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31. 发明授权

US06376197B1 Diagnosis of interstitial cystitis 有权
标题翻译：间质性膀胱炎诊断
公开(公告)号：US06376197B1
公开(公告)日：2002-04-23
申请号：US09576396
申请日：2000-05-22
申请人： Susan K. Keay , John W. Warren , Michael K. Hise
发明人： Susan K. Keay , John W. Warren , Michael K. Hise
IPC分类号： G01N3353
CPC分类号： G01N33/6893 , G01N33/74 , G01N2333/475 , G01N2333/485 , G01N2800/34 , G01N2800/348
摘要： Interstitial cystitis (IC) is a chronic bladder disease for which the exact etiology is unknown and for which there is no reliably effective treatment. However, it is known that the bladder epithelium is often abnormal in IC. We discovered that normal, adult, human bladder epithelial cells are inhibited from proliferating by an anti-proliferative factor (APF) present in IC urine specimens. Inhibited proliferation may cause epithelial abnormalities characteristic of IC such as ulcerations and multiple tears in the bladder epithelium. We further discovered that levels of heparin binding—epidermal growth factor-like growth factor (HB-EGF), a factor known be important for epithelial cell proliferation and wound healing in other tissues, are abnormally low in the urine of patients suffering from IC as compared to asymptomatic controls or patients with acute bacterial cystitis. The invention herein is directed to the use of urine levels of HB-EGF as a diagnostic marker for IC.
摘要翻译：间质性膀胱炎（IC）是一种慢性膀胱疾病，其确切的病因是未知的，并且没有可靠的有效治疗。然而，已知膀胱上皮在IC中通常是异常的。我们发现正常，成人，人膀胱上皮细胞被IC尿液标本中存在的抗增殖因子（APF）抑制增殖。抑制性增殖可能导致IC的特征性上皮异常，如膀胱上皮中的溃疡和多发性泪液。我们进一步发现肝素结合表皮生长因子样生长因子（HB-EGF）的水平是已知对其他组织中的上皮细胞增殖和伤口愈合重要的因素，在IC患者的尿液中异常低与无症状对照或急性细菌性膀胱炎患者相比。本发明涉及使用HB-EGF的尿液水平作为IC的诊断标记物。

32. 发明授权

US5591595A Detection of complexes which include basement membrane components as diagnostic of cancer and other diseases 失效
标题翻译：检测包括基底膜组分在内的复合物，以诊断癌症和其他疾病
公开(公告)号：US5591595A
公开(公告)日：1997-01-07
申请号：US457285
申请日：1995-06-01
申请人： Morgan Van Aken , Stefan L. Paskell
发明人： Morgan Van Aken , Stefan L. Paskell
IPC分类号： C07K16/30 , G01N33/543 , G01N33/574 , G01N33/576 , G01N33/68 , G01N33/53
CPC分类号： C07K16/3038 , G01N33/54313 , G01N33/57415 , G01N33/57423 , G01N33/5743 , G01N33/57438 , G01N33/57488 , G01N33/576 , G01N33/6887 , G01N2800/34 , Y10S436/811 , Y10S436/813 , Y10S436/82
摘要： Isolated complexes (which include basement membrane components), antibodies to such complexes or polypeptide constituents thereof, and methods for detecting such complexes or constituents are disclosed. Detection of such complexes in a biological sample by immunological and non-immunological methods allows the diagnosis of a variety of diseases, including cancers, collagen degenerative diseases, and hepatitis. Suitable biological samples include urine, cervical secretions, bronchial aspirates, sputum, saliva, feces, serum, synovial fluid, and cerebrospinal fluid.
摘要翻译：公开了分离的复合物（其包括基底膜组分），这种复合物或其多肽组分的抗体，以及用于检测这些复合物或组分的方法。通过免疫学和非免疫学方法检测生物样品中的这种复合物允许诊断各种疾病，包括癌症，胶原退行性疾病和肝炎。合适的生物样品包括尿液，宫颈分泌物，支气管抽吸物，痰液，唾液，粪便，血清，滑液和脑脊液。

33. 发明申请

US20170202916A1 METHODS OF USING PIGMENT EPITHELIUM DERIVED FACTOR (PEDF) FOR THE TREATMENT AND PREVENTION OF AGENT-INDUCED GONADAL OR UTERINE TOXICITY 审中-公开
公开(公告)号：US20170202916A1
公开(公告)日：2017-07-20
申请号：US15129007
申请日：2015-03-30
申请人： Ramot at Tel-Aviv University Ltd. , Mor Research Applications Ltd.
发明人： Ruth SHALGI , Dana CHUDERLAND , Hadas BAR-JOSEPH , Keren GOLDBERG , Irit BEN-AHARON , Salomon M. STEMMER
IPC分类号： A61K38/18 , C12N5/075 , G01N33/74 , A61K31/704 , A61K31/138
CPC分类号： A61K38/18 , A61K31/138 , A61K31/704 , C12N5/0609 , C12N2501/10 , G01N33/74 , G01N2333/475 , G01N2800/34 , G01N2800/36 , G01N2800/52 , G01N2800/709 , A61K2300/00
摘要： A method of treating or preventing gonadal or uterine toxicity induced by an agent in a subject is provided. Accordingly there is provided a method comprising administering to a subject a therapeutically effective amount of pigment epithelium-derived factor (PEDF), thereby treating or preventing the gonadal toxicity induced by the agent. Also provided is, a method comprising determining gonadal function in a subject; and administering to the subject a therapeutically effective amount of PEDF, thereby treating or preventing the gonadal toxicity induced by the agent. Also provided is a PEDF for use in the treatment or prevention of gonadal toxicity induced by an agent in a subject. Also provided are cell culture, a medium, a kit and method for improving oocyte quality ex-vivo.

34. 发明申请

US20160231332A1 Methods and Devices for Detecting Kidney Damage 审中-公开
标题翻译：检测肾损伤的方法和装置
公开(公告)号：US20160231332A1
公开(公告)日：2016-08-11
申请号：US15014993
申请日：2016-02-03
申请人： Rules-Based Medicine, Inc.
发明人： Samuel T. LaBrie , James P. Mapes , Michael D. Spain , Ralph L. McDade , Dominic P. Eisinger , Karri L. Ballard
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N33/5302 , G01N33/566 , G01N2333/47 , G01N2333/4703 , G01N2333/4706 , G01N2333/4725 , G01N2333/4727 , G01N2333/475 , G01N2333/52 , G01N2333/70503 , G01N2333/70539 , G01N2333/765 , G01N2333/775 , G01N2333/8139 , G01N2333/8146 , G01N2333/82 , G01N2333/91177 , G01N2800/34 , G01N2800/347 , G01N2800/52 , G01N2800/56 , G01N2800/60 , Y10T436/147777
摘要： Methods and devices for diagnosing, monitoring, or determining kidney damage in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining kidney damage using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.
摘要翻译：描述了用于诊断，监测或确定哺乳动物肾损伤的方法和装置。具体地说，描述了从哺乳动物取得的测试样品中使用测量浓度的三种或更多种分析物的组合来诊断，监测或确定肾损伤的方法和装置。

35. 发明授权

US09205135B2 Podocyte pH modulation and uses thereof 有权
标题翻译： Podocyte pH调节及其用途
公开(公告)号：US09205135B2
公开(公告)日：2015-12-08
申请号：US13497451
申请日：2010-09-22
申请人： Jochen Reiser
发明人： Jochen Reiser
IPC分类号： A61K31/198 , A61K38/48 , G01N33/50
CPC分类号： A61K38/4873 , A61K31/198 , G01N33/5044 , G01N2800/34
摘要： Compositions are directed to the treatment of kidney diseases in a cell-specific manner. Methods of treating kidney diseases comprise the use of the compositions. Assays for identification of further compounds are provided. Biomarkers for predisposition to kidney diseases and diagnosis are indentified.
摘要翻译：组合物以细胞特异性方式用于治疗肾脏疾病。治疗肾脏疾病的方法包括使用该组合物。提供了用于鉴定其它化合物的试验。识别患有肾脏疾病和诊断倾向的生物标志物。

36. 发明申请

US20150153363A1 MARKERS OF THE MALE UROGENITAL TRACT 审中-公开
标题翻译：男性乌拉圭的标记
公开(公告)号：US20150153363A1
公开(公告)日：2015-06-04
申请号：US14618244
申请日：2015-02-10
申请人： Mount Sinai Hospital
发明人： Keith Jarvi , Eleftherios P. Diamandis , Andrei Drabovich
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/68 , G01N33/689 , G01N2333/705 , G01N2333/78 , G01N2800/34 , G01N2800/342 , G01N2800/367
摘要： Methods for detecting urogenital conditions or urogenital status in a subject are described comprising measuring urogenital markers or polynucleotides, encoding the markers in a sample from the subject. The invention also provides localization or imaging methods for urogenital conditions, and kits for carrying out the methods of the invention. The invention also contemplates therapeutic applications for urogenital conditions employing urogenital markers, polynucleotides encoding the markers, and/or binding agents for the markers.
摘要翻译：描述了用于检测受试者中泌尿生殖系统状况或泌尿生殖状况的方法，包括测量在受试者的样品中编码标记物的泌尿生殖标志物或多核苷酸。本发明还提供泌尿生殖条件的定位或成像方法，以及用于实施本发明方法的试剂盒。本发明还考虑了使用泌尿生殖标志物，编码标记物的多核苷酸和/或标记物的结合剂的泌尿生殖条件的治疗应用。

37. 发明授权

US08940286B2 Urate transporter, as well as method and kit for evaluating urate transport-related disease factor and inflammation-related disease factor, and test sample and drug 有权
标题翻译：尿酸转运蛋白，以及评估尿酸运输相关疾病因子和炎症相关疾病因子的方法和试剂盒，以及测试样品和药物
公开(公告)号：US08940286B2
公开(公告)日：2015-01-27
申请号：US13379346
申请日：2010-06-22
申请人： Hirotaka Matsuo , Nariyoshi Shinomiya , Takahiro Nakamura , Tappei Takada , Hiroshi Suzuki , Yuki Ikebuchi , Kousei Ito , Kimiyoshi Ichida
发明人： Hirotaka Matsuo , Nariyoshi Shinomiya , Takahiro Nakamura , Tappei Takada , Hiroshi Suzuki , Yuki Ikebuchi , Kousei Ito , Kimiyoshi Ichida
IPC分类号： A61K48/00 , A61K38/00 , C07K14/47 , C07K14/705 , G01N33/566 , G01N33/68
CPC分类号： C12Q1/6883 , A61K38/177 , C07K14/705 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , G01N33/566 , G01N33/6893 , G01N2800/24 , G01N2800/32 , G01N2800/34
摘要： A method and evaluation kit are provided, in which a high-capacity urate transporter is identified to assist in the early treatment and prevention of urate transport-related disease and inflammation-related disease. The method can include a step for detecting variations in genes that encode ABCG2 protein. When a subject has an SNP of V12M, R113X, Q126X, Q141K, F208S, G268R, E334X, S441N, L447V, S486N, F506SfsX4, R575X, and/or C608X, it can be concluded that the subject has a factor that is capable of inducing urate transport failure, or a state or disease attributable to that failure. When a subject has an SNP of V12M, it can be concluded that, unlike the other SNPs, there is a possibility that the subject does not possess such a factor because, although this variation itself does not lead to a change in urate transport capability, said variation is related to linkage disequilibrium with other SNPs.
摘要翻译：提供了一种方法和评价试剂盒，其中确定了高容量尿酸转运蛋白，以协助早期治疗和预防与尿酸运输有关的疾病和炎症相关疾病。该方法可以包括用于检测编码ABCG2蛋白的基因变异的步骤。当受试者具有V12M，R113X，Q126X，Q141K，F208S，G268R，E334X，S441N，L447V，S486N，F506SfsX4，R575X和/或C608X的SNP时，可以得出结论，受试者具有能够诱导尿酸盐运输失败，或归因于该失败的状态或疾病。当受试者具有V12M的SNP时，可以得出结论，与其他SNP不同，存在受试者不具有这样的因素的可能性，因为尽管该变化本身不会导致尿酸盐转运能力的变化，所述变异与其他SNP的连锁不平衡有关。

38. 发明申请

US20140303021A1 METHODS AND DEVICES FOR DETECTING OBSTRUCTIVE UROPATHY AND ASSOCIATED DISORDERS 审中-公开
标题翻译：用于检测阻塞性尿路狭窄和相关疾病的方法和装置
公开(公告)号：US20140303021A1
公开(公告)日：2014-10-09
申请号：US14243659
申请日：2014-04-02
申请人： Rules-Based Medicine, Inc.
发明人： Samuel T. LaBrie , James P. Mapes , Michael D. Spain , Ralph L. McDade , Dominic P. Eisinger , Karri L. Ballard
IPC分类号： G01N33/566 , G01N33/53
CPC分类号： G01N33/6893 , G01N33/5302 , G01N33/566 , G01N2333/47 , G01N2333/4703 , G01N2333/4706 , G01N2333/4725 , G01N2333/4727 , G01N2333/475 , G01N2333/52 , G01N2333/70503 , G01N2333/70539 , G01N2333/765 , G01N2333/775 , G01N2333/8139 , G01N2333/8146 , G01N2333/82 , G01N2333/91177 , G01N2800/34 , G01N2800/347 , G01N2800/52 , G01N2800/56 , G01N2800/60 , Y10T436/147777
摘要： Methods and devices for diagnosing, monitoring, or determining obstructive uropathy or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining obstructive uropathy or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.
摘要翻译：描述了用于诊断，监测或确定哺乳动物中的阻塞性尿病或相关疾病的方法和装置。具体地，描述了使用从哺乳动物取得的测试样品中测量浓度的三种或更多种分析物的组合来诊断，监测或确定阻塞性尿病或相关疾病的方法和装置。

39. 发明申请

US20140193835A1 CELL-BASED DETECTION OF APF THROUGH ITS INTERACTION WITH CKAP4 FOR DIAGNOSIS OF INTERSTITIAL CYSTITIS 有权
标题翻译：基于细胞的APF通过与CKAP4相互作用来诊断间质性CYSTITIS
公开(公告)号：US20140193835A1
公开(公告)日：2014-07-10
申请号：US13911242
申请日：2013-06-06
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. , THE COMMONWEALTH MEDICAL COLLEGE
发明人： David Alan ZACHARIAS , Sonia Lobo PLANEY
IPC分类号： G01N33/50
CPC分类号： G01N33/5091 , C07K9/005 , C07K14/705 , C12Q1/6897 , G01N33/6893 , G01N2333/4728 , G01N2800/34 , Y10T436/110833 , Y10T436/112499
摘要： An assay system designed to detect a protein biomarker in urine that is diagnostic for interstitial cystitis (IC). The presence of a 9 amino acid glycopeptide, antiproliferative factor (APF), in urine is unique to patients with IC. Urine samples from patients who exhibit symptoms consistent with IC are added to the assay system. Binding of APF to the cytoskeletal associated protein 4 (CKAP4) is positive for the presence of APF in urine and diagnostic for IC. The diagnostic system is a significant and surprising advance in diagnosis of IC and has commercial applications relevant to women and men who suffer from symptoms consistent with IC.
摘要翻译：一种设计用于检测尿液中蛋白质生物标志物的诊断系统，用于诊断间质性膀胱炎（IC）。在尿液中存在9个氨基酸的糖肽，抗增殖因子（APF）是独特的IC患者。将显示与IC一致的症状的患者的尿液样品加入到测定系统中。 APF与细胞骨架相关蛋白4（CKAP4）的结合对于尿液中APF的存在和IC的诊断是阳性的。该诊断系统在诊断IC方面是一个重要且令人惊讶的进步，并且具有与IC一致的症状相关的妇女和男性的商业应用。

40. 发明授权

US08735080B2 Methods and devices for detecting obstructive uropathy and associated disorders 有权
标题翻译：用于检测阻塞性病变和相关疾病的方法和装置
公开(公告)号：US08735080B2
公开(公告)日：2014-05-27
申请号：US12852236
申请日：2010-08-06
申请人： Samuel T. Labrie , James P. Mapes , Ralph L. McDade , Dominic Eisinger , Karri L. Ballard , Michael D. Spain
发明人： Samuel T. Labrie , James P. Mapes , Ralph L. McDade , Dominic Eisinger , Karri L. Ballard , Michael D. Spain
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N33/5302 , G01N33/566 , G01N2333/47 , G01N2333/4703 , G01N2333/4706 , G01N2333/4725 , G01N2333/4727 , G01N2333/475 , G01N2333/52 , G01N2333/70503 , G01N2333/70539 , G01N2333/765 , G01N2333/775 , G01N2333/8139 , G01N2333/8146 , G01N2333/82 , G01N2333/91177 , G01N2800/34 , G01N2800/347 , G01N2800/52 , G01N2800/56 , G01N2800/60 , Y10T436/147777
摘要： Methods and devices for diagnosing, monitoring, or determining obstructive uropathy or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing, monitoring, or determining obstructive uropathy or an associated disorder using measured concentrations of a combination of three or more analytes in a test sample taken from the mammal are described.
摘要翻译：描述了用于诊断，监测或确定哺乳动物中的阻塞性尿病或相关疾病的方法和装置。具体地，描述了使用从哺乳动物取得的测试样品中测量浓度的三种或更多种分析物的组合来诊断，监测或确定阻塞性尿病或相关疾病的方法和装置。

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