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31. 发明申请

US20130022596A1 METHODS AND COMPOSITIONS FOR DIAGNOSTIC USE IN CANCER PATIENTS 审中-公开
公开(公告)号：US20130022596A1
公开(公告)日：2013-01-24
申请号：US13630860
申请日：2012-09-28
申请人： F. Hoffmann-La Roche AG
发明人： Yibing Yan , Paul J. Fielder , Qun Jenny Wu
IPC分类号： C12Q1/68 , A61P35/00 , C40B30/04 , A61K39/395
CPC分类号： G01N33/74 , A61K39/39558 , C12Q1/6886 , G01N33/574 , G01N33/57415 , G01N2333/471 , G01N2333/475
摘要： Disclosed herein are methods and compositions useful for identifying therapies likely to confer optimal clinical benefit for patients with cancer.

32. 发明授权

US08182999B2 Compositions and methods for early pregnancy diagnosis 有权
标题翻译：早孕诊断的组成和方法
公开(公告)号：US08182999B2
公开(公告)日：2012-05-22
申请号：US12825223
申请日：2010-06-28
申请人： Robert Michael Roberts , Jonathan Andrew Green , Sancai Xie
发明人： Robert Michael Roberts , Jonathan Andrew Green , Sancai Xie
IPC分类号： G01N33/53
CPC分类号： G01N33/689 , C07K14/47 , G01N2333/471 , G01N2800/368 , Y10S435/973
摘要： Pregnancy-associated glycoproteins (PAGs) are structurally related to the pepsins, thought to be restricted to the hoofed (ungulate) mammals and characterized by being expressed specifically in the outer epithelial cell layer (chorion/trophectoderm) of the placenta. By cloning expressed genes from ovine and bovine placental cDNA libraries, the inventors estimate that cattle, sheep, and most probably all ruminant Artiodactyla, possess possibly 100 or more PAG genes, many of which are placentally expressed. The PAGs are highly diverse in sequence, with regions of hypervariability confined largely to surface-exposed loops. Selected PAG that are products of the invasive binucleate cells, expressed highly in early pregnancy at the time of trophoblast invasion and expressed weakly, if at all, in late gestation are useful in the early diagnosis of pregnancy. In a preferred embodiment, the invention relates to immunoassays for detecting these PAGs.
摘要翻译：妊娠相关糖蛋白（PAG）在结构上与胃蛋白酶相关，被认为限于蹄（有蹄类）的哺乳动物，其特征在于在胎盘的外上皮细胞层（绒毛膜/滋养外胚层）中特异性表达。通过克隆来自绵羊和牛胎盘cDNA文库的表达基因，本发明人估计，牛，绵羊和大多数所有反刍动物偶蹄类动物都具有100个或更多个PAG基因，其中许多是胎盘表达的。 PAG的序列高度多样化，高变区域主要局限于表面暴露的环路。选择的PAG是侵入性双核细胞的产物，在滋养层侵袭时早期表达高度表达，如果在妊娠晚期，在妊娠早期诊断中很有用。在优选的实施方案中，本发明涉及用于检测这些PAG的免疫测定。

33. 发明申请

US20110281268A1 CIRCULATING MICRORNA AS A MARKER FOR HEPATOCELLULAR CARCINOMA 有权
标题翻译：循环MICRORNA作为肝细胞癌的标记
公开(公告)号：US20110281268A1
公开(公告)日：2011-11-17
申请号：US13047659
申请日：2011-03-14
申请人： Kevin Qu , Ke Zhang , Maher Albitar
发明人： Kevin Qu , Ke Zhang , Maher Albitar
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/178 , G01N33/57438 , G01N2333/471
摘要： Provided herein are methods for the diagnosis, or management of liver diseases, e.g. hepatocellular carcinoma, using profiles of the miRNAs determined from cellular or acellular body fluids.
摘要翻译：本文提供了用于诊断或治疗肝脏疾病的方法，例如，肝细胞癌，使用从细胞或非细胞体液测定的miRNA的谱。

34. 发明申请

US20110246077A1 Methods and Apparatus for Screening for Chromosomal Abnormalities 失效
标题翻译：筛选染色体异常的方法和装置
公开(公告)号：US20110246077A1
公开(公告)日：2011-10-06
申请号：US12986534
申请日：2011-01-07
申请人： David Edmund Wright
发明人： David Edmund Wright
IPC分类号： G06F19/00
CPC分类号： G01N33/743 , G01N33/76 , G01N2333/471 , G01N2333/575 , G01N2800/387 , Y10S436/811 , Y10S436/814
摘要： This invention generally relates to methods, apparatus, and computer program code for antenatal screening for chromosomal abnormalities, in particular Down's Syndrome. A method of determining a likelihood of a fetus carried by a pregnant mother having a chromosomal abnormality, a first biological, parameter being suitable for screening said fetus for said chromosomal abnormality, the method comprising: receiving first data from a first stage of pregnancy of said mother, said first data comprising data representing a first value of said first biological parameter; receiving second data from a second, later stage of said pregnancy, said second data comprising data representing a second value of said first biological parameter; and determining likelihood data from said first and second data, said likelihood data representing the likelihood of said fetus having a chromosomal abnormality.
摘要翻译：本发明一般涉及用于染色体异常的产前筛查的方法，装置和计算机程序代码，特别是唐氏综合征。一种确定由具有染色体异常的怀孕母亲携带的胎儿的可能性的方法，第一生物学参数适合于筛选所述胎儿用于所述染色体异常，所述方法包括：从所述第一阶段怀孕所述第一数据所述第一数据包括表示所述第一生物参数的第一值的数据; 从所述怀孕的第二后期接收第二数据，所述第二数据包括表示所述第一生物参数的第二值的数据; 以及从所述第一和第二数据确定似然数据，所述似然数据表示所述胎儿具有染色体异常的可能性。

35. 发明申请

US20070185200A1 Screen for pre-eclampsia 审中-公开
标题翻译：筛查先兆子痫
公开(公告)号：US20070185200A1
公开(公告)日：2007-08-09
申请号：US10553462
申请日：2004-04-19
申请人： Makrina Savvidou , Aroon Hingorani , Patrick Vallance , Kypros Nicolaides
发明人： Makrina Savvidou , Aroon Hingorani , Patrick Vallance , Kypros Nicolaides
IPC分类号： A61K31/205 , G01N33/48
CPC分类号： A01K67/027 , A01K2217/075 , A01K2227/105 , A01K2267/03 , G01N33/689 , G01N2333/471 , G01N2800/368
摘要： It has been demonstrated that the level of asymmetric dimethylarginine (ADMA) increases in women that subsequently develop pre-eclampsia or whose fetus subsequently develops intrauterine growth restriction (IUGR) and that ADMA plays a key role in the development of maternal hypertension. Accordingly, the level of ADMA in a pregnant woman can be used to determine whether or not a pregnant woman is at risk of developing pre-eclampsia or whether or not a fetus is at risk of developing IUGR. Furthermore, antagonists of ADMA activity are useful in the inhibition or prevention of pre-eclampsia or inhibition or prevention of IUGR.
摘要翻译：已经证明，随后发展为先兆子痫或其胎儿随后发展子宫内生长受限（IUGR）的妇女中，不对称二甲基精氨酸（ADMA）的水平增加，并且ADMA在孕产妇高血压发展中起关键作用。因此，怀孕妇女的ADMA水平可用于确定孕妇是否有发展先兆子痫的风险，或胎儿是否有发展IUGR的风险。此外，ADMA活性的拮抗剂可用于抑制或预防先兆子痫或抑制或预防IUGR。

36. 发明申请

US20070015208A1 Multimarker panel for diabetes type 1 and 2 审中-公开
标题翻译：糖尿病1型和2型多标记面板
公开(公告)号：US20070015208A1
公开(公告)日：2007-01-18
申请号：US11371871
申请日：2006-03-09
申请人： Georg Hess , Andera Horsch , Werner Poppe
发明人： Georg Hess , Andera Horsch , Werner Poppe
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2333/471 , G01N2333/58 , G01N2333/70578 , G01N2800/32
摘要： The present invention relates to a method and means for diagnosing or risk stratification of co-morbidities, particularly cardiovascular complications in diabetes patients. The invention particularly relates to a method for diagnosing whether a diabetes patient is suffering from a cardiovascular complication or is at risk of suffering from a cardiovascular complication, said method comprising the steps of (a) measuring, preferably iii vitro, the level(s) of at least one cardiac hormone or a variant thereof in a sample from the patient, and (b) diagnosing the cardiovascular complication or the risk of suffering from cardiovascular complication by comparing the measured level(s) to known level(s) associated with the cardiovascular complication or risk. The present invention also relates to combining the measurement of markers comprising cardiac hormones, natriuretic peptides, inflammation-associated markers, angiogenesis markers, and markers for platelet activation. Preferred markers are brain natriuretic peptides (particularly NT-proBNP), PIGF, and sCD40L.
摘要翻译：本发明涉及用于诊断或风险分层的方法和手段，尤其是糖尿病患者的心血管并发症。本发明特别涉及用于诊断糖尿病患者是否患有心血管并发症或患有心血管并发症的风险的方法，所述方法包括以下步骤：（a）优选地在体外测量水平，的至少一种心脏激素或其变体，以及（b）通过将所测量的水平与已知水平相关联来诊断心血管并发症或患有心血管并发症的风险心血管并发症或风险。本发明还涉及将包含心脏激素，利尿钠肽，炎症相关标志物，血管生成标记物和用于血小板活化的标记物的标记物的测量结合在一起。优选的标记物是脑利钠肽（特别是NT-proBNP），PIGF和sCD40L。

37. 发明授权

US6111089A Trophinin, trophinin-assisting proteins and methods to inhibit implantation 失效
标题翻译：营养蛋白，营养蛋白辅助蛋白质和抑制植入的方法
公开(公告)号：US6111089A
公开(公告)日：2000-08-29
申请号：US808599
申请日：1997-02-28
申请人： Michiko N. Fukuda
发明人： Michiko N. Fukuda
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61K45/00 , A61P13/02 , A61P15/00 , C07K7/06 , C07K14/47 , C07K14/78 , C07K16/18 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/28 , C12P21/02 , C12Q1/68 , C12R1/91 , G01N33/574 , G01N33/68
CPC分类号： G01N33/689 , C07K14/4715 , C07K16/18 , G01N33/57484 , A61K2039/505 , A61K38/00 , C07K2319/00 , G01N2333/471 , G01N2800/36 , G01N2800/368
摘要： The present invention provides a method to prevent pregnancy in an individual by administering a trophinin vaccine, which can elicit an immune response in the individual administered the vaccine. The method utilizes mammalian trophinin and peptides derived thereof from human or mice. The method also utilizes a nucleic acid molecule encoding trophinin as the trophinin vaccine, which is expressed in the individual administered the vaccine. The nucleic acid molecule can further encode a trophinin-assisting protein that can be co-expressed with trophinin in the individual administered the vaccine. The invention also provides a method to prevent adhesion between a trophoblast cell and a uterine epithelial cell by administering a trophinin vaccine or peptides thereof. The invention further provides an adjuvant or a carrier protein to enhance the immune response to the trophinin vaccine. The invention also provides mammalian trophinin active fragments, antibodies to the fragments, nucleic acid molecules encoding the fragments and nucleic acid probes that can hybridize to the nucleic acid molecules.
摘要翻译：本发明提供一种通过施用能够在给予疫苗的个体中引发免疫应答的营养蛋白疫苗来预防个体怀孕的方法。该方法利用人或小鼠的哺乳动物营养蛋白及其衍生的肽。该方法还使用编码营养蛋白的核酸分子作为营养蛋白疫苗，其在给予疫苗的个体中表达。核酸分子可以进一步编码能够在施用疫苗的个体中与营养蛋白共同表达的营养蛋白辅助性蛋白质。本发明还提供了通过施用营养蛋白疫苗或其肽来防止滋养层细胞与子宫上皮细胞之间的粘附的方法。本发明还提供了一种佐剂或载体蛋白，以增强对营养蛋白疫苗的免疫应答。本发明还提供哺乳动物营养蛋白活性片段，片段抗体，编码可与核酸分子杂交的片段的核酸分子和核酸探针。

38. 发明申请

US20180180625A1 DETERMINING CANDIDATE FOR INDUCTION OF LABOR AND EFFECTIVENESS OF INDUCTION OF LABOR 审中-公开
公开(公告)号：US20180180625A1
公开(公告)日：2018-06-28
申请号：US15850813
申请日：2017-12-21
申请人： Parsagen Diagnostics, Inc.
发明人： Ruben Salinas , Anthony Ausiello
IPC分类号： G01N33/68 , G01N33/577
CPC分类号： G01N33/689 , A61B2010/0074 , G01N33/577 , G01N2333/471 , G01N2800/368
摘要： A method of determining suitability of a pregnant woman to be a candidate for induction of labor can include: obtaining a vaginal fluid sample from a pregnant woman; contacting the vaginal fluid sample with a PAMG-1 antibody that binds with PAMG-1; detecting whether the PAMG-1 antibody binds with PAMG-1 in the vaginal fluid sample to form a PAMG-1-antibody complex; and providing the determination of suitability for induction of labor to the pregnant woman. When the PAMG-1-antibody complex forms, the pregnant woman is determined to be in a condition that is not suitable for induction of labor because PAMG-1 is detected in the vaginal sample. When the PAMG-1-antibody complex does not form, the pregnant woman is determined to be in a condition that is suitable to be a candidate for induction of labor because the PAMG-1 is not detected in the vaginal sample.

39. 发明授权

US09983215B2 Methods and compositions for diagnosis of ectopic pregnancy 有权
公开(公告)号：US09983215B2
公开(公告)日：2018-05-29
申请号：US15386714
申请日：2016-12-21
申请人： THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人： David W. Speicher , Kurt T. Barnhart , Lynn A. Beer
IPC分类号： G01N33/53 , G01N33/68
CPC分类号： G01N33/6893 , C07K14/705 , G01N33/76 , G01N2333/471 , G01N2333/70503 , G01N2560/00 , G01N2800/368 , G01N2800/60
摘要： Methods and compositions are provided for diagnosing ectopic pregnancy in a mammalian subject by detecting changes in expression of the selected genes, gene fragments or transcripts or expression products, or changes in the expression levels of one or more of proteins or peptide fragments, identified in Table 2 and FIGS. 8 and 9 herein. A selected gene, gene transcript or protein/peptide expression product, or profiles or signatures formed by combinations of same, detected in a biological fluid, preferably sera, of a subject, enables comparison of the corresponding genes, proteins or profiles from that of a reference or control having a normal intrauterine pregnancy. Detection of characteristic changes in the gene profile or protein expression signature of the subject is correlated with a diagnosis of ectopic pregnancy. Various compositions for use in such diagnosis include PCR primer-probe sets or ligands, labeled or immobilized, which are capable of detecting the changes in expression or translation of these targets.

40. 发明授权

US09891233B2 Methods for predicting time-to-delivery in pregnant women 有权
公开(公告)号：US09891233B2
公开(公告)日：2018-02-13
申请号：US15186140
申请日：2016-06-17
申请人： N-Dia, Inc.
发明人： Anthony Ausiello , Ruben Salinas , Michael Thompson , Daniel J. Mackey , Kaitlyn Nardozzi , Michael Friedman
IPC分类号： G01N33/558 , G01N33/68 , C07K16/18 , A61B10/00
CPC分类号： G01N33/689 , A61B2010/0074 , C07K16/18 , G01N2333/471 , G01N2800/368 , G01N2800/50
摘要： The present disclosure relates to methods for predicting time-to-delivery in pregnant women. The methods include predicting that a pregnant woman will deliver within a predetermined time frame if PAMG-1 is determined to be present at a level above a predetermined detection threshold in a vaginal fluid sample obtained from the pregnant woman. Also provided are methods for determining a patient's risk of preterm labor and/or spontaneous rupture of the chorioamniotic membrane.

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