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1. 发明申请

US20070185200A1 Screen for pre-eclampsia 审中-公开
标题翻译：筛查先兆子痫
公开(公告)号：US20070185200A1
公开(公告)日：2007-08-09
申请号：US10553462
申请日：2004-04-19
申请人： Makrina Savvidou , Aroon Hingorani , Patrick Vallance , Kypros Nicolaides
发明人： Makrina Savvidou , Aroon Hingorani , Patrick Vallance , Kypros Nicolaides
IPC分类号： A61K31/205 , G01N33/48
CPC分类号： A01K67/027 , A01K2217/075 , A01K2227/105 , A01K2267/03 , G01N33/689 , G01N2333/471 , G01N2800/368
摘要： It has been demonstrated that the level of asymmetric dimethylarginine (ADMA) increases in women that subsequently develop pre-eclampsia or whose fetus subsequently develops intrauterine growth restriction (IUGR) and that ADMA plays a key role in the development of maternal hypertension. Accordingly, the level of ADMA in a pregnant woman can be used to determine whether or not a pregnant woman is at risk of developing pre-eclampsia or whether or not a fetus is at risk of developing IUGR. Furthermore, antagonists of ADMA activity are useful in the inhibition or prevention of pre-eclampsia or inhibition or prevention of IUGR.
摘要翻译：已经证明，随后发展为先兆子痫或其胎儿随后发展子宫内生长受限（IUGR）的妇女中，不对称二甲基精氨酸（ADMA）的水平增加，并且ADMA在孕产妇高血压发展中起关键作用。因此，怀孕妇女的ADMA水平可用于确定孕妇是否有发展先兆子痫的风险，或胎儿是否有发展IUGR的风险。此外，ADMA活性的拮抗剂可用于抑制或预防先兆子痫或抑制或预防IUGR。

2. 发明申请

US20100304412A1 METHODS FOR DETERMINING THE RISK OF PRENATAL COMPLICATIONS 有权
标题翻译：确定预期合并风险的方法
公开(公告)号：US20100304412A1
公开(公告)日：2010-12-02
申请号：US12864625
申请日：2009-01-26
申请人： Howard Cuckle , Kypros Nicolaides , Tarja Ahola , Leona Poon
发明人： Howard Cuckle , Kypros Nicolaides , Tarja Ahola , Leona Poon
IPC分类号： G01N33/53 , C40B40/10 , G06N5/02
CPC分类号： G01N33/689 , A61B5/021 , G01N33/6893 , G01N2333/471 , G01N2333/515 , G01N2800/368 , G01N2800/50 , G06F19/00 , G06Q50/24 , G16H50/30
摘要： The disclosure relates to methods, medical profiles, kits and apparatus for use in determining the risk that a pregnant individual has for developing pre-eclampsia based on amounts of certain biochemical markers in a biological sample from the individual and biophysical markers. The disclosure also relates to methods, medical profiles, kits and apparatus for use in determining the risk that a pregnant individual is carrying a fetus having a chromosomal abnormality based on amounts of certain biochemical markers in a biological sample from the individual and biophysical markers.
摘要翻译：本公开涉及用于确定怀孕个体基于来自个体和生物物理标记的生物样品中某些生物化学标记物的量来发展先兆子痫的风险的方法，医学概况，试剂盒和装置。本公开还涉及用于确定怀孕个体携带具有染色体异常的胎儿的风险的方法，医学概况，试剂盒和装置，其基于来自个体和生物物理标记的生物样品中某些生化标志物的量。

3. 发明申请

US20130344503A1 METHODS FOR DETERMINING THE RISK OF PRENATAL COMPLICATIONS 有权
标题翻译：确定预期合并风险的方法
公开(公告)号：US20130344503A1
公开(公告)日：2013-12-26
申请号：US13945143
申请日：2013-07-18
申请人： Kypros Nicolaides , PerkinElmer Health Sciences, Inc. , The Fetal Medicine Foundation , Wallac Oy
发明人： Howard Cuckle , Kypros Nicolaides , Tarja Ahola , Leona Poon
IPC分类号： G01N33/68 , G06Q50/24 , G06F19/00
CPC分类号： G01N33/689 , A61B5/021 , G01N33/6893 , G01N2333/471 , G01N2333/515 , G01N2800/368 , G01N2800/50 , G06F19/00 , G06Q50/24 , G16H50/30
摘要： The disclosure relates to methods, medical profiles, kits and apparatus for use in determining the risk that a pregnant individual has for developing pre-eclampsia based on amounts of certain biochemical markers in a biological sample from the individual and biophysical markers. The disclosure also relates to methods, medical profiles, kits and apparatus for use in determining the risk that a pregnant individual is carrying a fetus having a chromosomal abnormality based on amounts of certain biochemical markers in a biological sample from the individual and biophysical markers.
摘要翻译：本公开涉及用于确定怀孕个体基于来自个体和生物物理标记的生物样品中某些生物化学标记物的量来发展先兆子痫的风险的方法，医学概况，试剂盒和装置。本公开还涉及用于确定怀孕个体携带具有染色体异常的胎儿的风险的方法，医学概况，试剂盒和装置，其基于来自个体和生物物理标记的生物样品中某些生化标志物的量。

4. 发明授权

US09250251B2 Methods for determining maternal health risks 有权
标题翻译：确定孕产妇健康风险的方法
公开(公告)号：US09250251B2
公开(公告)日：2016-02-02
申请号：US13259883
申请日：2010-04-23
申请人： Kypros Nicolaides , Tarja Ahola
发明人： Kypros Nicolaides , Tarja Ahola
IPC分类号： G01N31/00 , G01N33/53 , G01N33/74
CPC分类号： G01N33/74 , G01N2333/475 , G01N2800/368
摘要： The present description relates to a method for determining the risk of a pregnant woman developing a hypertensive disorder, more specifically gestational hyper-tension or late onset preeclampsia. The present description provides methods useful for determining risk that a pregnant individual will develop a hypertensive disorder or condition of pregnancy, such as gestational hypertension, early preeclampsia, late preeclampsia and related disorders. Several useful combinations of biochemical markers and related clinical population studies are described herein. Additionally, it is proposed herein that certain sets of biochemical markers can be used to determine risk of multiple hypertensive disorders in a single screen. The biochemical markers are PlGF, Activin A and optionally P-Selectin.
摘要翻译：本描述涉及一种用于确定孕妇发展为高血压病症，特别是妊娠期高血压或迟发性先兆子痫的风险的方法。本描述提供了用于确定怀孕个体将发展为高血压病症或妊娠状况（诸如妊娠高血压，早期先兆子痫，晚期先兆子痫和相关疾病）的风险的方法。本文描述了生化标记物和相关临床群体研究的几种有用组合。此外，在本文中提出，可以使用某些组生化标志物来确定单个筛选中的多种高血压疾病的风险。生化标志物是PlGF，活化素A和任选的P-选择素。

5. 发明授权

US08647832B2 Methods for determining the risk of prenatal complications 有权
公开(公告)号：US08647832B2
公开(公告)日：2014-02-11
申请号：US12864625
申请日：2009-01-26
申请人： Howard Cuckle , Kypros Nicolaides , Tarja Ahola , Leona Poon
发明人： Howard Cuckle , Kypros Nicolaides , Tarja Ahola , Leona Poon
IPC分类号： G01N33/53 , G01N31/00
CPC分类号： G01N33/689 , A61B5/021 , G01N33/6893 , G01N2333/471 , G01N2333/515 , G01N2800/368 , G01N2800/50 , G06F19/00 , G06Q50/24 , G16H50/30
摘要： The disclosure relates to methods, medical profiles, kits and apparatus for use in determining the risk that a pregnant individual has for developing pre-eclampsia based on amounts of certain biochemical markers in a biological sample from the individual and biophysical markers. The disclosure also relates to methods, medical profiles, kits and apparatus for use in determining the risk that a pregnant individual is carrying a fetus having a chromosomal abnormality based on amounts of certain biochemical markers in a biological sample from the individual and biophysical markers.

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