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31. 发明授权

US07402154B2 Method for compensating for pressure differences across valves in cassette type IV pump 有权
标题翻译：补充IV型泵的阀门压力差的方法
公开(公告)号：US07402154B2
公开(公告)日：2008-07-22
申请号：US11157758
申请日：2005-06-21
申请人： Peter A. Holst , David A. Krajewski , Rudolph J. Maske
发明人： Peter A. Holst , David A. Krajewski , Rudolph J. Maske
IPC分类号： A61M1/00
CPC分类号： A61M5/14224 , A61M5/16809 , A61M5/16827 , A61M5/365 , A61M2205/12 , A61M2205/3355 , A61M2205/50 , G05D16/2046
摘要： A pump used to infuse a fluid into a patient is controlled in accordance with an algorithm that enables a microprocessor to monitor and adjust each pump cycle to compensate for a differential pressure between the pump's inlet and outlet. The algorithm defines a fluid delivery protocol that is applied in controlling the operation of the pump to achieve a desired rate, volume, and timing of the fluid infusion. Fluid is delivered by the pump when a plunger compresses an elastomeric membrane overlying a fluid chamber. Due to the small volume of the chamber, an incremental change in the plunger position before the delivery stroke produces a significant change in the delivery pressure. At the beginning of a pump cycle, the microprocessor determines the differential pressure between the inlet and outlet of the pump, and adjusts the plunger position before the delivery stroke to compensate for the differential pressure. A retraction of the plunger from the home position decreases the delivery pressure of the fluid, and an advancement of the plunger increases it. After the position of the plunger is adjusted to compensate for the differential pressure, the pump cycle proceeds. Following the plunger stroke, the outlet pressure is used to determine the actual volume of fluid delivered. The duration of the plunger stroke in the next pump cycle is adjusted to compensate for any volume delivery error produced by the differential pressure compensation.
摘要翻译：用于将流体注入患者体内的泵根据能够使微处理器监测和调节每个泵循环以补偿泵的入口和出口之间的压差的算法来控制。该算法定义了流体输送协议，其被应用于控制泵的操作以实现流体输注的期望速率，体积和时间。当柱塞压缩覆盖流体室的弹性体膜时，流体由泵输送。由于室的体积小，在输送冲程之前的柱塞位置的增量变化产生输送压力的显着变化。在泵循环开始时，微处理器确定泵的入口和出口之间的压差，并在输送冲程之前调节柱塞位置，以补偿差压。柱塞从原始位置的缩回减小了流体的输送压力，并且柱塞的前进增加了其。在调节柱塞的位置以补偿差压之后，泵循环进行。在柱塞行程之后，出口压力用于确定输送的流体的实际体积。在下一个泵循环中的柱塞行程的持续时间被调整以补偿由差压补偿产生的任何体积传递误差。

32. 发明授权

US06980855B2 Microneedles for minimally invasive drug delivery 失效
标题翻译：用于微创药物递送的微针
公开(公告)号：US06980855B2
公开(公告)日：2005-12-27
申请号：US10767485
申请日：2004-01-29
申请人： Steve T. Cho
发明人： Steve T. Cho
IPC分类号： B81B1/00 , A61B5/15 , A61M5/32 , A61M37/00 , B81C1/00 , A61N1/30
CPC分类号： B81C1/00111 , A61B5/14514 , A61B5/150022 , A61B5/150221 , A61B5/150282 , A61B5/150748 , A61B5/15087 , A61B5/150969 , A61B5/150984 , A61B5/157 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2037/0038 , A61M2037/0053 , B81B2201/055
摘要： The present invention provides a microneedle incorporating a base that is broad relative to a height of the microneedle, to minimize breakage. The microneedle further includes a fluid channel and a beveled non-coring tip. Preferably arrays of such microneedles are fabricated utilizing conventional semiconductor derived micro-scale fabrication techniques. A dot pattern mask is formed on an upper surface of a silicon substrate, with each orifice of the dot pattern mask corresponding to a desired location of a microneedle. Orifices are formed that pass completely through the substrate by etching. A nitride pattern mask is formed to mask all areas in which a nitride layer is not desired. A nitride layer is then deposited on the bottom of the silicon substrate, on the walls of the orifice, and on the top of the silicon substrate around the periphery of the orifice. The nitride layer around the periphery of the orifice is offset somewhat, such that one side of the orifice has a larger nitride layer. Anisotropic etching is used to remove a substantial portion of the substrate, creating a plurality of angular, blunt, and generally pyramidal-shaped microneedles. A subsequent removal of the nitride layer, followed by an isotropic etching step, softens and rounds out the blunt angular microneedles, providing generally conical-shaped microneedles. The uneven nitride layer adjacent the orifice ensures that the microneedles will include a beveled tip. Such microneedle arrays are preferably incorporated into handheld diagnostic and drug delivery systems.
摘要翻译：本发明提供了一种结合了相对于微针的高度宽的基底的微针，以使破损最小化。微针还包括流体通道和倾斜的非取心尖端。优选地，使用常规的半导体衍生的微尺度制造技术制造这种微针的阵列。在硅基板的上表面上形成点阵图案掩模，点图案掩模的每个孔口对应于微针的期望位置。形成通过蚀刻完全通过基板的孔。形成氮化物图案掩模以掩盖不需要氮化物层的所有区域。然后将氮化物层沉积在硅衬底的底部，孔的壁上，以及围绕孔的周边的硅衬底的顶部上。围绕孔的周边的氮化物层稍微偏移，使得孔的一侧具有较大的氮化物层。使用各向异性蚀刻去除基本部分的大部分，产生多个角，钝，通常为锥形的微针。随后去除氮化物层，随后进行各向同性的蚀刻步骤，软化和圆化钝角微针，提供大致锥形的微针。邻近孔口的不均匀氮化物层确保了微针将包括一个倾斜尖端。这种微针阵列优选并入手持诊断和药物输送系统中。

33. 发明授权

US06958234B2 Automatic microbial air sampling system and method 失效
标题翻译：自动微生物空气取样系统及方法
公开(公告)号：US06958234B2
公开(公告)日：2005-10-25
申请号：US10406344
申请日：2003-04-03
申请人： Alan H. Aicher
发明人： Alan H. Aicher
IPC分类号： G01N1/10 , G01N1/22 , G01N1/24 , C12M1/26
CPC分类号： G01N1/2226 , G01N1/2202 , G01N1/24 , G01N2001/1037 , G01N2001/2223 , Y10T436/2525 , Y10T436/25875
摘要： A method and system for automated remote microbial air sampling includes a sampling enclosure positioned outside an isolator. An infeed sample receiver passes sample containers into the enclosure. An atrium is located within the enclosure and exposes containers to a gas sample. A remote sampling device collects the gas sample from the isolator and passes it to the atrium. A load arm is located within the enclosure. The load arm intermittently permits containers to enter the enclosure and moves containers to the atrium. An outfeed sample receiver passes containers out of the enclosure. The system allows addition and removal of containers from the air sampling system without interrupting the processing of the containers within the enclosure, and allows the first container supplied to the air sampling system to be the first exposed container removed therefrom.
摘要翻译：用于自动远程微生物空气取样的方法和系统包括位于隔离器外部的取样外壳。进料样品接收器将样品容器送入外壳。中庭位于外壳内，并将容器暴露于气体样品。远程采样装置从隔离器收集气体样品并将其传送到心房。负载臂位于外壳内。负载臂间歇地允许容器进入外壳并将容器移动到中庭。外送样品接收器将容器从外壳中取出。该系统允许从空气取样系统添加和移除容器，而不会中断外壳内的容器的处理，并且允许提供给空气取样系统的第一容器是从其中移除的第一暴露的容器。

34. 发明申请

US20200222282A1 Packaged Iron Sucrose Products 审中-公开
公开(公告)号：US20200222282A1
公开(公告)日：2020-07-16
申请号：US16829466
申请日：2020-03-25
申请人： Hospira, Inc.
发明人： Seshagiri R. Tata-Venkata , Xifeng Zhang , Fay Goldblatt , Minhaj Siddiqui
IPC分类号： A61J1/14 , B65D65/42 , A61J1/00 , B65B3/00
摘要： A packaged iron sucrose formulation including a container with an interior glass surface that is coated with layer of material containing silicon, such as a silicone polymer or silicon dioxide. The iron sucrose formulation is packaged inside the glass vessel and in contact with the layer of material containing silicon. The packaged formulation can be stored for extended periods without glass delamination.

35. 发明授权

US10016396B2 Dexmedetomidine premix formulation 有权
公开(公告)号：US10016396B2
公开(公告)日：2018-07-10
申请号：US15444932
申请日：2017-02-28
申请人： Hospira, Inc.
发明人： Priyanka Roychowdhury , Robert A. Cedergren
IPC分类号： A61K31/4174 , A61K31/4164 , A61K9/08 , A61K47/02 , A61L2/00 , A61K9/00
CPC分类号： A61K31/4174 , A61K9/0019 , A61K9/08 , A61K31/4164 , A61K47/02 , A61L2/0023 , A61P9/12 , A61P23/02 , A61P25/20 , A61P25/22 , A61P29/00 , Y10S514/816
摘要： The presently disclosed subject matter relates to pharmaceutical compositions comprising dexmedetomidine or a pharmaceutically acceptable salt thereof wherein the composition is formulated as a liquid for parenteral administration to a subject, and wherein the composition is disposed within a sealed container as a premixture. The pharmaceutical compositions can be used, for example, in perioperative care of a patient or for sedation.

36. 发明申请

US20170024534A1 MEDICAL DEVICE UPDATE SYSTEM 有权
标题翻译：医疗器械更新系统
公开(公告)号：US20170024534A1
公开(公告)日：2017-01-26
申请号：US15289483
申请日：2016-10-10
申请人： Hospira, Inc.
发明人： John Arrizza , James R. Shults , Thomas J. Vaccaro , Patrick A. Ward
IPC分类号： G06F19/00 , G06F9/445
CPC分类号： G16H40/40 , A61M5/142 , A61M5/14212 , A61M2205/3561 , G06F8/61 , G06F8/65 , G06F19/00 , G06F19/326 , G06F19/3468 , G06Q50/24 , G16H20/17
摘要： A system and method for providing updates to medical devices is disclosed. In one example, the medical devices are configured to pull update files in response to the reception of an update message from a server. Once the update files are downloaded by a medical device, the update files can be installed. While the medical device pulls the update files, the medical device can continue with its normal operation. If desired, a user can select which medical devices should be updated, based on any desired factors, such as the physical location of the device, the model of the device, the type of device, and the way the device is being used.
摘要翻译：公开了一种用于向医疗设备提供更新的系统和方法。在一个示例中，医疗设备被配置为响应于来自服务器的更新消息的接收而拉取更新文件。一旦更新文件由医疗设备下载，则可以安装更新文件。当医疗设备拉动更新文件时，医疗设备可以继续其正常操作。如果需要，用户可以基于任何期望的因素来选择哪些医疗设备应该被更新，例如设备的物理位置，设备的型号，设备的类型以及设备的使用方式。

37. 发明授权

US09468713B2 Apparatus and method of mitigating free flow in a fluid administration set 有权
标题翻译：减轻流体给药装置中自由流动的装置和方法
公开(公告)号：US09468713B2
公开(公告)日：2016-10-18
申请号：US14067083
申请日：2013-10-30
申请人： John C. Hoenninger, III
发明人： John C. Hoenninger, III
IPC分类号： A61M5/00 , A61M5/14 , A61M5/168 , A61M39/28
CPC分类号： A61M5/1413 , A61M5/16881 , A61M39/28 , A61M2205/12 , A61M2205/121 , A61M2205/6045 , Y10T29/49716
摘要： A free flow mitigating device for a fluid administration set includes a pump driver mechanism having a locator pin attached and positioned to register with a locator hole on the administration set, for example in a cassette. The locator pin has a surface area. A compressible material is attached to at least a portion of the surface area of the locator pin. The compressible material has a thickness such that it is frictionally received within the locator hole of the cassette sufficient to provide a retaining force to resist cassette movement during closing of a flow regulator valve of the cassette.
摘要翻译：用于流体给药装置的自由流动减轻装置包括泵驱动器机构，其具有附接并定位成与管理装置上的定位器孔对准的定位销，例如在盒中。定位销有一个表面积。可压缩材料附接到定位销的表面区域的至少一部分。可压缩材料具有这样的厚度，使得它被摩擦地容纳在盒的定位器孔内，足以在关闭盒的流量调节阀期间提供保持力以阻止盒移动。

38. 发明授权

US09393362B2 Infusion pump with configurable screen settings 有权
公开(公告)号：US09393362B2
公开(公告)日：2016-07-19
申请号：US12336981
申请日：2008-12-17
申请人： Mihaela Cozmi , John Arrizza , Glenn Davis , Marwan A. Fathallah , Wen Feng , Angela Marino , John Erik Michael Palmroos , James R. Shults , Suzanne Willey , Yu Xin
发明人： Mihaela Cozmi , John Arrizza , Glenn Davis , Marwan A. Fathallah , Wen Feng , Angela Marino , John Erik Michael Palmroos , James R. Shults , Suzanne Willey , Yu Xin
IPC分类号： G09G5/10 , A61M5/142 , G06Q50/24 , G06F19/00
CPC分类号： A61M5/142 , A61M2205/502 , A61M2205/505 , A61M2205/587 , A61M2205/8212 , G06F19/00 , G06F19/3468 , G06Q50/24
摘要： A method and apparatus provides for configuring the backlight brightness level. The backlight brightness level can be configured at the drug library and/or at the medical device, thereby improving the flexibility a user has in changing backlight parameters. A method and apparatus for managing a power saving mode allows the user to configure the power saving program at the drug library and/or at the medical device.

39. 发明申请

US20160175285A1 DEXMEDETOMIDINE PREMIX FORMULATION 有权
标题翻译：地塞米松精油配方
公开(公告)号：US20160175285A1
公开(公告)日：2016-06-23
申请号：US15058602
申请日：2016-03-02
申请人： Hospira, Inc.
发明人： Priyanka Roychowdhury , Robert A. Cedergren
IPC分类号： A61K31/4174 , A61L2/00 , A61K47/02 , A61K9/08
CPC分类号： A61K31/4174 , A61K9/0019 , A61K9/08 , A61K31/4164 , A61K47/02 , A61L2/0023 , A61P9/12 , A61P23/02 , A61P25/20 , A61P25/22 , A61P29/00 , Y10S514/816
摘要： The presently disclosed subject matter relates to pharmaceutical compositions comprising dexmedetomidine or a pharmaceutically acceptable salt thereof wherein the composition is formulated as a liquid for parenteral administration to a subject, and wherein the composition is disposed within a sealed container as a premixture. The pharmaceutical compositions can be used, for example, in perioperative care of a patient or for sedation.
摘要翻译：目前公开的主题涉及包含右美托咪定或其药学上可接受的盐的药物组合物，其中所述组合物配制成用于胃肠外给药于受试者的液体，并且其中所述组合物作为预混合物设置在密封容器内。药物组合物可用于例如患者的围手术期护理或镇静。

40. 发明授权

US09205026B2 Medicament admixing system 有权
标题翻译：药物混合系统
公开(公告)号：US09205026B2
公开(公告)日：2015-12-08
申请号：US13827884
申请日：2013-03-14
申请人： Yei F. Moy , Stanley F. Pytel , John S. Ziegler , Jesse C. Darley , Douglas S. Rodenkirch
发明人： Yei F. Moy , Stanley F. Pytel , John S. Ziegler , Jesse C. Darley , Douglas S. Rodenkirch
IPC分类号： A61B19/00 , A61J1/20 , A61J1/14 , B65D51/00 , B65D75/58 , B65D81/32 , B65B3/00 , A61J1/10 , A61M39/00
CPC分类号： A61J1/2093 , A61J1/10 , A61J1/1462 , A61J1/1475 , A61J1/2041 , A61J1/2051 , A61J1/2055 , A61J1/2089 , A61M2039/0036 , B65B3/003 , B65D51/002 , B65D75/5883 , B65D81/3211
摘要： A medicament container having an opening that provides access to a cavity defined by the medicament container. A stopper is sealingly positioned within the opening of the medicament container and configured to be forced into the cavity to open the medicament container. The medicament container also includes a mating member configured to mate with a complementary receiver associated with a second container to connect the medicament container to a second container. The medicament container further includes a radial seal configured to engage and seal against an interior seal wall associated with a second container prior to the stopper being forced into the cavity defined by the medicament container. A system is also provided for establishing fluid communication between a first container and a second container. The system includes a first container (e.g., a medicament container) having a radial seal, a second container, and a port assembly.
摘要翻译：一种具有开口的药物容器，该开口提供对由药物容器限定的空腔的通路。塞子被密封地定位在药物容器的开口内并构造成被迫进入空腔以打开药物容器。药物容器还包括配合构件，其配置成与与第二容器相关联的补充接收器配合，以将药物容器连接到第二容器。药物容器还包括径向密封件，其构造成在止动器被迫进入由药物容器限定的空腔之前与第二容器相关联的内部密封壁接合并密封。还提供了一种用于建立第一容器和第二容器之间的流体连通的系统。该系统包括具有径向密封件，第二容器和端口组件的第一容器（例如，药物容器）。

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