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1. 发明申请

US20100170400A1 Waste gas system for bioreactors 有权
标题翻译：生物反应器废气系统
公开(公告)号：US20100170400A1
公开(公告)日：2010-07-08
申请号：US12653506
申请日：2009-12-15
申请人： Juergen van den Boogard , Gerid Hellwig , Jens Ludwig , Oscar-Werner Reif , Stefan Weisshaar
发明人： Juergen van den Boogard , Gerid Hellwig , Jens Ludwig , Oscar-Werner Reif , Stefan Weisshaar
IPC分类号： B01D53/22
CPC分类号： C12M29/20
摘要： The invention relates to a waste gas system for bioreactors having a hydrophobic sterile filter, arranged at the end, and a heat exchanger which protects the sterile filter against blocking by liquid media. The gas outflow duct for discharging waste gas from a bioreactor vessel is divided in a cooling zone of the heat exchanger into a multiplicity of subducts and is extended in a heating zone of the heat exchanger to a calming zone. Due to the multiplicity of subducts, a considerably larger surface area for the removal of heat from the waste gas is available, with the result that in the case of laminar flow of the waste gas through the subducts a high effectiveness of the separation of liquids from the waste gas can be achieved. In the heating zone, the waste gas can heat up again due to the reduced flow rate until it reaches the hydrophobic sterile filter by way of taking up heat from the surroundings to a such a degree that the relative vapor contents are below 100% and separation of liquids from residual vapors at or in the hydrophobic sterile filter is precluded.
摘要翻译：本发明涉及一种用于生物反应器的废气系统，其具有布置在其末端的疏水性无菌过滤器和保护无菌过滤器免受液体介质堵塞的热交换器。用于从生物反应器容器排出废气的气体流出管在热交换器的冷却区中分成多个副产物，并在热交换器的加热区中延伸到一个镇定区。由于多余的下降，可以获得相当大的用于从废气中除去热量的表面积，结果是在废气通过下沉层流的情况下，液体从液体中分离的高效率可以实现废气。在加热区中，废气可以由于流速降低而再次加热，直到其通过从周围环境吸收热量达到疏水性无菌过滤器至相对蒸汽含量低于100％的程度并且分离的疏水性无菌过滤器中或其中残留蒸气的液体被排除。

2. 发明授权

US08268059B2 Waste gas system for bioreactors 有权
标题翻译：生物反应器废气系统
公开(公告)号：US08268059B2
公开(公告)日：2012-09-18
申请号：US12653506
申请日：2009-12-15
申请人： Juergen van den Boogard , Gerid Hellwig , Jens Ludwig , Oscar-Werner Reif , Stefan Weisshaar
发明人： Juergen van den Boogard , Gerid Hellwig , Jens Ludwig , Oscar-Werner Reif , Stefan Weisshaar
IPC分类号： B01D50/00
CPC分类号： C12M29/20
摘要： The invention relates to a waste gas system for bioreactors having a hydrophobic sterile filter, arranged at the end, and a heat exchanger which protects the sterile filter against blocking by liquid media. The gas outflow duct for discharging waste gas from a bioreactor vessel is divided in a cooling zone of the heat exchanger into a multiplicity of subducts and is extended in a heating zone of the heat exchanger to a calming zone. Due to the multiplicity of subducts, a considerably larger surface area for the removal of heat from the waste gas is available, with the result that in the case of laminar flow of the waste gas through the subducts a high effectiveness of the separation of liquids from the waste gas can be achieved. In the heating zone, the waste gas can heat up again due to the reduced flow rate until it reaches the hydrophobic sterile filter by way of taking up heat from the surroundings to a such a degree that the relative vapor contents are below 100% and separation of liquids from residual vapors at or in the hydrophobic sterile filter is precluded.
摘要翻译：本发明涉及一种用于生物反应器的废气系统，其具有布置在其末端的疏水性无菌过滤器和保护无菌过滤器免受液体介质堵塞的热交换器。用于从生物反应器容器排出废气的气体流出管在热交换器的冷却区中分成多个副产物，并在热交换器的加热区中延伸到一个镇定区。由于多余的下降，可以获得相当大的用于从废气中除去热量的表面积，结果是在废气通过下沉层流的情况下，液体从液体中分离的高效率可以实现废气。在加热区中，废气可以由于流速降低而再次加热，直到其通过从周围环境吸收热量达到疏水性无菌过滤器至相对蒸汽含量低于100％的程度并且分离的疏水性无菌过滤器中或其中残留蒸气的液体被排除。

3. 发明申请

US20120103579A1 PLATE HEAT EXCHANGER 有权
标题翻译：板式换热器
公开(公告)号：US20120103579A1
公开(公告)日：2012-05-03
申请号：US13379387
申请日：2010-06-10
申请人： Oscar-Werner Reif , Juergen van den Boogaard , Stefan Weisshaar
发明人： Oscar-Werner Reif , Juergen van den Boogaard , Stefan Weisshaar
IPC分类号： F28F3/08
CPC分类号： F28D9/005 , F28F17/005 , F28F21/06 , F28F2275/02 , F28F2275/06 , F28F2280/06
摘要： The invention relates to a plate heat exchanger comprising a plurality of plates having flow channels, wherein a first plate has a front side having at least one flow channel for a first fluid and a second plate has a front side having at least one flow channel for a second fluid, and wherein the plates have through openings via which the flow channels for the same fluid are respectively connected to one another, wherein a front plate, which is placed in front of the front side of the first plate, has ports for the first fluid and for the second fluid, wherein an end plate forms the end of the aligned plates, wherein the plates and ports are formed from plastic, and wherein the plates are bonded or welded tightly together.
摘要翻译：本发明涉及一种板式热交换器，其包括具有流动通道的多个板，其中第一板具有前侧，其具有用于第一流体的至少一个流动通道，而第二板的前侧具有至少一个流动通道，第二流体，并且其中所述板具有通孔，通过所述开口，用于相同流体的流动通道彼此分别连接，其中放置在所述第一板的前侧前面的前板具有用于第一流体和第二流体，其中端板形成对准的板的端部，其中板和端口由塑料形成，并且其中板被紧密地结合或焊接在一起。

4. 发明授权

US09636644B2 Aeration device for bioreactors 有权
公开(公告)号：US09636644B2
公开(公告)日：2017-05-02
申请号：US13508074
申请日：2010-10-28
申请人： Guenter Pradel , Stefan Weisshaar , Gerhard Greller , Ute Husemann
发明人： Guenter Pradel , Stefan Weisshaar , Gerhard Greller , Ute Husemann
IPC分类号： B01F3/04 , C12M1/00
CPC分类号： B01F3/04531 , B01F3/04099 , B01F3/04106 , B01F3/04262 , B01F2003/04673 , C12M29/06
摘要： Aeration device for bioreactors with a first aeration element with gas outlet openings of a first size and with at least one second aeration element with gas outlet openings of a second size, the aeration elements being formed by a common housing with separate aeration channels.

5. 发明申请

US20120267518A1 SENSOR PROTECTOR 有权
标题翻译：传感器保护器
公开(公告)号：US20120267518A1
公开(公告)日：2012-10-25
申请号：US13513344
申请日：2010-11-12
申请人： Stefan Weisshaar , Michael Bates , Christian Pradel , Volker Limpert
发明人： Stefan Weisshaar , Michael Bates , Christian Pradel , Volker Limpert
IPC分类号： G01J1/02
CPC分类号： G01N21/6428 , G01N2201/022
摘要： A sensor protector is intended to reduce the sensitivity of the optical sensor (4) to radiation products which, for example, are formed during sterilization with gamma radiation and to ensure simple and cost-effective manufacture. The sensor protector includes an upper part (1), a lower part (3) and an optical sensor (4). The optical sensor (4) situated on the lower part is positionable in an offset manner with respect to an opening (2) situated in the upper part and movable by means of displacement toward the opening (2) of the upper part (1). The sensor protector is suitable for use in containers and laboratory products that are sterilized by gamma radiation, for example disposable bioreactors.
摘要翻译：传感器保护器旨在降低光学传感器（4）对例如在用γ辐射灭菌期间形成的辐射产品的灵敏度，并确保简单且具有成本效益的制造。传感器保护器包括上部（1），下部（3）和光学传感器（4）。位于下部的光学传感器（4）可相对于位于上部的开口（2）以偏移的方式定位，并且通过向上部（1）的开口（2）移动而移动。传感器保护器适用于通过伽马辐射灭菌的容器和实验室产品，例如一次性生物反应器。

6. 发明授权

US10427112B2 Aeration device for bioreactors 有权
公开(公告)号：US10427112B2
公开(公告)日：2019-10-01
申请号：US13825072
申请日：2011-08-06
申请人： Stefan Weisshaar
发明人： Stefan Weisshaar
IPC分类号： B01F3/04 , B01F15/00 , C12M1/00
摘要： Aeration device for bioreactors with an aeration element with gas outlet openings arranged in a housing, the aeration element taking the form of a microsparger, the gas outlet openings of which are in each case spaced apart from one another and have a size of between 100 μm and 200 μm. At least one second aeration element with gas outlet openings of a second size is preferably provided, the aeration elements being formed by a common housing with separate aeration channels.

7. 发明授权

US08809765B2 Sensor protector 有权
标题翻译：传感器保护器
公开(公告)号：US08809765B2
公开(公告)日：2014-08-19
申请号：US13513344
申请日：2010-11-12
申请人： Stefan Weisshaar , Michael Bates , Christian Pradel , Volker Limpert
发明人： Stefan Weisshaar , Michael Bates , Christian Pradel , Volker Limpert
IPC分类号： G01J1/02
CPC分类号： G01N21/6428 , G01N2201/022
摘要： A sensor protector is intended to reduce the sensitivity of the optical sensor (4) to radiation products which, for example, are formed during sterilization with gamma radiation and to ensure simple and cost-effective manufacture. The sensor protector includes an upper part (1), a lower part (3) and an optical sensor (4). The optical sensor (4) situated on the lower part is positionable in an offset manner with respect to an opening (2) situated in the upper part and movable by means of displacement toward the opening (2) of the upper part (1). The sensor protector is suitable for use in containers and laboratory products that are sterilized by gamma radiation, for example disposable bioreactors.
摘要翻译：传感器保护器旨在降低光学传感器（4）对例如在用γ辐射灭菌期间形成的辐射产品的灵敏度，并确保简单且具有成本效益的制造。传感器保护器包括上部（1），下部（3）和光学传感器（4）。位于下部的光学传感器（4）可相对于位于上部的开口（2）以偏移的方式定位，并且通过位移朝向上部（1）的开口（2）移动。传感器保护器适用于通过伽马辐射灭菌的容器和实验室产品，例如一次性生物反应器。

8. 发明申请

US20130175716A1 AERATION DEVICE FOR BIOREACTORS 审中-公开
标题翻译：生物反应器的设备
公开(公告)号：US20130175716A1
公开(公告)日：2013-07-11
申请号：US13825072
申请日：2011-08-06
申请人： Stefan Weisshaar
发明人： Stefan Weisshaar
IPC分类号： B01F3/04
CPC分类号： B01F3/04106 , B01F3/04262 , B01F3/04531 , B01F15/0085 , B01F2003/04326 , B01F2003/04361 , B01F2003/04645 , B01F2003/04673 , B01F2215/0404 , B01F2215/0431 , C12M29/06
摘要： Aeration device for bioreactors with an aeration element with gas outlet openings arranged in a housing, the aeration element taking the form of a microsparger, the gas outlet openings of which are in each case spaced apart from one another and have a size of between 100 μm and 200 μm. At least one second aeration element with gas outlet openings of a second size is preferably provided, the aeration elements being formed by a common housing with separate aeration channels.
摘要翻译：用于具有布置在壳体中的气体出口开口的曝气元件的生物反应器的曝气装置，所述曝气元件采取微型放大器的形式，其气体出口开口各自彼此间隔开并且具有介于100μm之间的尺寸和200个妈妈。优选提供具有第二尺寸的气体出口开口的至少一个第二曝气元件，曝气元件由具有单独曝气通道的公共壳体形成。

9. 发明申请

US20120091326A1 SENSOR DEVICE, COMPRISING AN OPTICAL SENSOR, A CONTAINER AND A COMPARTMENTALIZATION MEANS 有权
标题翻译：包含光学传感器，集装箱和货物装置的传感器装置
公开(公告)号：US20120091326A1
公开(公告)日：2012-04-19
申请号：US13377845
申请日：2010-05-22
申请人： Reinhard Baumfalk , Stefan Weisshaar , Gerhard Greller , Daniel Riechers , Julia Lueders , Peter Pollossek
发明人： Reinhard Baumfalk , Stefan Weisshaar , Gerhard Greller , Daniel Riechers , Julia Lueders , Peter Pollossek
IPC分类号： H01J5/02
CPC分类号： A61L2/28 , A61L2/081 , G01N21/80 , G01N21/90 , G01N2021/7786
摘要： A sensor device has an optical sensor (1), a container (2) and a compartmentalizer (3) that temporarily divides the container into a main space (4) and an adjacent space (5), in which the optical sensor (1) is located. The gas volume in the direct vicinity of the optical sensor (1) is reduced, as are also, consequently, the reactive products generated by radiation sterilization. The adjacent space (5) can be united with the main space (4) after the sterilization as a result of the temporary compartmentalization. The optical sensor is suitable for implementation in containers and laboratory products, such as, for example, disposable bioreactors, that are sterilized by gamma radiation.
摘要翻译：传感器装置具有光学传感器（1），容器（2）和分隔器（3），其将容器暂时分为主空间（4）和相邻的空间（5），其中光传感器（1）位于。直接靠近光学传感器（1）的气体体积减少，因此减少由辐射灭菌产生的反应性产物。由于临时分隔，相邻的空间（5）可以在灭菌之后与主空间（4）结合。光学传感器适用于容器和实验室产品，例如通过γ辐射灭菌的一次性生物反应器。

10. 发明授权

US09228784B2 Plate heat exchanger 有权
标题翻译：板式换热器
公开(公告)号：US09228784B2
公开(公告)日：2016-01-05
申请号：US13379387
申请日：2010-06-10
申请人： Oscar-Werner Reif , Juergen van den Boogaard , Stefan Weisshaar
发明人： Oscar-Werner Reif , Juergen van den Boogaard , Stefan Weisshaar
IPC分类号： F28D9/00 , F28F17/00 , F28F21/06
CPC分类号： F28D9/005 , F28F17/005 , F28F21/06 , F28F2275/02 , F28F2275/06 , F28F2280/06
摘要： The invention relates to a plate heat exchanger comprising a plurality of plates having flow channels, wherein a first plate has a front side having at least one flow channel for a first fluid and a second plate has a front side having at least one flow channel for a second fluid, and wherein the plates have through openings via which the flow channels for the same fluid are respectively connected to one another, wherein a front plate, which is placed in front of the front side of the first plate, has ports for the first fluid and for the second fluid, wherein an end plate forms the end of the aligned plates, wherein the plates and ports are formed from plastic, and wherein the plates are bonded or welded tightly together.
摘要翻译：本发明涉及一种板式热交换器，其包括具有流动通道的多个板，其中第一板具有前侧，其具有用于第一流体的至少一个流动通道，而第二板的前侧具有至少一个流动通道，第二流体，并且其中所述板具有通孔，通过所述开口，用于相同流体的流动通道彼此分别连接，其中放置在所述第一板的前侧前面的前板具有用于第一流体和第二流体，其中端板形成对准的板的端部，其中板和端口由塑料形成，并且其中板被紧密地结合或焊接在一起。

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