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31. 发明授权

US4754018A Antibiotic prepared from lysobacter sp. SC 14,067 and analogs thereof 失效
标题翻译：溶解细菌制备的抗生素 SC 14,067及其类似物
公开(公告)号：US4754018A
公开(公告)日：1988-06-28
申请号：US23425
申请日：1987-03-09
申请人： Adrienne A. Tymiak , Donald R. Kirsch , Joseph O'Sullivan , John E. McCullough
发明人： Adrienne A. Tymiak , Donald R. Kirsch , Joseph O'Sullivan , John E. McCullough
IPC分类号： C07G11/00 , A61K35/74 , A61P31/04 , C12P1/04 , C12R1/01 , C07K5/12
CPC分类号： C12P1/04 , Y10S930/19
摘要： A novel antibiotic substance EM5587 is prepared by cultivation of a strain of the microorganism Lysobacter sp. SC 14,067, A.T.C.C. No. 53042. Chemical analogs of EM5587 are prepared by chemical synthesis.
摘要翻译：通过培养微生物溶菌杆菌属菌株制备新型抗生素物质EM5587。 SC 14,067，A.T.C.C. 号53042.通过化学合成制备EM5587的化学类似物。

32. 发明授权

US4684644A Basic monocarboxyamide derivatives of actagardine having antibiotic activity and compositions thereof 失效
标题翻译：具有抗生素活性的卡那定的基本单羧酰胺衍生物及其组合物
公开(公告)号：US4684644A
公开(公告)日：1987-08-04
申请号：US842523
申请日：1986-03-21
申请人： Adriano Malabarba , Bruno Cavalleri
发明人： Adriano Malabarba , Bruno Cavalleri
IPC分类号： C07G11/00 , A61K35/74 , A61P31/04 , C12P1/06 , A61K35/00 , C07D295/14
CPC分类号： C12P1/06
摘要： The present invention is directed to a class of basic monocarboxyamide derivatives of actagardine. Actagardine (INN) is an antibiotic substance produced by actinoplanes strains such as Actinoplanes Sp. ATCC 31048 and Actinoplanes Sp. ATCC 31049 which are described in U.S. Pat. No. 4,022,884. Actagardine shows antimicrobial in vitro and in vivo activity against gram-positive organisms. Its complete chemical structure is not yet known but there is only information on its chemical functions and main fragments. In particular, it has been found that actagardine has two carboxylic functions and a primary amino function and can therefore be represented as follows: ##STR1## The compounds of the invention are monoamide derivatives at one of the carboxy functions of actagardine. More particularly, they are basic monoamide derivatives of actagardine which may be schematically represented by the following formula I: ##STR2## The compound of the invention possess improved antimicrobial activity in particular against gram positive bacteria.
摘要翻译：本发明涉及一类基本的单加酰胺酰胺衍生物。放线菌肽（INN）是一种抗生素，由Actinoplanes Sp。 ATCC 31048和Actinoplanes Sp。 ATCC 31049，其描述于美国专利No. 第4,022,884号。阿卡加丁显示抗革兰氏阳性生物的体外和体内活性。其完整的化学结构尚不清楚，但只有其化学功能和主要碎片的信息。特别地，已经发现，阿格达加胺具有两个羧基官能团和伯氨基官能团，因此可以表示如下：本发明的化合物是在加马丁的羧基官能团之一的单酰胺衍生物。更具体地说，它们是阿加豆苷的碱性单酰胺衍生物，其可以由下式I示意性地表示：式I本发明的化合物具有改善的抗菌活性，特别是抗革兰氏阳性细菌。

33. 发明授权

US4612285A Novel antitumor antibiotic awamycin and its production 失效
标题翻译：新型抗肿瘤抗生素awamycin及其生产
公开(公告)号：US4612285A
公开(公告)日：1986-09-16
申请号：US545369
申请日：1983-10-25
申请人： Iwao Umezawa , Kanki Komiyama
发明人： Iwao Umezawa , Kanki Komiyama
IPC分类号： C07G11/00 , A61K35/74 , A61P35/00 , C12P1/06 , C12R1/465 , C12P13/00 , A61K35/00
CPC分类号： C12P1/06 , Y10S435/886
摘要： A novel antibiotic, awamycin, and its production. Awamycin is active against gram positive bacteria and exhibits growth inhibitory activity against Erhlich ascites and Sarcoma 180 cells. Some of the identifying characteristics of awamycin include a molecular weight of 744.+-.1 (mass spectrum analysis), an elementary analysis of 59.16% C, 6.48% H and 1.88% N; a melting point of 158.degree. C.; an optical rotation of [.alpha.].sub.D 24=+836.degree.. Awamycin is an acidic substance, which provides an orange colored powder, and is poorly soluble in water.
摘要翻译：一种新型抗生素，awamycin及其生产。 Awamycin对革兰氏阳性细菌具有活性，对Erhlich腹水和肉瘤180细胞具有生长抑制活性。 Awamycin的一些识别特征包括分子量为744 +/- 1（质谱分析），元素分析为59.16％C，6.48％H和1.88％N; 熔点158℃。 αD24 = + 836°的旋光度。 Awamycin是一种酸性物质，其提供橙色粉末，并且难溶于水。

34. 发明授权

US4563442A Glycopeptide bioconversion products 失效
标题翻译：糖肽生物转化产物
公开(公告)号：US4563442A
公开(公告)日：1986-01-07
申请号：US653259
申请日：1984-09-24
申请人： Gladys M. Clem , LaVerne D. Boeck , Marie T. Anderson , Karl H. Michel
发明人： Gladys M. Clem , LaVerne D. Boeck , Marie T. Anderson , Karl H. Michel
IPC分类号： C07G11/00 , A23K20/195 , A61K38/00 , A61P31/04 , C07K9/00 , C07K14/195 , C07K14/41 , C12P19/60 , C12P21/04 , C12R1/045 , A61K37/00 , A61K35/00
CPC分类号： C12R1/045 , A23K20/195 , C07K9/008 , Y10S930/19 , Y10S930/27
摘要： New glycopeptide antibiotics of the formula: ##STR1## wherein W is the remaining portion of a glycopeptide antibiotic selected from actaplanin factors B.sub.1, B.sub.2, B.sub.3, C.sub.1, C.sub.2, C.sub.3, D.sub.1, D.sub.2, E.sub.1, G, K, L, M, N, O and actaplanin .psi.aglycone, and salts thereof, particularly the pharmaceutically acceptable salts, are useful new antibiotics are active against gram-positive bacteria and increase feed-efficiency utilization and enhance milk production in ruminants.
摘要翻译：新型糖肽抗生素，其结构式如下：其中W是选自actaplanin因子B1，B2，B3，C1，C2，C3，D1，D2，E1，G，K，L，M的糖肽抗生素的剩余部分， N，O和actaplanin psi糖苷配基及其盐，特别是其药学上可接受的盐是有用的新型抗生素对革兰氏阳性细菌具有活性，并增加饲料效率的利用并提高反刍动物中的牛奶生产。

35. 发明授权

US4554162A CL-1724 Antibiotic compounds, their production and use 失效
标题翻译： CL-1724抗生素，其生产和使用
公开(公告)号：US4554162A
公开(公告)日：1985-11-19
申请号：US607056
申请日：1984-05-04
申请人： Cynthia A. Young , John P. Schaumberg , Gerard C. Hokanson , James C. French , Josefino B. Tunac
发明人： Cynthia A. Young , John P. Schaumberg , Gerard C. Hokanson , James C. French , Josefino B. Tunac
IPC分类号： C07G11/00 , A61K35/74 , A61P31/04 , A61P35/00 , C07H11/00 , C12P1/06 , C12R1/03
CPC分类号： C07H11/00 , C12P1/06
摘要： A strain of actinomycete, NRRL 15758, is capable of producing the CL-1724 complex of compounds under conditions of aerobic fermentation in the presence of assimilable sources of carbon and nitrogen. The compound CL-1724B-2 exhibiting antimicrobial and antitumor activity, is claimed together with pharmaceutical compositions and methods of treating microbial infections and tumors in mammals employing these pharmaceutical compositions.
摘要翻译：放线菌菌株NRRL 15758能够在需氧发酵的条件下在可同化的碳源和氮源的情况下生产化合物的CL-1724复合物。表现出抗微生物和抗肿瘤活性的化合物CL-1724B-2与使用这些药物组合物的哺乳动物中治疗微生物感染和肿瘤的药物组合物和方法一起是要求的。

36. 发明授权

US4552867A Antibiotic LL-BO1208.alpha. and LL-BO1208.beta., process of preparation, pharmaceutical composition and method of use 失效
标题翻译：抗生素LL-BO1208α和LL-BO1208β，制备方法，药物组合物和使用方法
公开(公告)号：US4552867A
公开(公告)日：1985-11-12
申请号：US510694
申请日：1983-07-05
申请人： John H. E. J. Martin , Jane P. Kirby , Donald B. Borders , Amedeo A. Fantini , Raymond T. Testa
发明人： John H. E. J. Martin , Jane P. Kirby , Donald B. Borders , Amedeo A. Fantini , Raymond T. Testa
IPC分类号： C12N1/20 , A61K35/74 , A61P31/04 , A61P35/00 , C07G11/00 , C07K9/00 , C12P1/06 , C12P19/58 , C12R1/625 , A61K37/02 , A61K31/71 , C12P19/12 , C12P21/02
CPC分类号： C12R1/625 , C07K9/003 , C12P1/06 , C12P19/58 , Y10S930/19
摘要： This invention relates to two new antibacterial and anti-tumor agents designated LL-BO1208.alpha. and LL-BO1208.beta. produced during microbiological fermentation, under controlled conditions, using the novel microorganism Streptoverticillium stramineum and mutants thereof.
摘要翻译：本发明涉及在微生物发酵期间，在受控条件下，使用新型微生物Streptoverticillium stramineum及其突变体的两种新的抗菌和抗肿瘤药物，称为LL-BO1208α和LL-BO1208β。

37. 发明授权

US4533547A Antiviral antibiotic substance AM-2722 and process for production thereof 失效
标题翻译：抗病毒抗生素AM-2722及其生产方法
公开(公告)号：US4533547A
公开(公告)日：1985-08-06
申请号：US262242
申请日：1981-05-11
申请人： Satoshi Omura , Akira Nakagawa , Hiroshi Hashimoto , Yasuhiko Kojima , Yuzuru Iwai , Ruiko Oiwa , Atsushi Hirano
发明人： Satoshi Omura , Akira Nakagawa , Hiroshi Hashimoto , Yasuhiko Kojima , Yuzuru Iwai , Ruiko Oiwa , Atsushi Hirano
IPC分类号： C07G11/00 , A61K35/74 , A61P31/12 , C12P1/06 , C12R1/465
CPC分类号： C12R1/465 , C12P1/06
摘要： A novel antiviral antibiotic AM-2722 is described represented by the molecular formula C.sub.19 H.sub.26 NO.sub.3 Cl, and having the following physicochemical properties:(1) specific rotary power: [.alpha.].sub.D.sup.20 -0.5 (C-1, chloroform);(2) the UV spectrum shown in FIG. 1; and(3) the IR spectrum shown in FIG. 2.Also described is a process for producing the antiviral antibiotic AM-2722, wherein a microorganism of Streptomyces which has the ability to produce the antibiotic AM-2722 is cultured aerobically in a nutrient medium and the antibiotic AM-2722 accumulated in the medium and the microorganism cells is recovered.
摘要翻译：描述了由分子式C 19 H 26 NO 3 Cl表示的新型抗病毒抗生素AM-2722，并且具有以下物理化学性质：（1）比旋光度：αD20-0.5（C-1，氯仿）; （2）图1所示的紫外光谱。 1; 和（3）图1所示的IR光谱。还描述了生产抗病毒抗生素AM-2722的方法，其中具有生产抗生素AM-2722能力的链霉菌微生物在营养培养基中有氧培养，抗生素AM-2722积累在培养基中，回收微生物细胞。

38. 发明授权

US4503152A Process for preparing antibiotic AM-2604-A 失效
标题翻译：制备抗生素AM-2604-A的方法
公开(公告)号：US4503152A
公开(公告)日：1985-03-05
申请号：US459912
申请日：1983-01-21
申请人： Satoshi Omura , Hideki Shimizu
发明人： Satoshi Omura , Hideki Shimizu
IPC分类号： C07G11/00 , A61K35/74 , A61P31/04 , A61P31/12 , C07D407/06 , C07H13/04 , C12P1/06 , C12P17/16 , C12P19/44 , C12R1/465
CPC分类号： C07D407/06 , C07H13/04 , C12P17/162 , C12P19/44 , C12R1/465 , Y10S435/886
摘要： An antibiotic substance designated as AM-2604-A is described, and is obtained by cultivating an antibiotic AM-2604-A substance-producing strain belonging to the genus Streptomyces in a nutrient medium and recovering the desired substance from the culture broth.
摘要翻译：描述了称为AM-2604-A的抗生素物质，并且通过在营养培养基中培养属于链霉菌属的抗生素AM-2604-A物质生产菌株并从培养液中回收所需物质而获得。

39. 发明授权

US4476111A Antibiotic S/433 and process for its preparation 失效
标题翻译：抗生素S / 433及其制备方法
公开(公告)号：US4476111A
公开(公告)日：1984-10-09
申请号：US312486
申请日：1981-10-19
申请人： Carolina Coronelli , Angelo Borghi , Giorgio Pirali , Giovanni Mistrello
发明人： Carolina Coronelli , Angelo Borghi , Giorgio Pirali , Giovanni Mistrello
IPC分类号： C12N1/20 , A61K35/74 , A61P31/04 , A61P35/00 , C07G11/00 , C12P1/06 , C12R1/465 , A61K35/00
CPC分类号： C12R1/465 , C12P1/06
摘要： A new antibiotic, designated S/433, is disclosed which is produced in a microbiological fermentation under controlled conditions using a new strain of Streptomyces. This new antibiotic is active against gram-positive and gram-negative bacteria and is also active in inhibiting the growth of transplanted tumors.
摘要翻译：公开了一种名为S / 433的新抗生素，其在受控条件下使用新的链霉菌菌株在微生物发酵中产生。这种新的抗生素对革兰氏阳性和革兰氏阴性细菌具有活性，并且在抑制移植肿瘤生长中也是有活性的。

40. 发明授权

US4470927A Method of extracting the flavoring substances from the vanilla capsule 失效
标题翻译：从香草胶囊中提取调味物质的方法
公开(公告)号：US4470927A
公开(公告)日：1984-09-11
申请号：US416732
申请日：1982-09-10
申请人： Erwin Sch/u/ tz , Heinz-R/u/ diger Vollbrecht , Klaus Sandner , Theodor Sand , Peter M/u/ hlnickel
发明人： Erwin Sch/u/ tz , Heinz-R/u/ diger Vollbrecht , Klaus Sandner , Theodor Sand , Peter M/u/ hlnickel
IPC分类号： C11B9/00 , A23L27/10 , B01D11/02 , C11B9/02 , C07G11/00
CPC分类号： B01D11/0203 , A23L27/11
摘要： A process for recovering flavoring substances from the vanilla capsule with carbon dioxide under fluid conditions is described, which consists in performing the extraction at temperatures between 10.degree. and 30.degree. C. and pressures of 80 to 350 bar, and producing the separation of the extract at temperatures of 0.degree. to 30.degree. C. and pressures of 30 to 60 bar. In this manner it is possible by a one-step process to extract all of the flavoring substances of the vanilla capsule with the recovery of a highly concentrated vanilla flavoring, and to obtain a material which is considerably superior to the products obtained by conventional extraction with organic solvents.
摘要翻译：描述了在流体条件下用二氧化碳从香草胶囊中回收调味物质的方法，其包括在10℃至30℃的温度和80至350巴的压力下进行萃取，并产生萃取物的分离在0℃至30℃的温度和30至60巴的压力下进行。以这种方式，通过一步法可以通过回收高度浓缩的香草调味剂来提取香草胶囊的所有调味物质，并获得显着优于通过常规提取获得的产品的材料，有机溶剂。

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