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31. 发明申请

US20070089978A1 Low molecular weight chitosan oligosaccharides and its preparation method 有权
标题翻译：低分子量壳聚糖寡糖及其制备方法
公开(公告)号：US20070089978A1
公开(公告)日：2007-04-26
申请号：US10560296
申请日：2003-10-08
申请人： Pengcheng Li , Ronge Xing , Song Liu , Huahua Yu
发明人： Pengcheng Li , Ronge Xing , Song Liu , Huahua Yu
IPC分类号： C08B37/08
CPC分类号： C08B37/003
摘要： The present invention relates to low molecular weight chitosan oligosaccharides and its preparation method. Chitosan oligosaccharides were obtained under microwave irradiation assisted the electrolyte. The method of preparing chitosan oligosaccharides was described as follows: acid solvent containing electrolyte was added to chitosan. The reaction was performed at 480˜800 W for 3˜12 min. After irradiation ceased, the reaction liquid was cooled to room temperature. Then the solution was adjusted to neutrality with 1˜10 M NaOH or KOH and obtained the pale yellow floc. The processes of precipitation, filtering, desiccation and crushing are settled sequentially. Finally, chitosan oligosaccharides were obtained. Method of the present invention makes chitosan degrade to water-soluble chitosan oligosaccharides and it makes some inert substance become active. The method of the present invention can cut down energy consumption, decrease pollution and save time and raw materials. It has applying perspective of industry and potentiality of extensive market.
摘要翻译：本发明涉及低分子量壳聚糖寡糖及其制备方法。在微波照射辅助电解质下获得壳聚糖寡糖。制备壳聚糖寡糖的方法描述如下：将含酸性溶剂的电解质加入到壳聚糖中。反应在480〜800W进行3〜12分钟。照射停止后，将反应液冷却至室温。然后将溶液用1〜10M NaOH或KOH调节至中性，得到淡黄色絮状物。沉淀，过滤，干燥和粉碎的过程顺序进行。最后得到壳聚糖寡糖。本发明的方法使壳聚糖降解为水溶性壳聚糖寡糖，并使一些惰性物质变得活性。本发明的方法可以降低能耗，减少污染，节省时间和原材料。它具有广泛市场的行业和潜力的应用视角。

32. 发明申请

US20070086976A1 Acyclic N-halamines in antibacterial materials 审中-公开
标题翻译：抗菌材料中的非环状N-卤代胺
公开(公告)号：US20070086976A1
公开(公告)日：2007-04-19
申请号：US11251354
申请日：2005-10-13
申请人： Gang Sun , Song Liu
发明人： Gang Sun , Song Liu
IPC分类号： A61K31/787 , A61K31/785 , C08L39/04
CPC分类号： C08F265/10 , C08F8/30 , C08F120/56 , C08F257/02 , C08L39/02 , C08L51/003 , D01F1/103 , C08L2666/02
摘要： The present invention provides biocidal polymers having N-halamine technology incorporated therein, which are useful for a wide range of applications. The microbiocidal polymer can be a homopolymer, a co-polymer or a grafted polymer. In certain aspects, the present invention provides polymers from acrylic amine-monomers such as acrylamide, which monomers readily form homopolymers, co-polymers, or a grafted polymer such as onto an existing textiles.
摘要翻译：本发明提供了其中并入有N-卤代胺技术的杀生物聚合物，其可用于广泛的应用。杀微生物聚合物可以是均聚物，共聚物或接枝聚合物。在某些方面，本发明提供了丙烯酸酯单体如丙烯酰胺的聚合物，该单体容易形成均聚物，共聚物或接枝聚合物，例如在现有纺织品上。

33. 发明授权

US06769012B1 Method and system for managing message transactions between a sender and recipient within a virtual mailbox 失效
标题翻译：用于管理虚拟邮箱内的发件人和收件人之间的邮件事务的方法和系统
公开(公告)号：US06769012B1
公开(公告)日：2004-07-27
申请号：US09621843
申请日：2000-07-24
申请人： Song Liu , Jon Song , Herb Wang
发明人： Song Liu , Jon Song , Herb Wang
IPC分类号： G06F1516
CPC分类号： H04L51/22
摘要： The invention is a computerized message management system that provides a method and system whereby sender's of one or more messages and recipient's of one or more messages each having digital or analog communications equipment can access a virtual mailbox wherein sender's can enter messages and recipients's can receive messages. Both sender and recipient being the only parties having authorization to view said messages. Furthermore, either the sender and/or recipient can reorder said messages without affecting the selective message structure of the other party.
摘要翻译：本发明是一种计算机化的消息管理系统，其提供一种方法和系统，由此发送者的一个或多个消息和接收者的一个或多个消息每个都具有数字或模拟通信设备可以访问虚拟信箱，其中发送者可以输入消息，并且接收者可以接收消息。发件人和收件人都是授权查看所述消息的唯一方。此外，发件人和/或接收者可以对所述消息重新排序，而不影响另一方的选择性消息结构。

34. 发明授权

US06596739B2 N-(1-phenylethyl)-5-phenyl-imidazole-2-amine compounds, their compositions and uses 失效
标题翻译： N-（1-苯基乙基）-5-苯基 - 咪唑-2-胺化合物，其组成和用途
公开(公告)号：US06596739B2
公开(公告)日：2003-07-22
申请号：US10149880
申请日：2002-06-14
申请人： Song Liu , Benjamin Eric Blass , David Edward Portlock
发明人： Song Liu , Benjamin Eric Blass , David Edward Portlock
IPC分类号： C07D23354
CPC分类号： C07D233/88
摘要： The subject invention involves compounds having structure (I): wherein each R1 is independently alkyl, aryl, or heterocycle; each R2, R4, R7, and R8 is independently hydrogen or other substituent; A is aryl or heterocycle; and pharmaceutically acceptable forms thereof. The subject invention also involves pharmaceutical compositions containing such compounds, and methods for treating or preventing diseases or disorders using such compounds.
摘要翻译：本发明涉及具有结构（I）的化合物：其中每个R 1独立地是烷基，芳基或杂环; 每个R 2，R 4，R 7和R 8独立地是氢或其它取代基; A是芳基或杂环; 及其药学上可接受的形式。本发明还涉及含有这些化合物的药物组合物，以及使用这些化合物治疗或预防疾病或病症的方法。

35. 发明授权

US5849889A Oligosaccharide-containing 14 aminosteroid compounds and novel diastereoselective aminosteroid process chemistry 失效
标题翻译：含寡糖的14种氨基甾体化合物和新型非对映选择性氨基甾体过程化学
公开(公告)号：US5849889A
公开(公告)日：1998-12-15
申请号：US802491
申请日：1997-02-20
申请人： Paul Michael Dybas , Roland Norman Johnson , Randy Stuart Muth , Song Liu , David Edward Portlock
发明人： Paul Michael Dybas , Roland Norman Johnson , Randy Stuart Muth , Song Liu , David Edward Portlock
IPC分类号： A61K31/7036 , A61K31/704 , A61P9/00 , C07J3/00 , C07J17/00 , C07J19/00 , C07J41/00 , A61K31/705
CPC分类号： C07J41/0011 , C07J17/005 , C07J19/005 , C07J3/005 , C07J41/00 , C07J41/0038
摘要： The present invention relates to new 14-aminosteroids, pharmaceutical compositions containing the new compounds and methods of treatment for humans or other mammals afflicted with congestive heart failure.
摘要翻译：本发明涉及新的14-氨基甾体，含有新化合物的药物组合物和治疗患有充血性心力衰竭的人或其他哺乳动物的方法。

36. 发明授权

US08903876B2 File storage system based on coordinated exhaustible and non-exhaustible storage 有权
标题翻译：文件存储系统基于协调的可耗尽和不可耗尽的存储
公开(公告)号：US08903876B2
公开(公告)日：2014-12-02
申请号：US13585967
申请日：2012-08-15
申请人： Amir Meir Michael , Song Liu , Jason Matthew Taylor , Yael Maguire , Per Brashers , Eitan Frachtenberg
发明人： Amir Meir Michael , Song Liu , Jason Matthew Taylor , Yael Maguire , Per Brashers , Eitan Frachtenberg
IPC分类号： G06F17/30
CPC分类号： G06F17/30168 , G06F17/30194 , G06F17/30221
摘要： A file storage system is implemented by coordinating non-exhaustible and exhaustible storage devices. The exhaustible storage devices include lower grade flash based storage devices. The non-exhaustible storage devices are based on magnetic recording mechanisms or higher grade flash storage. The file storage system stores received content items on the exhaustible storage devices, and stores metadata for the content items and/or the file storage system on the non-exhaustible storage devices. During operation, the file storage system globally optimizes the content items on the exhaustible storage devices such that more heavily accessed items are moved to exhaustible storage devices that have experienced relatively few data operations. The file storage system moves less frequently accessed content items to exhaustible storage devices that have experienced a relatively large number of data operations. As such, the operation lifetime of the exhaustible storage devices as a whole can be prolonged.
摘要翻译：文件存储系统通过协调不可耗尽和可耗尽的存储设备来实现。可耗尽的存储设备包括较低级别的闪存存储设备。不可耗尽的存储设备基于磁记录机构或更高等级的闪存存储。文件存储系统将可接收的内容项目存储在可耗尽的存储装置上，并将用于内容项目和/或文件存储系统的元数据存储在不可耗尽的存储装置上。在操作期间，文件存储系统全局地优化可耗尽存储设备上的内容项目，使得更多访问的项目被移动到经历相对较少的数据操作的可耗尽的存储设备。文件存储系统将经常访问的内容项目移动到经历了相对大量数据操作的可耗尽的存储设备。因此，可以延长整个可消耗的存储装置的操作寿命。

37. 发明申请

US20140322788A1 method for increasing protein thermal stability 有权
标题翻译：增加蛋白质热稳定性的方法
公开(公告)号：US20140322788A1
公开(公告)日：2014-10-30
申请号：US13870509
申请日：2013-04-25
申请人： Jian Chen , Guocheng Du , Xinyao Lu , Song Liu , Juan Zhang
发明人： Jian Chen , Guocheng Du , Xinyao Lu , Song Liu , Juan Zhang
IPC分类号： C12N9/96 , C12N9/26 , C12N9/10 , C12N9/02
CPC分类号： C12N9/96 , C12N9/0069 , C12N9/1044 , C12N9/2411
摘要： The invention provides a simple and effective method for increasing thermal stability of a wide range of proteins, comprising fusing a self-assembling amphipathic peptide to the C- or N-terminal of target proteins. The fusion protein can have a half life up to 26 times longer than that of the wild type protein.
摘要翻译：本发明提供了一种用于增加大范围蛋白质的热稳定性的简单且有效的方法，其包括将自组装两亲肽融合到靶蛋白的C-或N-末端。融合蛋白的半衰期比野生型蛋白质长达26倍。

38. 发明申请

US20140067778A1 SELECTIVE OFFLINING STORAGE MEDIA FILESYSTEM 审中-公开
标题翻译：选择性离线存储媒体文件系统
公开(公告)号：US20140067778A1
公开(公告)日：2014-03-06
申请号：US13601733
申请日：2012-08-31
申请人： Dhruba Borthakur , Per Brashers , Song Liu , Tomasz Nykiel
发明人： Dhruba Borthakur , Per Brashers , Song Liu , Tomasz Nykiel
IPC分类号： G06F17/30
CPC分类号： G06F16/185
摘要： A method of operation of a storage control system includes: configuring a state change policy on a data server, the state change policy including an online duration for a storage device; activating the storage device based on the state change policy; mounting the storage device based on the state change policy; and scheduling a filesystem maintenance task to be performed on the storage device based on the state change policy.
摘要翻译：存储控制系统的操作方法包括：在数据服务器上配置状态改变策略，所述状态改变策略包括存储设备的在线持续时间; 基于状态改变策略激活存储设备; 根据国家变更政策安装存储设备; 并根据状态改变策略调度对存储设备执行的文件系统维护任务。

39. 发明授权

US08543364B2 Method for optimizing well production in reservoirs having flow barriers 有权
标题翻译：在具有流动障碍的水库中优化井的生产方法
公开(公告)号：US08543364B2
公开(公告)日：2013-09-24
申请号：US12561830
申请日：2009-09-17
申请人： Song Liu , Lixin Tian , Xian-Huan Wen , Chunming Zhao , Qinghong Yang , Peng Zhang , Dengen Zhou , Bo Li , Lichuan Lan , Lizhen Ge , Xinwu Liao , Fengli Zhang , Michael Sheng-Wei Wei
发明人： Song Liu , Lixin Tian , Xian-Huan Wen , Chunming Zhao , Qinghong Yang , Peng Zhang , Dengen Zhou , Bo Li , Lichuan Lan , Lizhen Ge , Xinwu Liao , Fengli Zhang , Michael Sheng-Wei Wei
IPC分类号： G06G7/48
CPC分类号： E21B43/00
摘要： Computer-implemented systems and methods are provided for optimizing hydrocarbon recovery from subsurface formations, including subsurface formations having bottom water or edgewater. A system and method can be configured to receive data indicative of by-pass oil areas in the subsurface formation from reservoir simulation, identify flow barriers in the subsurface formation based on the by-pass oil areas identified by the reservoir simulation, and predict the lateral extension of the identified flow barriers in the subsurface formation. Infill horizontal wells can be placed at areas of the subsurface formation relative to the flow barriers such that production from a horizontal well in the subsurface formation optimizes hydrocarbon recovery.
摘要翻译：提供计算机实现的系统和方法，用于优化地下构造的烃回收，包括具有底部水或污水的地下地层。一种系统和方法可以被配置为接收指示来自储层模拟的地下地层旁路油区的数据，基于由油藏模拟识别的旁路油区，识别地下地层中的流动障碍，并预测横向在地下构造中识别的流动障碍的扩展。填充水平井可以放置在相对于流动屏障的地下地层的区域，使得地下地层中的水平井的生产优化了烃回收。

40. 发明申请

US20120035194A1 SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS 审中-公开
标题翻译：取代的2-AMINO-FUSED杂环化合物
公开(公告)号：US20120035194A1
公开(公告)日：2012-02-09
申请号：US13204741
申请日：2011-08-08
申请人： Liming Huang , Song Liu , Elizabeth A. Lunney , Simon P. Planken
发明人： Liming Huang , Song Liu , Elizabeth A. Lunney , Simon P. Planken
IPC分类号： A61K31/517 , C07D405/12 , C07D239/84 , A61P9/00 , C07D409/12 , A61P3/10 , A61P3/00 , A61P3/04 , A61P3/06 , A61P19/10 , A61P9/10 , A61P25/24 , A61P31/12 , A61P29/00 , A61P1/16 , C07D401/12
CPC分类号： C07D239/84 , C07D401/04 , C07D401/12 , C07D403/12
摘要： The present invention relates to compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof, wherein: R1, R2, Z1, t, and ring A are as defined in the specification. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and methods of treating a condition that is mediated by the modulation of JNK, such as diabetes, the method comprising administering to a mammal an effective amount of a compound of formula (I).
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐或溶剂合物，其中：R1，R2，Z1，t和环A如说明书中所定义。本发明还涉及包含式（I）化合物的药物组合物和治疗由调节JNK介导的病症如糖尿病的方法，所述方法包括向哺乳动物施用有效量的式（I）化合物一世）。

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