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31. 发明授权

US08883210B1 Tissue-derived tissuegenic implants, and methods of fabricating and using same 有权
公开(公告)号：US08883210B1
公开(公告)日：2014-11-11
申请号：US13108856
申请日：2011-05-16
申请人： Katherine Gomes Truncale , Arthur A. Gertzman , Yen-Chen Huang , Eric Semler , Evangelia Chnari , Anouska Dasgupta , Judith Yannariello-Brown , Terri Riley
发明人： Katherine Gomes Truncale , Arthur A. Gertzman , Yen-Chen Huang , Eric Semler , Evangelia Chnari , Anouska Dasgupta , Judith Yannariello-Brown , Terri Riley
IPC分类号： A61K9/14 , A01N1/02 , A01N1/00 , C12N5/077 , C12N5/073 , A61K35/32
CPC分类号： C12N5/0654 , A61K35/32 , A61K38/1825 , A61K38/1841 , A61K38/19 , C12N5/0605 , C12N5/0653 , C12N5/0667 , C12N5/0668 , C12N2501/155 , C12N2533/90 , A61K2300/00
摘要： The disclosure provides implants containing a plurality of particles containing at least one population of viable tissuegenic cells adherent to and resident in the growth-conductive matrix or at least viable population of tissuegenic cells caused to be in contact with the growth-conductive matrix; methods to fabricate implants; methods of fabricating the implants; and use of the implants in tissue repair.

32. 发明授权

US08828448B2 Decellularisation of tissue matrices for bladder implantation 有权
标题翻译：膀胱移植组织基质的脱细胞化
公开(公告)号：US08828448B2
公开(公告)日：2014-09-09
申请号：US12295190
申请日：2007-03-28
申请人： Sotirios Korossis , Eileen Ingham , Fiona Bolland , Jennifer Southgate
发明人： Sotirios Korossis , Eileen Ingham , Fiona Bolland , Jennifer Southgate
IPC分类号： A61K35/22 , A01N1/00
CPC分类号： A61K35/22 , A61F2/042 , A61L27/3604 , A61L27/3679 , A61L27/3687 , A61L27/38 , A61L2430/00 , A61L2430/22 , A61L2430/40 , C12N5/0068 , C12N5/0605 , C12N2509/00 , C12N2533/92 , G01N33/5088
摘要： The invention provides an improved method of producing a natural, acellular matrix scaffold for subsequent use in tissue-engineered replacement of tissues such as the bladder. Decellularization is carried out on an expanded or distended bladder and the product retains the strength and compliance of natural material. The invention also provides use of the matrix scaffolds as wound healing material and to investigate tissue structure and function in vitro.
摘要翻译：本发明提供了一种生产天然的无细胞基质支架的改进方法，用于随后用于组织工程化替代诸如膀胱的组织。脱细胞化在膨胀或膨胀的膀胱上进行，产品保持天然材料的强度和顺应性。本发明还提供了基质支架作为伤口愈合材料的用途，并且在体外研究组织结构和功能。

33. 发明授权

US08802361B2 Composition and method for the restoration and preservation of transplant organs procured from DCD donors 有权
标题翻译：从DCD供体采购的移植器官的恢复和保存的组成和方法
公开(公告)号：US08802361B2
公开(公告)日：2014-08-12
申请号：US13155608
申请日：2011-06-08
申请人： Charles Y. Lee , Mark G. Clemens , Jian X. Zhang , Shailendra Jain
发明人： Charles Y. Lee , Mark G. Clemens , Jian X. Zhang , Shailendra Jain
IPC分类号： A01N1/00
CPC分类号： A01N1/02 , A01N1/0226
摘要： The present invention provides a perfusion solution comprising specific metabolic agents, antioxidant agents, and membrane stabilizer agents that can help improve preservation, organ viability, and in some cases recover organs that would otherwise being unusable for transplantation. In a further embodiment, the perfusion solution can be used in combination with hypothermic machine perfusion. It has been found that combination of the perfusion solution and hypothermic machine perfusion can help prevent or reduce further damage to the organ and restore the organ's anti-oxidant system, stabilize the cellular cytoskeleton and cellular membranes, inhibit arachidonic acid pathway, provide oncotic support, reduce interstitial edema formation, and help restore energy stores within the organ. As a result, the method can be used to improve the viability of otherwise marginal donor organs.
摘要翻译：本发明提供了包含特异性代谢剂，抗氧化剂和膜稳定剂的灌注溶液，所述代谢剂，抗氧化剂和膜稳定剂可以帮助改善保存，器官活力，并且在某些情况下可以回收否则不能用于移植的器官。在另一个实施方案中，灌注溶液可以与低温机器灌注组合使用。已经发现灌注溶液和低温机器灌注的组合可以有助于预防或减少对器官的进一步损伤并恢复器官的抗氧化系统，稳定细胞细胞骨架和细胞膜，抑制花生四烯酸途径，提供花药支持，减少间质性水肿形成，并帮助恢复器官内的能量储存。因此，该方法可用于改善否则边缘供体器官的生存力。

34. 发明授权

US08790874B2 Device for investigation of a flow conduit 有权
标题翻译：流量调节装置
公开(公告)号：US08790874B2
公开(公告)日：2014-07-29
申请号：US12999943
申请日：2009-06-17
申请人： Axel Guenther , Steffen-Sebastian Bolz
发明人： Axel Guenther , Steffen-Sebastian Bolz
IPC分类号： C12Q1/68 , A01N1/00
CPC分类号： G01N33/4833 , A61F2/06 , A61F2/062 , G01N33/5088
摘要： A device for investigation of a flow conduit comprising: a base; and a module formed in the base, the module comprising: a main channel for the flow conduit, the main channel having a loading inlet for loading the flow conduit; a culture chamber in the main channel for at least one of perfusion and superfusion of the flow conduit; at least two fixation lines in communication with the main channel for providing fixation of the flow conduit at at least two fixation locations along the length of the flow conduit.
摘要翻译：一种用于调查流动管道的装置，包括：基座; 以及形成在所述基座中的模块，所述模块包括：用于所述流动管道的主通道，所述主通道具有用于装载所述流动管道的加载入口; 在主通道中的用于流动管道的灌注和灌注中的至少一个的培养室; 与主通道连通的至少两条固定线，用于在沿着流动管道的长度的至少两个固定位置处提供流动导管的固定。

35. 发明授权

US08785116B2 Methods for evaluating the suitability of an organ for transplant 有权
标题翻译：评估移植器官适宜性的方法
公开(公告)号：US08785116B2
公开(公告)日：2014-07-22
申请号：US13572332
申请日：2012-08-10
申请人： Lisa Maria Anderson , Jared Alden Judson
发明人： Lisa Maria Anderson , Jared Alden Judson
IPC分类号： A01N1/00
CPC分类号： A01N1/021 , A01N1/0247 , G01N33/483 , G01N33/487 , G06F19/00 , G06Q10/08 , G06Q50/22
摘要： Methods of determining the health of an organ, such as a transplant organ, by measuring the ex-situ oxygen consumption rate of the organ. Systems for preserving and transporting organs while monitoring viability by measuring oxygen consumption rates.
摘要翻译：通过测量器官的非原位氧气消耗率来测定器官如移植器官的健康的方法。通过测量氧气消耗率来监测生命力的保存和运输器官的系统。

36. 发明授权

US08771931B2 Perfusion culture method and perfusion culture device for organ or tissue 有权
标题翻译：灌注培养法和器官或组织灌注培养装置
公开(公告)号：US08771931B2
公开(公告)日：2014-07-08
申请号：US13574855
申请日：2011-01-25
申请人： Takashi Tsuji , Kazuhisa Nakao
发明人： Takashi Tsuji , Kazuhisa Nakao
IPC分类号： A01N1/00
CPC分类号： A01N1/0247 , C12M21/08 , C12M29/10
摘要： Disclosed are a perfusion culture method and a perfusion culture device whereby a perfusate can be delivered to all parts of an organ or tissue so that the organ or tissue can be preserved while sufficiently maintaining the function thereof. Specifically disclosed is a method for perfusion culture of an organ or tissue removed from a mammal, said organ or tissue having been removed together with a second organ or tissue connected to the aforesaid organ or tissue in vivo, which comprises a step for fixing said second organ or tissue so as to hang the aforesaid organ or tissue and a step for perfusing blood vessels in the aforesaid organ or tissue with a perfusate.
摘要翻译：公开了一种灌注培养方法和灌注培养装置，其中灌注液可以递送到器官或组织的所有部分，使得可以在充分保持其功能的同时保存器官或组织。具体公开了一种用于从哺乳动物，所述器官或组织移除的器官或组织的灌注培养的方法，所述器官或组织与连接到所述前述器官或组织的体内的第二器官或组织一起被去除，其包括用于固定所述第二器官或组织，以悬挂上述器官或组织，以及用灌注液灌注前述器官或组织中的血管的步骤。

37. 发明授权

US08765467B2 Multicellular compositions of pluripotent human embryonic stem cells and cancer cells 失效
标题翻译：多能人胚胎干细胞和癌细胞的多细胞组合物
公开(公告)号：US08765467B2
公开(公告)日：2014-07-01
申请号：US10555537
申请日：2004-05-05
申请人： Karl L. Skorecki , Maty Tzukerman
发明人： Karl L. Skorecki , Maty Tzukerman
IPC分类号： A01N1/00 , C12N5/00 , C12N5/07
CPC分类号： G01N33/5011 , A61K49/0008 , C12N5/0606 , C12N5/0693 , C12N2501/115 , C12N2502/02 , G01N33/57492 , G01N2500/10
摘要： Methods are provided for producing novel multicellular compositions comprising cancer cells together with pluripotent human stem cells, which are capable of proliferating and differentiating into various normal cell lines and tissue structures. These novel multicellular compositions are useful for investigating the properties of cancer cells in a normal human tissue microenvironment, and for studying interventions that will modulate these properties including devising, testing and screening therapeutic drugs.
摘要翻译：提供了用于生产新型多细胞组合物的方法，其包含癌细胞以及能够增殖和分化成各种正常细胞系和组织结构的多能人干细胞。这些新颖的多细胞组合物可用于研究正常人组织微环境中癌细胞的性质，并用于研究将调节这些性质的干预，包括设计，测试和筛选治疗药物。

38. 发明授权

US08741555B2 Apparatus and method for perfusion and determining the viability of an organ 有权
标题翻译：用于灌注和确定器官活力的装置和方法
公开(公告)号：US08741555B2
公开(公告)日：2014-06-03
申请号：US10845154
申请日：2004-05-14
申请人： John Brassil , Simona Baicu
发明人： John Brassil , Simona Baicu
IPC分类号： A01N1/00 , A01N1/02
CPC分类号： A61B5/14525 , A01N1/02 , A01N1/0247 , A61B5/413
摘要： An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. During the period in which the organ is preserved and/or maintained, the organ may be additionally be perfused to obtain data regarding the fluid and/or organ. The data may then be used to ultimately provide information regarding the perfusion efficacy and allow for altering of the perfusion parameters.
摘要翻译：器官灌注装置和方法监测，维持和/或恢复器官的活力并保存器官用于储存和/或运输。其他装置包括器官输送器，器官盒和器官诊断装置。该方法包括在低温和/或正常体温温度下灌注器官，优选在用于器官运输和/或储存的低温器官冲洗之后。该方法可以在先前或随后的器官的静态或灌注低温暴露下进行。在保存和/或保持器官的期间，可以另外灌注器官以获得关于流体和/或器官的数据。然后可以使用数据来最终提供关于灌注功效的信息并允许改变灌注参数。

39. 发明授权

US08722403B2 Specimen preservation chamber and method 有权
标题翻译：样品保存室和方法
公开(公告)号：US08722403B2
公开(公告)日：2014-05-13
申请号：US13353914
申请日：2012-01-19
申请人： Sanjay S. Kumar
发明人： Sanjay S. Kumar
IPC分类号： A01N1/00
CPC分类号： A01N1/0252 , A01N1/0263 , A61B10/0096
摘要： The present invention comprises a specimen preserver. A bubble reservoir is used to hold a preserving liquid such as artificial cerebrospinal liquid (aCSF). Oxygen is introduced into the aCSF by a gas diffuser which is attached to the bubble reservoir. The tissue samples are contained in one or more chambers in a holding platform. The platform is suspended well above the bottom of the bubble reservoir. The lower portion of each of the chambers is open toward the bottom of the bubble reservoir, but is covered by a fine mesh. The gas introduced into the aCSF circulates within the bubble reservoir. However, the tissue samples are not directly exposed to the gas bubbles because the fine mesh excludes the bubbles from the chambers in which the tissue samples are housed.
摘要翻译：本发明包括样品保存器。使用气泡储存器容纳诸如人造脑脊液（aCSF）的保存液体。氧气通过连接到气泡储存器的气体扩散器引入到aCSF中。组织样品包含在保持平台中的一个或多个室中。平台悬浮在气泡储存器底部的上方。每个室的下部朝向气泡储存器的底部开口，但被细网覆盖。引入aCSF的气体在气泡储存器内循环。然而，组织样品不直接暴露于气泡，因为细网不排除来自容纳组织样本的腔室中的气泡。

40. 发明授权

US08685709B2 Fluidics based pulsatile perfusion preservation device and method 有权
标题翻译：基于流体的脉动灌注保存装置及方法
公开(公告)号：US08685709B2
公开(公告)日：2014-04-01
申请号：US12890348
申请日：2010-09-24
申请人： Leonid Bunegin , Edward F. Gelineau
发明人： Leonid Bunegin , Edward F. Gelineau
IPC分类号： A01N1/00 , A01N1/02
CPC分类号： A01N1/0247
摘要： In one embodiment, a preservation apparatus is described that includes a storage compartment. The storage compartment is configured to hold an organ or tissue and a preservation fluid. A cover assembly is configured to engage the storage compartment. The cover assembly includes a support element, wherein the support element together with the storage compartment define a storage chamber. The cover assembly also includes a lid and a gas permeable membrane disposed between the lid and the support element. The gas permeable membrane and the support element together define a perfusion chamber configured to hold preservation fluid and an organ or tissue during use.
摘要翻译：在一个实施例中，描述了包括存储隔间的保存装置。储存室构造成保持器官或组织和保存液体。盖组件构造成接合储藏室。所述盖组件包括支撑元件，其中所述支撑元件与所述储存室一起限定存储室。盖组件还包括盖和设置在盖和支撑元件之间的透气膜。气体可渗透膜和支撑元件一起限定了在使用期间构造成保持保存流体和器官或组织的灌注室。

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