专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

41. 发明申请

US20130236416A1 SURFACE MODIFIED COLLOIDAL PARTICLES 审中-公开
标题翻译：表面改性胶体颗粒
公开(公告)号：US20130236416A1
公开(公告)日：2013-09-12
申请号：US13788568
申请日：2013-03-07
申请人： CLEMSON UNIVERSITY
发明人： Parul Rungta , Michael Daniele, JR. , Stephen H. Foulger , Ragini Jetty
IPC分类号： C08F138/00
CPC分类号： C08F138/00 , A61K41/0057 , A61K47/6933 , B82Y5/00 , B82Y30/00
摘要： The present invention generally relates to surface modified colloidal particles. The invention further relates to methods of preparing and methods of using the same.
摘要翻译：本发明一般涉及表面改性胶体颗粒。本发明还涉及制备方法及其使用方法。

42. 发明申请

US20130149723A1 Method of controlling insect pests in cotton 审中-公开
标题翻译：控制棉花害虫的方法
公开(公告)号：US20130149723A1
公开(公告)日：2013-06-13
申请号：US13507238
申请日：2012-06-14
申请人： Xi Wang , Feng Chen
发明人： Xi Wang , Feng Chen
IPC分类号： C07K17/10 , G01N33/68
CPC分类号： C07K17/10 , G01N33/5097 , G01N33/56966 , G01N33/6803 , G01N2333/415 , G01N2333/43552 , G01N2430/10 , Y10T428/2982
摘要： An assay system is provided in which gossypol is used as a biological marker to detect evolved resistance of insects to Bt cotton. Detection of gossypol using a monoclonal antibody ELISA-based protocol enables at risk populations of insects to be evaluated for evolved resistance to Bt present in a genetically modified cotton.The specificity of the monoclonal antibody to gossypol also enables the production of nanoparticles having a conjugated monoclonal antibody which retains the ability to selectively bind gossypol. Accordingly, nanoparticles can be provided with additional target ligands, such as antibodies, so as to specifically attach to tumors or cancer cells thereby delivering the gossypol to the target cells.
摘要翻译：提供了一种测定系统，其中使用棉酚作为生物标志物来检测昆虫对Bt棉的演变抗性。使用单克隆抗体检测棉酚基于ELISA的方案可使危险的昆虫种群被评估为在转基因棉花中存在的Bt的进化抗性。单克隆抗体对棉酚的特异性还能够生产具有共轭单克隆抗体的纳米颗粒，其保留选择性结合棉酚的能力。因此，可以向纳米颗粒提供额外的靶配体，例如抗体，以便特异性地附着于肿瘤或癌细胞，从而将棉酚递送至靶细胞。

43. 发明授权

US08100961B2 Elastin stabilization of connective tissue 有权
标题翻译：结缔组织弹性蛋白稳定
公开(公告)号：US08100961B2
公开(公告)日：2012-01-24
申请号：US12748849
申请日：2010-03-29
申请人： Narendra R. Vyavahare , Jason C. Isenburg , Dan T. Simionescu
发明人： Narendra R. Vyavahare , Jason C. Isenburg , Dan T. Simionescu
IPC分类号： A61F2/82 , C07H15/203 , A61M29/00
CPC分类号： A61K31/7024
摘要： A method and product are provided for the treatment of connective tissue weakened due to destruction of tissue architecture, and in particular due to elastin degradation. The treatment agents employ certain unique properties of phenolic compounds to develop a protocol for reducing elastin degradation, such as that occurring during aneurysm formation in vasculature. According to the invention, elastin can be stabilized in vivo and destruction of connective tissue, such as that leading to life-threatening aneurysms in vasculature, can be tempered or halted all together. The treatment agents can be delivered or administered acutely or chronically according to various delivery methods, including sustained release methods incorporating perivascular or endovascular patches, use of microsphere carriers, hydrogels, or osmotic pumps.
摘要翻译：提供了一种方法和产品，用于治疗由于组织结构破坏而变弱的结缔组织，特别是由于弹性蛋白降解。处理剂使用酚类化合物的某些独特性质来开发用于减少弹性蛋白降解的方案，例如在脉管系统中的动脉瘤形成期间发生的方案。根据本发明，弹性蛋白可以在体内稳定，并且结缔组织的破坏，例如导致脉管系统中危及生命的动脉瘤的结缔组织可以一起被调节或停止。根据各种递送方法，包括血管周围或血管内贴片的缓释方法，微球载体，水凝胶或渗透泵的使用，治疗剂可以急性或慢性递送或施用。

44. 发明申请

US20110049412A1 Fluorescent Carbon Nanoparticles 审中-公开
标题翻译：荧光碳纳米粒子
公开(公告)号：US20110049412A1
公开(公告)日：2011-03-03
申请号：US12941561
申请日：2010-11-08
申请人： Ya-Ping Sun
发明人： Ya-Ping Sun
IPC分类号： C09K11/08 , B32B5/16 , H01F1/00 , B82Y30/00
CPC分类号： C09K11/025 , C01B32/05 , C09K11/65 , G01N33/587 , Y10S977/70 , Y10S977/702 , Y10S977/703 , Y10S977/704 , Y10S977/705 , Y10S977/773 , Y10T428/2982 , Y10T428/2991 , Y10T428/2998
摘要： Disclosed are photoluminescent particles. The particles include a core nano-sized particle of carbon and a passivation agent bound to the surface of the nanoparticle. The passivation agent can be, for instance, a polymeric material. The passivation agent can also be derivatized for particular applications. For example, the photoluminescent carbon nanoparticles can be derivatized to recognize and bind to a target material, for instance a biologically active material, a pollutant, or a surface receptor on a tissue or cell surface, such as in a tagging or staining protocol.
摘要翻译：披露的是光致发光颗粒。颗粒包括核心纳米尺寸的碳颗粒和与纳米颗粒表面结合的钝化剂。钝化剂可以是例如聚合物材料。钝化剂也可以为特定应用衍生化。例如，可以将光致发光碳纳米颗粒衍生化以识别和结合目标材料，例如组织或细胞表面上的生物活性材料，污染物或表面受体，例如标记或染色方案。

45. 发明授权

US07754241B1 Macromonomer for preparation of a degradable hydrogel 失效
标题翻译：用于制备可降解水凝胶的大分子单体
公开(公告)号：US07754241B1
公开(公告)日：2010-07-13
申请号：US11271405
申请日：2005-11-10
申请人： Charles K. Webb , Naren R. Vyavahare
发明人： Charles K. Webb , Naren R. Vyavahare
IPC分类号： A61K9/14 , A61K9/00 , C12N11/08 , C12N11/04 , C07K17/04 , C07K17/08
CPC分类号： C12N5/0068 , A61K47/60 , A61L27/18 , A61L27/52 , A61L27/58 , Y10S530/815 , Y10S530/817 , C08L71/02
摘要： A degradable hydrogel and a method of making a degradable hydrogel is disclosed herein. The method comprises obtaining a hydrophilic polymer having at least two hydroxyl groups, reacting the hydrophilic polymer with a di-functional monomer comprised of an acid halide group and an alkyl halide group to form an intermediate having an ester bond and a terminal alkyl halide group, reacting the terminal alkyl halide group of the intermediate with a metallic salt of a vinyl acid monomer to form a macromonomer comprised of an ester, an alkyl group spacer, and a terminal vinyl group, and polymerizing the macromonomer to form a degradable hydrogel. A method is also disclosed for varying the degradation rate of the hydrogel as a function of the chemical composition of the alkyl group spacer in the terminal linkage of the macromonomer.
摘要翻译：本文公开了可降解水凝胶和制备可降解水凝胶的方法。该方法包括获得具有至少两个羟基的亲水性聚合物，使亲水性聚合物与由酰卤基团和烷基卤基团组成的二官能单体反应形成具有酯键和末端烷基卤基团的中间体，使中间体的末端烷基卤化物基团与乙烯基酸单体的金属盐反应形成由酯，烷基间隔基和末端乙烯基组成的大分子单体，并聚合大分子单体以形成可降解的水凝胶。还公开了改变水凝胶的降解速率的方法，其作为大分子单体的末端键中的烷基间隔基的化学组成的函数。

46. 发明授权

US07750071B2 Halogen containing-polymer nanocomposite compositions, methods, and products employing such compositions 失效
公开(公告)号：US07750071B2
公开(公告)日：2010-07-06
申请号：US11760861
申请日：2007-06-11
申请人： David Carroll , John Ballato , Stephen Foulger , Richard Czerw , Dennis Smith , Hiren Shah , Earl Wagener
发明人： David Carroll , John Ballato , Stephen Foulger , Richard Czerw , Dennis Smith , Hiren Shah , Earl Wagener
IPC分类号： C08K3/04
CPC分类号： C08J5/005 , B82Y15/00 , B82Y30/00 , C04B14/022 , C04B20/0008 , C04B20/008 , C04B26/08 , C08J2327/00 , C08K7/24 , Y10T428/30 , C04B14/026 , C04B2103/0046 , C04B14/04 , C04B14/10
摘要： The disclosure provides compositions prepared by combining nanomaterials with a halide-containing polymer, thereby forming a combined polymer matrix having dispersed nanomaterials within the matrix. The nanomaterials may be carbon-based nanotubes, in some applications. A halide-containing monomer is combined with nanotubes, and then polymerized in some compositions. In other applications, a halide-containing polymer is solution processed with nanotubes to form useful compositions in the invention. Also disclosed are probes for near field detection of radiation.

47. 发明授权

US07740763B2 Capillary-channeled polymeric fiber as solid phase extraction media 有权
标题翻译：毛细管通道聚合物纤维作为固相萃取介质
公开(公告)号：US07740763B2
公开(公告)日：2010-06-22
申请号：US11373900
申请日：2006-03-13
申请人： R. Kenneth Marcus , Philip J. Brown , Igor A. Luzinov , Yonnie S. Wu
发明人： R. Kenneth Marcus , Philip J. Brown , Igor A. Luzinov , Yonnie S. Wu
IPC分类号： B01D15/08
CPC分类号： G01N1/405 , B01D15/08 , B01D15/22 , B01J20/261 , B01J20/262 , B01J20/28004 , B01J20/28014 , B01J20/28023 , B01J20/28042 , B01J20/28095 , B01J20/285 , B01J2220/54 , B01J2220/62 , B01J2220/64 , B01J2220/82 , G01N30/6043 , G01N30/6078 , G01N30/6091 , G01N2030/009 , G01N2030/528 , G01N2035/103 , G01N2035/1053 , Y10T436/255
摘要： Solid phase extraction devices including a plurality of packed nominally aligned capillary-channeled polymeric fibers for use as stationary phase materials are disclosed. A plurality of fibers are packed together in a casing so as to provide good flow characteristics through the fibers and high surface area contact between a sample and the fibers. Different polymer compositions of the fibers permit the “chemical tuning” of the extraction process. The fibers can be physically or chemically derivatized to target specific analytes for separation from a test sample. Use of the fibers allows a wide range of liquid flow rates with very low backpressures. The fibers are easily packed into a micropipette tip or a conduit for use with a fluid flow device such as an aspirator or a pump. The devices can be used for isolation and pre-concentration of analytes from samples, for instance for proteins from buffer solutions or extraction of pollutants from remote locations.
摘要翻译：公开了包括用于固定相材料的多个包装名义上对准的毛细管通道聚合物纤维的固相萃取装置。多个纤维被包装在壳体中，以便通过纤维提供良好的流动特性并且在样品和纤维之间具有高的表面积接触。纤维的不同聚合物组成允许萃取过程的“化学调节”。纤维可以物理或化学衍生化，以靶向特定的分析物，以从测试样品中分离。纤维的使用允许具有非常低的背压的宽范围的液体流速。纤维容易地包装到微量移液器末端或与流体流动装置（例如吸气器或泵）一起使用的导管中。这些装置可用于从样品中分离和预浓缩分析物，例如来自缓冲溶液的蛋白质或从远程位置提取污染物。

48. 发明申请

US20090265795A1 Methods of Inhibiting Multiple Cytochrome P450 Genes with siRNA 有权
标题翻译：用siRNA抑制多种细胞色素P450基因的方法
公开(公告)号：US20090265795A1
公开(公告)日：2009-10-22
申请号：US12427791
申请日：2009-04-22
申请人： William S. Baldwin
发明人： William S. Baldwin
IPC分类号： A01K67/00 , C07H21/02 , C12N15/63 , C12N5/10 , C12Q1/68
CPC分类号： C12N15/1137 , A01K67/0275 , A01K2217/058 , A01K2227/105 , A01K2267/03 , C12N9/0077 , C12N2310/14
摘要： The present invention relates to siRNAs that are targeted to RNAs encoding two or more enzymes of a subfamily of cytochrome P450 (CYP) enzymes, along with vectors, cells, and kits comprising the siRNAs. The invention further relates to methods of decreasing expression of two or more CYP subfamily genes in a non-human animal, animals in which expression of two or more CYP subfamily genes has been decreased, and methods of using such animals to study the function of cytochrome P450 enzymes.
摘要翻译：本发明涉及靶向编码细胞色素P450（CYP）酶亚家族的两种或多种酶的RNA以及载体，细胞和包含siRNA的试剂盒的siRNA。本发明还涉及减少非人动物中两种或更多种CYP亚家族基因表达的方法，其中两种或更多种CYP亚族基因的表达降低的动物以及使用这些动物研究细胞色素的功能的方法 P450酶。

49. 发明授权

US07598751B2 Impedance-based arc fault determination device (IADD) and method 有权
标题翻译：基于阻抗的电弧故障确定装置（IADD）和方法
公开(公告)号：US07598751B2
公开(公告)日：2009-10-06
申请号：US11838831
申请日：2007-08-14
申请人： Edward Randolph Collins, Jr. , Timothy Lee Smith , Randall J. Emanuel
发明人： Edward Randolph Collins, Jr. , Timothy Lee Smith , Randall J. Emanuel
IPC分类号： G01R27/28 , H02H3/00
CPC分类号： G01R27/16 , G01R19/2513 , G01R31/025
摘要： Embodiments according to the present invention provide an Impedance-based Arc-Fault Determination Device (IADD) and method that, when attached to an electrical node on the power system and through observations on voltage, current and phase shift with a step load change, determine the effective Thevenin equivalent circuit or Norton equivalent circuit at the point of test. The device and method determine the expected bolted fault current at the test location of interest, which enables calculation of incident energy and the assignment of a flash-hazard risk category.
摘要翻译：根据本发明的实施例提供了一种基于阻抗的电弧故障确定装置（IADD）和方法，当其连接到电力系统上的电节点上时，并且通过对步进负载变化的电压，电流和相移进行观测，确定有效的戴维宁等效电路或诺顿等效电路在测试点。该装置和方法确定感兴趣的测试位置处的预期螺栓故障电流，这使得能够计算入射能量和分配闪电危险风险类别。

50. 发明申请

US20090215176A1 Differential Pressure Pump System 审中-公开
标题翻译：差压泵系统
公开(公告)号：US20090215176A1
公开(公告)日：2009-08-27
申请号：US12392146
申请日：2009-02-25
申请人： David E. Orr
发明人： David E. Orr
IPC分类号： C12N5/06 , C12M1/00
CPC分类号： C12M41/40 , C12M23/34 , C12M29/12
摘要： The present disclosure is directed to a fluid pumping mechanism that uses differential pressure to drive flow through one or more culture chambers. Fluid contained within a first chamber can be caused to flow through one or more culture chambers and thence to a second chamber upon establishment of a pressure differential between the two chambers. The differential pressure system can induce either steady state or pulsatile flow through a culture chamber. In one embodiment, a culture chamber can be held at a high or low pressure hydrostatic state through utilization of the disclosed systems.
摘要翻译：本公开涉及使用差压来驱动流过一个或多个培养室的流体泵送机构。容纳在第一室内的流体可以在两个室之间建立压力差时，使其流过一个或多个培养室，从而进入第二室。差压系统可以诱导通过培养室的稳态或脉动流。在一个实施例中，通过利用所公开的系统，可以将培养室保持在高压或低压静水压状态。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式