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31. 发明授权

US08491571B2 Orifice device having multiple channels with varying flow rates for drug delivery 有权
标题翻译：具有用于药物递送的具有变化的流速的多个通道的孔口装置
公开(公告)号：US08491571B2
公开(公告)日：2013-07-23
申请号：US10855239
申请日：2004-05-27
申请人： Scott M. Russell
发明人： Scott M. Russell
IPC分类号： A61K9/22
CPC分类号： A61M5/16877 , A61K9/0004 , A61M5/1408 , A61M5/141 , A61M5/14276 , A61M5/14526 , A61M5/16804 , A61M5/16813 , A61M2005/14513 , F16K1/40 , F16K47/12
摘要： An orifice device for delivering one or more drugs includes an inner member having a proximal end and a distal end; and a winding helically wound around the inner member. The winding includes a plurality of distinct wires helically wound in parallel around the inner member. The winding and the inner member define at least three separate channels for carrying one or more drugs therethrough. An inlet is at the proximal end of the winding and an outlet is at the distal end of the winding for the plurality of distinct wires. In some embodiments, at least two of the plurality of distinct wires have a different dimension. An outer member is used over the winding. Also, at least two of the at least three separate channels have a different fluid flow rate. And, in some embodiments, at least two of the at least three separate channels carry a different drug.
摘要翻译：用于递送一种或多种药物的孔装置包括具有近端和远端的内部构件; 以及围绕内部构件螺旋缠绕的绕组。绕组包括围绕内部构件平行地螺旋缠绕的多个不同的线。绕组和内部构件限定至少三个单独的通道，用于携带一种或多种药物通过其中。入口位于绕组的近端，并且出口位于绕组的远端，用于多个不同的导线。在一些实施例中，多个不同导线中的至少两个具有不同的尺寸。在绕组上使用外部构件。此外，至少三个独立通道中的至少两个具有不同的流体流速。而且，在一些实施方案中，至少三个独立通道中的至少两个携带不同的药物。

32. 发明申请

US20130156608A1 ELECTROKINETIC PUMP DESIGNS AND DRUG DELIVERY SYSTEMS 审中-公开
标题翻译：电动泵设计和药物输送系统
公开(公告)号：US20130156608A1
公开(公告)日：2013-06-20
申请号：US13764568
申请日：2013-02-11
申请人： Deon Stafford ANEX , Charles Martin SCHWIMMER , David Laurence BLACK , Richard Dean RUSH , Michael James GEARHART
发明人： Deon Stafford ANEX , Charles Martin SCHWIMMER , David Laurence BLACK , Richard Dean RUSH , Michael James GEARHART
IPC分类号： F04B19/04
CPC分类号： F04B19/04 , A61M5/14526 , A61M2005/14513 , A61M2209/045 , F04B17/00 , F04B19/006 , Y10T137/0391
摘要： The present invention provides a fluid delivery system having a first chamber, a second chamber and a third chamber; a flow-through pump element separating the first chamber from the second chamber; a moveable pump element separating the second chamber from the third chamber; a first outlet in communication with the third chamber; and second outlet in communication with the second chamber. Additionally, the present invention provides methods of operating a fluid delivery system having a first chamber, a second chamber and a delivery chamber by reducing the volume of the second chamber while increasing the volume of the delivery chamber without operation of a flow-through pump element that separates the second chamber from the first chamber.
摘要翻译：本发明提供一种具有第一室，第二室和第三室的流体输送系统; 将所述第一腔室与所述第二腔室分离的流通泵元件; 将所述第二腔室与所述第三腔室分离的可移动泵元件; 与第三室通信的第一出口; 以及与第二室连通的第二出口。另外，本发明提供了通过减小第二腔室的体积来操作具有第一腔室，第二腔室和输送室的流体输送系统的方法，同时增加了输送室的体积，而没有流过泵元件其将第二腔室与第一腔室分离。

33. 发明申请

US20130030417A1 Rapid Establishment and/or Termination of Substantial Steady-State Drug Delivery 审中-公开
标题翻译：快速建立和/或终止实质性稳态药物递送
公开(公告)号：US20130030417A1
公开(公告)日：2013-01-31
申请号：US13645422
申请日：2012-10-04
申请人： Thomas R. Alessi , Kenneth L. Luskey
发明人： Thomas R. Alessi , Kenneth L. Luskey
IPC分类号： A61M5/168
CPC分类号： A61K9/0004 , A61F5/0013 , A61K9/0024 , A61K38/00 , A61K38/26 , A61L27/54 , A61M5/14276 , A61M2005/14513 , A61M2205/04
摘要： The present invention is directed to treatment methods for a disease or condition, in a subject in need of such treatment, that provide alternatives to treatment by injection that give, relative to treatment by injection, improved treatment outcomes, 100% treatment compliance, reduced side effects, and rapid establishment and/or termination of substantial steady-state drug delivery. The method typically includes providing continuous delivery of a drug from an implanted osmotic delivery device, wherein substantial steady-state delivery of the drug at therapeutic concentrations is typically achieved within about 7 days or less after implantation of the osmotic delivery device in the subject and the substantial steady-state delivery of the drug from the osmotic delivery device is continuous over a period of at least about 3 months. In one embodiment, the present invention is directed to treatment of type 2 diabetes mellitus using incretin mimetics.
摘要翻译：本发明涉及在需要这种治疗的受试者中的疾病或病症的治疗方法，其提供了通过注射治疗相对于注射治疗提供改善的治疗结果的替代方案，100％的治疗依从性，减少的一侧影响，快速建立和/或终止稳定的药物递送。该方法通常包括提供药物从植入的渗透递送装置的连续输送，其中药物在治疗浓度下的基本稳态递送通常在植入受试者中的渗透递送装置后约7天或更短时间内完成，来自渗透输送装置的药物的大量稳态递送在至少约3个月的时间内是连续的。在一个实施方案中，本发明涉及使用肠降血糖素模拟物治疗2型糖尿病。

34. 发明授权

US08349261B2 Acoustically controlled reaction device 有权
公开(公告)号：US08349261B2
公开(公告)日：2013-01-08
申请号：US12378472
申请日：2009-02-12
申请人： Leroy E. Hood , Muriel Y. Ishikawa , Edward K. Y. Jung , Robert Langer , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood
发明人： Leroy E. Hood , Muriel Y. Ishikawa , Edward K. Y. Jung , Robert Langer , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood
IPC分类号： B01J19/00
CPC分类号： A61M5/145 , A61M5/14276 , A61M5/172 , A61M5/1723 , A61M2005/14513 , A61M2205/0266 , A61M2205/0288 , A61M2205/3507 , A61M2205/3523 , A61M2205/3569 , A61M2205/36
摘要： Embodiments of a system including a remotely controlled reaction device and associated controller are described. Methods of use and control of the device are also disclosed. According to various embodiments, a reaction device is placed in an environment in order to perform a chemical reaction in an environment. Exemplary environments include a body of an organism, a body of water, or an enclosed volume of a fluid. In selected embodiments, an acoustic control signal may be used.

35. 发明授权

US08322993B2 Osmotic pump comprising a pressure device for pressurizing the solvent 失效
标题翻译：渗透泵包括用于对溶剂加压的压力装置
公开(公告)号：US08322993B2
公开(公告)日：2012-12-04
申请号：US12268325
申请日：2008-11-10
申请人： Helge Adleff , Thilo Philipp Guschauski
发明人： Helge Adleff , Thilo Philipp Guschauski
IPC分类号： C25B9/08 , F04F99/00 , H02K44/02
CPC分类号： A61M5/145 , A61K9/0004 , A61M5/16881 , A61M2005/14513
摘要： An osmotic pump comprises a first chamber (8) comprising an osmotically active substance (18), a second chamber (15) arranged to be filled with a solvent (17), and a semi-permeable barrier (14) separating the first chamber (8) from the second chamber (15). The semi-permeable barrier (14) is impermeable to the osmotic active substance and permeable to the solvent (17). The osmotic pump further comprises a pressure device (60) in fluid communication with the second chamber (15), wherein the pressure device (60) is arranged for pressurizing the solvent in the second chamber.
摘要翻译：渗透泵包括包含渗透活性物质（18）的第一室（8），布置成填充有溶剂（17）的第二室（15）和分离第一室的半渗透屏障（14） 8）从第二室（15）。半渗透屏障（14）对于渗透活性物质是不可渗透的并且可溶于溶剂（17）。所述渗透泵还包括与所述第二腔室（15）流体连通的压力装置（60），其中所述压力装置（60）设置用于对所述第二腔室中的溶剂进行加压。

36. 发明授权

US08202697B2 Medical device for analyte monitoring and drug delivery 有权
标题翻译：用于分析物监测和药物输送的医疗设备
公开(公告)号：US08202697B2
公开(公告)日：2012-06-19
申请号：US11202231
申请日：2005-08-12
申请人： Elizabeth A. Holmes
发明人： Elizabeth A. Holmes
IPC分类号： G01N33/53
CPC分类号： A61B5/073 , A61B5/0024 , A61B5/0031 , A61B5/1411 , A61B5/145 , A61B5/14514 , A61B5/14532 , A61B5/14542 , A61B5/14546 , A61B5/1455 , A61B5/14556 , A61B5/1473 , A61B5/1477 , A61B5/1486 , A61B5/150022 , A61B5/150221 , A61B5/150229 , A61B5/150251 , A61B5/150282 , A61B5/150343 , A61B5/150854 , A61B5/150862 , A61B5/15087 , A61B5/150969 , A61B5/150984 , A61B5/15107 , A61B5/15117 , A61B5/15119 , A61B5/15121 , A61B5/15123 , A61B5/15125 , A61B5/1519 , A61B5/157 , A61B5/417 , A61B5/4238 , A61B5/4839 , A61B5/4848 , A61B5/6833 , A61B5/685 , A61B5/6865 , A61B5/7282 , A61B2560/0412 , A61M5/14276 , A61M37/0015 , A61M2005/14513 , A61M2005/1726 , A61M2037/0023 , A61M2205/0244 , A61M2205/3569 , A61M2205/3592 , A61M2205/50 , B01L3/5027 , B01L3/502707 , B01L3/502761 , B01L3/502776 , B01L2200/10 , B01L2300/023 , B01L2300/024 , B01L2300/0636 , B01L2300/0654 , B01L2300/0816 , B01L2400/0406 , B01L2400/0415 , B01L2400/0472 , B01L2400/0487 , G01N2035/00158
摘要： The invention relates to an ingestible, implantable or wearable medical device comprising a microarray which comprises a bioactive agent capable of interacting with a disease marker biological analyte; a reservoir which comprises at least one therapeutic agent and is capable of releasing the therapeutic agent(s) from the medical device; and a plurality of microchips comprising a microarray scanning device capable of obtaining physical parameter data of an interaction between the disease marker biological analyte with the bioactive agent; a biometric recognition device capable of comparing the physical parameter data with an analyte interaction profile; optionally a therapeutic agent releasing device capable of controlling release of the therapeutic agent from the reservoirs; an interface device capable of facilitating communications between the microarray scanning device, biometric recognition device and the therapeutic agent releasing device; and an energy source to power the medical device. Specifically, the invention relates to a medical device capable of detecting an analyte in a bodily fluid comprising at least one microneedle capable of obtaining a sample of a bodily fluid, a first microchannel through which the sample flows and is in fluid communication with the at least one microneedle, a second microchannel in fluid communication with the first microchannel, through which a buffer flows, wherein the second channel comprises a microarray with a bioactive agent, a microarray scanning device to detect an interaction between the bioactive agent and the analyte in the bodily fluid; and an interface device.
摘要翻译：本发明涉及一种可摄入的，可植入的或可穿戴的医疗装置，其包括微阵列，其包含能够与疾病标记生物分析物相互作用的生物活性剂; 储存器，其包含至少一种治疗剂并能够从所述医疗装置释放所述治疗剂; 以及多个微芯片，其包括微阵列扫描装置，其能够获得疾病标记生物分析物与生物活性剂之间的相互作用的物理参数数据; 能够将物理参数数据与分析物相互作用谱进行比较的生物识别装置; 任选的能够控制治疗剂从储存器释放的治疗剂释放装置; 能够促进微阵列扫描装置，生物识别装置和治疗剂释放装置之间的通信的接口装置; 以及为医疗装置供电的能量源。具体地说，本发明涉及一种能够检测体液中分析物的医疗装置，其包含能够获得体液样品的至少一个微针，所述样品流过的第一微通道至少与所述至少一个微流体连通一个微针，与第一微通道流体连通的第二微通道，缓冲液流过其中，其中第二通道包含具有生物活性剂的微阵列，微阵列扫描装置，用于检测身体中生物活性剂和分析物之间的相互作用流体; 和接口设备。

37. 发明申请

US20120141306A1 FLUID PUMP WITH DISPOSABLE COMPONENT 有权
标题翻译：流体泵与可配置的组件
公开(公告)号：US20120141306A1
公开(公告)日：2012-06-07
申请号：US13306671
申请日：2011-11-29
申请人： Robert D. Butterfield
发明人： Robert D. Butterfield
IPC分类号： F04B17/00
CPC分类号： A61M5/14593 , A61M5/1413 , A61M5/14224 , A61M2005/14513 , A61M2205/106 , A61M2205/122 , A61M2205/128
摘要： A pump having a disposable fluid contacting portion which defines a fluid inlet and outlet and a fluid path there between is presented. The pump includes a drive portion configured to engage the disposable portion to cause fluid to be moved from the fluid inlet to the fluid outlet. The disposable portion is configured to be selectively coupled to the drive portion. The disposable portion includes a driven membrane which forms a portion of the fluid path, and the drive portion includes a drive membrane. The two membranes are vacuum coupled to each other, whereby movement of the drive membrane causes the driven membrane to move, causing fluid to be pumped through the disposable portion. The pump has particular utility in the medical field for moving fluid from a source to a patient. The pump may include features such as an air-trap, bubble detection, fluid flow controls, and pressure detection.
摘要翻译：提供具有限定流体入口和出口的一次性流体接触部分和其间的流体路径的泵。泵包括构造成接合一次性部分以使流体从流体入口移动到流体出口的驱动部分。一次性部分构造成选择性地联接到驱动部分。一次性部分包括形成流体路径的一部分的驱动膜，驱动部分包括驱动膜。两个膜彼此真空联接，由此驱动膜的移动导致从动膜移动，使得流体被泵送通过一次性部分。该泵在医疗领域具有特别的用途，用于将流体从源运动到患者。泵可以包括诸如空气阱，气泡检测，流体流量控制和压力检测的特征。

38. 发明授权

US08192390B2 Method and system for control of osmotic pump device 有权
标题翻译：渗透泵装置控制方法及系统
公开(公告)号：US08192390B2
公开(公告)日：2012-06-05
申请号：US12229352
申请日：2008-08-22
申请人： Leroy E. Hood , Muriel Y. Ishikawa , Edward K. Y. Jung , Robert Langer , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood
发明人： Leroy E. Hood , Muriel Y. Ishikawa , Edward K. Y. Jung , Robert Langer , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood
IPC分类号： A61N1/30
CPC分类号： A61K9/0004 , A61K9/0009 , A61K9/0024 , A61M5/14276 , A61M5/145 , A61M5/172 , A61M5/1723 , A61M2005/14513 , A61M2205/0266 , A61M2205/0288 , A61M2205/3523 , A61M2205/3569 , A61M2205/36 , A61N1/08
摘要： Embodiments of a system including a remotely controlled osmotic pump device and associated controller are described. Methods of use and control of the device are also disclosed. According to some embodiments, an osmotic pump device is placed in an environment in order to pump a material into the environment or into an additional fluid handling structure within the osmotic pump device. Exemplary environments include a body of an organism, a body of water, or an enclosed volume of a fluid. In selected embodiments, a magnetic field, an electric field, or electromagnetic control signal may be used.
摘要翻译：描述了包括远程控制的渗透泵装置和相关控制器的系统的实施例。还公开了装置的使用和控制方法。根据一些实施例，将渗透泵装置放置在环境中以便将材料泵送到渗透泵装置内的环境或另外的流体处理结构中。示例性环境包括生物体，水体或封闭体积的流体。在所选择的实施例中，可以使用磁场，电场或电磁控制信号。

39. 发明授权

US08113390B2 Gas generation dispenser apparatus and method for on-demand fluid delivery 有权
标题翻译：用于按需流体输送的气体分配装置和方法
公开(公告)号：US08113390B2
公开(公告)日：2012-02-14
申请号：US11923490
申请日：2007-10-24
申请人： Truman Wold , John Howard Gordon , Ashok Joshi
发明人： Truman Wold , John Howard Gordon , Ashok Joshi
IPC分类号： G01F11/00
CPC分类号： A61M5/14526 , A61L9/12 , A61L2209/132 , A61M5/14244 , A61M11/007 , A61M2005/14204 , A61M2005/14513 , A61M2205/3368 , A61M2205/8206 , A61M2205/8231 , B05B11/025 , B05B11/04 , B05B11/061
摘要： An on-demand fluid dispenser to dispense fluid in response to gas generation by a gas cell. The on-demand fluid dispenser includes an expandable gas chamber, a fluid chamber, and an on-demand gas cell. The expandable gas chamber includes a moveable plunger forming a wall of the expandable gas chamber. The moveable plunger also forms a wall of the fluid chamber. The on-demand gas cell is configured to generate the gas on demand. The on-demand gas cell is also configured to direct the gas to the expandable gas chamber to expand the expandable gas chamber. Expansion of the expandable gas chamber moves the moveable plunger to reduce a volume of the fluid chamber and to dispense an amount of fluid from the fluid chamber.
摘要翻译：一种按需流体分配器，用于响应气体生成气体而分配流体。按需流体分配器包括可膨胀气体室，流体室和按需气体室。可膨胀气体室包括形成可膨胀气体室的壁的活动柱塞。可移动柱塞还形成流体室的壁。按需气体电池被配置成根据需要产生气体。按需气体室还构造成将气体引导到可膨胀气体室以膨胀可膨胀气体室。可膨胀气体室的膨胀使可移动的柱塞移动以减小流体室的体积并从流体室分配一定量的流体。

40. 发明授权

US08101402B2 Medical device for analyte monitoring and drug delivery 有权
公开(公告)号：US08101402B2
公开(公告)日：2012-01-24
申请号：US11202206
申请日：2005-08-12
申请人： Elizabeth A. Holmes
发明人： Elizabeth A. Holmes
IPC分类号： C12M3/00
CPC分类号： A61B5/073 , A61B5/0024 , A61B5/0031 , A61B5/1411 , A61B5/145 , A61B5/14514 , A61B5/14532 , A61B5/14542 , A61B5/14546 , A61B5/1455 , A61B5/14556 , A61B5/1473 , A61B5/1477 , A61B5/1486 , A61B5/150022 , A61B5/150221 , A61B5/150229 , A61B5/150251 , A61B5/150282 , A61B5/150343 , A61B5/150854 , A61B5/150862 , A61B5/15087 , A61B5/150969 , A61B5/150984 , A61B5/15107 , A61B5/15117 , A61B5/15119 , A61B5/15121 , A61B5/15123 , A61B5/15125 , A61B5/1519 , A61B5/157 , A61B5/417 , A61B5/4238 , A61B5/4839 , A61B5/4848 , A61B5/6833 , A61B5/685 , A61B5/6865 , A61B5/7282 , A61B2560/0412 , A61M5/14276 , A61M37/0015 , A61M2005/14513 , A61M2005/1726 , A61M2037/0023 , A61M2205/0244 , A61M2205/3569 , A61M2205/3592 , A61M2205/50 , B01L3/5027 , B01L3/502707 , B01L3/502761 , B01L3/502776 , B01L2200/10 , B01L2300/023 , B01L2300/024 , B01L2300/0636 , B01L2300/0654 , B01L2300/0816 , B01L2400/0406 , B01L2400/0415 , B01L2400/0472 , B01L2400/0487 , G01N2035/00158
摘要： The invention relates to an ingestible, implantable or wearable medical device comprising a microarray which comprises a bioactive agent capable of interacting with a disease marker biological analyte; a reservoir which comprises at least one therapeutic agent and is capable of releasing the therapeutic agent(s) from the medical device; and a plurality of microchips comprising a microarray scanning device capable of obtaining physical parameter data of an interaction between the disease marker biological analyte with the bioactive agent; a biometric recognition device capable of comparing the physical parameter data with an analyte interaction profile; optionally a therapeutic agent releasing device capable of controlling release of the therapeutic agent from the reservoirs; an interface device capable of facilitating communications between the microarray scanning device, biometric recognition device and the therapeutic agent releasing device; and an energy source to power the medical device. Specifically, the invention relates to a medical device capable of detecting an analyte in a bodily fluid comprising at least one microneedle capable of obtaining a sample of a bodily fluid, a first microchannel through which the sample flows and is in fluid communication with the at least one microneedle, a second microchannel in fluid communication with the first microchannel, through which a buffer flows, wherein the second channel comprises a microarray with a bioactive agent, a microarray scanning device to detect an interaction between the bioactive agent and the analyte in the bodily fluid; and an interface device.

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