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    • 36. 发明授权
    • Multi-dimensional gas chromatography chip with modulator
    • 具有调制器的多维气相色谱芯片
    • US08925368B2
    • 2015-01-06
    • US13717954
    • 2012-12-18
    • Sang-Goo KimSung-Min Lim
    • Sang-Goo KimSung-Min Lim
    • G01N30/02G01N30/46G01N30/60
    • G01N30/463G01N30/6095
    • Disclosed is a multi-dimensional gas chromatography chip with a modulator. The multi-dimensional gas chromatography chip includes a chip body including first to third substrates; first micro channel pattern parts including first micro channels; second micro channel pattern parts including second micro channels; a gas inlet to supply a mobile phase; a gas outlet to discharge the mobile phase; position alignment markers formed on one surface of the first substrate, both surfaces of the second substrates and one surface of the third substrate; a first stationary phase spin-coated between the first and second substrates and a second stationary phase spin-coated between the second and third substrates; and a modulator provided in a region serving as an inlet side of the first micro channel pattern parts as well as an outlet side of the second micro channel pattern parts.
    • 公开了一种具有调制器的多维气相色谱芯片。 该多维气相色谱芯片包括:第一至第三基板的芯片体; 第一微通道图形部分包括第一微通道; 第二微通道图案部件,包括第二微通道; 供应流动相的进气口; 气体出口排出流动相; 形成在第一基板的一个表面上的位置对准标记,第二基板的两个表面和第三基板的一个表面; 旋转涂覆在第一和第二基底之间的第一固定相和旋转涂覆在第二和第三基底之间的第二固定相; 以及设置在用作第一微通道图案部分的入口侧的区域中的调制器以及第二微通道图案部分的出口侧。
    • 40. 发明申请
    • METHOD FOR CLEANING MICROFLUIDIC DEVICE AND CLEANING LIQUID
    • 清洗微流体装置和清洗液的方法
    • US20140238444A1
    • 2014-08-28
    • US13778810
    • 2013-02-27
    • SHIMADZU CORPORATION
    • Akihiro Arai
    • C11D7/50
    • C11D7/5022B01L3/502753B08B3/04B08B3/08B08B9/00C11D7/265C11D7/28C11D7/34C11D7/5004C11D7/5013C11D11/0023G01N27/44791G01N30/6095
    • The present invention provides a cleaning method by which the performance of a microchip can be recovered and a cleaning liquid. A method for cleaning a microfluidic device comprising: cleaning a channel that is formed in the microfluidic device, has a surface having a polymer coating, and has been brought into contact with a sample containing nucleic acid and/or protein, by bringing the channel into contact with a cleaning liquid comprised only of an organic solvent having solubility in at least the same volume of water at 25° C., or a cleaning liquid containing 50 vol % or more of the organic solvent in a buffer solution. The method wherein the buffer solution has a pH of 8 to 10. The method wherein the buffer solution further contains 3 to 8M of a protein denaturant. The method wherein the buffer solution has a pH of 2 to 4.
    • 本发明提供一种能够回收微芯片性能的清洗方法和清洗液。 一种用于清洁微流体装置的方法,包括:清洁在微流体装置中形成的通道,具有聚合物涂层的表面,并且已经与含有核酸和/或蛋白质的样品接触,通过使通道进入 与仅在25℃下至少相同体积的水中溶解的有机溶剂的清洗液或在缓冲溶液中含有50体积%以上有机溶剂的清洗液接触。 其中缓冲溶液的pH为8〜10的方法,其中缓冲液还含有3〜8M的蛋白质变性剂。 缓冲溶液的pH为2〜4的方法。