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31. 发明申请

US20070041878A1 MICROFLUIDIC DEVICES, METHODS, AND SYSTEMS 有权
标题翻译：微流体装置，方法和系统
公开(公告)号：US20070041878A1
公开(公告)日：2007-02-22
申请号：US10336274
申请日：2003-01-03
申请人： Zbigniew Bryning , John Shigeura
发明人： Zbigniew Bryning , John Shigeura
IPC分类号： B01L11/00
CPC分类号： B01L3/502738 , B01L7/52 , B01L2200/10 , B01L2300/0803 , B01L2300/0816 , B01L2300/0864 , B01L2300/123 , B01L2400/0409 , B01L2400/0487 , B01L2400/0655 , B01L2400/0683
摘要： Microfluidic assemblies, systems, and methods are provided for manipulating fluid samples. Assemblies include an elastically deformable cover layer and a less elastically deformable substrate. The methods include deforming the substrate through the cover layer so that when the cover layer rebounds a new communication results in the assembly between the cover layer and the substrate and/or so that a new barrier wall is formed. Systems for carrying out the methods are also provided.
摘要翻译：提供微流体组件，系统和方法来操作流体样品。组件包括可弹性变形的覆盖层和较少可弹性变形的基底。所述方法包括通过覆盖层使基底变形，使得当覆盖层反弹新的通信导致覆盖层和基底之间的组装和/或使得形成新的阻挡壁时。还提供了执行方法的系统。

32. 发明授权

US07041258B2 Micro-channel design features that facilitate centripetal fluid transfer 有权
标题翻译：微通道设计特点，便于向心液传输
公开(公告)号：US07041258B2
公开(公告)日：2006-05-09
申请号：US10336330
申请日：2003-01-03
申请人： Sean M. Desmond , John Shigeura
发明人： Sean M. Desmond , John Shigeura
IPC分类号： G01N9/30 , B01L11/00 , C12M1/10
CPC分类号： B01L3/502746 , B01L2300/0806 , B01L2300/0864 , B01L2400/0409 , B33Y80/00 , Y10T436/111666 , Y10T436/25375 , Y10T436/2575
摘要： Microfluidic devices, assemblies, and systems are provided, as are methods of manipulating micro-sized samples of fluids. Microfluidic devices having a plurality of specialized processing features that facilitate centripetal fluid transfer are also provided.
摘要翻译：提供微流体装置，组件和系统，以及操纵微尺寸流体样品的方法。还提供了具有便于向心流体转移的多个特殊处理特征的微流体装置。

33. 发明申请

US20060046304A1 Thermal device, system, and method, for fluid processing device 有权
公开(公告)号：US20060046304A1
公开(公告)日：2006-03-02
申请号：US10926915
申请日：2004-08-26
申请人： John Shigeura , Janice Shigeura , Sean Desmond , David Cox
发明人： John Shigeura , Janice Shigeura , Sean Desmond , David Cox
IPC分类号： G01N33/00
CPC分类号： G05D23/24 , G05D23/192 , G05D23/20 , G05D23/22 , Y02P20/129 , Y10S435/809
摘要： A device, system, and method are provided for thermally treating a fluid processing device. According to various embodiments, a system is provided that can include a thermal device and a fluid processing device holder. The thermal device can include a first block having a thermal conductivity greater than 0.5 Watt per centimeter Kelvin (W/cm·K), a second block having a thermal conductivity greater than 0.5 W/cm·K, and a heat-pump device disposed between the first block and the second block. The heat-pump device can transfer thermal energy from at least one of the first block and the second block to the other of the first block and the second block. The fluid processing device holder can hold a fluid processing device in a heat-transfer position with respect to the first block and the second block. The fluid processing device can be a microfluidic device.

34. 发明申请

US20060006068A1 Capillary array assembly for loading samples from a device, and method 有权
标题翻译：用于从装置加载样品的毛细管阵列组件和方法
公开(公告)号：US20060006068A1
公开(公告)日：2006-01-12
申请号：US10887477
申请日：2004-07-08
申请人： Sean Desmond , John Shigeura , Janice Shigeura
发明人： Sean Desmond , John Shigeura , Janice Shigeura
IPC分类号： G01N27/26
CPC分类号： G01N27/44743 , G01N27/44782
摘要： A capillary array assembly is provided that can be used to inject samples into an electrophoresis device. The capillary array assembly can include an injection end that can be arranged to interface with output wells of a fluid processing device, for example, a microfluidic card-type device.
摘要翻译：提供了可用于将样品注入电泳装置的毛细管阵列组件。毛细管阵列组件可以包括注射端，其可被布置成与流体处理装置的输出孔（例如，微流控卡型装置）相接合。

35. 发明申请

US20050183957A1 Micro-channel design features that facilitate centripetal fluid transfer 审中-公开
标题翻译：微通道设计特点，便于向心液传输
公开(公告)号：US20050183957A1
公开(公告)日：2005-08-25
申请号：US11088709
申请日：2005-03-24
申请人： Sean Desmond , John Shigeura
发明人： Sean Desmond , John Shigeura
IPC分类号： B01L99/00 , G01N1/10 , G01N27/453
CPC分类号： B01L3/502746 , B01L2300/0806 , B01L2300/0864 , B01L2400/0409 , B33Y80/00 , Y10T436/111666 , Y10T436/25375 , Y10T436/2575
摘要： Microfluidic devices, assemblies, and systems are provided, as are methods of manipulating micro-sized samples of fluids. Microfluidic devices having a plurality of specialized processing features that facilitate centripetal fluid transfer are also provided.
摘要翻译：提供微流体装置，组件和系统，以及操纵微尺寸流体样品的方法。还提供了具有便于向心流体转移的多个特殊处理特征的微流体装置。

36. 发明申请

US20050161192A1 Heat transfer for thermal cycling 有权
标题翻译：热循环换热
公开(公告)号：US20050161192A1
公开(公告)日：2005-07-28
申请号：US10763537
申请日：2004-01-23
申请人： John Shigeura , Janice Shigeura
发明人： John Shigeura , Janice Shigeura
IPC分类号： B01L3/00 , B01L7/00 , B04B15/02 , G01N35/00 , F25B21/02 , B41B1/00 , B41F1/00 , B41J1/00 , F25B29/00 , F25D25/00 , F28D11/00 , F28F5/00 , G06F15/00 , G06K1/00
CPC分类号： B01L3/50851 , B01L7/52 , B01L2300/0803 , B01L2300/1822 , B01L2300/1838 , B01L2400/0409 , B01L2400/086 , G01N2035/00237 , G01N2035/00346
摘要： The present application relates to an apparatus and method for heat transfer for thermal cycling.
摘要翻译：本申请涉及用于热循环的热传递的装置和方法。

37. 发明授权

US06387236B2 Multi-channel capillary electrophoresis device including sheath-flow cuvette and replaceable capillary array 失效
标题翻译：多通道毛细管电泳装置，包括鞘流比色皿和可更换的毛细管阵列
公开(公告)号：US06387236B2
公开(公告)日：2002-05-14
申请号：US09805624
申请日：2001-03-13
申请人： Eric S. Nordman , John Shigeura , Albert L. Carrillo , David M. Demorest , Philip J. Wunderle
发明人： Eric S. Nordman , John Shigeura , Albert L. Carrillo , David M. Demorest , Philip J. Wunderle
IPC分类号： G01N2726
CPC分类号： G01N27/44782 , G01N2035/00237
摘要： A multi-channel capillary electrophoresis apparatus is disclosed. The apparatus includes a capillary array assembly comprising a plurality of capillaries, each capillary having a capillary outlet, and an outlet support for supporting the capillary outlets. The apparatus further includes a cuvette defining a receiving slot, a gap region, and a detection zone, where the receiving slot is adapted to removably receive the outlet support, and wherein when the outlet support is inserted into the receiving slot, the capillary outlets are positioned in the gap region in proximity to the detection zone, and a flow channel is formed by the outlet support and the receiving slot such that the flow channel is in fluid communication with the gap region. In addition, the apparatus includes a front plumbing block in fluid communication with the flow channel for supplying a fluid flow through the gap region sufficient to transport material downstream from the capillary outlets to the detection zone.
摘要翻译：公开了一种多通道毛细管电泳装置。该装置包括毛细管阵列组件，其包括多个毛细管，每个毛细管具有毛细管出口，以及用于支撑毛细管出口的出口支撑件。所述设备还包括限定接收槽，间隙区和检测区的比色皿，其中所述接收槽适于可移除地接收所述出口支撑，并且其中当所述出口支撑件插入所述接收槽时，所述毛细管出口是定位在接近检测区域的间隙区域中，并且流动通道由出口支撑件和接收槽形成，使得流动通道与间隙区域流体连通。此外，该装置包括与流动通道流体连通的前管道块，用于提供足以将材料从毛细管出口下游输送到检测区域的间隙区域的流体流。

38. 发明授权

US06231739B1 Multi-channel capillary electrophoresis device including sheath-flow cuvette and replacable capillary array 有权
标题翻译：多通道毛细管电泳装置，包括鞘流比色杯和可更换的毛细管阵列
公开(公告)号：US06231739B1
公开(公告)日：2001-05-15
申请号：US09621071
申请日：2000-07-21
申请人： Eric S. Nordman , John Shigeura , Albert L. Carrillo , David M. Demorest , Philip J. Wunderle
发明人： Eric S. Nordman , John Shigeura , Albert L. Carrillo , David M. Demorest , Philip J. Wunderle
IPC分类号： G01N2726
CPC分类号： G01N27/44782 , G01N2035/00237
摘要： A multi-channel capillary electrophoresis apparatus is disclosed. The apparatus includes a capillary array assembly comprising a plurality of capillaries, each capillary having a capillary outlet, and an outlet support for supporting the capillary outlets. The apparatus further includes a cuvette defining a receiving slot, a gap region, and a detection zone, where the receiving slot is adapted to removably receive the outlet support, and wherein when the outlet support is inserted into the receiving slot, the capillary outlets are positioned in the gap region in proximity to the detection zone, and a flow channel is formed by the outlet support and the receiving slot such that the flow channel is in fluid communication with the gap region. In addition, the apparatus includes a front plumbing block in fluid communication with the flow channel for supplying a fluid flow through the gap region sufficient to transport material downstream from the capillary outlets to the detection zone.
摘要翻译：公开了一种多通道毛细管电泳装置。该装置包括毛细管阵列组件，其包括多个毛细管，每个毛细管具有毛细管出口，以及用于支撑毛细管出口的出口支撑件。所述设备还包括限定接收槽，间隙区和检测区的比色皿，其中所述接收槽适于可移除地接收所述出口支撑，并且其中当所述出口支撑件插入所述接收槽时，所述毛细管出口是定位在接近检测区域的间隙区域中，并且流动通道由出口支撑件和接收槽形成，使得流动通道与间隙区域流体连通。此外，该装置包括与流动通道流体连通的前管道块，用于提供足以将材料从毛细管出口下游输送到检测区域的间隙区域的流体流。

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