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1. 发明申请

US20070015208A1 Multimarker panel for diabetes type 1 and 2 审中-公开
标题翻译：糖尿病1型和2型多标记面板
公开(公告)号：US20070015208A1
公开(公告)日：2007-01-18
申请号：US11371871
申请日：2006-03-09
申请人： Georg Hess , Andera Horsch , Werner Poppe
发明人： Georg Hess , Andera Horsch , Werner Poppe
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2333/471 , G01N2333/58 , G01N2333/70578 , G01N2800/32
摘要： The present invention relates to a method and means for diagnosing or risk stratification of co-morbidities, particularly cardiovascular complications in diabetes patients. The invention particularly relates to a method for diagnosing whether a diabetes patient is suffering from a cardiovascular complication or is at risk of suffering from a cardiovascular complication, said method comprising the steps of (a) measuring, preferably iii vitro, the level(s) of at least one cardiac hormone or a variant thereof in a sample from the patient, and (b) diagnosing the cardiovascular complication or the risk of suffering from cardiovascular complication by comparing the measured level(s) to known level(s) associated with the cardiovascular complication or risk. The present invention also relates to combining the measurement of markers comprising cardiac hormones, natriuretic peptides, inflammation-associated markers, angiogenesis markers, and markers for platelet activation. Preferred markers are brain natriuretic peptides (particularly NT-proBNP), PIGF, and sCD40L.
摘要翻译：本发明涉及用于诊断或风险分层的方法和手段，尤其是糖尿病患者的心血管并发症。本发明特别涉及用于诊断糖尿病患者是否患有心血管并发症或患有心血管并发症的风险的方法，所述方法包括以下步骤：（a）优选地在体外测量水平，的至少一种心脏激素或其变体，以及（b）通过将所测量的水平与已知水平相关联来诊断心血管并发症或患有心血管并发症的风险心血管并发症或风险。本发明还涉及将包含心脏激素，利尿钠肽，炎症相关标志物，血管生成标记物和用于血小板活化的标记物的标记物的测量结合在一起。优选的标记物是脑利钠肽（特别是NT-proBNP），PIGF和sCD40L。

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