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31. 发明授权

US07706893B2 High density array of micro-machined electrodes for neural stimulation 有权
标题翻译：用于神经刺激的高密度微加工电极阵列
公开(公告)号：US07706893B2
公开(公告)日：2010-04-27
申请号：US11488806
申请日：2006-07-17
申请人： Andy Hung , Robert Greenberg , Dau Min Zhou , Jack Judy , Neil Talbot
发明人： Andy Hung , Robert Greenberg , Dau Min Zhou , Jack Judy , Neil Talbot
IPC分类号： A61N1/00
CPC分类号： A61N1/05 , A61N1/0526 , A61N1/0541 , A61N1/0543 , A61N1/0551
摘要： The present invention is a micro-machined electrode for neural-electronic interfaces which can achieve a ten times lower impedance and higher charge injection limit for a given material and planar area.
摘要翻译：本发明是用于神经 - 电子接口的微加工电极，其可以为给定材料和平面区域实现十倍低阻抗和更高电荷注入极限。

32. 发明申请

US20070270919A1 Retinal prosthesis 有权
标题翻译：视网膜假体
公开(公告)号：US20070270919A1
公开(公告)日：2007-11-22
申请号：US11880009
申请日：2007-07-19
申请人： Robert Greenberg , Neil Talbot , Brian Mech , James Little
发明人： Robert Greenberg , Neil Talbot , Brian Mech , James Little
IPC分类号： A61N1/05
CPC分类号： A61N1/0543 , A61N1/36046
摘要： The invention is a retinal prosthesis with an improved configuration mounting necessary components within and surrounding the eye. The present invention better allows for the implantation of electronics within the delicate eye structure. The invention further limits the necessary width of a thin film conductor passing through the sclera by use of a multiplexer external to the sclera and a demultiplexer internal to the sclera.
摘要翻译：本发明是具有改进的构造的视网膜假体，其将眼睛内部和周围的必要部件安装。本发明更好地允许在精细的眼睛结构内植入电子装置。本发明通过使用巩膜外部的多路复用器和巩膜内部的解复用器进一步限制穿过巩膜的薄膜导体的必要宽度。

33. 发明申请

US20060247754A1 Flexible circuit electrode array 有权
公开(公告)号：US20060247754A1
公开(公告)日：2006-11-02
申请号：US11207644
申请日：2005-08-19
申请人： Robert Greenberg , Neil Talbot , Jordan Neysmith , Dilek Guven , James Little , Brian Mech , Mark Humayun
发明人： Robert Greenberg , Neil Talbot , Jordan Neysmith , Dilek Guven , James Little , Brian Mech , Mark Humayun
IPC分类号： A61N1/05
CPC分类号： H05K3/0011 , A61N1/0541 , A61N1/0543 , A61N1/36036 , A61N1/36046 , Y10T29/49124
摘要： Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced. With a thermoplastic polymer it may be further advantageous to repeatedly heat the flexible circuit in multiple molds, each with a decreasing radius. Further, it is advantageous to add material along the edges. It is further advantageous to provide a fold or twist in the flexible circuit array. Additional material may be added inside and outside the fold to promote a good seal with tissue.

34. 发明授权

US5532156A Hepatocyte cell line derived from the epiblast of pig blastocysts 失效
标题翻译：源自猪胚泡的上皮细胞的肝细胞细胞系
公开(公告)号：US5532156A
公开(公告)日：1996-07-02
申请号：US133589
申请日：1993-10-08
申请人： Neil Talbot , Caird E. Rexroad, Jr. , Vernon G. Pursel , Anne M. Powell
发明人： Neil Talbot , Caird E. Rexroad, Jr. , Vernon G. Pursel , Anne M. Powell
IPC分类号： C12N5/074 , C12N5/00
CPC分类号： C12N5/0672 , C12N2502/13
摘要： Continuous cultures of pluripotent parenchymal hepatocytes were derived from the epiblasts of pig blastocysts. The cultures are feeder-dependent and grow slowly with doubling times of 3 to 4 days. They differentiate into large secretory duct-like structures or form small canaliculi. Alternatively, the cells accumulate droplets that stain intensely with oil red O, a lipid-specific stain. .alpha.-Fetoprotein and albumin mRNA expression increases as the cells differentiate in culture.
摘要翻译：多能实质肝细胞的连续培养来自猪胚泡的表皮细胞。培养物为饲料依赖型，生长缓慢，倍增时间为3〜4天。它们分化成大分泌型管状结构或形成小小管。或者，细胞积聚着油红色O（一种脂质特异性染色剂）剧烈染色的液滴。 α-Fetoprotein和白蛋白mRNA表达随培养细胞分化而增加。

35. 发明授权

US08014878B2 Flexible circuit electrode array 有权
标题翻译：柔性电路电极阵列
公开(公告)号：US08014878B2
公开(公告)日：2011-09-06
申请号：US11207644
申请日：2005-08-19
申请人： Robert Greenberg , Neil Talbot , Jordan Neysmith , Dilek Guven , James Little , Brian Mech , Mark Humayun
发明人： Robert Greenberg , Neil Talbot , Jordan Neysmith , Dilek Guven , James Little , Brian Mech , Mark Humayun
IPC分类号： A61N1/36
CPC分类号： H05K3/0011 , A61N1/0541 , A61N1/0543 , A61N1/36036 , A61N1/36046 , Y10T29/49124
摘要： Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced. With a thermoplastic polymer it may be further advantageous to repeatedly heat the flexible circuit in multiple molds, each with a decreasing radius. Further, it is advantageous to add material along the edges. It is further advantageous to provide a fold or twist in the flexible circuit array. Additional material may be added inside and outside the fold to promote a good seal with tissue.
摘要翻译：聚合物材料可用作神经刺激的电极阵列体。它们对视网膜刺激特别有用，用于创建人造视觉，人工耳蜗刺激以创建人造听觉或皮质刺激许多目的。通过电极阵列对视网膜或其他神经组织施加的压力是至关重要的。太小的压力会导致电阻增加以及电场分散。太大的压力可能会阻止血液流动。通常的柔性电路制造技术通常需要使柔性电路电极阵列平坦。由于神经组织几乎从不平坦，平面阵列必然会施加不均匀的压力。此外，柔性电路聚合物阵列的边缘可以是尖锐的并切割精细的神经组织。通过将适量的热应用于完整的阵列，可以引起曲线。对于热塑性聚合物，可以进一步有利的是在多个模具中反复加热柔性电路，每个模具具有减小的半径。此外，沿着边缘添加材料是有利的。在柔性电路阵列中提供折叠或扭曲是更有利的。可以在折叠内部和外部添加附加材料以促进与组织的良好密封。

36. 发明申请

US20110130806A1 Retinal Prosthesis 有权
标题翻译：视网膜假体
公开(公告)号：US20110130806A1
公开(公告)日：2011-06-02
申请号：US13004538
申请日：2011-01-11
申请人： Robert Greenberg , Neil Talbot , Brian V. Mech , James Little
发明人： Robert Greenberg , Neil Talbot , Brian V. Mech , James Little
IPC分类号： A61F9/08 , A61N1/36
CPC分类号： A61N1/0543 , A61N1/36046
摘要： The invention is a retinal prosthesis with an improved configuration mounting necessary components within and surrounding the eye. The present invention better allows for the implantation of electronics within the delicate eye structure. The invention further limits the necessary width of a thin film conductor passing through the sclera by use of a multiplexer external to the sclera and a demultiplexer internal to the sclera.
摘要翻译：本发明是具有改进的构造的视网膜假体，其将眼睛内部和周围的必要部件安装。本发明更好地允许在精细的眼睛结构内植入电子装置。本发明通过使用巩膜外部的多路复用器和巩膜内部的解复用器进一步限制穿过巩膜的薄膜导体的必要宽度。

37. 发明授权

US07676274B2 High-density array of micro-machined electrodes for neural stimulation 有权
标题翻译：用于神经刺激的高密度微加工电极阵列
公开(公告)号：US07676274B2
公开(公告)日：2010-03-09
申请号：US10160468
申请日：2002-05-01
申请人： Andy Hung , Robert Greenberg , Dau Min Zhou , Jack Judy , Neil Talbot
发明人： Andy Hung , Robert Greenberg , Dau Min Zhou , Jack Judy , Neil Talbot
IPC分类号： A61N1/00
CPC分类号： A61N1/05 , A61N1/0526 , A61N1/0541 , A61N1/0543 , A61N1/0551
摘要： The present invention is a micro-machined electrode for neural-electronic interfaces which can achieve a ten times lower impedance and higher charge injection limit for a given material and planar area.
摘要翻译：本发明是用于神经 - 电子接口的微加工电极，其可以为给定材料和平面区域实现十倍低阻抗和更高电荷注入极限。

38. 发明申请

US20080064946A1 Flexible Circuit Electrode Array 审中-公开
标题翻译：柔性电路电极阵列
公开(公告)号：US20080064946A1
公开(公告)日：2008-03-13
申请号：US11928151
申请日：2007-10-30
申请人： Robert Greenberg , Neil Talbot , Jordan Neysmith , James Little , Brian Mech , Mark Humayun , Dilek Guven , Anne-Marie De Merlier Ripley
发明人： Robert Greenberg , Neil Talbot , Jordan Neysmith , James Little , Brian Mech , Mark Humayun , Dilek Guven , Anne-Marie De Merlier Ripley
IPC分类号： A61N1/04
CPC分类号： H05K3/0011 , A61N1/0541 , A61N1/0543 , A61N1/36036 , A61N1/36046 , Y10T29/49124
摘要： Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced. With a thermoplastic polymer it may be further advantageous to repeatedly heat the flexible circuit in multiple molds, each with a decreasing radius. Further, it is advantageous to add material along the edges. It is further advantageous to provide a fold or twist in the flexible circuit array. Additional material may be added inside and outside the fold to promote a good seal with tissue.
摘要翻译：聚合物材料可用作用于神经刺激的电极阵列体。它们对视网膜刺激特别有用，用于创建人造视觉，人工耳蜗刺激以创建人造听觉或皮质刺激许多目的。通过电极阵列对视网膜或其他神经组织施加的压力是至关重要的。太小的压力会导致电阻增加以及电场分散。太大的压力可能会阻止血液流动。通常的柔性电路制造技术通常需要使柔性电路电极阵列平坦。由于神经组织几乎从不平坦，平面阵列必然会施加不均匀的压力。此外，柔性电路聚合物阵列的边缘可以是尖锐的并切割精细的神经组织。通过将适量的热应用于完整的阵列，可以引起曲线。对于热塑性聚合物，可以进一步有利的是在多个模具中反复加热柔性电路，每个模具具有减小的半径。此外，沿着边缘添加材料是有利的。在柔性电路阵列中提供折叠或扭曲是更有利的。可以在折叠内部和外部添加附加材料以促进与组织的良好密封。

39. 发明申请

US20070055336A1 Retinal prosthesis with a new configuration 有权
标题翻译：视网膜假体具有新配置
公开(公告)号：US20070055336A1
公开(公告)日：2007-03-08
申请号：US11523965
申请日：2006-09-19
申请人： Robert Greenberg , Matthew McMahon , James Little , Kelly McClure , Brian Mech , Neil Talbot , Jordan Neysmith
发明人： Robert Greenberg , Matthew McMahon , James Little , Kelly McClure , Brian Mech , Neil Talbot , Jordan Neysmith
IPC分类号： A61N1/04
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/37223 , H05K1/028 , H05K1/0281 , H05K1/118 , H05K3/0014 , H05K3/28 , H05K2201/0133 , H05K2201/09018 , H05K2201/09145 , H05K2201/09909 , H05K2201/2009 , H05K2203/1105 , H05K2203/1476 , H05K2203/302 , Y10T29/49158
摘要： Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, and cortical stimulation, and many related purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced. With a thermoplastic polymer it may be further advantageous to repeatedly heat the flexible circuit in multiple molds, each with a decreasing radius. Further, it is advantageous to add material along the edges. It is further advantageous to provide a fold or twist in the flexible circuit array. Additional material may be added inside and outside the fold to promote a good seal with tissue.
摘要翻译：聚合物材料可用作神经刺激的电极阵列体。它们特别有用于视网膜刺激以产生人造视觉，耳蜗刺激以产生人造听觉和皮质刺激以及许多相关目的。通过电极阵列对视网膜或其他神经组织施加的压力是至关重要的。太小的压力会导致电阻增加以及电场分散。太大的压力可能会阻止血液流动。通常的柔性电路制造技术通常需要使柔性电路电极阵列平坦。由于神经组织几乎从不平坦，平面阵列必然会施加不均匀的压力。此外，柔性电路聚合物阵列的边缘可以是尖锐的并切割精细的神经组织。通过将适量的热应用于完整的阵列，可以引起曲线。对于热塑性聚合物，可以进一步有利的是在多个模具中反复加热柔性电路，每个模具具有减小的半径。此外，沿着边缘添加材料是有利的。在柔性电路阵列中提供折叠或扭曲是更有利的。可以在折叠内部和外部添加附加材料以促进与组织的良好密封。

40. 发明申请

US20060155288A1 Medical tack with a variable effective length 有权
公开(公告)号：US20060155288A1
公开(公告)日：2006-07-13
申请号：US11352168
申请日：2006-02-13
申请人： James Little , Gaillard Nolan , Neil Talbot , Robert Greenberg
发明人： James Little , Gaillard Nolan , Neil Talbot , Robert Greenberg
IPC分类号： A61F2/30
CPC分类号： A61F9/00727 , A61B17/064 , A61B17/068 , A61B17/10 , A61B2017/0646 , A61B2017/0647 , A61F9/007 , A61F11/004
摘要： The present invention is an improved medical tack. The tack of the present invention includes attachment points at each end where at least one of the attachment points is moveable, varying the effective length of the tack. Varying the length of the medical tack adapts the tack for use with tissue of different thickness.

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