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1. 发明授权

US08802361B2 Composition and method for the restoration and preservation of transplant organs procured from DCD donors 有权
标题翻译：从DCD供体采购的移植器官的恢复和保存的组成和方法
公开(公告)号：US08802361B2
公开(公告)日：2014-08-12
申请号：US13155608
申请日：2011-06-08
申请人： Charles Y. Lee , Mark G. Clemens , Jian X. Zhang , Shailendra Jain
发明人： Charles Y. Lee , Mark G. Clemens , Jian X. Zhang , Shailendra Jain
IPC分类号： A01N1/00
CPC分类号： A01N1/02 , A01N1/0226
摘要： The present invention provides a perfusion solution comprising specific metabolic agents, antioxidant agents, and membrane stabilizer agents that can help improve preservation, organ viability, and in some cases recover organs that would otherwise being unusable for transplantation. In a further embodiment, the perfusion solution can be used in combination with hypothermic machine perfusion. It has been found that combination of the perfusion solution and hypothermic machine perfusion can help prevent or reduce further damage to the organ and restore the organ's anti-oxidant system, stabilize the cellular cytoskeleton and cellular membranes, inhibit arachidonic acid pathway, provide oncotic support, reduce interstitial edema formation, and help restore energy stores within the organ. As a result, the method can be used to improve the viability of otherwise marginal donor organs.
摘要翻译：本发明提供了包含特异性代谢剂，抗氧化剂和膜稳定剂的灌注溶液，所述代谢剂，抗氧化剂和膜稳定剂可以帮助改善保存，器官活力，并且在某些情况下可以回收否则不能用于移植的器官。在另一个实施方案中，灌注溶液可以与低温机器灌注组合使用。已经发现灌注溶液和低温机器灌注的组合可以有助于预防或减少对器官的进一步损伤并恢复器官的抗氧化系统，稳定细胞细胞骨架和细胞膜，抑制花生四烯酸途径，提供花药支持，减少间质性水肿形成，并帮助恢复器官内的能量储存。因此，该方法可用于改善否则边缘供体器官的生存力。

2. 发明申请

US20110236875A1 Composition and Method for the Restoration and Preservation of Transplant Organs Procured From DCD Donors 有权
标题翻译：从DCD捐赠者采购的移植器官的恢复和保存的组成和方法
公开(公告)号：US20110236875A1
公开(公告)日：2011-09-29
申请号：US13155608
申请日：2011-06-08
申请人： Charles Y. Lee , Mark G. Clemens , Jian X. Zhang , Shailendra Jain
发明人： Charles Y. Lee , Mark G. Clemens , Jian X. Zhang , Shailendra Jain
IPC分类号： A01N1/02
CPC分类号： A01N1/02 , A01N1/0226
摘要： The present invention provides a perfusion solution comprising specific metabolic agents, antioxidant agents, and membrane stabilizer agents that can help improve preservation, organ viability, and in some cases recover organs that would otherwise being unusable for transplantation. In a further embodiment, the perfusion solution can be used in combination with hypothermic machine perfusion. It has been found that combination of the perfusion solution and hypothermic machine perfusion can help prevent or reduce further damage to the organ and restore the organ's anti-oxidant system, stabilize the cellular cytoskeleton and cellular membranes, inhibit arachidonic acid pathway, provide oncotic support, reduce interstitial edema formation, and help restore energy stores within the organ. As a result, the method can be used to improve the viability of otherwise marginal donor organs.
摘要翻译：本发明提供了包含特异性代谢剂，抗氧化剂和膜稳定剂的灌注溶液，所述代谢剂，抗氧化剂和膜稳定剂可以帮助改善保存，器官活力，并且在某些情况下可以回收否则不能用于移植的器官。在另一个实施方案中，灌注溶液可以与低温机器灌注组合使用。已经发现灌注溶液和低温机器灌注的组合可以有助于预防或减少对器官的进一步损伤并恢复器官的抗氧化系统，稳定细胞细胞骨架和细胞膜，抑制花生四烯酸途径，提供花药支持，减少间质性水肿形成，并帮助恢复器官内的能量储存。因此，该方法可用于改善否则边缘供体器官的生存力。

3. 发明授权

US07977042B2 Composition and method for the restoration and preservation of transplant organs procured from DCD donors 有权
标题翻译：从DCD供体采购的移植器官的恢复和保存的组成和方法
公开(公告)号：US07977042B2
公开(公告)日：2011-07-12
申请号：US11460261
申请日：2006-07-27
申请人： Charles Y. Lee , Mark G. Clemens , Jian X. Zhang , Shailendra Jain
发明人： Charles Y. Lee , Mark G. Clemens , Jian X. Zhang , Shailendra Jain
IPC分类号： A01N1/00
CPC分类号： A01N1/02 , A01N1/0226
摘要： The present invention provides a perfusion solution comprising specific metabolic agents, antioxidant agents, and membrane stabilizer agents that can help improve preservation, organ viability, and in some cases recover organs that would otherwise being unusable for transplantation. In a further embodiment, the perfusion solution can be used in combination with hypothermic machine perfusion. It has been found that combination of the perfusion solution and hypothermic machine perfusion can help prevent or reduce further damage to the organ and restore the organ's anti-oxidant system, stabilize the cellular cytoskeleton and cellular membranes, inhibit arachidonic acid pathway, provide oncotic support, reduce interstitial edema formation, and help restore energy stores within the organ. As a result, the method can be used to improve the viability of otherwise marginal donor organs.
摘要翻译：本发明提供了包含特异性代谢剂，抗氧化剂和膜稳定剂的灌注溶液，所述代谢剂，抗氧化剂和膜稳定剂可以帮助改善保存，器官活力，并且在某些情况下可以回收否则不能用于移植的器官。在另一个实施方案中，灌注溶液可以与低温机器灌注组合使用。已经发现灌注溶液和低温机器灌注的组合可以有助于预防或减少对器官的进一步损伤并恢复器官的抗氧化系统，稳定细胞细胞骨架和细胞膜，抑制花生四烯酸途径，提供花药支持，减少间质性水肿形成，并帮助恢复器官内的能量储存。因此，该方法可用于改善否则边缘供体器官的生存力。

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