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1. 发明申请

US20170029460A1 LIMONIN EXTRACTION METHOD 有权
标题翻译：柠檬提取法
公开(公告)号：US20170029460A1
公开(公告)日：2017-02-02
申请号：US15302983
申请日：2015-04-30
申请人： JIMEI UNIVERSITY
发明人： Hui NI , Huinong CAI , Yuanfan YANG , Qiufen GAO , Feng CHEN , Xiping DU , Gaoling HUANG , Ling WU , Anfeng XIAO
IPC分类号： C07J73/00 , A23L33/105
CPC分类号： C07J73/00 , A23L33/105 , A23V2002/00 , C07J73/008
摘要： A limonin extraction method, comprising the following steps: step one, raw material extracting or juicing: directly soaking raw material in water or using a presser to directly juice the raw material to obtain the extract; step two, adding salt and adjusting pH: adding a sulfate solid material or saturated sulfate solution to the extract; adjusting pH to 3-7; step three, heating and preserving heat: heating to 20° C.-100° C. and keeping at the temperature for 10 minutes-110 minutes; step four, centrifuging: centrifuging for 10 minutes at a rotational speed of 2500×g, and obtaining limonin precipitation. Compared with a traditional method, the raw material in the present invention can directly use the extract liquid or juicing liquid without drying, and recover most limonin in water using a precipitation method without complicated apparatus, and is easy to operate and has a low process cost.
摘要翻译：一种柠檬苦素提取方法，包括以下步骤：第一步，原料提取或榨汁：将原料直接浸泡在水中或使用压榨机直接将原料榨汁获得提取物; 第二步，加盐调节pH：向提取物中加入硫酸固体物质或饱和硫酸盐溶液; 调节pH至3-7; 第三步，加热保温：加热至20°C-100°C，并保温10分钟至110分钟; 第四步，离心：以2500×g的转速离心10分钟，得到柠檬苦素沉淀。与传统方法相比，本发明的原料可以直接使用提取液或榨汁液而不干燥，并且使用无复杂装置的沉淀法在水中回收大多数柠檬苦素，易于操作且工艺成本低。

2. 发明申请

US20150274638A1 COMPLEX AND STRUCTURALLY DIVERSE COMPOUNDS 审中-公开
标题翻译：复杂和结构多样化合物
公开(公告)号：US20150274638A1
公开(公告)日：2015-10-01
申请号：US14387028
申请日：2013-03-25
申请人： The Board of Trustees of the University of Illinois
发明人： Paul J. Hergenrother , Robert W. Huigens, III , Karen C. Morrison , Robert W. Hicklin, II , Timothy A. Flood, JR.
IPC分类号： C07C69/757 , C07D513/04 , C07D307/93 , C07D311/94 , C07D493/08 , C07B37/08 , C07D413/06 , C07D405/06 , C07D313/08 , C07J71/00 , C07B37/06 , C07D223/14 , C07D405/12
CPC分类号： C07C69/757 , C07B37/06 , C07B37/08 , C07C59/205 , C07C62/32 , C07C62/38 , C07C2601/16 , C07C2602/44 , C07C2603/86 , C07D223/14 , C07D303/10 , C07D307/93 , C07D311/94 , C07D313/06 , C07D313/08 , C07D401/04 , C07D401/14 , C07D405/06 , C07D405/12 , C07D413/06 , C07D471/04 , C07D471/08 , C07D493/08 , C07D513/04 , C07D519/00 , C07J21/008 , C07J69/00 , C07J71/001 , C07J71/0031 , C07J73/005 , C07J73/008 , C07J75/005
摘要： The invention provides a novel, general, and facile strategy for the creation of small molecules with high structural and stereochemical complexity. Aspects of the methods include ring system distortion reactions that are systematically applied to rapidly convert readily available natural products to structurally complex compounds with diverse molecular architectures. Through evaluation of chemical properties including fraction of sp3 carbons, ClogP, and the number of stereogenic centers, these compounds are shown to be significantly more complex and diverse than those in standard screening collections. This approach is demonstrated with natural products (gibberellic acid, adrenosterone, and quinine) from three different structural classes, and methods are described for the application of this strategy to any suitable natural product.
摘要翻译：本发明提供了创造具有高结构和立体化学复杂性的小分子的新颖，一般和简便的策略。方法的方面包括系统应用的环系变形反应，以将易于获得的天然产物快速转化成具有不同分子结构的结构复杂的化合物。通过评估化学性质，包括sp3碳的分数，ClogP和立体中心数，这些化合物显示出比标准筛选收集中显着更复杂和多样化。用三种不同结构类别的天然产物（赤霉酸，肾上腺素和奎宁）证明了这一方法，并且描述了将该策略应用于任何合适的天然产物的方法。

3. 发明授权

US08980352B2 Control of flavor characteristics of and indicator of freshness in fruit juice 有权
标题翻译：控制果汁的风味特征和新鲜度指标
公开(公告)号：US08980352B2
公开(公告)日：2015-03-17
申请号：US12248621
申请日：2008-10-09
申请人： Margaret Havekotte , Thomas Hofmann , Anneke Glabasnia , Cheryl Nagle , Michael J. Morello , Todd A. Rakofsky , Rachel L. Jordan
发明人： Margaret Havekotte , Thomas Hofmann , Anneke Glabasnia , Cheryl Nagle , Michael J. Morello , Todd A. Rakofsky , Rachel L. Jordan
IPC分类号： C12C3/08 , C12C3/12 , C12C7/00 , C12C7/14 , C12H1/04 , A23C9/14 , C12H1/14 , A23L2/02 , A23L2/70 , C07J73/00 , G01N33/14
CPC分类号： A23L2/02 , A23L2/70 , C07J73/008 , G01N33/14
摘要： Control of flavor characteristics of and fresh taste in fruit juice, particularly citrus fruit juice, and especially orange juice.
摘要翻译：控制果汁，特别是柑橘类果汁，特别是橙汁中的风味特征和鲜味。

4. 发明授权

US3389150A 4, 17-dioxa-a, d-bishomo-steroidal lactone 失效
标题翻译： 4,7-二氧杂-α，d-双氧 - 甾类内酯
公开(公告)号：US3389150A
公开(公告)日：1968-06-18
申请号：US53567766
申请日：1966-03-21
申请人： SQUIBB & SONS INC
发明人： KRAKOWER GERALD W
IPC分类号： C07J73/00
CPC分类号： C07J73/008

5. 发明授权

US08952003B2 Sterol derivative 有权
标题翻译：甾醇衍生物
公开(公告)号：US08952003B2
公开(公告)日：2015-02-10
申请号：US13386542
申请日：2010-07-22
申请人： Kenji Uchida , Tsutomu Agatsuma , Kazuhiro Hibino , Setsuya Sasho , Kyoichiro Iida , Hideyuki Onodera
发明人： Kenji Uchida , Tsutomu Agatsuma , Kazuhiro Hibino , Setsuya Sasho , Kyoichiro Iida , Hideyuki Onodera
IPC分类号： A61K31/55 , A61K31/585 , C07J73/00
CPC分类号： C07J73/003 , A61K31/585 , C07J9/00 , C07J73/008 , C07J75/005
摘要： The present invention provides a sterol derivative or a pharmaceutically acceptable salt thereof having an activity to promote proliferation of neural stem cells. Namely, the present invention provides a sterol derivative represented by the general formula (I) (wherein Y represents optionally substituted lower alkyl or the like; Xa and Xb are the same or different, and represent a bond or the like; R1, R2, R3, R4, R7 and R8 are the same or different, and represent a hydrogen atom or the like; R5 and R6 are the same or different, and represent a hydrogen atom or the like; R9 represents a hydrogen atom or the like; R10 and R11 together represent a bond or the like; and R12 represents a hydrogen atom or the like) or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供具有促进神经干细胞增殖的活性的甾醇衍生物或其药学上可接受的盐。即，本发明提供由通式（I）表示的固醇衍生物（其中Y表示任选取代的低级烷基等; Xa和Xb相同或不同，表示键或类似物; R1，R2， R3，R4，R7和R8相同或不同，表示氢原子等; R5和R6相同或不同，表示氢原子等; R9表示氢原子等; R10 和R 11一起表示键等; R 12表示氢原子等）或其药学上可接受的盐。

6. 发明申请

US20130252930A1 CYP11B, CYP17, AND/OR CYP21 INHIBITORS 审中-公开
标题翻译： CYP11B，CYP17，AND / OR CYP21抑制剂
公开(公告)号：US20130252930A1
公开(公告)日：2013-09-26
申请号：US13881411
申请日：2011-12-16
申请人： Daniel Chu , Bing Wang , Tao Ye
发明人： Daniel Chu , Bing Wang , Tao Ye
IPC分类号： C07J73/00 , C07J43/00 , C07J61/00 , C07J63/00
CPC分类号： C07J73/008 , C07D401/08 , C07D403/08 , C07D405/08 , C07D413/08 , C07D471/04 , C07J1/0011 , C07J13/005 , C07J21/005 , C07J31/006 , C07J43/003 , C07J61/00 , C07J63/002 , C07J73/003 , C07J73/005
摘要： Provided herein are inhibitors of CYP11B, CYP17, and/or CYP21 enzymes of Formula (Z), (IX), (X), (XI), (XII), (XIII), (XIV), (XV), (XVI), or (XVII). Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat androgen-dependent diseases, disorders and conditions. Formula (Z)
摘要翻译：本文提供式（Z），（IX），（X），（XI），（XII），（XIII），（XIV），（XV），（XVI）的CYP11B，CYP17和/ ）或（XVII）。本文还描述了包含本文所述的至少一种化合物和本文所述的化合物或药物组合物用于治疗雄激素依赖性疾病，病症和病症的药物组合物。式（Z）

7. 发明授权

US3987055A Azasteroids compounds and derivatives 失效
标题翻译： AZASTEROIDS化合物和衍生物
公开(公告)号：US3987055A
公开(公告)日：1976-10-19
申请号：US505136
申请日：1974-09-11
申请人： Kenneth Darrell Berlin , Norman Nevill Durham , Claude Desjardins
发明人： Kenneth Darrell Berlin , Norman Nevill Durham , Claude Desjardins
IPC分类号： C07C59/90 , C07D231/54 , C07J73/00 , C07D231/56
CPC分类号： C07J73/008 , C07C59/90 , C07D231/54 , C07J73/005 , C07C2103/26
摘要： Azasteroids and certain derivatives each of a five ring system containing at least one aromatic nucleus and at least one nitrogen atom. The ring system is fused to a tetrahydrotetralin system or a tetrahydrophenanthrene system. The compounds have solubility in water and disclose antimicrobial, antifertility and potentiate the activity of antibiotics and certain anticancer agents.

8. 发明授权

US10081592B2 Complex and structurally diverse compounds 有权
公开(公告)号：US10081592B2
公开(公告)日：2018-09-25
申请号：US14387028
申请日：2013-03-25
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , Paul J. Hergenrother , Robert W. Huigens, III , Karen C. Morrison , Robert W. Hicklin, II , Timothy A. Flood, Jr.
发明人： Paul J. Hergenrother , Robert W. Huigens, III , Karen C. Morrison , Robert W. Hicklin, II , Timothy A. Flood, Jr.
IPC分类号： C07D401/14 , C07C69/757 , C07D311/94 , C07D313/06 , C07D223/14 , C07D401/04 , C07D471/04 , C07D471/08 , C07D493/08 , C07D513/04 , C07D519/00 , C07D303/10 , C07C59/205 , C07C62/32 , C07C62/38 , C07B37/06 , C07B37/08 , C07D307/93 , C07D313/08 , C07D405/06 , C07D405/12 , C07D413/06 , C07J21/00 , C07J69/00 , C07J71/00 , C07J73/00 , C07J75/00
CPC分类号： C07C69/757 , C07B37/06 , C07B37/08 , C07C59/205 , C07C62/32 , C07C62/38 , C07C2601/16 , C07C2602/44 , C07C2603/86 , C07D223/14 , C07D303/10 , C07D307/93 , C07D311/94 , C07D313/06 , C07D313/08 , C07D401/04 , C07D401/14 , C07D405/06 , C07D405/12 , C07D413/06 , C07D471/04 , C07D471/08 , C07D493/08 , C07D513/04 , C07D519/00 , C07J21/008 , C07J69/00 , C07J71/001 , C07J71/0031 , C07J73/005 , C07J73/008 , C07J75/005
摘要： The invention a novel, general, and facile strategy for the creation of small molecules with high structural and stereochemical complexity. Aspects of the methods include ring system distortion reactions that are systematically applied to rapidly convert readily available natural products to structurally complex compounds with diverse molecular architectures. Through evaluation of chemical properties including fraction of sp3 carbons, ClogP, and the number of stereogenic centers, these compounds are shown to be significantly more complex and diverse than those in standard screening collections. This approach is demonstrated with natural products (gibberellic acid, adrenosterone, and quinine) from three different structural classes, and methods are described for the application of this strategy to any suitable natural product.

9. 发明申请

US20110178065A1 NOVEL CYP17 INHIBITORS 审中-公开
标题翻译：新CYP17抑制剂
公开(公告)号：US20110178065A1
公开(公告)日：2011-07-21
申请号：US13005646
申请日：2011-01-13
申请人： Daniel Chu , Bing Wang , Tao Ye
发明人： Daniel Chu , Bing Wang , Tao Ye
IPC分类号： A61K31/55 , A61P35/00 , C12N9/99 , A61K31/366 , C07D335/04 , C07D405/08 , C07D487/04 , C07D333/50 , A61K31/365 , A61K31/443 , C07D401/08 , A61K31/497
CPC分类号： C07J73/003 , C07D211/76 , C07D233/60 , C07D241/12 , C07D249/04 , C07D401/04 , C07D403/04 , C07D405/04 , C07J61/00 , C07J73/005 , C07J73/006 , C07J73/008
摘要： Provided herein are inhibitors of CYP17 enzyme. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat androgen-dependent diseases, disorders and conditions.
摘要翻译：本文提供了CYP17酶的抑制剂。本文还描述了包含本文所述的至少一种化合物和本文所述的化合物或药物组合物用于治疗雄激素依赖性疾病，病症和病症的药物组合物。

10. 发明授权

US3803178A 9-oxa-polyhydrophenanthrene-2-carboxylic acids and derivatives thereof 失效
标题翻译： 9-氧代 - 多羟基二烯-2-羧酸及其衍生物
公开(公告)号：US3803178A
公开(公告)日：1974-04-09
申请号：US3387370
申请日：1970-05-01
申请人： SYNTEX CORP
发明人： FRIED J
IPC分类号： C07D311/58 , C07D311/80 , C07D493/04 , C07J73/00 , C07D7/18
CPC分类号： C07D493/04 , C07D311/58 , C07D311/80 , C07J73/008
摘要： NOVEL 9-OXA-POLYHYDROPHENANTHRENE-2-CARBOXYLIC ACIDS AND DERIVATIVES THEREOF, USEFUL AS ESTEROGENIC AND ANTIFERTILITY AGENTS, PROCESSES AND INTERMEDIATES FOR THEIR PREPARATION.

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