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31. 发明申请

US20140005660A1 SPHINCTER TREATMENT APPARATUS 有权
标题翻译：喷头处理设备
公开(公告)号：US20140005660A1
公开(公告)日：2014-01-02
申请号：US14015993
申请日：2013-08-30
申请人： Stuart D. Edwards , John W. Gaiser , David S. Utley , Jay J. Qin
发明人： Stuart D. Edwards , John W. Gaiser , David S. Utley , Jay J. Qin
IPC分类号： A61B18/18
CPC分类号： A61B18/14 , A61B17/32 , A61B18/1206 , A61B18/1477 , A61B18/148 , A61B18/1485 , A61B18/1492 , A61B18/18 , A61B18/1815 , A61B2017/00084 , A61B2017/00106 , A61B2017/003 , A61B2017/22061 , A61B2017/4216 , A61B2018/00011 , A61B2018/00023 , A61B2018/00029 , A61B2018/00065 , A61B2018/00077 , A61B2018/00083 , A61B2018/00113 , A61B2018/00148 , A61B2018/0016 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00488 , A61B2018/00494 , A61B2018/00553 , A61B2018/00577 , A61B2018/00648 , A61B2018/00654 , A61B2018/00666 , A61B2018/00678 , A61B2018/00702 , A61B2018/00708 , A61B2018/00726 , A61B2018/00744 , A61B2018/00755 , A61B2018/00761 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00827 , A61B2018/00875 , A61B2018/00886 , A61B2018/00892 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/00982 , A61B2018/0262 , A61B2018/046 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1273 , A61B2018/1405 , A61B2018/1467 , A61B2018/1472 , A61B2018/183 , A61B2090/3614 , A61B2090/3782 , A61B2217/007 , A61B2218/002 , A61M3/0279 , A61M16/0438 , A61M16/0481 , A61M25/1002 , A61M2025/1052 , A61M2025/1086 , A61N1/056 , A61N1/06 , A61N1/08 , A61N1/40
摘要： An apparatus treats tissue at or near a sphincter. The apparatus has an elongated member having at least one lumen including an inflation lumen, and a basket assembly including a first and a second arm. An inflatable member is coupled to the inflation lumen and has a deployed and a non-deployed state. In the deployed state, the inflatable member expands the basket assembly into contact with tissue. At least one of the first and second arms of the basket assembly has a fluid lumen having an aperture for conveying a fluid from the basket assembly. A source of fluid is coupled to the fluid lumen for conveyance of fluid through the aperture. The fluid can be, e.g., an electrolytic solution, and/or an anti-infection agent, and/or an echogenic media, and/or a steroid, and/or an anesthetic, and/or a medicament, and/or a tissue cooling agent. The source can be a drug delivery device.
摘要翻译：装置处理括约肌处或附近的组织。该装置具有细长构件，其具有包括充气腔的至少一个腔，以及包括第一臂和第二臂的篮组件。可膨胀构件联接到膨胀腔并具有展开和非展开状态。在展开状态下，可膨胀构件将篮组件膨胀成与组织接触。篮组件的第一和第二臂中的至少一个具有流体腔，其具有用于从篮组件输送流体的孔。流体源耦合到流体腔，用于输送流体通过该孔。流体可以是例如电解溶液和/或抗感染剂和/或回声介质，和/或类固醇，和/或麻醉剂，和/或药物，和/或组织冷却剂。来源可以是药物递送装置。

32. 发明申请

US20090118699A1 Systems and methods for treating obesity and other gastrointestinal conditions 审中-公开
标题翻译：用于治疗肥胖症和其他胃肠病症的系统和方法
公开(公告)号：US20090118699A1
公开(公告)日：2009-05-07
申请号：US12317332
申请日：2008-12-22
申请人： David S. Utley , Rachel E. Croft , John W. Gaiser
发明人： David S. Utley , Rachel E. Croft , John W. Gaiser
IPC分类号： A61K38/19 , A61B18/04 , A61N2/00 , A61P3/04 , A61B17/03 , A61M5/178
CPC分类号： A61F5/005 , A61B18/1477 , A61B18/1492 , A61B2017/00818 , A61B2018/00214 , A61B2018/00494 , A61B2018/00553 , A61B2018/1425 , A61B2018/143 , A61B2218/002 , A61F5/0079 , A61F5/0089
摘要： Systems and methods affect tightening of the pyloric sphincter and/or serve to mediate or moderate receptive relaxation of muscles in the stomach, to treat or mitigate various physiologic conditions, such as obesity, biliary reflex, GERD, and/or Barrett's esophagus. The systems and methods may be used as either a primary treatment modality, or applied as a supplementary treatment before, during or after a primary intervention.
摘要翻译：系统和方法影响幽门括约肌的收缩和/或用于介导或调节胃中肌肉的接受松弛，治疗或减轻各种生理条件，例如肥胖，胆汁反射，GERD和/或巴雷特食管。系统和方法可以用作主要治疗方式，或者在主要干预之前，期间或之后作为补充治疗使用。

33. 发明授权

US06673070B2 Sphincter treatment apparatus 有权
标题翻译：括约肌治疗仪
公开(公告)号：US06673070B2
公开(公告)日：2004-01-06
申请号：US09776140
申请日：2001-02-02
申请人： Stuart D Edwards , John W. Gaiser , David S. Utley , Jay J. Qin
发明人： Stuart D Edwards , John W. Gaiser , David S. Utley , Jay J. Qin
IPC分类号： A61B1818
CPC分类号： A61B18/1477 , A61B17/32 , A61B18/1206 , A61B18/148 , A61B18/1485 , A61B18/1492 , A61B18/18 , A61B18/1815 , A61B2017/00084 , A61B2017/00106 , A61B2017/003 , A61B2017/22061 , A61B2017/4216 , A61B2018/00011 , A61B2018/00023 , A61B2018/00029 , A61B2018/00065 , A61B2018/00077 , A61B2018/00083 , A61B2018/00113 , A61B2018/00148 , A61B2018/0016 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00494 , A61B2018/00553 , A61B2018/00577 , A61B2018/00654 , A61B2018/00666 , A61B2018/00678 , A61B2018/00702 , A61B2018/00708 , A61B2018/00726 , A61B2018/00744 , A61B2018/00755 , A61B2018/00761 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00827 , A61B2018/00869 , A61B2018/00875 , A61B2018/00886 , A61B2018/00892 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/00982 , A61B2018/0262 , A61B2018/046 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1273 , A61B2018/1425 , A61B2018/1467 , A61B2018/1472 , A61B2018/183 , A61B2090/3614 , A61B2090/3782 , A61B2218/002 , A61M3/0279 , A61M16/0438 , A61M16/0481 , A61M25/1002 , A61M2025/1052 , A61M2025/1086 , A61N1/056 , A61N1/06 , A61N1/08 , A61N1/40
摘要： A sphincter treatment apparatus includes an elongated member having at least one lumen including an inflation lumen and a basket assembly with first and second arms. The basket assembly is coupled to the elongated member and has deployed and non-deployed configurations. An inflatable member is coupled to the elongated member and positioned in an interior of the basket assembly. The inflatable member has deployed and non-deployed states and is coupled to the inflation lumen. In the deployed state, the inflatable member expands the basket assembly to its deployed configuration. A first energy delivery device is positionable in the first arm and advanceable from the first arm to a selected treatment site. A second energy delivery device is positionable in the second arm and advanceable from the second arm to a selected treatment site.
摘要翻译：括约肌治疗装置包括细长构件，其具有包括充气腔的至少一个内腔和具有第一和第二臂的篮组件。筐组件联接到细长构件并且具有展开和非展开构造。可膨胀构件联接到细长构件并且定位在篮组件的内部。充气构件具有展开状态和非展开状态，并且连接到膨胀腔。在展开状态下，可膨胀构件将篮组件膨胀到其展开构型。第一能量输送装置可定位在第一臂中并且可从第一臂推进到选定的处理部位。第二能量输送装置可定位在第二臂中并且可从第二臂推进到选定的治疗部位。

34. 发明申请

US20130226171A1 SYSTEMS AND METHODS EMPLOYING A GUIDEWIRE FOR POSITIONING AND STABILIZING EXTERNAL INSTRUMENTS DEPLOYED WITHIN THE BODY 审中-公开
标题翻译：使用用于定位和稳定身体内部的外部仪器的指南的系统和方法
公开(公告)号：US20130226171A1
公开(公告)日：2013-08-29
申请号：US13854662
申请日：2013-04-01
申请人： John W. Gaiser , Scott H. West , David S. Utley , David Huynh
发明人： John W. Gaiser , Scott H. West , David S. Utley , David Huynh
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B1/00154 , A61M16/0493 , A61M25/02 , A61M2025/024
摘要： Systems and methods for treating a tissue region employ an expandable structure projecting beyond the distal end of a catheter tube. A distal tail projects beyond the far end of the basket assembly. The distal tail includes a guidewire lumen that accommodates passage of a guidewire without threading the guidewire through the catheter tube.
摘要翻译：用于治疗组织区域的系统和方法使用突出超过导管管的远端的可扩张结构。远端的尾巴超出了篮子组件的远端。远端尾部包括导丝管腔，该导丝腔容纳导丝的通道，而不将导丝穿过导管。

35. 发明申请

US20120209144A1 SYSTEMS AND METHODS FOR APPLYING A SELECTED TREATMENT AGENT INTO CONTACT WITH TISSUE 审中-公开
标题翻译：将选择的治疗剂与组织接触的系统和方法
公开(公告)号：US20120209144A1
公开(公告)日：2012-08-16
申请号：US13454842
申请日：2012-04-24
申请人： DAVID S. UTLEY , John W. Gaiser , Rachel Croft
发明人： DAVID S. UTLEY , John W. Gaiser , Rachel Croft
IPC分类号： A61B1/018 , A61M25/09 , A61M25/06
CPC分类号： A61B18/1492 , A61B18/1477 , A61B2018/00214 , A61B2018/00232 , A61B2018/00553 , A61B2018/00797 , A61B2018/00815 , A61B2018/1425 , A61M25/0084
摘要： Systems and methods that treat disorders of the gastrointestinal tract by applying one or more treatment agents to tissue at or near the region where abnormal neurological symptoms or abnormal tissue conditions exist. The treatment agent is selected to either disrupt the abnormal nerve pathways and/or to alleviate the abnormal tissue conditions. The treatment agent can include at least one cytokine and/or at least one vanilloid compound to evoke a desired tissue response. The systems and methods can be used a primary treatment modality, or as a neoadjuvent or adjuvant treatment modality.
摘要翻译：通过将一种或多种治疗剂施用于存在异常神经症状或异常组织病状的区域处或附近的组织来治疗胃肠道疾病的系统和方法。选择治疗剂以破坏异常神经通路和/或减轻异常组织状况。治疗剂可以包括至少一种细胞因子和/或至少一种香草酸化合物以引起所需的组织应答。系统和方法可以用作主要治疗方式，或作为新辅助治疗方式。

36. 发明申请

US20110071468A1 Systems and methods for applying a selected treatment agent into contact with tissue to treat sphincter dysfunction 审中-公开
标题翻译：用于将选定的治疗剂与组织接触以治疗括约肌功能障碍的系统和方法
公开(公告)号：US20110071468A1
公开(公告)日：2011-03-24
申请号：US12927517
申请日：2010-11-17
申请人： David S. Utley , John W. Gaiser , Rachel Croft
发明人： David S. Utley , John W. Gaiser , Rachel Croft
IPC分类号： A61M31/00
CPC分类号： A61B18/1477 , A61B1/31 , A61B18/02 , A61B18/08 , A61B18/1492 , A61B18/1815 , A61B18/20 , A61B2018/00214 , A61B2018/00232 , A61B2018/00267 , A61B2018/00482 , A61B2018/00553 , A61B2018/00797 , A61B2018/00815 , A61B2018/0091 , A61B2018/00916 , A61B2018/1861 , A61B2090/3782 , A61B2218/007
摘要： Systems and methods apply a selected treatment agent or agents into contact with tissue at or in the region of a dysfunctional sphincter (in the case of GERD, fecal incontinence, or other dysfunctional sphincter disorders) to affect improved sphincter barrier function and/or to disrupt abnormal nerve pathways. The treatment agent can include at least one cytokine and/or at least one tissue bulking agent and/or at least one vanilloid compound to evoke a desired tissue response. The systems and methods can be used a primary treatment modality, or applied as a supplementary treatment before; during or after a primary intervention.
摘要翻译：系统和方法将选定的治疗剂或药剂与功能异常括约肌区域（或GERD，大便失禁或其他功能失调的括约肌疾病）区域或组织接触，以影响改善的括约肌屏障功能和/或破坏异常神经通路。处理剂可以包括至少一种细胞因子和/或至少一种组织填充剂和/或至少一种香草酸化合物以引起所需的组织应答。系统和方法可以用作主要治疗方式，或作为补充治疗应用; 在主要干预期间或之后。

37. 发明授权

US07122031B2 Graphical user interface for association with an electrode structure deployed in contact with a tissue region 有权
公开(公告)号：US07122031B2
公开(公告)日：2006-10-17
申请号：US10024747
申请日：2001-12-19
申请人： Stuart D Edwards , John W. Gaiser , David S Utley , Scott H. West , Jay Qin
发明人： Stuart D Edwards , John W. Gaiser , David S Utley , Scott H. West , Jay Qin
IPC分类号： A61B18/18
CPC分类号： A61B18/1233 , A61B18/12 , A61B18/1206 , A61B18/14 , A61B18/1477 , A61B18/1485 , A61B18/1492 , A61B2018/00011 , A61B2018/00029 , A61B2018/00035 , A61B2018/00077 , A61B2018/00148 , A61B2018/0016 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00488 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1425 , A61B2018/1475 , A61B2090/3782 , A61B2218/002 , A61B2218/007 , Y10S128/922
摘要： Systems and methods deploy an electrode structure in contact with the tissue region. The electrode structure carries a sensor at a known location on the electrode structure to monitor an operating condition. The systems and methods provide an interface, which generate an idealized image of the electrode structure and an indicator image to represent the monitored operating condition in a spatial position on the idealized image corresponding to the location of the sensor on the electrode structure. The interface displays a view image comprising the idealized image and indicator image. The systems and methods cause the electrode structure to apply energy to heat the tissue region while the view image is displayed on the display screen.

38. 发明申请

US20100217197A1 System and methods employing a bite block insert for positioning and stabilizing external instruments deployed within the body 审中-公开
标题翻译：使用咬入块插入件来定位和稳定部署在体内的外部器械的系统和方法
公开(公告)号：US20100217197A1
公开(公告)日：2010-08-26
申请号：US12799623
申请日：2010-04-28
申请人： Scott West , Utley S. David , John W. Gaiser
发明人： Scott West , Utley S. David , John W. Gaiser
IPC分类号： A61M25/02
CPC分类号： A61B18/1485 , A61B1/00154 , A61M16/0493 , A61M25/02 , A61M29/02 , A61M2025/024 , Y10S128/06 , Y10S128/26
摘要： Systems and methods are provided for positioning and stabilizing an external instrument during insertion of the instrument through the oral cavity (e.g., insertion of a catheter through the oral cavity and into the esophagus or cardia for treatment of gastroesophageal reflux disease (GERD)). The systems and methods provide a gripping tool for association with a bite block, capable of selectively moving between an open position in which the instrument may be inserted or removed, and a closed position in which the external instrument is held in a fixed position.
摘要翻译：提供了系统和方法，用于在将器械插入口腔（例如，将导管穿过口腔插入食管或贲门以治疗胃食管反流病（GERD））期间定位和稳定外部器械。这些系统和方法提供了一种用于与咬合块相关联的夹持工具，其能够选择性地在可以插入或移除该器械的打开位置之间移动，以及将外部器械保持在固定位置的关闭位置。

39. 发明授权

US6066126A Precurved, dual curve cardiac introducer sheath 失效
标题翻译：双曲线心脏引导器鞘
公开(公告)号：US6066126A
公开(公告)日：2000-05-23
申请号：US993217
申请日：1997-12-18
申请人： Hong Li , John W. Gaiser
发明人： Hong Li , John W. Gaiser
IPC分类号： A61M25/00 , A61M25/06
CPC分类号： A61M25/0041 , A61M25/0662
摘要： A precurved cardiac introducer sheath (4) includes an elongate, hollow body having main and tip portions (24, 22). The tip portion includes first through fifth segments (26, 28, 30, 32, 34). The first, second, and third segments lie in a first plane (36) while the fourth and fifth segments lie in a second plane (38) oriented at a second angle (37) of about .+-.10 to 170.degree. to the first plane. The second segment defines an arc extending along a first, included angle of about 90-110.degree. while the fourth segment defines an arc extending along a third, included angle of about 90-140.degree. . The first, third, and fifth segments are preferably generally straight segments. The precurved introducer sheath is preferably configured to direct the electrophysiology catheter (18) directly at the posterior region (52) of the left atrium (40). The precurved introducer sheath is preferably housed within an outer introducer sheath (46) having a radially deflectable distal end (46), or a fixed distal curve.
摘要翻译：一种预先安装的心脏引导器护套（4）包括具有主和末端部分（24,22）的细长的中空体。尖端部分包括第一至第五段（26,28,30,32,34）。第一，第二和第三段位于第一平面（36）中，而第四和第五段位于第二平面（38）中，第二平面（38）以大约+/- 10至170°的第二角度（37）定向，飞机第二段限定沿着第一夹角约90-110°延伸的弧，而第四段限定沿第三夹角约90-140°延伸的弧。第一，第三和第五段优选地是大致直段。优选的引导器护套优选地构造成直接在左心房（40）的后部区域（52）处引导电生理学导管（18）。优选的引导器护套优选地容纳在具有可径向偏转的远端（46）或固定远端曲线的外引导器护套（46）内。

40. 发明授权

US5957961A Multiple sensor, temperature controlled R-F ablation system 失效
标题翻译：多传感器，温度控制R-F消融系统
公开(公告)号：US5957961A
公开(公告)日：1999-09-28
申请号：US5405
申请日：1998-01-09
申请人： Mark A. Maguire , Kevin C. Ladd , John W. Gaiser , Le T. Le
发明人： Mark A. Maguire , Kevin C. Ladd , John W. Gaiser , Le T. Le
IPC分类号： A61B5/042 , A61B17/00 , A61B18/00 , A61B18/14 , A61M25/01 , A61N1/08
CPC分类号： A61M25/0138 , A61B18/1492 , A61B5/0422 , A61B5/6855 , A61B5/6857 , A61B5/6859 , A61M25/0147 , A61B2017/00101 , A61B2018/00351 , A61B2018/00577 , A61B2018/00654 , A61B2018/00702 , A61B2018/00761 , A61B2018/00791 , A61B2018/00797 , A61B2018/00821 , A61B2018/00839 , A61B2018/00916 , A61B2018/1226 , A61B2018/124 , A61B2018/1273 , A61B2018/1861 , A61B2562/0209 , A61B2562/043 , A61M2025/015 , A61M2025/0161
摘要： A catheter ablation system including a catheter having a distal segment carrying at least one electrode extending along the segment and having a number of temperature sensors arranged along the distal segment adjacent the electrode, each providing an output indicative of temperature. The catheter is coupled to a power source which provides R-F energy to the electrode and with temperature processing circuitry coupled to the temperature sensors and the power source which controls power output from the power source as a function of the outputs of the temperature sensors. In a preferred embodiment, the temperature processing circuitry includes circuitry for comparing the temperature indicated by the temperature sensors to a known reference sensor and circuitry for disabling subsequent use of an output of one of the sensors if the output from the sensor differs from the referenced temperature by more than a defined value. In an alternative preferred embodiment, the temperature processing circuitry includes circuitry responsive to the rate of change of the output of the temperature sensors and circuitry for disabling a sensor if the output of the sensor changes at a rate greater than a defined referenced rate of change.
摘要翻译：一种导管消融系统，其包括具有远端段的导管，所述远端段承载沿着所述段延伸的至少一个电极，并且具有沿着与所述电极相邻的远侧段布置的多个温度传感器，每个提供指示温度的输出。导管耦合到电源，该电源为电极提供R-F能量，并且具有耦合到温度传感器的温度处理电路和控制从电源输出的功率作为温度传感器输出的功能的电源。在优选实施例中，温度处理电路包括用于将由温度传感器指示的温度与已知参考传感器和用于如果传感器的输出与参考温度不同的随后使用传感器之一的输出的电路进行比较的电路超过定义的值。在替代的优选实施例中，温度处理电路包括响应于温度传感器的输出的变化速率和用于在传感器的输出以大于所定义的参考变化率的速率变化的情况下禁用传感器的电路的电路。

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