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31. 发明授权

US10962158B2 Connection system 有权
公开(公告)号：US10962158B2
公开(公告)日：2021-03-30
申请号：US15740890
申请日：2016-06-29
申请人： Sartorius Stedim Biotech GmbH
发明人： Jochen Scholz , Sebastian Purmann , Michael Bates
IPC分类号： F16L37/12 , G01L19/00 , G01L19/14 , F16L37/20 , A61M39/02 , F16L37/252 , F16L23/04 , A61M39/10
摘要： Disclosed is a connection system for releasably coupling a first body (5) with a flange (25) to a fluid-conducting system in a force-fitting manner, and the invention also relates to a connection system for releasably coupling the interior of a first fluid-conducting body (5) to the interior of a second fluid-conducting body (3) in a force-fitting manner. The second body (3) has a second end with a circumferential wall (22), a membrane contact portion (9) which can be found on the wall, and an opening (43). A retaining element (2) has a passage (35) and a peripheral outer edge (24). One side and/or the passage (35) of the retaining element (2) is coupled to the membrane (1), and an annular wall (26) is arranged on the same side, said annular wall being connected to the circumferential wall (22) of the second body (3). The other side is designed to contact the surface of the flange (25) of the first body (5). The retaining element (2) can also be integrated into the second body (3) when the first body (5) is fluid-conductive. The releasable connection element (4) is designed to at least partly surround the peripheral outer edge (24) of the retaining element (2) and the flange (25) of the first body (5).

32. 发明授权

US10947489B2 Bioreactor system and method 有权
公开(公告)号：US10947489B2
公开(公告)日：2021-03-16
申请号：US15577574
申请日：2016-03-08
申请人： Sartorius Stedim Biotech GmbH
发明人： Bernward Husemann , Simon Topp-Manske , Bjoern Nickel , Marco Leupold
IPC分类号： C12M1/00 , C12M3/00 , C12M1/34 , C12M1/06
摘要： A bioreactor (1; 2; 3) includes a receiving container (10) for receiving a disposable bag (44). A bottom surface (11) of the receiving container (10) is designed to support the disposable bag (44) in the receiving container (10). An outlet opening (5) is formed in the bottom surface (11) and tapers down with respect to the ground for receiving a drain port (45) of the disposable bag (44). The drain port is complementary to the outlet opening (5).

33. 发明授权

US10913200B2 Dispensing device and system for biological products 有权
公开(公告)号：US10913200B2
公开(公告)日：2021-02-09
申请号：US15409669
申请日：2017-01-19
申请人： Sartorius Stedim Biotech GmbH
发明人： Frank Maggiore
IPC分类号： B29C64/106 , B33Y30/00 , B29C64/20 , B33Y10/00 , B29C48/02 , B29C48/00 , B65D83/20 , B65D83/68 , B65D81/32 , B01L3/02 , C12M1/00 , C12M1/26 , C12M1/36 , B25J13/00 , C12M1/12
摘要： A dispensing system has a sterilizable chamber. At least one robotic arm assembly and a dispensing device are within the sterilizable chamber. The dispensing device comprising a first dispensing element and a second dispensing element. The first dispensing element is connectable to the second dispensing element The at least one robotic assembly is configured to move the dispensing device. An external control device is connected to the at least one robotic arm assembly and is configured to control the at least one robotic arm assembly. The first dispensing element is configured to dispense a structural material and the second dispensing element is configured to dispense a biological material.

34. 发明申请

US20210037297A1 SENSING ELEMENT AND WIRELESS COMMUNICATION DEVICE FOR SINGLE-USE ELEMENTS 有权
公开(公告)号：US20210037297A1
公开(公告)日：2021-02-04
申请号：US16967338
申请日：2019-01-21
申请人： Sartorius Stedim Biotech GmbH
发明人： Christian Grimm , Jochen Scholz , Matthias Bode , Andreas Prediger , Patrick Courtney
IPC分类号： H04Q9/00 , H05K1/02
摘要： Summarizing the invention, a sensing element for monitoring the state of a single-use sterilizable element such as a single-use bioreactor, wherein the state of the single-use sterilizable element is determined by at least one environmental condition is provided. The sensing element comprises: a variable component having at least one physical property that is configured to change in response to the at least one environmental condition and/or a change thereof, wherein the variable component comprises a sensing material with changing absorption characteristics for electromagnetic radiation configured to change in response to the at least one environmental condition and/or a change thereof.

35. 发明授权

US10816127B2 Anti-kink device for a hose 有权
公开(公告)号：US10816127B2
公开(公告)日：2020-10-27
申请号：US16329266
申请日：2017-08-17
申请人： SARTORIUS STEDIM BIOTECH GMBH
发明人： Diana Kronenberg
IPC分类号： F16L57/02
摘要： An anti-kink device for a hose has a strip-shaped base body, at least one fastening protrusion protruding from the base body and at least one fastening depression provided in the base body. The fastening protrusion is configured such that it can engage into the at least one fastening depression.

36. 发明授权

US10525413B2 Connecting system for filter cassettes 有权
公开(公告)号：US10525413B2
公开(公告)日：2020-01-07
申请号：US15035764
申请日：2014-10-30
申请人： Sartorius Stedim Biotech GmbH
发明人： Thomas Krumbein , Stefan Weisshaar , Michael Bates
IPC分类号： B01D65/00 , B01D63/08 , F16B5/06 , B01J29/00
摘要： A connecting system (1) has at least one connector (2) for a filter cassette (4) that can be inserted into a filter holder and has filter layers (5) between two end plates (6), and seals (7) between the filter layers (5) and/or between the end plates (6) and an adjacent filter layer (5). The connector has tensioning parts that engage in one another in a longitudinally displaceable manner and that can be fixed to the end plates (6) via their ends facing away from one another. The connector exerts a pretensioning force onto the end plates (6) when it is deflected to its maximum extent. The pretensioning force pulls the end plates (6) towards the filter layers (5), and when a contact-pressure force superimposed on the pretensioning force is applied to the end plates (6), the tensioning parts can be pushed towards one another correspondingly with the end plates (6).

37. 发明授权

US10493407B2 Filtration device 有权
公开(公告)号：US10493407B2
公开(公告)日：2019-12-03
申请号：US15328976
申请日：2015-07-18
申请人： Sartorius Stedim Biotech GmbH
发明人： Wilhelm Requate , Gerid Hellwig
IPC分类号： B01D65/02 , B01D65/00 , B01D63/04 , B01D63/02
CPC分类号： B01D65/022 , B01D63/02 , B01D63/04 , B01D65/00 , B01D2311/2653 , B01D2311/2657 , B01D2313/13 , B01D2313/16 , B01D2313/20 , B01D2313/23 , B01D2313/32 , B01D2315/08 , B01D2319/04
摘要： A filtration device (1) has a housing (4) and a filter module (2) with hollow fibers (32) surrounded by an outer shell (5). The hollow fiber bundle (6) is sealed to the outer shell (5) at each end by an adhesive (11) transverse to the longitudinal direction (10). Each end of the hollow fibers (32) is unclosed. An unfiltered product chamber (20) is between the outer shell (5) and a wall (19) of the filter housing (4) and a filtered product chamber (13) is inside the filter module (2). The bottom end of the filter module (2) connects with an intermediate section (3) that connects with a receptacle (17) of a bottom portion (15) of the filter housing (4). The intermediate section (3) forms a connection chamber (26) facing the hollow fiber ends (29) and radial feed channels (28) connect the connection chamber (26) with the unfiltered product chamber (20).

38. 发明申请

US20190329172A1 SHEET MATERIAL AND FILTER ELEMENT WITH HYDROPHOBIC SEPARATING LAYER, USE THEREOF AND PROCESS FOR PRODUCTION OF SAME 审中-公开
公开(公告)号：US20190329172A1
公开(公告)日：2019-10-31
申请号：US16395164
申请日：2019-04-25
申请人： Sartorius Stedim Biotech GmbH
发明人： Eberhard Wünn , Thomas Friese , Benjamin Schneider , Mario Strauss
IPC分类号： B01D46/54 , B01D39/16
摘要： The present invention relates to a sheet material and filter element, where the sheet material and the filter element have a hydrophobic separating layer, and also to use thereof and to a process for production of same.

39. 发明授权

US10427112B2 Aeration device for bioreactors 有权
公开(公告)号：US10427112B2
公开(公告)日：2019-10-01
申请号：US13825072
申请日：2011-08-06
申请人： Stefan Weisshaar
发明人： Stefan Weisshaar
IPC分类号： B01F3/04 , B01F15/00 , C12M1/00
摘要： Aeration device for bioreactors with an aeration element with gas outlet openings arranged in a housing, the aeration element taking the form of a microsparger, the gas outlet openings of which are in each case spaced apart from one another and have a size of between 100 μm and 200 μm. At least one second aeration element with gas outlet openings of a second size is preferably provided, the aeration elements being formed by a common housing with separate aeration channels.

40. 发明授权

US10386285B2 Integrity and functionality test for adsorptive depth filter layers with an inorganic layered double hydroxide 有权
公开(公告)号：US10386285B2
公开(公告)日：2019-08-20
申请号：US15032220
申请日：2014-09-03
申请人： Sartorius Stedim Biotech GmbH
发明人： Rebecca Petersen , Axel Thiefes , Katrin Köhler , Wolfgang Demmer , Sven Dankenbrink
IPC分类号： G01N15/08 , G01N30/88 , G01N30/89
摘要： The present invention relates to a method for determining the functionality and integrity of depth filter sheets and depth filter sheet systems comprising inorganic layered double hydroxide for contaminant removal in biotechnological processes.

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