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31. 发明申请

US20060148118A1 Fabrication of array pH sensitive EGFET and its readout circuit 失效
标题翻译：阵列pH敏感EGFET及其读出电路的制作
公开(公告)号：US20060148118A1
公开(公告)日：2006-07-06
申请号：US11342185
申请日：2006-01-26
申请人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Chung-We Pan , Jing-Sheng Chiang
发明人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Chung-We Pan , Jing-Sheng Chiang
IPC分类号： H01L21/00
CPC分类号： G01N27/4148
摘要： A method for fabricating an array pH sensor and a readout circuit device of such array pH sensor are implemented by utilizing an extended ion sensitive field effect transistor to construct the array pH sensor and related readout circuit. The structure of the array sensor having this extended ion sensitive field effect transistor comprises a tin dioxide/metal/silicon dioxide multi-layer structure sensor and a tin dioxide/indium tin oxide/glass multi-layer structure sensor and has excellent properties. Furthermore, the readout circuit and the sensor utilize two signal generators for controlling and reading signals. In particular, the sensor can be effective for increasing the accuracy of measurement and reducing the interference of noise.
摘要翻译：通过利用扩展的离子敏感场效应晶体管构成阵列pH传感器和相关读出电路来实现阵列pH传感器的制造方法和这种阵列pH传感器的读出电路装置。具有该扩展离子敏感场效应晶体管的阵列传感器的结构包括二氧化锡/金属/二氧化硅多层结构传感器和二氧化锡/铟锡氧化物/玻璃多层结构传感器，并且具有优异的性能。此外，读出电路和传感器利用两个信号发生器来控制和读取信号。特别地，传感器可以有效地提高测量的精度并降低噪声的干扰。

32. 发明授权

US06218208B1 Fabrication of a multi-structure ion sensitive field effect transistor with a pH sensing layer of a tin oxide thin film 有权
标题翻译：制造具有氧化锡薄膜的pH感应层的多结构离子敏感场效应晶体管
公开(公告)号：US06218208B1
公开(公告)日：2001-04-17
申请号：US09347226
申请日：1999-07-02
申请人： Jung-Chuan Chou , Wen-Yaw Chung , Shen-Kan Hsiung , Tai-Ping Sun , Hung-Kwei Liao
发明人： Jung-Chuan Chou , Wen-Yaw Chung , Shen-Kan Hsiung , Tai-Ping Sun , Hung-Kwei Liao
IPC分类号： H01L2100
CPC分类号： G01N27/414
摘要： A sensitive material-tin oxide (SnO2) obtained by thermal evaporation or by r.f. reactive sputtering is used as a high-pH-sensitive material for a Multi-Structure Ion Sensitive Field Effect Transistor. The multi-structure of this Ion Sensitive Field Effect Transistor (ISFET) includes SnO2/SiO2 gate ISFET or SnO2/Si3N4/SiO2 gate ISFET respectively, and which have high performances such as a linear pH sensitivity of approximately 56˜58 mV/pH in a concentration range between pH2 and pH10. A low drift characteristics of approximately 5 mv/day, response time is less than 0.1 second, and an isothermal point of this ISFET sensor can be obtained if the device operates with an adequate drain-source current. In addition, this invention has other advantages, such as the inexpensive fabrication system, low cost, and mass production characteristics. Based on these characteristics, a disposal sensing device can be achieved. Thus, this invention has a high feasibility in Ion Sensitive Field Effect Transistor.
摘要翻译：通过热蒸发或r.f.获得的敏感材料 - 氧化锡（SnO 2）。反应溅射用作多结构离子敏感场效应晶体管的高pH敏感材料。该离子敏感场效应晶体管（ISFET）的多结构分别包括SnO 2 / SiO 2栅极ISFET或SnO 2 / Si 3 N 4 / SiO 2栅极ISFET，并且具有高性能，例如约56〜58mV / pH的线性pH灵敏度 pH2和pH10之间的浓度范围。大约5mv /天的低漂移特性，响应时间小于0.1秒，如果器件以足够的漏源电流工作，则可以获得该ISFET传感器的等温点。此外，本发明还具有廉价的制造系统，低成本和批量生产特性等其它优点。基于这些特性，可以实现处置感测装置。因此，本发明在离子敏感场效应晶体管中具有很高的可行性。

33. 发明授权

US07794778B2 Amperometric sensor for uric acid and method for the same 失效
标题翻译：用于尿酸的电流传感器及其方法
公开(公告)号：US07794778B2
公开(公告)日：2010-09-14
申请号：US11211679
申请日：2005-08-26
申请人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Mei-Ling Cheng
发明人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Mei-Ling Cheng
IPC分类号： G01N1/31 , B05D3/00 , C25B11/12 , H01L21/00
CPC分类号： G01N27/26
摘要： An amperometric sensor for uric acid and a manufacturing method thereof are disclosed, in which polyacrylamide is used to fix catalase, uricase and ferrocenecarboxylic acid on a working electrode. In determining concentration of uric acid, hydrogen peroxide is produced when enzyme and uric acid react with each other and then a reduction current generated from enzyme on the electrode with an external voltage 200 mV applied is detected. In determining concentration of uric acid, a concentration range of 2.5-20 mg/dl is achieved and sensibility of the sensor in a linear portion is 5.17 uAcm−2(mg/dl)−1. In addition, reaction time required for the reaction between enzyme and uric acid is 5.17 uAcm−2(mg/dl)−1.
摘要翻译：公开了一种用于尿酸的电流传感器及其制造方法，其中使用聚丙烯酰胺将过氧化氢酶，尿酸酶和二茂铁羧酸固定在工作电极上。在确定尿酸浓度时，酶和尿酸相互反应产生过氧化氢，然后检测到施加外部电压为200 mV的电极上由酶产生的还原电流。在确定尿酸浓度时，达到浓度范围为2.5-20mg / dl，传感器在线性部分的敏感性为5.17uAcm-2（mg / dl）-1。此外，酶和尿酸之间反应所需的反应时间为5.17 uAcm-2（mg / dl）-1。

34. 发明申请

US20090009193A1 Moisture-Sensitive Element with an Interdigital Capacitor and Fabrication thereof 审中-公开
标题翻译：具有交叉电容器的水分敏感元件及其制造
公开(公告)号：US20090009193A1
公开(公告)日：2009-01-08
申请号：US11774541
申请日：2007-07-06
申请人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Ting-Hsiang Huang
发明人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Ting-Hsiang Huang
IPC分类号： G01R27/26 , H05K3/30
CPC分类号： G01N27/223 , H05K1/162 , Y10T29/4913
摘要： A moisture-sensitive element with an interdigital capacitor (IDC) and fabrication thereof are disclosed, wherein the moisture-sensitive element with the interdigital capacitor investigates a moisture sensor for the determination of human skin moisture based on the interdigital capacitor. The moisture-sensitive element with an interdigital capacitor comprises a printed circuit board (PCB), an interdigital capacitor formed on the printed circuit board, and a moisture sensing layer formed on the interdigital capacitor.
摘要翻译：公开了具有叉指电容器（IDC）及其制造的湿度敏感元件，其中具有叉指电容器的湿度敏感元件根据叉指电容器调查水分传感器以确定人体皮肤水分。具有叉指电容器的湿敏元件包括印刷电路板（PCB），形成在印刷电路板上的叉指电容器和形成在叉指电容器上的湿度感测层。

35. 发明申请

US20080099331A1 SOLID-STATE UREA BIOSENSOR AND ITS DATA ACQUISITION SYSTEM 审中-公开
标题翻译：固态尿素生物传感器及其数据采集系统
公开(公告)号：US20080099331A1
公开(公告)日：2008-05-01
申请号：US11306809
申请日：2006-01-12
申请人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Chung-We Pan
发明人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Chung-We Pan
IPC分类号： G01N33/487 , G01N27/26
CPC分类号： C12Q1/58
摘要： The invention provides a method of fabrication of a solid-state urea biosensor and its data acquisition system. The biosensor includes a substrate, and three individual sensing areas separated by an insulating layer on the substrate. Each individual sensing area contains a conductive layer on the substrate, and a pH sensitive membrane is deposited thereon. An enzyme layer is deposited on one of the pH sensitive membranes to form a working electrode. The other two sensing areas are a quasi-reference electrode and a contrast electrode, respectively. The sensing signals are transferred to an instrumentation amplifier by conductive wires. The sensing signals are then transferred to a low-pass filter to reduce the high frequency noise. A data acquisition card is employed to transfer the sensing signals to a computer. The sensing signals are analyzed by the program of the data acquisition system. The data are then displayed on the display panel.
摘要翻译：本发明提供一种固态尿素生物传感器及其数据采集系统的制造方法。生物传感器包括基板和由基板上的绝缘层分隔开的三个单独的感测区域。每个单独的感测区域在衬底上包含导电层，并且在其上沉积pH敏感膜。酶层沉积在一个pH敏感膜上以形成工作电极。其他两个感测区域分别是准参考电极和对比电极。传感信号通过导线传输到仪表放大器。然后将感测信号传送到低通滤波器以降低高频噪声。使用数据采集卡将感测信号传送到计算机。感测信号由数据采集系统的程序进行分析。然后将数据显示在显示面板上。

36. 发明申请

US20080041721A1 Wireless pH Measurement System 有权
标题翻译：无线pH测量系统
公开(公告)号：US20080041721A1
公开(公告)日：2008-02-21
申请号：US11465780
申请日：2006-08-18
申请人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Jun-Jie Feng
发明人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Jun-Jie Feng
IPC分类号： G01N27/26
CPC分类号： G01N27/4167 , G01N27/286
摘要： A wireless pH measurement system is disclosed, the wireless pH measurement system includes a portable module and a receiver end. The portable module comprises a signal detecting and processing portion and a wireless transmission portion. The signal detecting and processing portion comprises a sensor unit for detecting a pH signal, amplifying, filtering noise, analog/digital conversion and numerical processing to generate a pH measurement signal. The wireless transmission portion receives the pH measurement signal via a transmission interface and transmits by a Bluetooth module. The receiver end includes a Bluetooth receiver for receiving the pH measurement signal. The receiver end processes the pH measurement signal by programs, displays, analyzes and stores the pH measurement signal and transmits warning signal when an abnormal pH measurement signal is received.
摘要翻译：公开了无线pH测量系统，无线pH测量系统包括便携式模块和接收器端。便携式模块包括信号检测和处理部分和无线传输部分。信号检测和处理部分包括用于检测pH信号，放大，滤波噪声，模拟/数字转换和数值处理以产生pH测量信号的传感器单元。无线传输部分通过传输接口接收pH测量信号，并由蓝牙模块进行传输。接收器端包括用于接收pH测量信号的蓝牙接收器。接收端通过程序，显示，分析和存储pH测量信号处理pH测量信号，并在收到异常pH测量信号时发送警告信号。

37. 发明申请

US20070001253A1 Using extended gate field effect transistor to design and analyze the chinese medicine biosensor 审中-公开
标题翻译：使用扩展门场效应晶体管设计和分析中药生物传感器
公开(公告)号：US20070001253A1
公开(公告)日：2007-01-04
申请号：US11284810
申请日：2005-11-23
申请人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Chia-Yu Yen
发明人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Chia-Yu Yen
IPC分类号： H01L31/0203
CPC分类号： C12Q1/001
摘要： In this invention, an extended gate FET with a tin dioxide membrane is applied to fabricate a berberine sensor. There are two methods for fabricating the berberine sensor. First, it is mixed by the macromolecule polymer and electrocatalytic activities. The membrane is adsorbed on the SnO2/ITO glass and the berberine sensor is completed. Second, a polymer is used to immobilize enzyme on the substrate and detect the berberine. In this invention, the extended gate field effect transistor of the SnO2/ITO glass is applied to fabricate a durable berberine detection electrode. One of the berberine sensors that is macromolecule polymer, the optimal measurement environment is in distilled water and the best response curve can be realized, the detection rang is from 1×10−3M to 5×10−7M and the linear range is about 121.47 mV/pC. The berberine sensor based on the enzyme that optimal measurement environment is in 0.1M phosphate buffer solution at pH7.4 and better response curves can be obtained. Although the detection rang is from 1×10−3M to 1×10−7M, the linear range is not better which is about 20.05 mV/pC.
摘要翻译：在本发明中，应用具有二氧化锡膜的扩展栅FET以制造小檗碱传感器。制造小檗碱传感器有两种方法。首先由高分子聚合物和电催化活性混合。膜被吸附在SnO 2 / ITO玻璃上，小檗碱传感器完成。第二，使用聚合物将酶固定在底物上并检测小檗碱。在本发明中，施加SnO 2 / ITO玻璃的扩展栅极场效应晶体管以制造耐用的小檗碱检测电极。作为大分子聚合物的小檗碱传感器之一，最佳测量环境在蒸馏水中，可以实现最佳响应曲线，检测范围为1×10 -3 -3至5×10 -7 M和线性范围约为121.47mV / pC。基于该酶的小檗碱传感器可以获得最佳测量环境在0.1M磷酸盐缓冲溶液中，pH7.4和更好的响应曲线。虽然检测范围为1×10 -3 -3至1×10 -7 M，但线性范围不是更好，约为20.05mV / pC。

38. 发明申请

US20060011951A1 Process for fabricating non-volatile memory by tilt-angle ion implantation 失效
标题翻译：通过倾角离子注入制造非易失性存储器的方法
公开(公告)号：US20060011951A1
公开(公告)日：2006-01-19
申请号：US10891569
申请日：2004-07-15
申请人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Chung-We Pan , I-Kone Kao
发明人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Chung-We Pan , I-Kone Kao
IPC分类号： H01L29/80 , H01L21/8238
CPC分类号： G01N27/414
摘要： A potassium/sodium ion sensing device applying an extended-gate field effect transistor, which using an extended-gate ion sensitive field effect transistor (EGFET) as base to fabricate a potassium/sodium ion sensing device, using the extended gate of the extended-gate ion sensitive field effect transistor as a signal intercept electrode, and immobilizing the hydro-aliphatic urethane diacrylate (EB2001) intermixed with electronegative additive, potassium ionophore, sodium ionophore, and the like, to fabricate a potassium/sodium ion sensing electrode. The present invention utilizes the photocurability and good hydrophilicity of the hydro-aliphatic urethane diacrylate (EB2001), and fixes potassium/sodium ionophore, can obtain a non-wave filter, single-layer, stable signal potassium and sodium ion sensor. Thus, when the present invention is applied to measure the concentration of potassium/sodium ions in a sample, the mutual interference between potassium/sodium ion electrodes can be reduced, so the measured value can be more close to the actual value.
摘要翻译：一种使用扩展栅极离子敏感场效应晶体管（EGFET）作为基极的扩展栅极场效应晶体管的钾/钠离子感测装置，使用扩展栅极场效应晶体管的扩展栅极，栅极离子敏感场效应晶体管作为信号截距电极，并将与负电性添加剂，钾离子载体，钠离子载体等混合的氢 - 脂族氨基甲酸酯二丙烯酸酯（EB2001）固定，制造钾/钠离子感测电极。本发明利用了水解脂肪族聚氨酯二丙烯酸酯（EB2001）的光固化性和亲水性，并且固定了钾/钠离子载体，可以得到非波长的过滤器，单层，稳定的信号钾离子和钠离子传感器。因此，当本发明用于测量样品中钾/钠离子的浓度时，可以减少钾离子/钠离子电极之间的相互干扰，因此测量值可以更接近实际值。

39. 发明申请

US20050147741A1 Fabrication of array PH sensitive EGFET and its readout circuit 审中-公开
标题翻译：阵列PH敏感EGFET及其读出电路的制作
公开(公告)号：US20050147741A1
公开(公告)日：2005-07-07
申请号：US10750073
申请日：2003-12-31
申请人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Chung-We Pan , Jing-Sheng Chiang
发明人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Chung-We Pan , Jing-Sheng Chiang
IPC分类号： H01L21/00
CPC分类号： G01N27/4148
摘要： A method for fabricating an array pH sensor and a readout circuit device of such array pH sensor are implemented by utilizing an extended ion sensitive field effect transistor to construct the array pH sensor and related readout circuit. The structure of the array sensor having this extended ion sensitive field effect transistor comprises a tin dioxide/metal/silicon dioxide multi-layer structure sensor and a tin dioxide/indium tin oxide/glass multi-layer structure sensor and has excellent properties. Furthermore, the readout circuit and the sensor utilize two signal generators for controlling and reading signals. In particular, the sensor can be effective for increasing the accuracy of measurement and reducing the interference of noise.
摘要翻译：通过利用扩展的离子敏感场效应晶体管构成阵列pH传感器和相关读出电路来实现阵列pH传感器的制造方法和这种阵列pH传感器的读出电路装置。具有该扩展离子敏感场效应晶体管的阵列传感器的结构包括二氧化锡/金属/二氧化硅多层结构传感器和二氧化锡/铟锡氧化物/玻璃多层结构传感器，并且具有优异的性能。此外，读出电路和传感器利用两个信号发生器来控制和读取信号。特别地，传感器可以有效地提高测量的精度并降低噪声的干扰。

40. 发明申请

US20050147736A1 Using polypyrrole as the contrast pH detector to fabricate a whole solid-state pH sensing device 审中-公开
标题翻译：使用聚吡咯作为对比度pH检测器来制造整个固态pH感测装置
公开(公告)号：US20050147736A1
公开(公告)日：2005-07-07
申请号：US10750072
申请日：2003-12-31
申请人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Chung-We Pan
发明人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Chung-We Pan
IPC分类号： A61L2/00 , B05D5/12 , G01N27/333 , G01N27/403
CPC分类号： G01N27/4035 , G01N27/3335
摘要： A process for fabricating a whole solid-state pH sensing device by using the polypyrrole as the contrast pH detector and a whole solid-state pH sensing device fabricated by the process are disclosed, wherein said device is a differential pair framework potential electrochemical sensing device fabricated by using a non-insulating solid-state inorganic ion-sensing membrane and a polypyrrole sensing membrane. The largest difference between the device of the present invention and the conventional potentiometric type pH sensor is that the sensor of the invention is a solid-state planar sensor. The differential pair framework uses tin dioxide as the ion-sensing membrane and the reference electrode, and uses a polypyrrole sensor as the differential sensor, wherein the sensitivity of tin dioxide is good and has a value up to 57 mV/pH, and the sensitivity of polypyrrole is about 27 mV/pH. These lead the sensitivity of the whole solid-state pH Sensing device to a value of 30 mV/pH and exhibits good linearity, so that the sensing device framework has practicability. Since the sensitivity of the polypyrrole can be controlled by means of its polymerization, a sensing device with controllable sensitivity can be fabricated for applying to the fabrication of a pH sensor or a biosensor.
摘要翻译：公开了一种通过使用聚吡咯作为对比pH检测器和通过该方法制造的整个固态pH感测装置来制造整个固态pH感测装置的方法，其中所述装置是制造的差分对框架电位电化学感测装置通过使用非绝缘固态无机离子感测膜和聚吡咯感测膜。本发明装置与常规电位式pH传感器之间的最大差异在于本发明的传感器是固态平面传感器。差分对框架使用二氧化锡作为离子感测膜和参比电极，并使用聚吡咯传感器作为差示传感器，其中二氧化锡的灵敏度良好，并且具有高达57mV / pH的值，灵敏度的聚吡咯约为27mV / pH。这些将整个固态pH传感装置的灵敏度提高到30 mV / pH值，呈现出良好的线性度，使感应装置框架具有实用性。由于可以通过其聚合来控制聚吡咯的灵敏度，因此可以制造具有可控感光度的感测装置，用于制造pH传感器或生物传感器。

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