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    • 35. 发明授权
    • Aluminum alloy piping material for automotive piping excelling in corrosion resistance and workability
    • 用于汽车管道的铝合金管道材料具有优异的耐腐蚀性和可加工性
    • US06638377B2
    • 2003-10-28
    • US09954430
    • 2001-09-17
    • Takahiro KoyamaHirokazu TanakaYoshifusa Shoji
    • Takahiro KoyamaHirokazu TanakaYoshifusa Shoji
    • C22C2100
    • C22F1/04C22C21/00F16L9/02
    • An aluminum alloy piping material for automotive piping excelling in corrosion resistance and workability and a method of fabricating the same. The aluminum alloy piping material is made of an aluminum alloy which contains 0.3-1.5% of Mn, 0.01-0.20% of Fe, and 0.01-0.20% of Si, wherein the content of Cu as impurities is limited to 0.05% or less, with the balance being Al and impurities, wherein, among Si compounds, Fe compounds, and Mn compounds present in the alloy's matrix, the number of compounds with a particle diameter (equivalent circle diameter, hereinafter the same) of 0.5 &mgr;m or more is 3×104 or less per mm2. The aluminum alloy piping material has a tensile strength of 70-130 MPa (temper: O material). An ingot of an aluminum alloy having the composition is hot extruded. The resulting extruded pipe is cold drawn at a working ratio of 30% or more and annealed.
    • 一种用于汽车管道的铝合金管道材料,其耐腐蚀性和加工性优良,且其制造方法。 铝合金管材由铝合金制成,其含有0.3-1.5%的Mn,0.01-0.20%的Fe和0.01-0.20%的Si,其中作为杂质的Cu的含量被限制在0.05%以下, 余量为Al和杂质,其中,在Si化合物中,Fe化合物和存在于合金基体中的Mn化合物中,粒径(当量圆直径,以下相同)为0.5μm以上的化合物的数量为3×10 <4>以下/ mm 2。 铝合金管材的拉伸强度为70-130MPa(回火:O材料)。 具有该组成的铝合金锭被热挤压。 将得到的挤出管以30%以上的加工率进行冷拉伸并退火。
    • 40. 发明授权
    • Peptide compounds, their preparation and uses
    • 肽化合物,其制备和用途
    • US5888972A
    • 1999-03-30
    • US564271
    • 1997-06-24
    • Keiji Hemmi, deceasedMasahiro NeyaNaoki FukamiNatsuko KayakiriHirokazu Tanaka
    • Keiji Hemmi, deceasedMasahiro NeyaNaoki FukamiNatsuko KayakiriHirokazu Tanaka
    • A61K38/00A61P9/12C07K5/02C07K5/03C07K5/062C07K5/08C07K5/083A61K38/06A61K38/07
    • C07K5/0808C07K5/0207C07K5/0827A61K38/00Y02P20/55
    • A compound of the formula: ##STR1## in which R.sup.4 is acyl,R.sup.5 is lower alkyl,R.sup.6 is optionally substituted ar(lower)alkyl or optionally substituted heterocyclic-(lower)alkyl,R.sup.7 is lower alkyl or lower alkylthio(lower)alkyl,R.sup.8 is carboxy or protected carboxy,A is lower alkylene,Z is a group of the formula: ##STR2## wherein R.sup.1 is hydrogen, lower alkyl, common amino-protective group or optionally substituted ar(lower)alkyl,R.sup.2 is hydrogen, lower alkyl, optionally substituted ar(lower)alkyl, optionally substituted heterocyclic-(lower)alkyl, optionally substituted cyclo(lower)alkyl(lower)alkyl, common amino-protective group, amino(or protected amino)(lower)alkyl, optionally substituted heterocyclic-carbonyl or cyclo(lower)alkyl, andR.sup.3 is optionally substituted heterocyclic(lower)alkyl, andm is an integer of 0 to 2,or pharmaceutically acceptable salts thereof, useful as endothelin antagonist.
    • PCT No.PCT / JP94 / 01042 Sec。 371日期1996年6月24日 102(e)1996年6月24日PCT 1994年6月28日PCT公布。 公开号WO95 / 00537 日期1995年1月5日具有下式的化合物:其中R 4为酰基,R 5为低级烷基,R 6为任选取代的芳(低级)烷基或任选取代的杂环 - (低级)烷基,R 7为低级烷基或低级 烷硫基(低级)烷基,R 8为羧基或被保护的羧基,A为低级亚烷基,Z为下式基团:其中R 1为氢,低级烷基,普通氨基保护基或任选取代的芳(低级)烷基 (低级)烷基,任选取代的杂环 - (低级)烷基,任选取代的环(低级)烷基(低级)烷基,常用氨基保护基,氨基(或被保护的氨基)( 低级烷基,任选取代的杂环羰基或环(低级)烷基,R 3为任选取代的杂环(低级)烷基,m为0-2的整数,或其药学上可接受的盐,可用作内皮素拮抗剂。