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31. 发明申请

US20100105654A1 SUBSTITUTED QUINAZOLINONE COMPOUNDS 审中-公开
标题翻译：替代喹唑啉酮化合物
公开(公告)号：US20100105654A1
公开(公告)日：2010-04-29
申请号：US12605174
申请日：2009-10-23
申请人： Rustum S. BOYCE , Natalia Aurrecoechea , Daniel Chu , Aaron Smith , Christopher R. Conlee , Brian D. Thompson , Judith de Armas Kuntz , David L. Musso , Kevin K. Barvian , Stephen A. Thomson , William R. Swain , Kien S. Du , Brian A. Chauder , Jason D. Speake , Michael J. Bishop
发明人： Rustum S. BOYCE , Natalia Aurrecoechea , Daniel Chu , Aaron Smith , Christopher R. Conlee , Brian D. Thompson , Judith de Armas Kuntz , David L. Musso , Kevin K. Barvian , Stephen A. Thomson , William R. Swain , Kien S. Du , Brian A. Chauder , Jason D. Speake , Michael J. Bishop
IPC分类号： A61K31/517 , C07D403/12 , C07D239/86 , C07D403/14 , C07D413/14 , C07D417/14 , A61K31/5377 , A61P3/04 , A61P3/10
CPC分类号： C07D217/24 , C07D239/91 , C07D239/95 , C07D239/96 , C07D253/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04
摘要： A variety of small molecule, guanidine-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases when administered to subjects. The compounds have the structures VA, VB, VIIA and VIIB where the values of the variables are defined herein.
摘要翻译：提供了能够作为MC4-R激动剂的各种小分子，含胍分子。当给予受试者时，这些化合物可用于治疗MC4-R介导的疾病。化合物具有结构VA，VB，VIIA和VIIB，其中变量的值在本文中定义。

32. 发明申请

US20060235019A1 Substituted quinazolinone compounds 失效
标题翻译：取代喹唑啉酮化合物
公开(公告)号：US20060235019A1
公开(公告)日：2006-10-19
申请号：US10515434
申请日：2003-05-23
申请人： Rustum Boyce , Natalia Aurrecoechea , Daniel Chu , Aaron Smith
发明人： Rustum Boyce , Natalia Aurrecoechea , Daniel Chu , Aaron Smith
IPC分类号： A61K31/53 , A61K31/525 , A61K31/519 , C07D487/02 , C07D475/02
CPC分类号： C07D253/08 , C07D217/24 , C07D239/88 , C07D239/90 , C07D239/91 , C07D239/96 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/12 , C07D417/04 , C07D471/04
摘要： A variety of low molecular weight, guanidino-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases. The compounds have the structure of Formulas (IA), (IB), or (IC): where the values of the variable are defined herein.
摘要翻译：提供了能够作为MC4-R激动剂的各种低分子量含胍基分子。该化合物可用于治疗MC4-R介导的疾病。化合物具有式（IA），（IB）或（IC）的结构：其中变量的值在本文中定义。

33. 发明申请

US20050101548A1 Antimicrobial derivatives 审中-公开
标题翻译：抗微生物衍生物
公开(公告)号：US20050101548A1
公开(公告)日：2005-05-12
申请号：US10940900
申请日：2004-09-13
申请人： Xiaodong Lin , Daniel Chu
发明人： Xiaodong Lin , Daniel Chu
IPC分类号： A61K31/7048 , A61P31/04 , C07H17/08
CPC分类号： C07H17/08
摘要： Antimicrobial compounds are provided having the formula (Q): as well as tautomers, stereoisomers, pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
摘要翻译：提供具有式（Q）的抗微生物化合物：以及互变异构体，立体异构体，其药学上可接受的盐，酯或前药; 包含这些化合物的药物组合物; 通过施用这些化合物治疗细菌感染的方法; 和化合物的制备方法。

34. 发明申请

US20050009764A1 Pyridyl substituted ketolide antibiotics 失效
标题翻译：吡啶基取代的酮内酯抗生素
公开(公告)号：US20050009764A1
公开(公告)日：2005-01-13
申请号：US10831749
申请日：2004-04-23
申请人： Matthew Burger , Georgia Carroll , Daniel Chu , Xiaodong Lin , Jacob Plattner , Alice Rico
发明人： Matthew Burger , Georgia Carroll , Daniel Chu , Xiaodong Lin , Jacob Plattner , Alice Rico
IPC分类号： A61P31/04 , C07H17/08 , A61K31/7052
CPC分类号： C07H17/08
摘要： Antimicrobial macrolide and ketolide compounds are provided having formulas XII: as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
摘要翻译：提供抗微生物大环内酯和酮内酯化合物，其具有式XII：及其药学上可接受的盐，酯或前药; 包含这些化合物的药物组合物; 通过施用这些化合物治疗细菌感染的方法; 和化合物的制备方法。

35. 发明授权

US06756359B2 C12 modified erythromycin macrolides and ketolides having antibacterial activity 失效
标题翻译： C12改性红霉素大环内酯类和具有抗菌活性的酮内酯
公开(公告)号：US06756359B2
公开(公告)日：2004-06-29
申请号：US10190431
申请日：2002-07-03
申请人： Daniel Chu , Matthew Burger , Xiaodong Lin , Georgia Law Carroll , Jacob Plattner , Alice Rico
发明人： Daniel Chu , Matthew Burger , Xiaodong Lin , Georgia Law Carroll , Jacob Plattner , Alice Rico
IPC分类号： A61K3170
CPC分类号： C07H17/08
摘要： Antimicrobial macrolide compounds are provided having formulas II: as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
摘要翻译：提供具有式II的抗微生物大环内酯类化合物及其药学上可接受的盐，酯或前药; 包含这些化合物的药物组合物; 通过施用这些化合物治疗细菌感染的方法; 和化合物的制备方法。

36. 发明授权

US06716840B2 Guanidino compounds 失效
标题翻译：胍基化合物
公开(公告)号：US06716840B2
公开(公告)日：2004-04-06
申请号：US10118730
申请日：2002-04-08
申请人： Daniel Chu , Rustum S. Boyce , David Duhl , Bryan H. Chang
发明人： Daniel Chu , Rustum S. Boyce , David Duhl , Bryan H. Chang
IPC分类号： A61K315375
CPC分类号： C07D209/46 , C07D209/48 , C07D217/24 , C07D235/08 , C07D235/10
摘要： Compounds having the general structure I are provided: X and Y are independently selected from the group consisting of CH2, N, NR9, C═O, C═S, S═O, SO2, S, O, (CR6R7)n, C(═O)—(CR6R7)n, and C(═S)—(CR6R7)n, where n is 1, 2, or 3. W is selected from the group consisting of and L is selected from the group consisting of N, O, S, S═O, SO2, C(O), NC(O), NC(S), OC(O), OC(S), C(NR10), C(NOR10), and a covalent bond. Z1, Z2, and Z3 are independently selected from the group consisting of substituted carbon and nitrogen. Compounds of formula I are agonists of the melanocortin-4 receptor (“MC-4r”) and therefore may have useful properties for controlling diseases related to MC-4r action in humans, such as obesity and type II diabetes.
摘要翻译：提供具有通式结构I的化合物：X和Y独立地选自CH 2，N，NR 9，C = O，C = S，S = O，SO 2，S，O，（R 6 R 7）n，C（= O） - （CR 6 R 7）n和C（= S） - （CR 6 R 7）n，其中n为1 W选自N，O，S，S = O，SO 2，C（O），NC（O），NC（S），OC （O），OC（S），C（NR 10），C（NOR 10））和共价键。 Z 1，Z 2和Z 3独立地选自取代的碳和氮。式I化合物是黑皮质素-4受体（“MC-4r”）的激动剂，因此可能具有控制人类MC-4r作用相关疾病如肥胖和II型糖尿病的有用性质。

37. 发明授权

US10905158B2 Two way humidity control pack 有权
公开(公告)号：US10905158B2
公开(公告)日：2021-02-02
申请号：US16181438
申请日：2018-11-06
申请人： Jason Kang , Daniel Chu , Delia Aguilar
发明人： Jason Kang , Daniel Chu , Delia Aguilar
IPC分类号： A24F25/02 , A24F9/10 , A24C1/34 , A24C5/10 , C06F5/00 , A24F13/24 , A24F29/00 , A24F23/00 , A24C1/04
摘要： The embodiments disclose an apparatus including a smoking material care kit, a matchstick and pick combination device for igniting smoking materials, a two-way humidity control pack device for controlling humidity of a smoking material stored in a smoking material protective container, and a protective container safety cap device coupled to the protective container to prevent access to smoking materials inside the protective container by children.

38. 发明申请

US20130252930A1 CYP11B, CYP17, AND/OR CYP21 INHIBITORS 审中-公开
标题翻译： CYP11B，CYP17，AND / OR CYP21抑制剂
公开(公告)号：US20130252930A1
公开(公告)日：2013-09-26
申请号：US13881411
申请日：2011-12-16
申请人： Daniel Chu , Bing Wang , Tao Ye
发明人： Daniel Chu , Bing Wang , Tao Ye
IPC分类号： C07J73/00 , C07J43/00 , C07J61/00 , C07J63/00
CPC分类号： C07J73/008 , C07D401/08 , C07D403/08 , C07D405/08 , C07D413/08 , C07D471/04 , C07J1/0011 , C07J13/005 , C07J21/005 , C07J31/006 , C07J43/003 , C07J61/00 , C07J63/002 , C07J73/003 , C07J73/005
摘要： Provided herein are inhibitors of CYP11B, CYP17, and/or CYP21 enzymes of Formula (Z), (IX), (X), (XI), (XII), (XIII), (XIV), (XV), (XVI), or (XVII). Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat androgen-dependent diseases, disorders and conditions. Formula (Z)
摘要翻译：本文提供式（Z），（IX），（X），（XI），（XII），（XIII），（XIV），（XV），（XVI）的CYP11B，CYP17和/ ）或（XVII）。本文还描述了包含本文所述的至少一种化合物和本文所述的化合物或药物组合物用于治疗雄激素依赖性疾病，病症和病症的药物组合物。式（Z）

39. 发明授权

US08420650B2 Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP) 有权
公开(公告)号：US08420650B2
公开(公告)日：2013-04-16
申请号：US13077785
申请日：2011-03-31
申请人： Bing Wang , Daniel Chu
发明人： Bing Wang , Daniel Chu
IPC分类号： A61K31/50 , A01N43/58 , C07D237/36
CPC分类号： A61K31/5025 , A61K31/282 , A61K31/4745 , A61K31/495 , A61K31/5377 , A61K33/24 , A61N5/10 , A61N2005/1098 , C07D471/06
摘要： A compound having the structure set forth in Formula (I) and Formula (II): wherein the substituents Y, Z, A, B, R1, R2, R3, R4 and R5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.

40. 发明申请

US20120129763A1 NOVEL SEMI-SYNTHETIC GLYCOPEPTIDES AS ANTIBACTERIAL AGENTS 审中-公开
标题翻译：新型半合成糖苷作为抗菌剂
公开(公告)号：US20120129763A1
公开(公告)日：2012-05-24
申请号：US13358374
申请日：2012-01-25
申请人： Daniel Chu , Tao Ye
发明人： Daniel Chu , Tao Ye
IPC分类号： A61K38/14 , A61P31/04 , C07K9/00
CPC分类号： C07K9/008
摘要： Semi-synthetic glycopeptides having antibacterial activity are described, in particular, the semi-synthetic glycopeptides described herein are made by chemical modification of a glycopeptide (Compound A, Compound B, Compound H or Compound C) or monosaccharide made by hydrolyzing the disaccharide moiety of the amino acid-4 of the parent glycopeptide in acidic medium to give the amino acid-4 monosaccharide; conversion of the monosaccharide to the amino-sugar derivative; acylation of the amino substituent on the amino acid-4 amino-substituted sugar moiety on these scaffolds with certain acyl groups; and conversion of the acid moiety on the macrocyclic ring of these scaffolds to certain substituted amides. Key reaction is the treatment of properly protected intermediate compound with isocyanate or carrying a Hofmann degradation of the primary amide of the 3rd amino acid asparagines with phenyl-bis-trifluoroacetate to give the primary amine. Also provided are methods for the synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.
摘要翻译：具体描述了具有抗菌活性的半合成糖肽，特别是本文所述的半合成糖肽通过化学修饰糖肽（化合物A，化合物B，化合物H或化合物C）或通过水解二糖部分在酸性介质中母体糖肽的氨基酸-4得到氨基酸-4单糖; 单糖转化为氨基糖衍生物; 在这些支架上的氨基酸4氨基取代的糖部分上的氨基取代基被某些酰基酰化; 并将这些支架的大环上的酸部分转化为某些取代的酰胺。关键反应是用异氰酸酯处理适当保护的中间体化合物或者用苯基二 - 三氟乙酸盐对第三氨基酸天门冬酰胺的伯酰胺进行霍夫曼降解，得到伯胺。还提供了合成化合物的方法，含有该化合物的药物组合物，以及该化合物用于治疗和/或预防疾病，特别是细菌感染的方法。

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