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31. 发明授权

US07214654B1 Agent for the manufacture of biological parts including an active ingredient complex and carrying materials suitable for the active ingredient complex 失效
标题翻译：用于生产生物部件的试剂，包括活性成分复合物和携带适用于活性成分复合物的材料
公开(公告)号：US07214654B1
公开(公告)日：2007-05-08
申请号：US09295302
申请日：1999-04-21
申请人： Karlheinz Schmidt
发明人： Karlheinz Schmidt
IPC分类号： A61K38/16 , A61K38/18
CPC分类号： A61K38/19 , A61L27/227 , A61L27/3608 , A61L27/365 , A61L27/3687 , A61L27/54 , A61L31/121 , A61L31/125 , A61L31/16 , A61L2300/252 , A61L2300/412 , A61L2430/02
摘要： The invention concerns a means for the at least partial production of reproduction of biological parts, especially or organs for living beings in which a carrier with an active ingredient complex is coated or in which the carrier contains an active ingredient complex, and the active ingredient complex has the following components, which are difference from one another and are specifically suited to each biological part to be produced, in the form of at least one structural component on the basis of extracellular material specifically suited to the cells of each of the biological parts to be produced, at least one recruiting component, at least one adhesion component, and at least one growth and/or maturation component. The method according to the invention can be used for the production, reproduction, or stabilization of vertebral structures; to treat osteoporosis, psuedoarthrosis, and bone defects; to fill large bone defects; and to heal endoprostheses.
摘要翻译：本发明涉及用于至少部分生产生物部件的生物的方法，特别是生物体的器官，其中具有活性成分复合物的载体被包被或其中载体含有活性成分复合物，以及活性成分复合物具有以下组分，它们彼此不同，并且特别适合于待生产的每个生物部分，其形式基于特别适合于每个生物部分的细胞的细胞外材料，至少一种结构组分的形式，至少一种引入组分，至少一种粘附组分和至少一种生长和/或成熟组分。根据本发明的方法可用于椎体结构的生产，繁殖或稳定; 治疗骨质疏松症，关节炎和骨缺损; 填补大骨缺损; 并治愈内假体。

32. 发明申请

US20060060207A1 Airway implant and methods of making and using 有权
标题翻译：气道植入及其使用方法
公开(公告)号：US20060060207A1
公开(公告)日：2006-03-23
申请号：US10946435
申请日：2004-09-21
申请人： Anant Hegde , George Choi , Wally Buch
发明人： Anant Hegde , George Choi , Wally Buch
IPC分类号： A61F5/56
CPC分类号： A61L31/125 , A61B2017/248 , A61C7/00 , A61F2/00 , A61F5/56 , A61F5/566 , A61F2210/0023 , A61L31/14 , A61N1/0517 , A61N1/0519 , A61N1/0548 , A61N1/3601 , Y10S602/902
摘要： A system and device for maintaining and/or creating patency in airways is disclosed. The methods of using the system and device are also disclosed. The system includes a power source that energizes a electro-active polymer implant. The energized polymer implant provides stiffness and shape to the airway, thereby minimizing collapse or deformation of the airway. A method of making the device is also disclosed.
摘要翻译：公开了一种用于在气道中维持和/或产生通畅的系统和装置。还公开了使用该系统和装置的方法。该系统包括为电活性聚合物植入物通电的电源。通电的聚合物植入物为气道提供刚度和形状，从而最小化气道的塌陷或变形。还公开了制造该器件的方法。

33. 发明授权

US07012106B2 Reinforced implantable medical devices 有权
标题翻译：强化可植入医疗器械
公开(公告)号：US07012106B2
公开(公告)日：2006-03-14
申请号：US10401469
申请日：2003-03-28
申请人： Jenny J. Yuan , Joseph H. Contiliano , Yufu Li , Zhigang Li , Mark B. Roller , Murty N. Vyakarnam
发明人： Jenny J. Yuan , Joseph H. Contiliano , Yufu Li , Zhigang Li , Mark B. Roller , Murty N. Vyakarnam
IPC分类号： A61F2/00 , C08G63/06
CPC分类号： A61L31/127 , A61L31/125 , A61L31/148 , Y10S525/937
摘要： The present invention is directed to reinforced, biocompatible, biodegradable compositions suitable for use in implantable medical devices and medical devices made at least in part from such compositions, where the compositions include a biocompatible, biodegradable polymer; a biocompatible, biodegradable wax; and greater than about 30 weight percent of an inorganic filler material.
摘要翻译：本发明涉及适用于至少部分由这样的组合物制备的可植入医疗装置和医疗装置的增强的，生物相容的，可生物降解的组合物，其中组合物包括生物相容的可生物降解的聚合物; 生物相容的，可生物降解的蜡; 和大于约30重量％的无机填料。

34. 发明申请

US20050037052A1 Stent coating with gradient porosity 审中-公开
标题翻译：具有梯度孔隙率的支架涂层
公开(公告)号：US20050037052A1
公开(公告)日：2005-02-17
申请号：US10917849
申请日：2004-08-12
申请人： Kishore Udipi , Peiwen Cheng
发明人： Kishore Udipi , Peiwen Cheng
IPC分类号： A61F2/00 , A61F2/06 , A61F2/90
CPC分类号： A61L31/16 , A61F2/91 , A61F2250/0023 , A61F2250/0035 , A61F2250/0067 , A61L27/44 , A61L27/54 , A61L27/56 , A61L29/126 , A61L29/146 , A61L29/16 , A61L31/125 , A61L31/146 , A61L2300/416 , A61L2300/61
摘要： Biocompatible coatings for medical devices are disclosed. Specifically, polymer coatings designed to control the release of drugs from medical devices in vivo are disclosed wherein the porosity of the polymer coatings is varied to control elute rate profiles. Also disclosed are vascular stents and stent grafts with controlled release coatings and related methods for making these coatings.
摘要翻译：公开了用于医疗装置的生物相容性涂层。具体地，公开了设计用于控制体内从医疗装置释放药物的聚合物涂层，其中改变聚合物涂层的孔隙率以控制洗脱速率曲线。还公开了具有控制释放涂层的血管支架和支架移植物以及用于制备这些涂层的相关方法。

35. 发明申请

US20040151930A1 Lubricious coating for medical devices 有权
公开(公告)号：US20040151930A1
公开(公告)日：2004-08-05
申请号：US10705751
申请日：2003-11-10
申请人： Kimberly-Clark Worldwide, Inc.
发明人： Cameron Rouns , James Perrault
IPC分类号： B32B027/00
CPC分类号： A61L29/145 , A61L27/34 , A61L27/44 , A61L27/52 , A61L29/041 , A61L29/085 , A61L29/126 , A61L29/14 , A61L31/10 , A61L31/125 , A61L31/14 , A61L2400/10 , A61L2420/02 , Y10T428/1393 , Y10T428/31576 , Y10T428/31663 , Y10T428/31855 , Y10T428/31928 , Y10T428/31935 , C08L33/00
摘要： Medical devices having at least a portion thereof coated with a lubricious polymer are disclosed. The lubricious polymer can be, for instance, a hydrogel polymer, such as a quaternary amine acrylate polymer. To bond the lubricious polymer to the surface of the medical device, the medical device is first subjected to a solvent and a multi-functional monomer. The solvent causes the multi-functional monomer to become imbibed into the surface of the medical device. Thereafter, a polymer having lubricious properties is polymerized on the surface of the device. The multi-functional monomer reacts with the polymer coating securely affixing the polymer coating to the device.

36. 发明申请

US20030093107A1 Medical devices comprising nanocomposites 有权
公开(公告)号：US20030093107A1
公开(公告)日：2003-05-15
申请号：US10259545
申请日：2002-09-27
发明人： Edward Parsonage , Daniel J. Horn , John J. Chen , Paul J. Miller , Douglas A. Devens JR. , Jan Weber
IPC分类号： A61M029/00
CPC分类号： A61F2/95 , A61F2/01 , A61F2/02 , A61F2/958 , A61F2002/018 , A61F2230/0006 , A61F2230/005 , A61F2230/0067 , A61L29/126 , A61L31/125 , Y10S623/90 , Y10S977/905
摘要： The present invention provides medical devices comprising nanocomposite materials. By utilizing nanocomposites in the production thereof, the inventive medical devices can be produced with various advantageous properties. Methods of producing the inventive medical devices are also provided. Inasmuch as the inventive devices are expected to provide certain advantages in their use, there is also provide a method of medical care including methods of treatment or diagnosis, wherein the inventive devices are brought into therapeutic contact with a body to be treated or diagnosed thereby.

37. 发明申请

US20020049495A1 Medical device with coating that promotes endothelial cell adherence 有权
标题翻译：具有促进内皮细胞粘附的涂层的医疗装置
公开(公告)号：US20020049495A1
公开(公告)日：2002-04-25
申请号：US09808867
申请日：2001-03-15
发明人： Michael John Bradley Kutryk , Robert John Cottone , Stephen Maxwell Rowland
IPC分类号： A61F002/06
CPC分类号： A61L31/10 , A61F2/07 , A61F2/2412 , A61F2/82 , A61K38/363 , A61K38/39 , A61K39/39558 , A61L27/08 , A61L27/227 , A61L27/303 , A61L27/44 , A61L27/54 , A61L29/103 , A61L29/126 , A61L29/16 , A61L31/022 , A61L31/047 , A61L31/084 , A61L31/125 , A61L31/148 , A61L31/16 , A61L2300/256 , A61L2300/416 , A61L2300/422 , A61L2300/432 , A61L2300/606 , A61L2420/04 , B82Y30/00 , C07K16/2896 , C07K2317/55 , C12N5/0692 , C12N2510/00 , A61K2300/00
摘要： This invention provides compositions and methods for producing a medical device coated with a matrix and an antibody which reacts with an endothelial cell antigen. The matrix coating the medical device may be composed of synthetic material, such as polyurethane, poly-L-lactic acid, cellulose ester or polyethylene glycol. In another embodiment, the matrix is composed of naturally occurring materials, such as collagen, fibrin, elastin, amorphous carbon. In a third embodiment, the matrix may be composed of fullerenes. The fullerenes range from about C60 to about C100. The medical device may be a stent or a synthetic graft. The antibodies promote adherence of endothelial cells on the medical device. The antibodies may be mixed with the matrix or covalently tethered through a linker molecule to the matrix. Following adherence to the medical device, the endothelial cells differentiate and proliferate on the medical device. The antibodies may be different types of monoclonal antibodies. Methods of preparing such composition and methods of treating a mammal with atherosclerosis or other types of vessel obstruction are disclosed. By facilitating adherence of endothelial cells to the surface of the medical device, the methods and compositions of this invention will decrease the incidence of restenosis as well as other thromboembolic complications resulting from implantation of medical devices.
摘要翻译：本发明提供了用于制备涂覆有基质和与内皮细胞抗原反应的抗体的医疗器械的组合物和方法。涂覆医疗装置的基质可以由合成材料如聚氨酯，聚-L-乳酸，纤维素酯或聚乙二醇组成。在另一个实施方案中，基质由天然存在的材料组成，例如胶原，纤维蛋白，弹性蛋白，无定形碳。在第三实施方案中，基质可以由富勒烯构成。富勒烯的范围为约C60至约C100。医疗装置可以是支架或合成移植物。抗体促进内皮细胞在医疗装置上的粘附。可以将抗体与基质混合或通过连接体分子共价连接到基质上。在粘附于医疗装置之后，内皮细胞在医疗装置上分化和增殖。抗体可以是不同类型的单克隆抗体。公开了制备这种组合物的方法和治疗动脉粥样硬化或其它类型的血管阻塞的哺乳动物的方法。通过促进内皮细胞粘附到医疗装置的表面，本发明的方法和组合物将降低再狭窄的发生率以及由植入医疗装置引起的其它血栓栓塞并发症。

38. 发明授权

US5510121A Glycosaminoglycan-synthetic polymer conjugates 失效
标题翻译：糖胺聚糖合成聚合物共轭物
公开(公告)号：US5510121A
公开(公告)日：1996-04-23
申请号：US434958
申请日：1995-05-04
申请人： Woonza M. Rhee , Richard A. Berg
发明人： Woonza M. Rhee , Richard A. Berg
IPC分类号： A61L27/00 , A61F2/00 , A61F2/06 , A61K38/00 , A61K47/48 , A61L24/10 , A61L26/00 , A61L27/18 , A61L27/20 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L29/04 , A61L29/06 , A61L29/16 , A61L31/04 , A61L31/10 , A61L31/12 , C07K14/495 , C07K14/78 , C08B37/00 , C08B37/08 , C08H1/06 , C08L89/06 , C09J189/06 , A61K35/12 , A61K35/14 , A61K35/24 , A61K35/37
CPC分类号： A61K47/48215 , A61K47/4823 , A61K47/48292 , A61L24/102 , A61L26/0033 , A61L27/18 , A61L27/20 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L29/043 , A61L29/045 , A61L29/06 , A61L29/16 , A61L31/041 , A61L31/042 , A61L31/044 , A61L31/10 , A61L31/125 , C07K14/495 , C07K14/78 , C08B37/0069 , C08B37/0072 , C08H1/06 , C08L89/06 , C09J189/06 , A61F2/07 , A61F2310/00365 , A61K38/00 , A61L2300/236 , A61L2300/252 , A61L2300/414 , A61L2300/802 , A61L2430/16 , Y10S525/937
摘要： Pharmaceutically acceptable, nonimmunogenic compositions are formed by covalently binding glycosaminoglycans or derivatives thereof, to hydrophilic synthetic polymers via specific types of chemical bonds to provide biocompatible conjugates. Useful glycosaminoglycans include hyaluronic acid, the chondroitin sulfates, keratan sulfate, chitin and heparin, each of which is chemically derivatized to react with a hydrophilic synthetic polymer. The conjugate comprising a glycosaminoglycan covalently bound to a hydrophilic synthetic polymer may be further bound to collagen to form a three component conjugate having different properties. The hydrophilic synthetic polymer may be polyethylene glycol and derivatives thereof having an average molecular weight over a range of from about 100 to about 100,000. The compositions may include other components such as fluid, pharmaceutically acceptable carders to form injectable formulations, and/or biologically active proteins such as growth factors or cytokines. The conjugates of the invention generally contain large amounts of water when formed. The conjugates can be dehydrated to form a relatively solid implant for use in hard tissue augmentation. The dehydrated, solid implant can further be ground into particles which can be suspended in a non-aqueous fluid and injected into a living being (preferably human) for soft tissue augmentation. Once in place, the solid implants or particles rehydrate and expand in size approximately three- to five-fold.
摘要翻译：药学上可接受的非免疫原性组合物通过将糖胺聚糖或其衍生物与亲水性合成聚合物共价结合而形成，通过特定类型的化学键提供生物相容性缀合物。有用的糖胺聚糖包括透明质酸，硫酸软骨素，硫酸角质素，几丁质和肝素，其中每一种都被化学衍生以与亲水性合成聚合物反应。共价结合亲水性合成聚合物的糖胺聚糖的缀合物可以进一步与胶原结合，形成具有不同性质的三组分共轭物。亲水性合成聚合物可以是平均分子量在约100至约100,000范围内的聚乙二醇及其衍生物。组合物可以包括其它组分如流体，药学上可接受的梳理剂以形成可注射制剂，和/或生物活性蛋白质例如生长因子或细胞因子。当形成时，本发明的共轭物通常含有大量的水。可以将缀合物脱水以形成用于硬组织增加的相对固体植入物。脱水的固体植入物可以进一步研磨成可以悬浮在非水性流体中的颗粒，并注入到生物体（优选人）中用于软组织增加。一旦到位，固体植入物或颗粒再水化并且尺寸扩大约三至五倍。

39. 发明授权

US5413791A Collagen-polymer conjugates 失效
标题翻译：胶原 - 聚合物共轭物
公开(公告)号：US5413791A
公开(公告)日：1995-05-09
申请号：US198128
申请日：1994-02-17
申请人： Woonza Rhee , Donald G. Wallace , Alan S. Michaels , Ramon A. Burns, Jr. , Louis Fries , Frank DeLustro , Hanne Bentz
发明人： Woonza Rhee , Donald G. Wallace , Alan S. Michaels , Ramon A. Burns, Jr. , Louis Fries , Frank DeLustro , Hanne Bentz
IPC分类号： A61L27/00 , A61F2/00 , A61F2/06 , A61K38/00 , A61K38/17 , A61K38/21 , A61K38/22 , A61K45/06 , A61K47/48 , A61L15/22 , A61L24/10 , A61L26/00 , A61L27/18 , A61L27/20 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L29/04 , A61L29/06 , A61L29/16 , A61L31/04 , A61L31/10 , A61L31/12 , A61P17/00 , A61P43/00 , C07K14/495 , C07K14/78 , C08B37/08 , C08G81/00 , C08H1/00 , C08H1/06 , C08L89/00 , C08L89/06 , C09J189/06 , G02B1/04 , A61F13/00 , A61K9/14 , A61K9/50
CPC分类号： C08L89/06 , A61K47/48215 , A61K47/4823 , A61K47/48292 , A61L15/225 , A61L24/102 , A61L26/0033 , A61L27/18 , A61L27/20 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L29/043 , A61L29/045 , A61L29/06 , A61L29/16 , A61L31/041 , A61L31/042 , A61L31/044 , A61L31/10 , A61L31/125 , C07K14/495 , C07K14/78 , C08B37/0069 , C08B37/0072 , C08H1/06 , C09J189/06 , G02B1/043 , A61F2/07 , A61F2310/00365 , A61K38/00 , A61L2300/252 , A61L2300/414 , A61L2300/426 , A61L2300/62 , A61L2300/802 , A61L2430/16 , Y10S525/937
摘要： Pharmaceutically acceptable, non-immunogenic compositions are formed by covalently binding atelopeptide collagen to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide collagen/polymer conjugates. The atelopeptide collagen can be type I, type II or type III and may be fibrillar or non-fibrillar. The synthetic hydrophilic polymer may be polyethylene glycol and derivatives thereof having a weight average molecular weight over a range of from about 100 to about 20,000. The compositions may include other components such as liquid, pharmaceutically acceptable, carriers to form injectable formulations, and/or biologically active proteins such as growth factors. The collagen-polymer conjugates of the invention generally contain large amounts of water when formed. The conjugates can be dehydrated to form a relatively solid object. The dehydrated, solid object can be ground into particles which can be suspended in a non-aqueous fluid such as an oil and injected into a living being for the purpose of providing soft tissue augmentation. Once in place, the particles rehydrate and expand in size five fold or more.
摘要翻译：药学上可接受的非免疫原性组合物通过经由特定类型的化学键共价结合肽肽胶原与药学纯合成的亲水性聚合物形成，以提供胶原/聚合物共轭物。糖尿病胶原可以是I型，II型或III型，并且可以是纤维状或非纤维状的。合成亲水性聚合物可以是重均分子量在约100至约20,000范围内的聚乙二醇及其衍生物。组合物可以包括其它组分，例如液体，药学上可接受的，载体以形成可注射制剂，和/或生物活性蛋白质例如生长因子。当形成时，本发明的胶原 - 聚合物共轭物通常含有大量的水。可以将共轭物脱水形成相对固体的物体。脱水的固体可以被研磨成可以悬浮在诸如油之类的非水性流体中的颗粒，并注入活体以提供软组织增加。一旦就位，颗粒再水合并扩大五倍以上。

40. 发明授权

US5308889A Dehydrated collagen-polymer strings 失效
标题翻译：脱水胶原聚合物串
公开(公告)号：US5308889A
公开(公告)日：1994-05-03
申请号：US984197
申请日：1992-12-02
申请人： Woonza Rhee , Louis Fries , Ramesh Damani , Kimberly McCullough , Frank DeLustro
发明人： Woonza Rhee , Louis Fries , Ramesh Damani , Kimberly McCullough , Frank DeLustro
IPC分类号： A61L27/00 , A61F2/00 , A61F2/06 , A61K38/00 , A61K38/17 , A61K38/21 , A61K38/22 , A61K45/06 , A61K47/48 , A61L15/22 , A61L24/10 , A61L26/00 , A61L27/18 , A61L27/20 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L29/04 , A61L29/06 , A61L29/16 , A61L31/04 , A61L31/10 , A61L31/12 , A61P17/00 , A61P43/00 , C07K14/495 , C07K14/78 , C08B37/08 , C08G81/00 , C08H1/00 , C08H1/06 , C08L89/00 , C08L89/06 , C09J189/06 , G02B1/04 , C08G63/48 , C08G63/91
CPC分类号： C08L89/06 , A61K47/48215 , A61K47/4823 , A61K47/48292 , A61L15/225 , A61L24/102 , A61L26/0033 , A61L27/18 , A61L27/20 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L29/043 , A61L29/045 , A61L29/06 , A61L29/16 , A61L31/041 , A61L31/042 , A61L31/044 , A61L31/10 , A61L31/125 , C07K14/495 , C07K14/78 , C08B37/0069 , C08B37/0072 , C08H1/06 , C09J189/06 , G02B1/043 , A61F2/07 , A61F2310/00365 , A61K38/00 , A61L2300/252 , A61L2300/414 , A61L2300/426 , A61L2300/62 , A61L2300/802 , A61L2430/16 , Y10S525/937
摘要： Medical articles in the form of strings are formed by covalently binding collagen to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide collagen/polymer conjugate formulations which are extruded to make the strings. The collagen may be recombinantly produced human collagen or collagen extracted from any source, such as a bovine source or human placenta, and purified and can be of various types and may be fibrillar or non-fibrillar. The synthetic hydrophilic polymer may be polyethylene glycol and derivatives thereof having an average molecular weight over a range of from about 100 to about 20,000. The string can be designed to incorporate other components such as fluid, pharmaceutically acceptable carriers to form injectable formulations, and/or biologically active proteins such as growth factors or cytokines. The strings contain large amounts of water when extruded and may then be dehydrated to form relatively solid but flexible strings. The strings can be injected into a living being for the purpose of providing soft tissue augmentation. Once in place, the strings rehydrate and expand in size five fold or more. Aqueous solution can be provided to enhance the rate of rehydration. The strings can also be used to suture wounds which strings can be chemically designed to dissolve in situ.
摘要翻译：通过特定类型的化学键将胶原与药学上纯的，合成的亲水性聚合物共价结合形成的药物形式，以提供被挤出以制备丝束的胶原/聚合物缀合物制剂。胶原蛋白可以是重组产生的人胶原或从任何来源例如牛源或人胎盘提取的胶原，并且可以是各种类型的，并且可以是纤维状或非纤维状的。合成亲水性聚合物可以是平均分子量在约100至约20,000范围内的聚乙二醇及其衍生物。该串可被设计成结合其它组分如流体，药学上可接受的载体以形成可注射制剂，和/或生物活性蛋白如生长因子或细胞因子。当挤出时，该串含有大量的水，然后可以脱水以形成相对固体但柔性的串。为了提供软组织增加的目的，可以将线注射到活体中。一旦到位，字符串水合并扩大五倍以上。可以提供水溶液以提高再水合速率。弦也可用于缝合可以化学设计的弦可以原位溶解的伤口。

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