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    • 37. 发明授权
    • Salts of substituted 5-membered azacycle and use thereof in the treatment of diseases related to protein aging
    • 取代的5元氮环的盐及其在治疗与蛋白质老化相关的疾病中的用途
    • US07799813B2
    • 2010-09-21
    • US12223236
    • 2007-01-29
    • Song LiHao CuiJunhai XiaoWu ZhongLili WangGang Cheng
    • Song LiHao CuiJunhai XiaoWu ZhongLili WangGang Cheng
    • C07D277/60C07D277/30A61K31/428A61K31/426
    • C07D277/62A23L3/3526
    • The present invention relates to 5-membered azacycle compounds of formula (I), pharmaceutically acceptable salts thereof and hydrates thereof, wherein the groups are as defined in the specification. The present invention further relates to pharmaceutical compositions containing said compounds or pharmaceutically acceptable salts thereof or hydrates thereof, and to use of the pharmaceutical compositions in (i) improving skin elasticity or reducing skin wrinkles, (ii) treating diabetes, (iii) treating or relieving adverse sequelae of diabetes, (iv) treating or relieving kidney damage, (v) treating or relieving damage to blood vasculature, (vi) treating or relieving hypertension, (vii) treating or relieving retinopathy, (viii) treating or relieving damage to lens proteins, (ix) treating or relieving cataract, (x) treating or relieving peripheral neuropathy, or (xi) treating or relieving osteoarthritis. The present invention further relates to use of said compounds or pharmaceutically acceptable salts thereof or hydrates thereof in the preparation of oral formulations for inhibiting or reversing tooth staining, or in the preparation of fresh-keeping agents for plant proteins of crops or animal proteins.
    • 本发明涉及式(I)的5元氮环化合物,其药学上可接受的盐及其水合物,其中基团如说明书中所定义。 本发明还涉及含有所述化合物或其药学上可接受的盐或其水合物的药物组合物,以及(i)改善皮肤弹性或减少皮肤皱纹,(ii)治疗糖尿病,(iii)治疗或 减轻糖尿病的不良后遗症,(iv)治疗或缓解肾脏损害,(v)治疗或缓解血液血管系统损伤,(vi)治疗或缓解高血压,(vii)治疗或缓解视网膜病变,(viii)治疗或缓解对 (ix)治疗或缓解白内障,(x)治疗或缓解周围神经病变,或(xi)治疗或缓解骨关节炎。 本发明还涉及所述化合物或其药学上可接受的盐或其水合物在制备用于抑制或逆转牙齿染色的口服制剂中的用途,或用于制备作物或动物蛋白质的植物蛋白质的保鲜剂。