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1. 发明授权

US07829327B2 Optical waveguide type antibody chip and method of measuring antigen concentration 有权
标题翻译：光波导型抗体芯片及抗原浓度测定方法
公开(公告)号：US07829327B2
公开(公告)日：2010-11-09
申请号：US12047670
申请日：2008-03-13
申请人： Ikuo Uematsu , Masatoshi Sakai , Shingo Kasai
发明人： Ikuo Uematsu , Masatoshi Sakai , Shingo Kasai
IPC分类号： G01N33/551 , G01N33/552
CPC分类号： G01N33/54373 , Y10S435/808 , Y10S436/805 , Y10S436/807
摘要： An optical waveguide type antibody chip includes a transparent substrate, an incident-side optical element and an emitting-side optical element placed at a distance from each other on a primary face of the substrate, a water repellent resin film formed on the primary face of the substrate including an optical waveguide layer formed between the optical elements, the water repellent resin film includes a reaction hole having exposed the optical waveguide layer on its bottom and a frame-shaped trench surrounding the reaction hole, a rectangular frame-shaped cell wall which is fixed in the trench of the water repellent resin film and which forms a cell capable of infusion and discharge of a specimen solution together with the reaction hole, and an antibody immobilization layer formed on the bottom of the reaction hole, the surface of the antibody immobilization layer being masked with at least a buffer agent and a salt.
摘要翻译：光波导型抗体芯片包括在基板的主面上彼此相隔一定距离放置的透明基板，入射侧光学元件和发光侧光学元件，形成在基板的主面上的防水树脂膜所述基板包括形成在所述光学元件之间的光波导层，所述防水树脂膜包括在其底部露出光波导层的反应孔和围绕所述反应孔的框状沟槽，矩形框状电池壁，固定在防水树脂膜的沟槽中，并且形成能够与反应孔一起输注和排出样品溶液的电池，以及形成在反应孔底部的抗体固定层，抗体表面固定层用至少缓冲剂和盐掩蔽。

2. 发明授权

US06750257B2 Colloidal silica slurry 有权
标题翻译：胶体二氧化硅浆液
公开(公告)号：US06750257B2
公开(公告)日：2004-06-15
申请号：US09761043
申请日：2001-01-15
申请人： Shigetoyo Matsumura , Yukio Okada , Tatsuo Manaki , Keiji Toyama , Masatoshi Sakai
发明人： Shigetoyo Matsumura , Yukio Okada , Tatsuo Manaki , Keiji Toyama , Masatoshi Sakai
IPC分类号： B01F312
CPC分类号： B01J13/0008 , C01B33/1417 , C01B33/145 , C09K3/1463
摘要： The present invention provides the colloidal silica slurry which does not have a bad influence, such as corrosion, to a silicon wafer and wiring material on a silicon wafer and inhibits growth of microbes, and whereof preserving stability is high because stability of particle diameters of a colloidal particle is superior and using for a long period continuously is possible. For providing the above, the colloidal silica slurry wherein hydrogen peroxide from 5 to 100 ppm is added.
摘要翻译：本发明提供对硅晶片和硅晶片上的布线材料没有不利影响的胶体二氧化硅浆料，并抑制微生物的生长，其保留稳定性高，因为粒径的稳定性胶体粒子优越，连续使用长时间。为了提供上述方法，加入5-100ppm过氧化氢的胶体二氧化硅淤浆。

3. 发明授权

US5678299A Method for assembling an enclosed motor compressor of a two cylinder type using integral structures 失效
标题翻译：使用整体结构组装两缸式封闭式电动压缩机的方法
公开(公告)号：US5678299A
公开(公告)日：1997-10-21
申请号：US586935
申请日：1996-01-11
申请人： Tetsuya Mochizuki , Susumu Kawaguchi , Masatoshi Sakai , Koichi Sato , Hideaki Maeyama
发明人： Tetsuya Mochizuki , Susumu Kawaguchi , Masatoshi Sakai , Koichi Sato , Hideaki Maeyama
IPC分类号： F04C23/00 , F04C29/00 , F04C29/06 , H02K15/14
CPC分类号： F04C23/001 , F04C23/008 , F04C29/00 , F04C2230/60 , Y10T29/49009 , Y10T29/49245 , Y10T29/53143
摘要： An enclosed motor compressor of a two cylinder type in which a clearance between the eccentric portion of the second rotary shaft and the second sub bearing is set greater than a clearance between the eccentric portion of the first rotary shaft and the first main bearing, and also there is formed a clearance between the eccentric portion of the second rotary shaft and the second main bearing, so that, even when the second rotary shaft moves in the axial direction thereof, there is eliminated the possibility that the eccentric portion of the second rotary shaft can be in touch with the second main bearing and second sub bearing in the axial direction, thereby being able to reduce noise. Also, the pair of main bearings further include, on the side of the compression elements, assembling jig mounting portions to which the assembling jig can be mounted. Due to this, when assembling the main bearings, the accuracy with which the main bearings are made parallel to each other can be improved, and thus the performance and reliability of the compressor can be improved, thereby being able to reduce noise.
摘要翻译：一种双缸型封闭式电动压缩机，其中第二旋转轴的偏心部分和第二副轴承之间的间隙被设定为大于第一旋转轴的偏心部分和第一主轴承之间的间隙，并且还在第二旋转轴的偏心部分和第二主轴承之间形成间隙，使得即使当第二旋转轴沿其轴向移动时，也消除了第二旋转轴的偏心部分可以与第二主轴承和第二副轴承沿轴向接触，从而能够降低噪音。此外，一对主轴承还包括在压缩元件侧的组装夹具安装部分，组装夹具可以安装在该组装夹具安装部分上。因此，在组装主轴承时，可以提高使主轴承彼此平行的精度，从而能够提高压缩机的性能和可靠性，能够降低噪音。

4. 发明授权

US08859212B2 Method of extracting food component, food inspection method and food inspection kit 有权
标题翻译：食品成分提取方法，食品检验方法和食品检验试剂盒
公开(公告)号：US08859212B2
公开(公告)日：2014-10-14
申请号：US12744832
申请日：2008-11-28
申请人： Yuriko Oyama , Tsutomu Honjoh , Masatoshi Sakai , Eriko Watanabe , Kaori Itoh , Rieko Tsuruma
发明人： Yuriko Oyama , Tsutomu Honjoh , Masatoshi Sakai , Eriko Watanabe , Kaori Itoh , Rieko Tsuruma
IPC分类号： G01N33/53 , G01N33/558 , G01N33/02 , G01N33/68
CPC分类号： G01N33/558 , A23L5/20 , A23V2002/00 , G01N1/4044 , G01N33/02 , G01N33/538 , G01N33/68 , G01N2333/415 , G01N2333/4731 , A23V2200/08
摘要： Provided is a technique of extracting a component in a food from the food by using a reducing agent that is inexpensive and has a mild reducing action. A component in a food is extracted by mixing the food with an extractant containing a sulfite. In addition, the resultant food extract is brought into contact with a specific antibody that specifically recognizes a substance included in a specified ingredient of interest for inspection, to thereby inspect the presence or absence and/or the amount of a specified ingredient in a food by utilizing an immunological measurement method. Further provided is a food inspection kit for inspection of the presence or absence and/or the amount of a specified ingredient in a food, including: (1) an extractant and a sulfite to be added to the extractant, or an extractant including a sulfite added; and (2) an antibody that specifically recognizes a substance included in a specified ingredient of interest for inspection.
摘要翻译：提供了一种通过使用廉价且具有温和还原作用的还原剂从食物中提取食物中的成分的技术。通过将食物与含有亚硫酸盐的提取剂混合来提取食物中的成分。此外，使得到的食品提取物与特异性识别特定目的成分物质的特定抗体接触以进行检查，从而通过以下方式检查食品中特定成分的存在或不存在和/或数量：利用免疫学测量方法。还提供了用于检查食品中特定成分的存在或不存在和/或数量的食品检验试剂盒，其包括：（1）提取剂和要添加到萃取剂中的亚硫酸盐或包含亚硫酸盐的萃取剂添加; 和（2）特异性识别特定成分的物质进行检查的抗体。

5. 发明申请

US20080227126A1 OPTICAL WAVEGUIDE TYPE ANTIBODY CHIP AND METHOD OF MEASURING ANTIGEN CONCENTRATION 有权
标题翻译：光波导型抗体芯片和测量抗原浓度的方法
公开(公告)号：US20080227126A1
公开(公告)日：2008-09-18
申请号：US12047670
申请日：2008-03-13
申请人： Ikuo Uematsu , Masatoshi Sakai , Shingo Kasai
发明人： Ikuo Uematsu , Masatoshi Sakai , Shingo Kasai
IPC分类号： G01N33/543
CPC分类号： G01N33/54373 , Y10S435/808 , Y10S436/805 , Y10S436/807
摘要： An optical waveguide type antibody chip includes a transparent substrate, an incident-side optical element and an emitting-side optical element placed at a distance from each other on a primary face of the substrate, a water repellent resin film formed on the primary face of the substrate including an optical waveguide layer formed between the optical elements, the water repellent resin film includes a reaction hole having exposed the optical waveguide layer on its bottom and a frame-shaped trench surrounding the reaction hole, a rectangular frame-shaped cell wall which is fixed in the trench of the water repellent resin film and which forms a cell capable of infusion and discharge of a specimen solution together with the reaction hole, and an antibody immobilization layer formed on the bottom of the reaction hole, the surface of the antibody immobilization layer being masked with at least a buffer agent and a salt.
摘要翻译：光波导型抗体芯片包括在基板的主面上彼此相隔一定距离放置的透明基板，入射侧光学元件和发光侧光学元件，形成在基板的主面上的防水树脂膜所述基板包括形成在所述光学元件之间的光波导层，所述防水树脂膜包括在其底部露出光波导层的反应孔和围绕所述反应孔的框状沟槽，矩形框状电池壁，固定在防水树脂膜的沟槽中，并且形成能够与反应孔一起输注和排出样品溶液的电池，以及形成在反应孔底部的抗体固定层，抗体表面固定层用至少缓冲剂和盐掩蔽。

6. 发明申请

US20050158793A1 Immunoassays 审中-公开
标题翻译：免疫测定
公开(公告)号：US20050158793A1
公开(公告)日：2005-07-21
申请号：US10501110
申请日：2004-03-03
申请人： Shiroo Muraoka , Yumiko Watanabe , Masatoshi Sakai , Tsutomu Honjoh
发明人： Shiroo Muraoka , Yumiko Watanabe , Masatoshi Sakai , Tsutomu Honjoh
IPC分类号： G01N33/531 , C07K14/415 , C07K16/16 , C07K16/18 , G01N33/53 , G01N33/68
CPC分类号： G01N33/5306
摘要： This invention provides a method wherein a protein sparingly soluble in water, or a protein in a hardly extractable state, is detected sharply and easily in subsequent immunoreaction while high efficiency of extraction from a sample is maintained. Disclosed is a highly sensitive and easy immunoassay characterized in that a water-sparingly-soluble protein in a sample, or a protein in a hardly extractable state, is extracted/solubilized with an aqueous solvent containing an ionic surfactant at relatively high concentration, and then the protein in the extract is detected directly by an antibody raised against the protein previously denatured with the ionic surfactant.
摘要翻译：本发明提供了一种方法，其中在保持从样品中提取高效率的同时，在随后的免疫反应中，清楚地检测到难溶于水的蛋白质或难以提取的蛋白质的蛋白质。公开了一种高灵敏度和容易的免疫测定法，其特征在于样品中的水分微溶蛋白或难以提取的状态的蛋白质用含有较高浓度的离子表面活性剂的水性溶剂萃取/溶解，然后提取物中的蛋白质通过针对先前用离子表面活性剂变性的蛋白产生的抗体直接检测。

7. 发明授权

US5789590A Double cone-like crystal form of 2-amino-6-chloropurine and preparation 失效
标题翻译：双锥形晶体形式的2-氨基-6-氯嘌呤及其制备方法
公开(公告)号：US5789590A
公开(公告)日：1998-08-04
申请号：US741223
申请日：1996-10-29
申请人： Masatoshi Sakai , Masaki Fujiwara , Toshio Nakamatsu
发明人： Masatoshi Sakai , Masaki Fujiwara , Toshio Nakamatsu
IPC分类号： C07D473/40
CPC分类号： C07D473/40
摘要： The present invention is directed to a method for preparing 2-amino-6-chloropurine having a double cone-like crystal form, comprising the steps of: (A) suspending 2-amino-6-chloropurine having an acicular or irregular-shaped crystal form in a liquid consisting essentially of water having a pH of from 3 to 10; and (B) heating the resulting suspension at a temperature of from 70.degree. to 100.degree. C. to complete the double cone-like crystal form conversion.
摘要翻译：本发明涉及一种制备具有双锥状晶体形式的2-氨基-6-氯嘌呤的方法，包括以下步骤：（A）悬浮具有针状或不规则形状晶体的2-氨基-6-氯嘌呤在基本上由pH为3至10的水组成的液体中形成; 和（B）在70℃至100℃的温度下加热得到的悬浮液以完成双锥状晶体形式的转化。

8. 发明授权

US5326233A Enclosed motor compressor of a two cylinder type 失效
标题翻译：封闭式电动压缩机为双缸式
公开(公告)号：US5326233A
公开(公告)日：1994-07-05
申请号：US9229
申请日：1993-01-26
申请人： Tetsuya Mochizuki , Susumu Kawaguchi , Masatoshi Sakai , Koichi Sato , Hideaki Maeyama
发明人： Tetsuya Mochizuki , Susumu Kawaguchi , Masatoshi Sakai , Koichi Sato , Hideaki Maeyama
IPC分类号： F04C23/00 , F04C29/00 , F04C29/06 , F04B27/08
CPC分类号： F04C23/001 , F04C23/008 , F04C29/00 , F04C2230/60 , Y10T29/49009 , Y10T29/49245 , Y10T29/53143
摘要： An enclosed motor compressor of a two cylinder type in which a clearance between the eccentric portion of the second rotary shaft and the second sub bearing is set greater than a clearance between the eccentric portion of the first rotary shaft and the first main bearing, and also there is formed a clearance between the eccentric portion of the second rotary shaft and the second main bearing, so that, even when the second rotary shaft moves in the axial direction thereof, there is eliminated the possibility that the eccentric portion of the second rotary shaft can be in touch with the second main bearing and second sub bearing in the axial direction, thereby being able to reduce noise. Also, the pair of main bearings further include, on the side of the compression elements, assembling jig mounting portions to which the assembling jig can be mounted. Due to this, when assembling the main bearings, the accuracy with which the main bearings are made parallel to each other can be improved, and thus the performance and reliability of the compressor can be improved, thereby being able to reduce noise.
摘要翻译：一种双缸型封闭式电动压缩机，其中第二旋转轴的偏心部分和第二副轴承之间的间隙被设定为大于第一旋转轴的偏心部分和第一主轴承之间的间隙，并且还在第二旋转轴的偏心部分和第二主轴承之间形成间隙，使得即使当第二旋转轴沿其轴向移动时，也消除了第二旋转轴的偏心部分可以与第二主轴承和第二副轴承沿轴向接触，从而能够降低噪音。此外，一对主轴承还包括在压缩元件侧的组装夹具安装部分，组装夹具可以安装在该组装夹具安装部分上。因此，在组装主轴承时，可以提高使主轴承彼此平行的精度，从而能够提高压缩机的性能和可靠性，能够降低噪音。

9. 发明授权

US4764649A Snap switch with a separate leaf spring biasing member 失效
标题翻译：具有单独的板簧偏置构件的卡扣开关
公开(公告)号：US4764649A
公开(公告)日：1988-08-16
申请号：US924757
申请日：1986-10-30
申请人： Masatoshi Sakai , Takeshi Nishii
发明人： Masatoshi Sakai , Takeshi Nishii
IPC分类号： H01H13/42 , H01H13/12 , H01H13/36 , H01H13/38
CPC分类号： H01H13/36
摘要： An electrical switch includes a movable contactor which is actuated by a push button to engage a movable contact with a normally-open contact. A spring yieldably resists depression of the push button and normally maintains a clearance between the push button and the contactor. The spring is superimposed relative to the connector and engages the latter to act as a heat conducting fin. A free end of the spring slides in a notch of the push button. In one embodiment, the spring produces a varying rate of resistance to depression of the button. In another embodiment, the spring urges the connector to its normal position in response to release of the button.
摘要翻译：电开关包括由按钮致动的活动接触器，以将活动触点与常开触点接合。弹簧可以抵抗按钮的按压，并且通常保持按钮和接触器之间的间隙。弹簧相对于连接器重叠，并与其接合，用作导热翅片。弹簧的自由端在按钮的凹口中滑动。在一个实施例中，弹簧产生对按钮按压的不同的阻力。在另一个实施例中，响应于按钮的释放，弹簧促使连接器处于其正常位置。

10. 发明授权

US06187921B1 2-amino-6-chloropurine and method for preparing the same 失效
标题翻译： 2-氨基-6-氯嘌呤及其制备方法
公开(公告)号：US06187921B1
公开(公告)日：2001-02-13
申请号：US09104192
申请日：1998-06-25
申请人： Masatoshi Sakai , Masaki Fujiwara , Toshio Nakamatsu
发明人： Masatoshi Sakai , Masaki Fujiwara , Toshio Nakamatsu
IPC分类号： C07D47340
CPC分类号： C07D473/40
摘要： 2-Amino-6-chloropurine having a double cone-like crystal form.
摘要翻译：具有双锥状晶体形式的2-氨基-6-氯嘌呤

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