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31. 发明授权

US5690683A After potential removal in cardiac rhythm management device 失效
标题翻译：心脏节律管理装置中潜在去除后
公开(公告)号：US5690683A
公开(公告)日：1997-11-25
申请号：US492199
申请日：1995-06-19
申请人： Paul A. Haefner , Mark A. Stockburger , William J. Linder
发明人： Paul A. Haefner , Mark A. Stockburger , William J. Linder
IPC分类号： A61N1/37 , A61N1/39
CPC分类号： A61N1/3704 , Y10S128/901
摘要： An apparatus effectively removes after potential occurring after a electrical pulse is delivered in a cardiac rhythm management system such as a pacemaker system or cardioverter/defibrillator system having an electrode used for both sensing electrical activity of the heart and carrying the electrical pulse to the heart and a sense amplifier for detecting the electrical activity from the electrode. The apparatus includes a lowpass filter coupled to the electrode to filter the sensed electrical activity. A highpass filter is coupled between the lowpass filter and the sense amplifier to further filter the electrical activity passed from the lowpass filter. Equilibrium circuitry is included to allow passive filter components of the lowpass filter and the highpass filter to return to an equilibrium state following delivery of the electrical pulse.
摘要翻译：一种装置在电脉冲在诸如起搏器系统或心脏转复器/除颤器系统的心律管理系统中传递之后有效地消除，所述心脏起搏器系统或心脏转复器/除颤器系统具有用于感测心脏的电活动并将心电的脉搏传送到心脏的电极，用于检测来自电极的电活动的读出放大器。该装置包括耦合到电极的低通滤波器以滤波感测的电活动。低通滤波器耦合在低通滤波器和读出放大器之间，以进一步滤除从低通滤波器传递的电活动。包括平衡电路，以允许低通滤波器的无源滤波器组件和高通滤波器在电脉冲传递后恢复平衡状态。

32. 发明授权

US4728931A Charge redistribution capacitance detection apparatus 失效
标题翻译：电荷再分配电容检测装置
公开(公告)号：US4728931A
公开(公告)日：1988-03-01
申请号：US890215
申请日：1986-07-25
申请人： William J. Linder , James D. Reinke
发明人： William J. Linder , James D. Reinke
IPC分类号： G01R27/26 , H03K5/24 , H03K17/96 , G06F3/02
CPC分类号： H03K17/9622 , G01R27/2605 , H03K5/249 , H03K2017/9613 , Y10T307/766
摘要： A charge redistribution capacitance detector is disclosed for detecting whether the capacitance of a variable capacitor is smaller or larger than that of a reference capacitor. First plates of the variable and reference capacitors are connected to a sense node, and a switching device responsive to a clock signal periodically impresses a reference voltage on the sense node during one phase of the clock signal and allows the sense node to electrically float during the alternate phase of the clock signal. Second plates of the sense and reference capacitors are alternately charged and discharged by equal voltage differences in opposite senses during successive clock phases. The voltage on the first plates of the capacitors changes in a sense dependent on the relative capacitance values of the capacitors and is compared with the reference voltage by a comparator which produces a corresponding detector output.
摘要翻译：公开了一种用于检测可变电容器的电容是否小于或大于参考电容器的电荷再分配电容检测器。可变参考电容器的第一板连接到感测节点，并且响应于时钟信号的开关装置在时钟信号的一个相位期间周期性地在感测节点上施加参考电压，并允许感测节点在时钟信号的交替相位。感测和参考电容器的第二板在连续的时钟相位期间以相反的感测相等的电压差交替地充电和放电。电容器的第一板上的电压在某种意义上根据电容器的相对电容值而改变，并且通过产生相应检测器输出的比较器与参考电压进行比较。

33. 发明授权

US4503340A CMOS Window detector with hysteresis 失效
标题翻译：具有滞后的CMOS窗口检测器
公开(公告)号：US4503340A
公开(公告)日：1985-03-05
申请号：US418512
申请日：1982-09-16
申请人： William J. Linder
发明人： William J. Linder
IPC分类号： H03K3/3565 , H03K5/153
CPC分类号： H03K3/3565
摘要： A CMOS window detector provides an output signal which indicates the relationship of an input signal to a voltage "window" as a function of the previous output signal. The window detector includes first and second current source circuits and first and second inverter circuits. A bias current is established in each current source circuit as a function of a different reference voltage. The first and second inverter circuits each include a current mirror field effect transistor (FET) and a current control FET connected in a series current path. The current mirror FET of each inverter circuit is connected to its respective current source circuit and establishes a current in the inverter current path equal in magnitude to its respective bias current. The input signal is applied to the gates of the current control FETs. Each current control FET changes conductivity state when the input signal reaches the reference voltage level used to establish the respective inverter current flow. Each reference voltage therefore represents a window voltage level. The difference in window voltage levels defines the voltage window. An output circuit formed by a CMOS NAND-latch is connected to the first and second inverter circuits and provides the output signal which exhibits hysteresis with respect to the input signal.
摘要翻译： CMOS窗口检测器提供输出信号，其指示输入信号与作为先前输出信号的函数的电压“窗口”的关系。窗口检测器包括第一和第二电流源电路以及第一和第二反相器电路。在每个电流源电路中建立偏置电流作为不同参考电压的函数。第一和第二逆变器电路各自包括电流镜效应晶体管（FET）和连接在串联电流路径中的电流控制FET。每个逆变器电路的电流反射镜FET连接到其各自的电流源电路，并且在逆变器电流路径中建立与其相应的偏置电流大小相等的电流。输入信号被施加到电流控制FET的栅极。当输入信号达到用于建立相应逆变器电流的基准电压电平时，每个电流控制FET改变导电状态。因此，每个参考电压表示窗口电压电平。窗口电压电平的差异定义了电压窗口。由CMOS NAND锁存器形成的输出电路连接到第一和第二反相器电路，并提供相对于输入信号呈现迟滞的输出信号。

34. 发明授权

US08755886B2 Implantable device with bias for MRI 有权
标题翻译：具有偏心MRI的植入式装置
公开(公告)号：US08755886B2
公开(公告)日：2014-06-17
申请号：US12976862
申请日：2010-12-22
申请人： Nicholas J. Stessman , Michael J. Lyden , Thomas M. Bocek , William J. Linder , Joseph M. Bocek
发明人： Nicholas J. Stessman , Michael J. Lyden , Thomas M. Bocek , William J. Linder , Joseph M. Bocek
IPC分类号： A61N1/00 , A61B5/05
CPC分类号： A61N1/08 , A61N1/086 , A61N1/37 , A61N1/3718
摘要： An ambulatory or implantable device, such as a pacer, defibrillator, or other cardiac rhythm management device, can tolerate magnetic resonance imaging (MRI) or other noise without turning on an integrated circuit diode by selectively providing a bias voltage that can overcome an expected induced voltage resulting from the MRI or other noise.
摘要翻译：诸如起搏器，除颤器或其他心律管理装置的移动或可植入装置可以容忍磁共振成像（MRI）或其他噪声，而不通过选择性地提供可以克服预期诱导的偏置电压而导通集成电路二极管由MRI或其他噪音引起的电压。

35. 发明申请

US20130245718A1 SYSTEMS AND METHODS FOR MONITORING NEUROSTIMULATION DOSING 有权
标题翻译：用于监测神经调节剂量的系统和方法
公开(公告)号：US20130245718A1
公开(公告)日：2013-09-19
申请号：US13780903
申请日：2013-02-28
申请人： Doug M. Birkholz , Douglas J. Brandner , Douglas J. Gifford , David J. Ternes , William J. Linder
发明人： Doug M. Birkholz , Douglas J. Brandner , Douglas J. Gifford , David J. Ternes , William J. Linder
IPC分类号： A61N1/36
CPC分类号： A61N1/3727 , A61N1/3605 , A61N1/36082 , A61N1/36125 , A61N1/36142 , A61N1/36178 , A61N1/378
摘要： Various implantable device embodiments may comprise a neural stimulator configured to deliver a neurostimulation therapy with stimulation ON times and stimulation OFF times where a dose of the neurostimulation therapy is provided by a number of neurostimulation pulses over a period of time. The neural stimulator may be configured to monitor the dose of the delivered neurostimulation therapy against dosing parameters. The neural stimulator may be configured to declare a fault if the monitored dose does not favorably compare to a desired dose for the neurostimulation therapy, or may be configured to record data for the monitored dose of the delivered neurostimulation therapy, or may be configured to both record data for the monitored dose of the delivered neurostimulation therapy and declare a fault if the monitored dose does not favorably compare to a desired dose for the neurostimulation therapy.
摘要翻译：各种可植入装置实施例可以包括神经刺激器，所述神经刺激器被配置为在刺激ON次数和刺激OFF时间递送神经刺激疗法，其中神经刺激疗法的剂量在一段时间内由许多神经刺激脉冲提供。神经刺激器可以被配置为监测所输送的神经刺激疗法针对给药参数的剂量。如果所监测的剂量与用于神经刺激疗法的期望剂量不利地比较，则神经刺激器可以被配置为宣告故障，或者可被配置为记录所输送的神经刺激疗法的监测剂量的数据，或者可以被配置为两者记录所输送的神经刺激疗法的监测剂量的数据，并且如果所监测的剂量与用于神经刺激疗法的期望剂量不利地相比较，则声明故障。

36. 发明授权

US08504149B2 System and method to deliver therapy in presence of another therapy 有权
公开(公告)号：US08504149B2
公开(公告)日：2013-08-06
申请号：US13397115
申请日：2012-02-15
申请人： Imad Libbus , Andrew P. Kramer , William J. Linder , Jeffrey E. Stahmann
发明人： Imad Libbus , Andrew P. Kramer , William J. Linder , Jeffrey E. Stahmann
IPC分类号： A61N1/05
CPC分类号： A61N1/37 , A61N1/36114 , A61N1/36125 , A61N1/362 , A61N1/36514 , A61N1/36564 , A61N1/36592 , A61N1/3987
摘要： Various aspects relate to a method. In various embodiments, a therapy of a first therapy type is delivered, and it is identified whether a therapy of a second therapy type is present to affect the therapy of the first therapy type. Delivery of the therapy is controlled based on the presence of the therapy of the second therapy type. Some embodiments deliver the therapy of the first type using one set of parameters in the presence of a therapy of a second type, and deliver the therapy of the first type using another set of parameters when the therapy of the second type is not present. In various embodiments, one of the therapy types includes a cardiac rhythm management therapy, and the other includes a neural stimulation therapy. Other aspects and embodiments are provided herein.

37. 发明授权

US08473049B2 Implantable neural stimulator with mode switching 有权
标题翻译：具有模式切换的植入型神经刺激器
公开(公告)号：US08473049B2
公开(公告)日：2013-06-25
申请号：US11137038
申请日：2005-05-25
申请人： Imad Libbus , Andrew P. Kramer , William J. Linder , Jeffrey E. Stahmann
发明人： Imad Libbus , Andrew P. Kramer , William J. Linder , Jeffrey E. Stahmann
IPC分类号： A61N1/00
CPC分类号： A61N1/36128 , A61M5/1723 , A61N1/3605 , A61N1/36053 , A61N1/36114 , A61N1/36135 , A61N1/3688
摘要： Various aspects of the present subject matter relate to an implantable device. Various device embodiments comprise at least one port to connect to at least one lead with at least electrode, stimulation circuitry connected to the at least one port and adapted to provide at least one neural stimulation therapy to at least one neural stimulation target using the at least one electrode, sensing circuitry connected to the at least one port and adapted to provide a sensed signal, and a controller connected to the stimulation circuitry to provide the at least one neural stimulation therapy and to the sensing circuitry to receive the sensed signal. In response to a triggering event, the controller is adapted to switch between at least two modes. Other aspects and embodiments are provided herein.
摘要翻译：本主题的各个方面涉及可植入装置。各种装置实施例包括至少一个端口，以连接至少一个引线，至少电极，刺激电路连接到至少一个端口，并且适于使用至少一个至少一个端口向至少一个神经刺激目标提供至少一个神经刺激治疗一个电极，连接到所述至少一个端口并适于提供感测信号的感测电路，以及连接到所述刺激电路以提供所述至少一个神经刺激治疗的控制器，以及所述感测电路以接收感测到的信号。响应于触发事件，控制器适于在至少两种模式之间切换。本文提供了其它方面和实施例。

38. 发明授权

US08433406B2 Implantable medical device with temperature measuring and storing capability 有权
公开(公告)号：US08433406B2
公开(公告)日：2013-04-30
申请号：US13287751
申请日：2011-11-02
申请人： Ron A. Balczewski , Jeffrey A. Von Arx , William J. Linder , Mark D. Amundson
发明人： Ron A. Balczewski , Jeffrey A. Von Arx , William J. Linder , Mark D. Amundson
IPC分类号： A61N1/00
CPC分类号： G01K13/002 , A61B5/0008 , A61B5/0031 , A61B5/7285 , A61N1/3655
摘要： An implantable medical device such as a cardiac pacemaker or implantable cardioverter/defibrillator with the capability of storing body temperature measurements taken periodically and/or when triggered by particular events.

39. 发明授权

US08364266B2 Implantable medical device with embedded programmable non-volatile memory 有权
标题翻译：具有嵌入式可编程非易失性存储器的可植入医疗器械
公开(公告)号：US08364266B2
公开(公告)日：2013-01-29
申请号：US13052231
申请日：2011-03-21
申请人： Jeremy Maniak , William L. Zimmer , Ron A. Balczewski , William J. Linder
发明人： Jeremy Maniak , William L. Zimmer , Ron A. Balczewski , William J. Linder
IPC分类号： A61N1/02
CPC分类号： A61B5/04
摘要： A method comprising providing a programmable non-volatile memory (PNVM) circuit fabricated together with a processor on an integrated circuit chip (IC) in an implantable medical device (IMD), partitioning the PNVM circuit into a plurality of portions based on how often that the processor accesses a portion, and selectively providing power or selectively restricting power to one or more of the portions according to how often that the processor accesses a portion.
摘要翻译：一种方法，包括提供与可植入医疗装置（IMD）中的集成电路芯片（IC）上的处理器一起制造的可编程非易失性存储器（PNVM）电路，基于所述多个部分，将PNVM电路分成多个部分，处理器访问一部分，并且根据处理器访问部分的频率，选择性地向一个或多个部分提供功率或选择性地限制功率。

40. 发明授权

US08214164B2 Abnormal battery depletion detection in an implantable device 有权
标题翻译：在可植入装置中异常电池耗尽检测
公开(公告)号：US08214164B2
公开(公告)日：2012-07-03
申请号：US12277091
申请日：2008-11-24
申请人： Rajesh K. Gandhi , William J. Linder , Scott Vanderlinde , James Kalgren , Hal M. Propp
发明人： Rajesh K. Gandhi , William J. Linder , Scott Vanderlinde , James Kalgren , Hal M. Propp
IPC分类号： G01R31/36
CPC分类号： A61N1/3708 , A61B5/0084 , A61B5/746 , A61N1/37247 , A61N1/37258 , G01R19/16542 , G01R31/3606
摘要： Abnormal battery depletion can be detected in an implantable medical device. Battery capacity consumed can be measured using a coulometer and using a capacity-by-voltage device, and the measurements can be blended to determine battery status. A drop in battery voltage below a specified threshold can be detected to identify a high-current depletion fault, and an alarm can be provided to indicate the fault has been detected. The specified threshold can be determined as a function of battery capacity consumed. Other aspects and embodiments are provided herein.
摘要翻译：在可植入的医疗设备中可以检测到电池耗尽异常。可以使用电量计和使用逐个电压装置测量消耗的电池容量，并且可以混合测量以确定电池状态。可以检测到低于指定阈值的电池电压下降以识别大电流耗尽故障，并且可以提供警报以指示已经检测到故障。可以根据所消耗的电池容量确定指定的阈值。本文提供了其它方面和实施例。

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