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    • 41. 发明授权
    • Method for release of active substances and active substance release systems
    • 释放活性物质和活性物质释放系统的方法
    • US09072834B2
    • 2015-07-07
    • US14065738
    • 2013-10-29
    • Heraeus Medical GmbH
    • Sebastian Vogt
    • A61M37/00A61M5/20A61K9/00A61L27/50A61L27/54
    • A61M5/2046A61K9/0009A61K9/0024A61L27/50A61L27/54A61L2300/406A61L2300/602
    • A device releases a fluid active substance, the device has at least one hollow space containing the fluid active substance, whereby the device contains water and a reducing agent, which are or can be made to be in communication such that a chemical reaction of the water and the reducing agent produces a gas and the gas effectively communicates with the fluid active substance such that the gas pressure thus generated presses the fluid active substance out of at least one opening of the hollow space out of the device. A medical implant incorporates the device, and a method releases a fluid active substance from a hollow space of the medical implant, in which a gas is produced through a chemical reaction of liquid water and a reducing agent, and the resulting gas pressure is used to expel the fluid active substance out of at least one opening of the hollow space.
    • 装置释放流体活性物质,该装置具有至少一个含有流体活性物质的中空空间,由此该装置含有水和还原剂,其可以或可以使其连通,使得水的化学反应 并且还原剂产生气体,气体与流体活性物质有效连通,使得由此产生的气体压力将流体活性物质从中空空间的至少一个开口排出装置。 医疗植入物结合该装置,并且方法从医用植入物的中空空间释放流体活性物质,其中通过液态水和还原剂的化学反应产生气体,并且将所得到的气体压力用于 从中空空间的至少一个开口排出流体活性物质。
    • 42. 发明授权
    • Multi-component cartridge system with shiftable closures in the cartridges
    • 多组分墨盒系统,带有可移动的墨盒盒盖
    • US08986313B2
    • 2015-03-24
    • US13682051
    • 2012-11-20
    • Heraeus Medical GmbH
    • Sebastian VogtTim Schnieber
    • A61B17/58A61B17/60A61F2/00A61B17/88B05C17/005
    • A61B17/8802A61B2017/8838B05C17/0052B05C17/00553B05C17/00596
    • A cartridge system for mixing and applying a mixing ware. The cartridges are arranged parallel and they are connected to a mixing space and an outlet opening. The cartridges each comprise a feed plunger for expelling starting components of the mixing ware from the cartridges through the openings, and each cartridge has at least one closure allocated to it that is shiftable in longitudinal direction of the cartridges, whereby the closures close the openings of the cartridges in a starting position, and the openings are open, at least in part, in an end position of the shiftable closures. In open position, the closure is shifted into a hollow space. The closures are cylindrical in shape and in their end position are capable of being lowered into cylindrical hollow spaces of the cartridges in order to uncover the openings.
    • 用于混合和应用混合器的盒式系统。 墨盒平行布置,并且它们连接到混合空间和出口开口。 每个盒包括用于从盒穿过开口排出混合物的起始部件的进料柱塞,并且每个筒具有分配给其的至少一个封闭件,其可沿盒的纵向方向移位,由此封闭件关闭 盒子处于起始位置,并且开口至少部分地打开在可移动封闭件的终端位置。 在打开位置,封闭件移入中空空间。 封闭件是圆柱形的,并且其端部位置能够降低到盒的圆柱形中空空间中,以便露出开口。
    • 44. 发明申请
    • DEVICE AND METHOD FOR THE IN-SITU PRODUCTION OF ARTICULATED SPACERS
    • 用于现场生产空间的装置和方法
    • US20140343560A1
    • 2014-11-20
    • US14278528
    • 2014-05-15
    • Heraeus Medical GmbH
    • Sebastian Vogt
    • A61B17/88
    • A61F2/38A61F2/30942A61F2002/30672A61F2002/30677A61F2002/30957A61F2310/00353B29C33/42B29C33/424
    • Devices and methods in-situ produce articular spacers from a bone cement. The devices and methods have a punch surface for forming an articulation surface of a spacer in the bone cement, whereby the bone cement is arranged on a bone surface for fixation of the spacer, whereby the punch surface has a negative image of the articulation surface to be produced, and the surface forming the negative image is open on the side, at least in part, such that the bone cement can be pushed towards the side, away from the articulation surface to be formed. Moreover, the method for producing an articular spacer on a bone may have one or more of the following steps: A) Applying a bone cement to a prepared bone; B) Pressing said device onto the bone cement; and C) Detaching the device from the cured bone cement.
    • 装置和方法从骨水泥原位生产关节间隔物。 装置和方法具有用于在骨水泥中形成间隔件的关节表面的冲压表面,由此骨粘固剂布置在骨表面上用于固定间隔件,由此冲压表面具有关节表面的负像, 并且形成负像的表面在侧面至少部分地开放,使得骨粘固剂可以被推向侧面,远离待形成的关节表面。 此外,骨骼上的关节间隔物的制造方法可以具有以下一个或多个步骤:A)将骨水泥施加到制备的骨上; B)将所述装置压在骨水泥上; 和C)从固化的骨水泥中分离设备。
    • 45. 发明授权
    • Coating method and coating device for medical implants
    • 用于医疗植入物的涂覆方法和涂覆装置
    • US08852669B2
    • 2014-10-07
    • US13666553
    • 2012-11-01
    • Heraeus Medical GmbH
    • Sebastian VogtEkaterini CopanakiSebastian Gaiser
    • B05C11/00B05D3/00B05D1/28B05C1/06B05D1/24
    • B05D1/28B05C1/06B05D1/24
    • Methods and devices coat, at least regions of, a medical implant, preferably of an artificial joint or a fixation for a joint. The method provides a medical implant, fills a device with a liquid having at least one pharmaceutically active substance, wherein the device has a compressed, at least over regions thereof, elastic, porous transfer means increases a volume of the transfer means, whereby the liquid is taken up at least partly into the pores of the transfer means, and transfers the liquid from the transfer means to a medical implant surface to be coated. The device coats, at least regions of, a medical implant, by means of the method, whereby the device has a compressed, at least over regions thereof, elastic, porous transfer means.
    • 方法和装置至少覆盖医疗植入物的区域,优选为人造关节或关节的固定。 所述方法提供医用植入物,用具有至少一种药物活性物质的液体填充装置,其中所述装置具有压缩的至少其上部区域的弹性多孔转移装置增加所述转移装置的体积,由此液体 至少部分地被吸收到转移装置的孔中,并将液体从转移装置转移到待涂覆的医用植入物表面。 该装置通过该方法涂覆医疗植入物的至少区域,由此该装置具有压缩的至少其上部的弹性多孔转移装置。
    • 48. 发明申请
    • Method and Device for Coating of a Medical Implant
    • 医疗植入物的涂覆方法和装置
    • US20140033970A1
    • 2014-02-06
    • US14048644
    • 2013-10-08
    • Heraeus Medical GmbH
    • Sebastian VogtHubert Buchner
    • A61L27/12
    • A61L27/12A61L27/306A61L27/32A61L2420/02B05D1/28C23C26/00
    • The invention relates to a method for coating of a medical implant that can be used to apply a calcium salt to the surface of a medical implant easily and without expensive coating equipment and little expenditure of time.Accordingly, a method is provided that includes (I) providing a medical implant that includes at least one surface to be coated; (ii) providing a body that includes at least one calcium salt with a Mohs hardness of no more than 5.5 on at least one of its surfaces; and (iii) rubbing said body having the calcium salt-containing surface onto the at least one medical implant surface to be coated in order to coat said surface of the medical implant with the at least one calcium salt.
    • 本发明涉及一种医用植入物的涂覆方法,该方法可用于将钙盐轻易应用于医用植入物的表面,并且不需要昂贵的涂层设备和少量的时间消耗。 因此,提供了一种方法,其包括(I)提供包括至少一个待涂覆表面的医用植入物; (ii)在其表面的至少一个上提供包含莫希硬度不超过5.5的至少一种钙盐的主体; 和(iii)将具有含钙盐表面的所述身体摩擦至待涂覆的至少一个医用植入物表面上,以便用所述至少一种钙盐涂覆医用植入物的所述表面。
    • 49. 发明授权
    • Medical system, pulling device and method for pulling an active substance chain
    • 医疗系统,拉动装置和拉动活性物质链的方法
    • US08613942B2
    • 2013-12-24
    • US12815463
    • 2010-06-15
    • Sebastian VogtHubert BuechnerHans Boesebeck
    • Sebastian VogtHubert BuechnerHans Boesebeck
    • A61F13/00
    • A61M37/00A61K9/0014A61K9/2072A61M37/0069
    • A medical system (10) is provided having a pulling device (20) and an active substance chain (50). The active substance chain (50) has at least two storage units (51) arranged like a chain, and at least one of the storage units (51) is loaded with a medicinal active substance. The pulling device (20) has a grip element (30) and a coupling element (40), and the coupling element (40) has at least one recess (41, 41′). In a free position (100) the active substance chain (50) is arranged separated from the pulling device (20), while in an inserted position (110) at least one of the storage units (51) is arranged form-fitting in a recess (41, 41′). The active substance chain (50) can be moved reversibly from the free position (100) into the inserted position (110).
    • 提供具有拉动装置(20)和活性物质链(50)的医疗系统(10)。 活性物质链(50)具有至少两个如链状排列的存储单元(51),至少一个存储单元(51)装载有药用活性物质。 牵引装置(20)具有抓握元件(30)和联接元件(40),并且联接元件(40)具有至少一个凹部(41,41')。 在自由位置(100)中,活性物质链(50)与牵引装置(20)分离设置,而在插入位置(110)中,至少一个存储单元(51)被布置成 凹部(41,41')。 活性物质链(50)可以从空闲位置(100)可逆地移动到插入位置(110)中。
    • 50. 发明授权
    • Cartridge system with compressed gas cartridge
    • 带有压缩气瓶的墨盒系统
    • US08608030B2
    • 2013-12-17
    • US13096156
    • 2011-04-28
    • Sebastian VogtHubert BüchnerTim Schnieber
    • Sebastian VogtHubert BüchnerTim Schnieber
    • B67D7/70
    • B05C17/00553B05B1/3026B05C17/0146B05C17/015
    • Cartridge systems for application of a material have at least one cartridge having cartridge walls, a cartridge head having at least one opening in the cartridge head, and a bracket arranged on the cartridge head. A valve is mounted in rotatable manner in the bracket and has at least one passage through the valve that is connected to an outlet opening of the valve. In a closed position, the valve closes the at least one opening of at least one cartridge in a sealed manner. The at least one passage of the valve is connected to the at least one opening when the valve is located in an open position such that the cartridge content is squeezable out of the at least one cartridge through the outlet opening, and further wherein the valve is configured to be transitioned from a closed position to an open position through a rotation of the valve about an axis of symmetry of the valve.
    • 用于施加材料的盒式系统具有至少一个具有盒壁的盒,具有盒头中的至少一个开口的盒头和布置在盒头上的支架。 阀以可旋转的方式安装在支架中,并且具有至少一个通过阀的通道,其连接到阀的出口开口。 在关闭位置,阀以密封方式关闭至少一个盒的至少一个开口。 当阀位于打开位置时,阀的至少一个通道连接到至少一个开口,使得盒内容物可通过出口开口挤压出至少一个盒,而且其中阀是 构造成通过所述阀围绕所述阀的对称轴的旋转而从关闭位置转换到打开位置。