气从该空气入口提供用于吸入，吸气止回阀允许大气空气的单向流动，以及大气抽气器。第二导管分支具有单向呼气止回阀和呼气气体储存器。单向止回阀用于互连第一和第二导管分支，当微小通气超过大气时，从呼吸气体储存器中吸入的呼吸气体流向第一导管支路与大气混合。

47. 发明授权

US5937854A Ventilator pressure optimization method and apparatus 失效
标题翻译：呼吸机压力优化方法及装置
公开(公告)号：US5937854A
公开(公告)日：1999-08-17
申请号：US3717
申请日：1998-01-06
申请人： Alex Stenzler
发明人： Alex Stenzler
IPC分类号： A61M16/00
CPC分类号： A61M16/00 , A61M2230/40
摘要： A method and apparatus for ventilator pressure and optimization administers fixed stepwise pressure changes to the lungs of a patient and measures the lung volume change resulting from each pressure change. Critical opening pressure, critical closing pressure, and overdistention pressure are determined by changes in lung volume corresponding to the fixed stepwise pressure changes.
摘要翻译：用于呼吸机压力和优化的方法和装置对患者的肺进行固定的逐步压力变化，并测量由每个压力变化导致的肺体积变化。临界开启压力，临界闭合压力和过度停止压力由对应于固定逐步压力变化的肺容积变化确定。

48. 发明申请

US20180147371A1 FLAVORING ELEMENT FOR AN INHALATION DEVICE 审中-公开
公开(公告)号：US20180147371A1
公开(公告)日：2018-05-31
申请号：US15566426
申请日：2016-04-13
申请人： Alex Stenzler , Sansa Corporation (Barbados) Inc.
发明人： Alex Stenzler , Steve Han , Arthur Slutsky , Steven Ellis , Noe Zamel , Bildad Nyambura
IPC分类号： A61M15/00 , A61M15/06 , A24F47/00
CPC分类号： A61M15/0003 , A24F47/002 , A61M15/0036 , A61M15/0041 , A61M15/06 , A61M2202/064 , A61M2206/18
摘要： A device for adding a flavor and/or cough suppressant component to an inhaler is described. The device includes a housing having an interior chamber, wherein the housing includes at least one air inlet and at least one air outlet connected to the interior chamber, thereby forming an airflow pathway through the interior chamber, and at least one flavoring and/or cough suppressant component positioned within the interior chamber, wherein the housing is attachable to an exterior surface of an inhaler having at least one air inlet, such that the at least one air outlet of the device aligns with the at least one air inlet of the inhaler to form an airflow path through the device and into the inhaler.

49. 发明申请

US20180125882A1 Compositions And Methods For Treating Diseases Or Disorders Using Extended Release Nitric Oxide Releasing Solutions 审中-公开
公开(公告)号：US20180125882A1
公开(公告)日：2018-05-10
申请号：US15675773
申请日：2017-08-13
申请人： Alex Stenzler , Christopher C. Miller , Gilly Regev-Shoshani
发明人： Alex Stenzler , Christopher C. Miller , Gilly Regev-Shoshani
IPC分类号： A61K33/00 , A61K9/00 , A61K9/08 , A61K9/70 , A61K47/12 , C01B21/24
CPC分类号： A61K33/00 , A61K9/0043 , A61K9/08 , A61K9/7007 , A61K47/12 , C01B21/24
摘要： The present invention relates to a liquid nitric oxide releasing solution (NORS) comprised of at least one nitric oxide releasing compound and at least one acidifying agent, wherein the NORS provides an extended release of a therapeutically effective amount of nitric oxide gas (gNO). The present invention also relates to a liquid NORS comprised of at least one nitrite compound having a concentration of no greater than about 0.5% w/v and at least one acidifying agent, wherein the NORS releases a therapeutically effective amount of gNO. The present invention also relates to a method for the treatment of a wound in a human, the method comprising administering to the human a liquid NORS comprised of at least one nitric oxide releasing compound and at least one acidifying agent, wherein the NORS provides an extended release of a therapeutically effective amount of gNO. The present invention also relates to a method for the treatment, prevention, or reduction of incidence of a disease or disorder in a human in need thereof, the method comprising administering to the human a liquid NORS comprised of at least one nitrite compound at a concentration of no greater than about 0.5% w/v and at least one acidifying agent, wherein the NORS releases a therapeutically effective amount of gNO.

50. 发明申请

US20160051579A1 NITRIC OXIDE TREATMENT OF BOVINE RESPIRATORY DISEASE COMPLEX AND OTHER RESPIRATORY CONDITIONS 审中-公开
标题翻译：牛血液呼吸综合征和其他呼吸道疾病的氧化氮治疗
公开(公告)号：US20160051579A1
公开(公告)日：2016-02-25
申请号：US14779541
申请日：2014-12-30
申请人： Alex STENZLER , Chrlstopher C. MILLER , Gilly REGEV-SHOSHANI
发明人： Alex Stenzler , Christopher C. Miller , Gilly Regev-Shoshani
IPC分类号： A61K33/00 , A61K9/00
CPC分类号： A61K33/00 , A61K9/0043 , A61K9/0078 , A61K47/12
摘要： Methods, devices, and systems for treating a respiratory condition using gNO delivered from a nitric oxide releasing solution (NORS) are disclosed and described. In one embodiment, the respiratory condition may be bovine respiratory disease complex (BRDc).
摘要翻译：公开和描述了使用从一氧化氮释放溶液（NORS）递送的gNO治疗呼吸状况的方法，装置和系统。在一个实施方案中，呼吸状况可以是牛呼吸道疾病复合物（BRDc）。

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