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1. 发明申请

US20230033990A1 DEVICE AND METHOD FOR APPLYING A PHARMACEUTICAL FLUID 有权
公开(公告)号：US20230033990A1
公开(公告)日：2023-02-02
申请号：US17814385
申请日：2022-07-22
申请人： Heraeus Medical GmbH
发明人： Sebastian VOGT , Thomas KLUGE
IPC分类号： A61B1/015 , A61B1/018
摘要： A device and method for applying a pharmaceutical fluid comprising a hollow cylindrical body, which surrounds a channel that extends through the body from a proximal body end to a distal body end of the body, wherein an outer surface of the body has at least partially an external thread, and has a connecting element arranged at the proximal body end, via which a proximal channel end of the channel can be reversibly connected in terms of fluid conduction to a reservoir for the pharmaceutical fluid.

2. 发明申请

US20210361872A1 DEVICE AND METHOD FOR MIXING LIQUIDS 有权
公开(公告)号：US20210361872A1
公开(公告)日：2021-11-25
申请号：US17324702
申请日：2021-05-19
申请人： Heraeus Medical GmbH
发明人： Sebastian Vogt , Thomas Kluge
IPC分类号： A61M5/28 , A61M5/19 , A61B17/00
摘要： One aspect relates to a device for mixing two liquids including a tube having an open end, a main line connected to the tube in a liquid-permeable manner, a rubber-elastic body delimiting a line wall of the main line, at least one secondary line in the rubber-elastic body, wherein the at least one secondary line extends from at least one secondary opening up to the main line and opens via at least one mouth into the main line, a main connection for introducing a first liquid into the main line, at least one feed line for introducing a second liquid into the at least one secondary line, which is connected to the at least one secondary opening in a liquid-permeable manner. The at least one secondary line is closed in the rubber-elastic body without the action of a force and is hydraulically openable by a pressure being exerted on a second liquid fed to the at least one secondary line by an elastic deformation of the at least one rubber-elastic body. The open at least one secondary line closes without a pressure being exerted on the supplied second liquid by the restoring force of the elastically deformed rubber-elastic body.

3. 发明申请

US20210015493A1 ENGINE 有权
公开(公告)号：US20210015493A1
公开(公告)日：2021-01-21
申请号：US16931668
申请日：2020-07-17
申请人： Heraeus Medical GmbH
发明人： Sebastian Vogt , Thomas Kluge
IPC分类号： A61B17/16 , F04B53/10 , F04B53/14 , G05D16/04 , A61B17/14
摘要： One aspect relates to an engine including a working system, having a first piston-cylinder system, comprising a working piston and a working cylinder. The working piston divides the working cylinder into a first working cylinder portion and a second working cylinder portion, a valve system, having a first valve connection and a valve element. The valve system and the working system are connected in a gas conducting manner, the first valve connection can be connected to a negative pressure source, and the valve element is movably arranged in the valve system such that, in a first valve position, the valve element connects the first valve connection to the first working cylinder portion, and, in a second valve position, connects the first valve connection to the second working cylinder portion in a gas conducting manner. One aspect furthermore relates to a medical device having the engine and a method for treating a mammal.

4. 发明授权

US10729841B2 Femoral hip joint spacer with irrigation device 有权
公开(公告)号：US10729841B2
公开(公告)日：2020-08-04
申请号：US16356782
申请日：2019-03-18
申请人： Heraeus Medical GmbH
发明人： Sebastian Vogt , Thomas Kluge
IPC分类号： A61F2/36 , A61M3/02 , A61F2/46 , A61M39/10 , A61M39/24 , A61F2/30
摘要： A femoral hip joint spacer including a prosthesis body having a ball head with a sliding surface, a neck, a collar and a stem. A fastening area is arranged on the stem. The femoral hip joint spacer further has a first connector for feeding a medical irrigation liquid into the body, a second connector for draining the irrigation liquid from the body, and an irrigation liquid inlet opening. The first connector is connected in a liquid-conveying manner to the irrigation liquid inlet opening and an irrigation liquid outlet opening. The second connector is connected in a liquid-conveying manner to the irrigation liquid outlet opening, an irrigation liquid discharge opening and an irrigation liquid intake opening. The irrigation liquid discharge opening is connected inside the body to the irrigation liquid inlet opening and the irrigation liquid intake opening is connected inside the body to the irrigation liquid outlet opening.

5. 发明申请

US20200179023A1 DEVICE FOR MIXING A BONE CEMENT WITH HOLLOW SPACE FOR MONOMER TRANSFER 审中-公开
公开(公告)号：US20200179023A1
公开(公告)日：2020-06-11
申请号：US16705881
申请日：2019-12-06
申请人： Heraeus Medical GmbH
发明人： Sebastian Vogt , Thomas Kluge
IPC分类号： A61B17/88
摘要： One aspect relates to a device for the production of a bone cement dough from a monomer liquid and a cement powder comprising a cartridge with an internal space; a cartridge head with a dispensing opening; a conveying plunger that is supported in the internal space of the cartridge such that it is pushable in the direction of the dispensing opening; a dispensing plunger between the dispensing opening and the conveying plunger that is supported in the internal space of the cartridge such that it is pushable in the direction of the dispensing opening; a first hollow space, in which the cement powder is arranged; a second hollow space that is bordered by the dispensing plunger and the conveying plunger; a rear-side part of the internal space of the cartridge; and a conducting means that connects the second hollow space to the rear-side part of the internal space of the cartridge such as to bypass the conveying plunger and be permeable to the monomer liquid. The conducting means can be closed by the conveying plunger with respect to the second hollow space by shifting the conveying plunger in the direction of the dispensing plunger, and a feedthrough in the dispensing plunger that connects the first hollow space and the second hollow space such as to be permeable to the monomer liquid.

6. 发明授权

US10517661B2 Bone cement applicator with three-way valve for pressure relief 有权
公开(公告)号：US10517661B2
公开(公告)日：2019-12-31
申请号：US15656383
申请日：2017-07-21
申请人： Heraeus Medical Gmbh
发明人： Sebastian Vogt , Thomas Kluge
IPC分类号： A61B17/88 , A61L27/16 , A61L27/50 , B01F3/12 , B01F3/14 , B01F5/06 , B01F7/00 , B01F7/16 , B01F13/00 , B01F13/10 , B01F15/02
摘要： Bone cement applicators and methods for application of a bone cement dough, the applicators and methods comprise a tubular cartridge with an internal space, a dispensing plunger for expelling the starting components through an opening of the cartridge opposite from the dispensing plunger, wherein the dispensing plunger is mobile in longitudinal direction in the internal space of the cartridge. The applicators and methods further comprise a hose, an application opening, a three-way valve operable from outside and arranged or arrangeable in the hose or on a side of the hose facing the cartridge, and a collecting container arranged on the three-way valve. The three-way valve is designed and arranged or arrangeable in the applicator such that it, being in a first position, provides a fluid connection between the application opening and the opening of the cartridge and closes a feed-through to the collecting container and, being in a second position, provides a fluid connection between the application opening and the collecting container and closes a passage to the opening of the cartridge.

7. 发明授权

US10463413B2 Storage and mixing system for pasty cement components and method therefor 有权
公开(公告)号：US10463413B2
公开(公告)日：2019-11-05
申请号：US15460530
申请日：2017-03-16
申请人： Heraeus Medical GmbH
发明人： Sebastian Vogt , Thomas Kluge
IPC分类号： A61B17/58 , A61B17/60 , A61F2/00 , A61B17/88 , B01F3/10 , B01F15/02 , C08F120/18 , A61L27/16 , B05C17/005 , B01F5/06 , B01F13/00 , B05C17/01
摘要： Storage and mixing systems for pasty two-component polymethyl methacrylate bone cements comprise a tubular cartridge having a cylindrical inner chamber, a cartridge head, which closes one end of the tubular cartridge at the front side, a partition that is disposed axially in the cylindrical inner chamber of the cartridge. The partition divides the cylindrical inner chamber of the cartridge bounded by the cartridge head into two cavities that are spatially separated from one another, wherein a first pasty cement component is present in the first cavity and a second pasty cement component is present in the separate second cavity. The systems further comprising two dispensing plungers axially displaceable in the two cavities of the cartridge, wherein the dispensing plungers close the two cavities on the back side of the cavities situated opposite the cartridge head, a bending device for deforming the partition, wherein the bending device is axially movable in the cartridge and is disposed, or is to be disposed, behind the dispensing plungers, as seen from the cartridge head, wherein the bending device has a deflection surface that is inclined with respect to the axis of the cartridge and pushes the partition laterally in the direction of the inside wall of the cartridge when the bending device is pushed into the cartridge.

8. 发明申请

US20190314546A1 ANTIBIOTIC POLYMETHYLMETHACRYLATE BONE CEMENT 审中-公开
公开(公告)号：US20190314546A1
公开(公告)日：2019-10-17
申请号：US16432333
申请日：2019-06-05
申请人： HERAEUS MEDICAL GMBH
发明人： SEBASTIAN VOGT , SUSANN KLIMAS
IPC分类号： A61L24/06 , A61L24/00 , A61L27/54 , A61L27/16 , A61L27/50
摘要： An antibiotic polymethylmethacrylate bone cement that is composed of methylmethacrylate, at least one polymethylmethacrylate or a polymethylmethacrylate-copolymer, at least one polymerisation initiator, such as in radical initiator, at least one polymerisation accelerator, and at least one radiopaquer, whereby the components are present in a powdered component and a liquid monomer component or in two components that are pasty at room temperature. The polymethylmethacrylate bone cement comprises the cyclical lipopeptide, daptomycin, a pharmacologically tolerable salt of daptomycin, a solvate and/or a hydrate containing daptomycin and at least one calcium salt, which preferably comprises at least two different release profiles. The bone cement is useful in one-stage or two-stage septic revision surgery.

9. 发明授权

US10350327B2 Method and composition for sterilization of a polymerizable monomer 有权
公开(公告)号：US10350327B2
公开(公告)日：2019-07-16
申请号：US15231885
申请日：2016-08-09
申请人： Heraeus Medical GmbH
发明人： Sebastian Vogt
IPC分类号： D21H21/16 , A61L24/06 , A61L2/18 , A61L24/04 , A61L2/16 , C08F20/56 , C08L33/26
摘要： A methods and mixtures are provided for sterilization of a polymerizable monomer, in which the mixture contains at least the polymerizable monomer, a compound (a), and a compound (b). Compound (a) is selected from the group of compounds (a1), compounds (a2), and compounds (a3), wherein compounds (a1) are represented by general formula (I): wherein R1, R2, R3, and R4, independent of each other, represent a substituted alkyl residue, a non-substituted alkyl residue, a halogen, a nitro group, or a cyano group; compounds (a2) are selected from the group of dimers of compounds (a1); and compounds (a3) are selected from the group of dialkyldicarbonates. Compound (b) is selected from the group of water and alcohols.

10. 发明授权

US10307496B2 Method for sterilization of aqueous polysaccharide solutions and sterile aqueous polysaccharide solutions 有权
公开(公告)号：US10307496B2
公开(公告)日：2019-06-04
申请号：US15375666
申请日：2016-12-12
申请人： Heraeus Medical GmbH
发明人： Sebastian Vogt , Thomas Kluge
IPC分类号： A61L2/00 , A61K47/36 , A61K47/12 , A61K47/02 , C08L1/28 , C08L3/08 , C08L5/00 , C08L5/08 , C08B11/02 , C08B11/12 , C08B37/08
摘要： Sterilization method according to which an aqueous polysaccharide solution is stored in the presence of a lactone and a buffer system for a period of at least 24 hours, and a sterile polysaccharide solution produced in this way.

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