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31. 发明授权

US5741652A Anti-human type IV collagen antibodies and use thereof 失效
标题翻译：抗人IV型胶原抗体及其用途
公开(公告)号：US5741652A
公开(公告)日：1998-04-21
申请号：US536740
申请日：1995-09-29
申请人： Akitaka Shibuya , Shunji Saitoh , Toshio Takahashi , Masanori Kamei , Naoko Maruo
发明人： Akitaka Shibuya , Shunji Saitoh , Toshio Takahashi , Masanori Kamei , Naoko Maruo
IPC分类号： G01N33/53 , C07K16/00 , C07K16/18 , C07K19/00 , C12N5/10 , C12N15/02 , C12P21/08 , G01N33/577 , G01N33/68
CPC分类号： C07K16/18 , G01N33/6887 , Y10S435/975
摘要： A method for one-step immunoassay of human type IV collagen, which uses a carrier immobilizing monoclonal antibody against human type IV collagen and a labelled polyclonal antibody against human type IV collagen, as well as a kit therefor and monoclonal antibodies which are particularly suited therefor. It is possible to accurately and quickly measure human type IV collagen in blood serum, for example, and obtain measurement results which accurately reflect pathological conditions.
摘要翻译：使用针对人IV型胶原的针对人IV型胶原的载体固定化单克隆抗体和针对人IV型胶原的标记多克隆抗体的人IV型胶原的一步免疫测定方法及其特别适用的单克隆抗体。例如，可以准确，快速地测量血清中的IV型胶原，并获得准确反映病理状况的测定结果。

32. 发明授权

US5341648A Process for producing ices 失效
标题翻译：生产冰糕的过程
公开(公告)号：US5341648A
公开(公告)日：1994-08-30
申请号：US24677
申请日：1993-03-01
申请人： Shin-ichi Umemura , Sadao Yashiro
发明人： Shin-ichi Umemura , Sadao Yashiro
IPC分类号： A23G9/04 , A23G9/14 , A23G9/18 , F25C1/12 , F25C5/10
CPC分类号： A23G9/045 , A23G9/14 , A23G9/18 , F25C1/12
摘要： A process for producing an ice, comprising the steps of allowing a material solution containing a sweetener to flow downward from the upper part of and along the surface of a freezing plate provided substantially upright, to thereby cause the material solution to freeze on and stick to the surface of the freezing plate to form an ice plate; breaking the ice place into ice pieces having a diameter of about 20 mm at maximum; and filling a container with the ice pieces. The material solution is so controlled as to flow down in such a quantity that at least 30% of the solution freezes on and sticks to the freezing plate before the solution reaches the lower end thereof, and has a concentration so adjusted that the ice plate has a fragmentation resistance of 1,000 mm or less as measured by the dropping test method.
摘要翻译：一种生产冰的方法，包括以下步骤：使含有甜味剂的材料溶液从基本上直立设置的冷冻板的上部和下部的表面向下流动，从而使材料溶液冷冻并粘附冷冻板的表面形成冰板; 将冰块最大限度地打破直径约20毫米的冰块; 并用冰块填充容器。该材料溶液被控制为使得至少30％的溶液在溶液到达其下端之前冻结并粘附到冷冻板上，并且具有如此调节的浓度以使得冰盘具有通过滴下试验方法测定的破碎电阻为1000mm以下。

33. 发明授权

US5094942A Detection of antibodies binding carboxypeptidase in serum of cancer patients 失效
标题翻译：检测抗体在癌症患者血清中结合羧酸酶
公开(公告)号：US5094942A
公开(公告)日：1992-03-10
申请号：US347638
申请日：1989-05-05
申请人： Shuichi Hashizume , Katsumi Mochizuki
发明人： Shuichi Hashizume , Katsumi Mochizuki
IPC分类号： G01N33/573 , G01N33/574 , G01N33/577
CPC分类号： G01N33/57488 , G01N33/57423 , G01N2333/948 , Y10S436/813
摘要： The present invention provides a serodiagnosis method for the detection of cancers, which comprises employing an antigen recognizable by a human monoclonal antibody and derived from animals other than human.
摘要翻译：本发明提供了一种用于检测癌症的血清诊断方法，其包括使用可被人单克隆抗体识别并由人以外的动物得到的抗原。

34. 发明申请

US20170049124A1 METHOD FOR MANUFACTURING AERATED CHOCOLATE DOUGH AND METHOD FOR MANUFACTURING BAKED CHOCOLATE 审中-公开
标题翻译：制造食品巧克力的方法及其制造方法
公开(公告)号：US20170049124A1
公开(公告)日：2017-02-23
申请号：US15307201
申请日：2014-10-06
申请人： MORINAGA & CO., LTD.
发明人： Takashi ONO , Hiroyuki WATANABE , Naoki IEMOTO
IPC分类号： A23G1/52 , A23G1/36
CPC分类号： A23G1/52 , A23G1/36 , A23V2002/00
摘要： Provided is a method for manufacturing an aerated chocolate from a non-tempered type chocolate containing a non-tempered type non-cocoa fat and having reduced bloom, the chocolate being improved by uniform introduction of fine air bubbles. Also provided is a method for manufacturing baked chocolate, using the aerated chocolate obtained by the above manufacturing method. This method for manufacturing an aerated chocolate involves chilling a chocolate containing a non-tempered type non-cocoa fat from a completely molten state to a temperature 0.5-5° C. lower than the solidification temperature, reheating to a temperature 1-5° C. higher than said temperature, and providing aeration to bring the specific gravity to 0.3-1.1. Baked chocolate is obtained by forming the aerated chocolate obtained by said method to a prescribed shape, and baking the chocolate.
摘要翻译：本发明提供一种由含有非回火型不可可脂的非回火型巧克力制造充气巧克力的方法，其具有减少的开花，通过均匀引入细小的气泡来改进巧克力。还提供了使用通过上述制造方法获得的充气巧克力制造焙烤巧克力的方法。用于制造充气巧克力的方法包括将来自完全熔融状态的含有非回火型非可可脂的巧克力冷却至比凝固温度低0.5-5℃的温度，再加热至1-5℃ 高于所述温度，并提供通气使比重达到0.3-1.1。通过将通过所述方法获得的充气巧克力形成规定的形状并烘烤巧克力，从而获得烘烤的巧克力。

35. 发明授权

US08859212B2 Method of extracting food component, food inspection method and food inspection kit 有权
标题翻译：食品成分提取方法，食品检验方法和食品检验试剂盒
公开(公告)号：US08859212B2
公开(公告)日：2014-10-14
申请号：US12744832
申请日：2008-11-28
申请人： Yuriko Oyama , Tsutomu Honjoh , Masatoshi Sakai , Eriko Watanabe , Kaori Itoh , Rieko Tsuruma
发明人： Yuriko Oyama , Tsutomu Honjoh , Masatoshi Sakai , Eriko Watanabe , Kaori Itoh , Rieko Tsuruma
IPC分类号： G01N33/53 , G01N33/558 , G01N33/02 , G01N33/68
CPC分类号： G01N33/558 , A23L5/20 , A23V2002/00 , G01N1/4044 , G01N33/02 , G01N33/538 , G01N33/68 , G01N2333/415 , G01N2333/4731 , A23V2200/08
摘要： Provided is a technique of extracting a component in a food from the food by using a reducing agent that is inexpensive and has a mild reducing action. A component in a food is extracted by mixing the food with an extractant containing a sulfite. In addition, the resultant food extract is brought into contact with a specific antibody that specifically recognizes a substance included in a specified ingredient of interest for inspection, to thereby inspect the presence or absence and/or the amount of a specified ingredient in a food by utilizing an immunological measurement method. Further provided is a food inspection kit for inspection of the presence or absence and/or the amount of a specified ingredient in a food, including: (1) an extractant and a sulfite to be added to the extractant, or an extractant including a sulfite added; and (2) an antibody that specifically recognizes a substance included in a specified ingredient of interest for inspection.
摘要翻译：提供了一种通过使用廉价且具有温和还原作用的还原剂从食物中提取食物中的成分的技术。通过将食物与含有亚硫酸盐的提取剂混合来提取食物中的成分。此外，使得到的食品提取物与特异性识别特定目的成分物质的特定抗体接触以进行检查，从而通过以下方式检查食品中特定成分的存在或不存在和/或数量：利用免疫学测量方法。还提供了用于检查食品中特定成分的存在或不存在和/或数量的食品检验试剂盒，其包括：（1）提取剂和要添加到萃取剂中的亚硫酸盐或包含亚硫酸盐的萃取剂添加; 和（2）特异性识别特定成分的物质进行检查的抗体。

36. 发明申请

US20140057292A1 Immunochromatographic Device 审中-公开
标题翻译：免疫色谱装置
公开(公告)号：US20140057292A1
公开(公告)日：2014-02-27
申请号：US13973298
申请日：2013-08-22
申请人： MORINAGA & CO., LTD.
发明人： Tsutomu HONJO
IPC分类号： G01N33/558
CPC分类号： G01N33/558 , B01L3/50273 , B01L2300/0681 , B01L2300/069 , B01L2300/0822 , B01L2300/0825 , B01L2400/0406
摘要： The present invention is directed to provide a highly quantitative immunochromatographic device.It is an immunochromatographic device comprising: a glass plate including: a sample application portion for applying a sample containing an antigen to the device; a sample recovery portion for recovering the sample applied to the sample application portion from the device; a developing portion for developing the sample from the sample application portion to the sample recovery portion; and an antibody-carrying portion for carrying an antibody capable of binding to the antigen in the developing portion; wherein the developing portion comprises a transparent plate, the glass plate and the transparent plate are placed in parallel with each other with a gap, and the sample can migrate in the gap of the developing portion by capillary action.
摘要翻译：本发明旨在提供高度定量的免疫色谱装置。它是一种免疫色谱装置，包括：玻璃板，包括：样品施加部分，用于将含有抗原的样品施加到所述装置; 样品回收部，用于从所述装置回收施加到所述样品施加部的样品; 用于将样品从样品施加部分显影到样品回收部分的显影部分; 以及用于携带能够结合显影部分中的抗原的抗体的抗体携带部分; 其中显影部分包括透明板，玻璃板和透明板以间隙彼此平行地放置，并且样品可以通过毛细管作用在显影部分的间隙中迁移。

37. 发明申请

US20030169636A1 Kneading device and ropesizer 有权
标题翻译：揉捏装置和研磨机
公开(公告)号：US20030169636A1
公开(公告)日：2003-09-11
申请号：US10397253
申请日：2003-03-27
申请人： Morinaga & Co., Ltd.
发明人： Tsuguo Kimura , Sumio Masukawa , Yoshihiro Ohno , Akishige Kanai
IPC分类号： B29B007/00
CPC分类号： A23G3/0215 , B01F3/10 , B01F7/00416 , B01F7/00425 , B01F7/083 , B01F15/00883 , B01F2003/105
摘要： A kneading device kneads a main raw material of high viscosity and a secondary raw material of liquid or powder and continuously delivers a kneaded raw material obtained, and a ropesizer includes a sheet forming unit, and a delivering unit applies a second raw material onto a first raw material, which is elongated into a sheet shape and is conveyed by the sheet forming unit, so as to be in a strand form.
摘要翻译：捏合装置将高粘度的主要原料和液体或粉末的二次原料捏合并连续地输送所得到的捏合原料，并且发光器包括片材形成单元，并且输送单元将第二原料施加到第一原料，其被拉伸成片状并由片材形成单元输送，以使其成为股线形式。

38. 发明授权

US6060255A Type IV collagen high molecular form and production and diagnostic use thereof 失效
标题翻译： IV型胶原蛋白高分子形式及其生产和诊断用途
公开(公告)号：US6060255A
公开(公告)日：2000-05-09
申请号：US164461
申请日：1998-10-01
申请人： Akitaka Shibuya , Shunji Saitoh , Toshio Takahashi , Naoko Maruo
发明人： Akitaka Shibuya , Shunji Saitoh , Toshio Takahashi , Naoko Maruo
IPC分类号： C07K14/78 , C07K16/18 , G01N33/68 , G01N33/53
CPC分类号： C07K16/18 , C07K14/78 , G01N33/6887 , G01N2333/78 , Y10S435/975 , Y10S530/846
摘要： A type IV collagen high molecular form having a higher molecular weight than the 7S domain of type IV collagen and including the 7S domain in its structure, is obtained from the supernatant being recovered from a collagen solution digested by pepsin in the following steps;1) salt precipitating with sodium chloride at a concentration no higher than 1.2 M,2) dissolving the precipitates,3) salt precipitating with sodium chloride at a concentration no higher than previous concentration. By reacting a sample with an antibody which reacts with this form, the type IV collagen high molecular form in the sample can be measured to allow diagnosis of the degree of liver fibrosis in patients with liver diseases.
摘要翻译：从以下步骤从胃蛋白酶消化的胶原溶液中回收的上清液获得具有比IV型胶原的7S结构域更高分子量并包含其结构的7S结构域的IV型胶原高分子形式; 1）浓度不高于1.2M的氯化钠沉淀，2）溶解沉淀物，3）以不高于先前浓度的浓度用氯化钠沉淀。通过使样品与与该形式反应的抗体反应，可以测量样品中的IV型胶原蛋白高分子形式，以诊断肝脏疾病患者的肝纤维化程度。

39. 发明授权

US5968451A Process and apparatus for sterilizing container holding fluid diet 失效
标题翻译：用于消毒容器保持液体饮食的方法和装置
公开(公告)号：US5968451A
公开(公告)日：1999-10-19
申请号：US873885
申请日：1997-06-12
申请人： Tsutomu Iwamoto , Yoshinori Ohtsuka , Nobuo Kiriu , Norihito Watanabe
发明人： Tsutomu Iwamoto , Yoshinori Ohtsuka , Nobuo Kiriu , Norihito Watanabe
IPC分类号： B65B55/06 , A23L3/04 , B65B55/02 , A61L2/00
CPC分类号： B65B55/025 , A23L3/04
摘要： A process for sterilizing a container holding a fluid diet, the container having a long and slender mouth and being filled with the fluid diet and sealed; the process includes the steps of filling the container with the fluid diet in a heated state, sealing the container at the mouth thereof, and thereafter turning the container with its mouth side down to immerse only the mouth and the vicinity thereof in a hot-water bath for a period of time sufficient to achieve sterilization. An apparatus for carrying out the process includes a bucket conveyor, a feed conveyor, a bucket and a bath. The process and apparatus can well sterilize containers holding a fluid diet and having a long and slender mouth. The process and apparatus can well sterilize containers holding a fluid diet and having a long and slender mouth.
摘要翻译：一种用于对容纳流体饮食的容器进行消毒的方法，所述容器具有长而细长的口并充满流体饮食并被密封; 该方法包括以加热状态将流体饮食填充容器的步骤，在其口部密封容器，然后将容器的口侧向下转动，仅将口及其附近浸入热水中洗澡一段时间足以实现灭菌。用于执行该过程的装置包括铲斗输送机，进料输送机，铲斗和洗涤槽。该方法和装置可以对容纳流体饮食并具有长而细长的口的容器进行消毒。该方法和装置可以对容纳流体饮食并具有长而细长的口的容器进行消毒。

40. 发明授权

US5773263A Production aflastatin A from streptomyces sp., a pharmaceutical composition and methods of use 失效
标题翻译：来自链霉菌的生产aflastatin A，药物组合物和使用方法
公开(公告)号：US5773263A
公开(公告)日：1998-06-30
申请号：US810368
申请日：1997-03-03
申请人： Makoto Ono , Akinori Suzuki , Akira Isogai , Shouhei Sakuda
发明人： Makoto Ono , Akinori Suzuki , Akira Isogai , Shouhei Sakuda
IPC分类号： A01N43/36 , A01N63/00 , A61K31/40 , A61K31/70 , A61P31/00 , A61P31/04 , A61P31/10 , A61P35/00 , C07D405/06 , C07H7/06 , C12P17/16 , C12P19/02 , C07D205/00 , C12N1/20
CPC分类号： A01N43/36 , A01N63/00 , C07H7/06 , C12P17/16 , C12P19/02
摘要： The antibiotic aflastatin A or its salt and its production by Streptomyces sp. MRI 142, FERM BP-5841 is presented. Aflastatin A is incorporated into a pharmaceutical composition and is employed as an aflatoxin contamination inhibitor, antimicrobial agent, antifungal agent and antitumor agent.
摘要翻译：抗生素aflastatin A或其盐及其生产由Streptomyces sp。提供MRI 142，FERM BP-5841。青霉素A被掺入药物组合物中，用作黄曲霉毒素污染抑制剂，抗微生物剂，抗真菌剂和抗肿瘤剂。

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