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31. 发明授权

US07135667B2 Array imaging system 失效
标题翻译：阵列成像系统
公开(公告)号：US07135667B2
公开(公告)日：2006-11-14
申请号：US11188243
申请日：2005-07-22
申请人： Mark F. Oldham , Howard G. King , Douwe D. Haga , Tracy L. Ferea
发明人： Mark F. Oldham , Howard G. King , Douwe D. Haga , Tracy L. Ferea
IPC分类号： H01L27/00 , G01T1/20 , G01N21/86 , G01V8/00
CPC分类号： G01N21/76 , G01J3/10 , G01J3/4406 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N21/6456 , G01N2201/062 , G01N2201/0627 , G01N2201/0633 , G01N2201/0634
摘要： An apparatus for imaging an array of a plurality of features associated with a sample tile. The apparatus can comprise a stage that supports the sample tile in an illumination region, and an illumination source having a plurality of LEDs adapted to emit light. At least a portion of the light can illuminate the illumination region. Additionally, the apparatus can comprise an image collecting device adapted to selectively collect images of either a first signal when the illumination source is illuminating the illumination region, or a second signal absent illumination of the illumination region. The first signal can have wavelengths effectively different from the wavelengths of the portion of the light emitted by the LEDs that illuminates the illumination region.
摘要翻译：一种用于对与样本瓦片相关联的多个特征的阵列进行成像的装置。该装置可以包括在照明区域中支撑样品瓦的台，以及具有适于发光的多个LED的照明源。光的至少一部分可以照亮照明区域。另外，该装置可以包括图像采集装置，适于当照明源照射照明区域时选择性地收集第一信号的图像，或者不存在照明区域的照明的第二信号。第一信号可以具有与照亮照明区域的LED发射的光的部分的波长有效地不同的波长。

32. 发明授权

US06970240B2 Combination reader 有权
标题翻译：组合阅读器
公开(公告)号：US06970240B2
公开(公告)日：2005-11-29
申请号：US10384995
申请日：2003-03-10
申请人： Mark F. Oldham , Howard G. King , Douwe D. Haga , Tracy L. Ferea
发明人： Mark F. Oldham , Howard G. King , Douwe D. Haga , Tracy L. Ferea
IPC分类号： G01N21/64 , G01J3/30
CPC分类号： G01N21/76 , G01J3/10 , G01J3/4406 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N21/6456 , G01N2201/062 , G01N2201/0627 , G01N2201/0633 , G01N2201/0634
摘要： An apparatus for imaging an array of a plurality of features associated with a sample tile. The apparatus includes a stage that supports the sample tile in an illumination region, and an illumination source having a plurality of LEDs adapted to emit light. At least a portion of the light illuminates the illumination region. Additionally, the apparatus includes an image collecting device adapted to selectively collect images of either a first signal when the illumination source is illuminating the illumination region, or a second signal absent illumination of the illumination region. The first signal has wavelengths effectively different from the wavelengths of the portion of the light emitted by the LEDs that illuminates the illumination region.
摘要翻译：一种用于对与样本瓦片相关联的多个特征的阵列进行成像的装置。该装置包括在照明区域中支撑样品瓦的台，以及具有适于发光的多个LED的照明源。至少一部分光照射照明区域。另外，该装置包括图像采集装置，适于当照明源照射照明区域时选择性地收集第一信号的图像，或者不存在照明区域的照明的第二信号。第一信号具有与照亮照明区域的由LED发射的光的部分的波长有效不同的波长。

33. 发明授权

US08361785B2 Optical instrument comprising multi-notch beam splitter 有权
公开(公告)号：US08361785B2
公开(公告)日：2013-01-29
申请号：US12321830
申请日：2009-01-26
申请人： Mark F. Oldham , Eugene F. Young
发明人： Mark F. Oldham , Eugene F. Young
IPC分类号： C12M1/34 , C12M3/00 , G01N21/64
CPC分类号： G01N21/6486 , B01L3/5085 , B01L7/52 , C12Q2545/101 , G01N21/274 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0245 , G01N2201/0628 , G01N2201/0635 , Y10S435/808 , Y10S435/809
摘要： An instrument is provided that can monitor nucleic acid sequence amplification reactions, for example, PCR amplification of DNA and DNA fragments. The instrument includes a multi-notch filter disposed along one or both of an excitation beam path and an emission beam path. Methods are also provided for monitoring nucleic acid sequence amplifications using an instrument that includes a multi-notch filter disposed along a beam path.

34. 发明申请

US20090141272A1 Optical instrument comprising multi-notch beam splitter 有权
标题翻译：光学仪器包括多槽分光镜
公开(公告)号：US20090141272A1
公开(公告)日：2009-06-04
申请号：US12321830
申请日：2009-01-26
申请人： Mark F. Oldham , Eugene F. Young
发明人： Mark F. Oldham , Eugene F. Young
IPC分类号： G01J3/28
CPC分类号： G01N21/6486 , B01L3/5085 , B01L7/52 , C12Q2545/101 , G01N21/274 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0245 , G01N2201/0628 , G01N2201/0635 , Y10S435/808 , Y10S435/809
摘要： An instrument is provided that can monitor nucleic acid sequence amplification reactions, for example, PCR amplification of DNA and DNA fragments. The instrument includes a multi-notch filter disposed along one or both of an excitation beam path and an emission beam path. Methods are also provided for monitoring nucleic acid sequence amplifications using an instrument that includes a multi-notch filter disposed along a beam path.
摘要翻译：提供了可以监测核酸序列扩增反应的仪器，例如DNA和DNA片段的PCR扩增。仪器包括沿激发光束路径和发射光束路径中的一个或两个设置的多陷波滤波器。还提供了使用包括沿着光束路径设置的多陷波滤波器的仪器来监测核酸序列扩增的方法。

35. 发明授权

US06563581B1 Scanning system and method for scanning a plurality of samples 有权
标题翻译：用于扫描多个样本的扫描系统和方法
公开(公告)号：US06563581B1
公开(公告)日：2003-05-13
申请号：US09617549
申请日：2000-07-14
申请人： Mark F. Oldham , Eugene F. Young
发明人： Mark F. Oldham , Eugene F. Young
IPC分类号： G01J330
CPC分类号： G01N21/6452 , B01L3/5085 , B01L2200/025 , B01L2300/0806 , B01L2300/0819
摘要： A system for detecting fluorescence emitted from a plurality of samples in a sample tray is provided. The system generally includes a plurality of lenses positioned in a linear arrangement, a linear actuator configured to translate the plurality of lenses, an excitation light source for generating an excitation light, an excitation light direction mechanism for directing the excitation light to a single lens of the plurality of lenses at a time so that a single sample holder aligned with the lens is illuminated at a time, and an optical detection system for analyzing light from the sample holders. In certain embodiments, the optical detection system includes a light dispersing element configured to spectrally disperse the light from the sample holder being illuminated, and a lens element configured to receive light from the light dispersing element and direct the light onto a light detection device. A method of scanning a sample tray having a plurality of samples positioned in sample holders to detect fluorescence is also provided.
摘要翻译：提供了一种用于检测从样品盘中的多个样品发出的荧光的系统。该系统通常包括以线性布置定位的多个透镜，被配置为平移多个透镜的线性致动器，用于产生激发光的激发光源，用于将激发光引导到单个透镜的激发光方向机构一次使多个透镜一次照射与镜片对准的单个样品保持器，以及用于分析来自样品保持器的光的光学检测系统。在某些实施例中，光学检测系统包括光分散元件，其被配置为光谱地分散来自被照亮的样品保持器的光;以及透镜元件，被配置为接收来自光分散元件的光并将光引导到光检测装置。还提供了扫描具有位于样品架中的多个样品以检测荧光的样品盘的方法。

36. 发明授权

US07498164B2 Instrument for monitoring nucleic acid sequence amplification reaction 有权
标题翻译：监测核酸序列扩增反应的仪器
公开(公告)号：US07498164B2
公开(公告)日：2009-03-03
申请号：US10456196
申请日：2003-06-06
申请人： Mark F. Oldham , Eugene F. Young
发明人： Mark F. Oldham , Eugene F. Young
IPC分类号： C12M1/34 , C12M3/00 , G01N21/64 , G01J1/58 , F21V9/16
CPC分类号： G01N21/6486 , B01L3/5085 , B01L7/52 , C12Q2545/101 , G01N21/274 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/6482 , G01N2201/0245 , G01N2201/0628 , G01N2201/0635 , Y10S435/808 , Y10S435/809
摘要： An instrument is provided that can monitor nucleic acid sequence amplifications reactions, for example, PCR amplification of DNA and DNA fragments. The instrument includes a multi-notch filter disposed along one or both of an excitation beam path and an emission beam path. Methods are also provided for monitoring nucleic acid sequence amplifications using an instrument that includes a multi-notch filter disposed along a beam path.
摘要翻译：提供了可以监测核酸序列扩增反应的仪器，例如DNA和DNA片段的PCR扩增。仪器包括沿激发光束路径和发射光束路径中的一个或两个设置的多陷波滤波器。还提供了使用包括沿着光束路径设置的多陷波滤波器的仪器来监测核酸序列扩增的方法。

37. 发明授权

US06965105B2 Scanning system and method for scanning a plurality of samples 有权
标题翻译：用于扫描多个样本的扫描系统和方法
公开(公告)号：US06965105B2
公开(公告)日：2005-11-15
申请号：US10387755
申请日：2003-03-13
申请人： Mark F. Oldham , Eugene F. Young
发明人： Mark F. Oldham , Eugene F. Young
IPC分类号： B01L3/00 , G01N21/25 , G01N21/64 , H01J3/14 , H01J5/16 , H01J40/14
CPC分类号： G01N21/6452 , B01L3/5085 , B01L2200/025 , B01L2300/0806 , B01L2300/0819
摘要： A system for detecting fluorescence emitted from a plurality of samples in a sample tray is provided. The system generally includes a plurality of lenses positioned in a linear arrangement, a linear actuator configured to translate the plurality of lenses, an excitation light source for generating an excitation light, an excitation light direction mechanism for directing the excitation light to a single lens of the plurality of lenses at a time so that a single sample holder aligned with the lens is illuminated at a time, and an optical detection system for analyzing light from the sample holders. In certain embodiments, the optical detection system includes a light dispersing element configured to spectrally disperse the light from the sample holder being illuminated, and a lens element configured to receive light from the light dispersing element and direct the light onto a light detection device. A method of scanning a sample tray having a plurality of samples positioned in sample holders to detect fluorescence is also provided.
摘要翻译：提供了一种用于检测从样品盘中的多个样品发出的荧光的系统。该系统通常包括以线性布置定位的多个透镜，被配置为平移多个透镜的线性致动器，用于产生激发光的激发光源，用于将激发光引导到单个透镜的激发光方向机构一次使多个透镜一次照射与镜片对准的单个样品保持器，以及用于分析来自样品保持器的光的光学检测系统。在某些实施例中，光学检测系统包括光分散元件，其被配置为光谱地分散来自被照亮的样品保持器的光;以及透镜元件，被配置为接收来自光分散元件的光并将光引导到光检测装置。还提供了扫描具有位于样品架中的多个样品以检测荧光的样品盘的方法。

38. 发明授权

US08906325B2 Vacuum assist for a microplate 有权
标题翻译：真空辅助微孔板
公开(公告)号：US08906325B2
公开(公告)日：2014-12-09
申请号：US12859143
申请日：2010-08-18
申请人： Mark F. Oldham , Adrian Fawcett
发明人： Mark F. Oldham , Adrian Fawcett
IPC分类号： B01L3/00 , G01N35/02 , G01N21/64 , G01N35/04 , G01N35/00 , G01N35/10 , B01L7/00 , B01L9/00 , G01N21/27 , B01L3/02
CPC分类号： B01L3/5085 , B01L3/0293 , B01L3/5025 , B01L3/5027 , B01L3/50851 , B01L3/50853 , B01L3/545 , B01L7/52 , B01L9/50 , B01L9/523 , B01L2200/021 , B01L2200/025 , B01L2200/0605 , B01L2200/0642 , B01L2200/0689 , B01L2200/14 , B01L2200/142 , B01L2300/021 , B01L2300/022 , B01L2300/044 , B01L2300/046 , B01L2300/0829 , B01L2300/0851 , B01L2300/0864 , B01L2300/1883 , B01L2400/0406 , B01L2400/0409 , B01L2400/0487 , C12Q1/686 , G01N21/274 , G01N21/6452 , G01N21/6486 , G01N35/0099 , G01N35/028 , G01N35/1002 , G01N35/1074 , G01N2035/00287 , G01N2035/00366 , G01N2035/0405 , G01N2035/0425 , G01N2035/1039
摘要： A vacuum assist apparatus can comprise a microplate. The microplate can comprise a first surface and an opposing second surface. A plurality of wells can be formed in the first surface of the microplate. Each of the plurality of wells can be sized to receive an assay therein. A support base can comprise a fluid passage. The microplate can be positioned adjacent and in contact with the support base. A pressure device, in fluid communication with the fluid passage, can exert a vacuum within the fluid passage to actively retain the microplate in the contact with the support base.
摘要翻译：真空辅助装置可以包括微孔板。微板可以包括第一表面和相对的第二表面。可以在微板的第一表面中形成多个孔。可以将多个孔中的每一个的尺寸设定为在其中接受测定。支撑基座可以包括流体通道。微板可以定位成与支撑基座相邻并与支撑基座接触。与流体通道流体连通的压力装置可以在流体通道内施加真空以主动地保持微板与支撑基座的接触。

39. 发明授权

US08274650B2 Signal noise reduction for imaging in biological analysis 有权
标题翻译：生物分析中成像信号降噪
公开(公告)号：US08274650B2
公开(公告)日：2012-09-25
申请号：US12775391
申请日：2010-05-06
申请人： Austin B. Tomaney , Mark F. Oldham
发明人： Austin B. Tomaney , Mark F. Oldham
IPC分类号： G01J1/42
CPC分类号： G01N21/6486 , G01N21/6428 , G01N2201/06113 , G01N2201/062 , G01N2201/08 , G01N2201/121 , H04N5/225 , H04N5/357 , H04N5/361 , H04N5/367
摘要： A system and method for characterizing contributions to signal noise associated with charge-coupled devices adapted for use in biological analysis. Dark current contribution, readout offset contribution, photo response non-uniformity, and spurious charge contribution can be determined by the methods of the present teachings and used for signal correction by systems of the present teachings.
摘要翻译：用于表征与适用于生物分析的电荷耦合器件相关的信号噪声的贡献的系统和方法。暗电流贡献，读出偏移贡献，光响应不均匀性和杂散电荷贡献可以由本教导的方法确定并用于本教导的系统的信号校正。

40. 发明申请

US20120214246A1 System and Method for Extending Dynamic Range for a Detector 审中-公开
标题翻译：用于扩展检测器动态范围的系统和方法
公开(公告)号：US20120214246A1
公开(公告)日：2012-08-23
申请号：US13361875
申请日：2012-01-30
申请人： Mark F. Oldham , Austin B. Tomaney
发明人： Mark F. Oldham , Austin B. Tomaney
IPC分类号： G01N21/75
CPC分类号： G01J1/42 , G01J2001/4406 , Y10T436/143333
摘要： A system and method for measuring signals having a wide range of intensity components using detectors adapted for use in biological analysis devices. In certain biological analysis applications, signals emitted by a sample may have intensity components that vary over several orders of magnitude. Measurement of such a signal may yield an acceptable quality for one intensity component at the expense of another component. For example, a detector configured to measure a relatively weak intensity component may cause it to overflow when subjected to a relatively strong intensity component. The detector can be adapted to be operated at different configurations to allow measurements of different components of the signal, and the results can be combined to yield an accurate representation of the signal.
摘要翻译：一种用于使用适用于生物分析装置的检测器来测量具有宽范围的强度分量的信号的系统和方法。在某些生物分析应用中，由样品发射的信号可以具有在几个数量级上变化的强度分量。这种信号的测量可以以另一个组件为代价产生一个强度分量的可接受的质量。例如，被配置为测量相对弱的强度分量的检测器可以在经受相对强的强度分量时使其溢出。检测器可以适于以不同的配置操作，以允许对信号的不同部件进行测量，并且可以将结果组合以产生信号的精确表示。

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