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31. 发明授权

US09267109B2 Patterned cell sheets and a method for production of the same 有权
标题翻译：图案化电池片及其制造方法
公开(公告)号：US09267109B2
公开(公告)日：2016-02-23
申请号：US12746767
申请日：2008-12-05
申请人： Emiel Peeters , Roel Penterman , Ralph Kurt , Dirk Jan Wilfred Broer
发明人： Emiel Peeters , Roel Penterman , Ralph Kurt , Dirk Jan Wilfred Broer
IPC分类号： C12N5/00
CPC分类号： C12N5/0068 , C12N2535/10 , C12N2539/10
摘要： The present invention is related to a method for the production of cell sheets comprising at least two different cell types, said method comprising the steps of providing a continuous cell sheet which is disposed on a substrate comprising shape transition properties and/or alterable surface characteristics; exposing said continuous cell sheet to a releasing agent in a patterned fashion; washing the cell sheet after exposure to the releasing agent in order to remove cells which have been affected by the releasing agent, and repopulating the gaps remaining after the cells which have been affected by the releasing agent have been removed with a second cell type.
摘要翻译：本发明涉及生产包含至少两种不同细胞类型的细胞片的方法，所述方法包括以下步骤：提供设置在包含形状转变特性和/或可变表面特性的基底上的连续细胞片; 以图案方式将所述连续细胞片暴露于脱模剂; 在暴露于脱模剂之后洗涤细胞片以除去已经被脱模剂影响的细胞，并且在第二细胞类型已经去除了已经被脱模剂影响的细胞之后剩余的间隙。

32. 发明授权

US09157598B2 Heat managing device 有权
标题翻译：热管理装置
公开(公告)号：US09157598B2
公开(公告)日：2015-10-13
申请号：US13380535
申请日：2010-06-21
申请人： Aldo Tralli , Theodoor Cornelis Treurniet , Ralph Kurt
发明人： Aldo Tralli , Theodoor Cornelis Treurniet , Ralph Kurt
IPC分类号： F21V29/00 , F21S8/10 , F21K99/00 , F21V29/505 , F21V29/67 , F21V29/71 , F21V29/74 , F21V29/77 , F21Y101/02
CPC分类号： F21V29/717 , F21K9/00 , F21K9/23 , F21S45/43 , F21V29/505 , F21V29/677 , F21V29/713 , F21V29/74 , F21V29/773 , F21V29/89 , F21Y2113/13 , F21Y2115/10
摘要： It is presented a heat managing device for a light source (100) which combines heat managing by means of a heat sink, heat pipes and forced convection, thereby achieving efficient cooling of high power lighting applications. The heat managing device comprises a heat spreading element (104) having an upper side arranged for thermally connecting to at least one light source (106). The light emitted from the light source is controlled by secondary optics (103). The heat managing device comprises a heat sink which is thermally connected to the heat spreader, and to a first set of heat pipes which is thermally connected to the heat spreader. At least a portion of the heat sink is arranged to encompass the secondary optics. The heat pipes are embedded in the heat sink. Further, a fan for providing forced air convection at the heat sink is comprised in the device. A corresponding lighting device is also presented.
摘要翻译：提出了一种用于光源（100）的热管理装置，其结合了通过散热器，热管和强制对流的热管理，从而实现高功率照明应用的有效冷却。热量管理装置包括一个散热元件（104），其具有被布置成热连接到至少一个光源（106）的上侧。从光源发射的光由二次光学器件（103）控制。热管理装置包括热连接到散热器的散热器，以及热连接到散热器的第一组热管。散热器的至少一部分布置成包围次级光学器件。热管嵌入散热器。此外，在该装置中包括用于在散热器处提供强制空气对流的风扇。还提出了相应的照明装置。

33. 发明申请

US20140197740A1 LED LIGHT SOURCE 有权
标题翻译： LED光源
公开(公告)号：US20140197740A1
公开(公告)日：2014-07-17
申请号：US14239166
申请日：2012-08-21
申请人： Henricus Marius Joseph Maria Kahlman , Ralph Kurt , Haimin Tao
发明人： Henricus Marius Joseph Maria Kahlman , Ralph Kurt , Haimin Tao
IPC分类号： H05B33/08
CPC分类号： H05B33/0815 , H05B33/083
摘要： A LED light source comprises a first rectifier (DB1) having input terminals coupled to an AC voltage source and output terminals connected by a first series arrangement comprising N LED loads and further comprises circuitry (I1, I2, I3, CC) for making the LED loads one by one carry a current when the momentary value of the AC voltage increases and one by one stop carrying a current when the momentary value of the AC voltage decreases. The LED light source also comprises a second rectifier (DB2) having input terminals coupled to the AC voltage source via a reactive element and LED1 LED2 LED3 output terminals connected by a second series arrangement comprising M LED loads and further comprises circuitry (I4) for making the LED loads one by one carry a current when the momentary value of the AC voltage present at the input terminals of the second rectifier increases and one by one stop carrying a current when the momentary value of the AC voltage decreases.
摘要翻译： LED光源包括具有耦合到AC电压源的输入端和通过包括N个LED负载的第一串联装置连接的输出端的第一整流器（DB1），并且还包括用于制造LED的电路（I1，I2，I3，CC）当交流电压的瞬时值增加时，逐个负载一个负载一个电流，并且当交流电压的瞬时值减小时一个接一个地停止传输电流。 LED光源还包括具有经由电抗元件耦合到AC电压源的输入端的第二整流器（DB2），以及由包括M LED负载的第二串联装置连接的LED1 LED2 LED3输出端子，并且还包括用于制造的电路（I4）当交流电压的瞬时值减小时，当第二整流器的输入端存在的交流电压的瞬时值增加时，一个接一个地负载电流。

34. 发明申请

US20140119046A1 Arrangement for light balancing 审中-公开
标题翻译：光平衡布置
公开(公告)号：US20140119046A1
公开(公告)日：2014-05-01
申请号：US14124097
申请日：2012-06-06
申请人： Ralph Kurt , Stefan Marcus Verbrugh , Jorrit Ernst De Vries , Henricus Marius Joseph Maria Kahlman
发明人： Ralph Kurt , Stefan Marcus Verbrugh , Jorrit Ernst De Vries , Henricus Marius Joseph Maria Kahlman
IPC分类号： H05B33/08
CPC分类号： H05B33/0869 , F21V23/0457 , G01J1/0425 , G01J1/1626 , G01J3/505 , G01J2001/4252
摘要： There is provided an arrangement for light balancing. The arrangement provides light balancing and robust flux feedback and comprises a light source array, a plurality of light sources arranged as a plurality of strings of individual light emitting diodes, at least one light guide structure, and at least one optical sensor. The arrangement provides feedback relating to the optical contribution for each one of the plurality of strings of individual light emitting diodes and is thereby maintaining the emitted light at a balanced level.
摘要翻译：提供了用于光平衡的布置。该装置提供光平衡和稳健的通量反馈，并且包括光源阵列，布置为多个单独的发光二极管串的多个光源，至少一个导光结构和至少一个光学传感器。这种布置提供了与单个发光二极管的多个串中的每一个的光学贡献有关的反馈，从而将发射的光保持在平衡的水平。

35. 发明申请

US20140015430A1 LED LIGHT SOURCE 有权
标题翻译： LED光源
公开(公告)号：US20140015430A1
公开(公告)日：2014-01-16
申请号：US14006979
申请日：2012-03-19
申请人： Ralph Kurt , Haimin Tao , Martinus Petrus Creusen
发明人： Ralph Kurt , Haimin Tao , Martinus Petrus Creusen
IPC分类号： H05B33/08
CPC分类号： H05B33/083
摘要： A series arrangement of LED loads (LP1-LP4) is coupled between output terminals of a rectifier having its input terminals coupled to a mains supply supplying a low frequency AC voltage. Control means render the LED loads conductive one by one, when the amplitude of the supply voltage increases, and non-conductive one by one when the amplitude of the supply voltage decreases. The first LED load (LP1, LP2) has a forward voltage that is substantially higher than that of the other LED loads. As a consequence, the LED utilization is comparatively high, thus allowing the LED loads used in the series arrangement to be comparatively cheap.
摘要翻译： LED负载（LP1-LP4）的串联布置耦合在整流器的输出端子之间，其输入端子耦合到提供低频AC电压的电源。当电源电压的幅度增加时，控制装置使LED负载一个接一个，当电源电压的幅度减小时，LED逐一导通。第一个LED负载（LP1，LP2）具有远高于其他LED负载的正向电压。因此，LED利用率相对较高，从而允许串联装置中使用的LED负载相当便宜。

36. 发明授权

US08529103B2 Illumination system for spot illumination 失效
标题翻译：点光照明系统
公开(公告)号：US08529103B2
公开(公告)日：2013-09-10
申请号：US13378411
申请日：2010-06-14
申请人： Teunis Willem Tukker , Erik Boonekamp , Ralph Kurt , Mark Eduard Johan Sipkes
发明人： Teunis Willem Tukker , Erik Boonekamp , Ralph Kurt , Mark Eduard Johan Sipkes
IPC分类号： F21V7/00
CPC分类号： F21V5/002 , F21K9/00 , F21V3/04 , F21V5/003 , F21V7/041 , F21Y2105/10 , F21Y2105/12 , F21Y2113/13 , F21Y2115/10
摘要： An illumination system (10) for spot illumination comprising a tubular reflector (2) with a reflective inner surface, the tubular reflector (2) having an entrance aperture (7) and an exit aperture (8) being larger than the entrance aperture (7); a light-source array (1) comprising a plurality of light-sources (13a-c; 30a-d, 31a-d, 32a-d) arranged to emit light into the tubular reflector (2) at the entrance aperture thereof; and a light-diffusing optical member (9) arranged to diffuse light emitted by the illumination system (10). The light-diffusing member (9) is configured to exhibit an increasing diffusing capability with increasing distance from an optic axis (12) of the illumination system.
摘要翻译：一种用于点照明的照明系统（10），包括具有反射内表面的管状反射器（2），所述管状反射器（2）具有大于入口孔（7）的入口孔（7）和出口孔（8））; 包括多个光源（13a-c; 30a-d，31a-d，32a-d）的光源阵列（1），其布置成在其入射孔处将光发射到所述管状反射器（2）中; 以及布置成漫射由所述照明系统（10）发射的光的光漫射光学构件（9）。光扩散构件（9）构造成随着距离照明系统的光轴（12）的距离增加而呈现增大的漫射能力。

37. 发明授权

US08475736B2 Microfluidic device and method of manufacturing the same and sensor incorporating the same 有权
标题翻译：微流体装置及其制造方法及其结合的传感器
公开(公告)号：US08475736B2
公开(公告)日：2013-07-02
申请号：US12746940
申请日：2008-12-08
申请人： Reinhold Wimberger-Friedl , Roel Penterman , Ralph Kurt , Emiel Peeters
发明人： Reinhold Wimberger-Friedl , Roel Penterman , Ralph Kurt , Emiel Peeters
IPC分类号： B01L3/00
CPC分类号： B01L3/5023 , B01L3/502753 , B01L2200/12 , B01L2300/0636 , B01L2300/0654 , B01L2300/0681 , B01L2300/069 , B01L2300/0887 , B01L2300/168 , B01L2400/0406 , B01L2400/0487 , B01L2400/065 , Y10T29/49826
摘要： The present invention provides a microfluidic device, for instance for molecular sieving or for detecting a target substance in a sample fluid. The device comprises a first substrate (120) having a substantially flat first surface that is provided with first recesses (124), and a second substrate (128) having a substantially flat second surface that is provided with second recesses (130). At least some of the first recesses are filled with a porous material (114). Alternate first recesses and second recesses form a meandering channel for a sample fluid. The second recesses may be filled with a further porous material. In an embodiment, a capture substance for binding a target substance is arranged in or on the porous material.
摘要翻译：本发明提供了微流体装置，例如用于分子筛或用于检测样品流体中的目标物质。该装置包括具有基本平坦的第一表面的第一基底（120），第一基底具有第一凹槽（124），第二基底（128）具有基本平坦的第二表面，该第二基底具有第二凹槽（130）。至少一些第一凹部填充有多孔材料（114）。替代的第一凹槽和第二凹槽形成用于样品流体的曲折通道。第二凹部可以被另外的多孔材料填充。在一个实施方案中，用于结合目标物质的捕获物质被布置在多孔材料中或其上。

38. 发明申请

US20130163239A1 MIXING OPTICAL ZOOM SYSTEM WITH MOVING GATE AND GOBO 审中-公开
标题翻译：混合光学变焦系统与移动门和GOBO
公开(公告)号：US20130163239A1
公开(公告)日：2013-06-27
申请号：US13821102
申请日：2011-09-06
申请人： Teunis Willem Tukker , Ralph Kurt
发明人： Teunis Willem Tukker , Ralph Kurt
IPC分类号： F21V14/00
CPC分类号： F21S10/007 , F21V5/008 , F21V5/04 , F21V7/04 , F21V14/08 , F21W2131/406 , F21Y2105/00 , F21Y2113/13 , F21Y2115/10 , F21Y2115/15
摘要： An illumination device (100) is disclosed. The illumination device (100) comprises a collimation module (110) configured to collimate light, a lens assembly (120) configured to controllably focus/defocus light, and an intermediate module (130) arranged between the collimation module (110) and the lens assembly (120) such as to receive collimated light output from the collimation module (110), wherein at least some light output from the intermediate module (130) impinges on the lens assembly (120).
摘要翻译：公开了一种照明装置（100）。照明装置（100）包括被配置为准直光的准直模块（110），被配置为可控制地聚焦/散焦光的透镜组件（120）和布置在准直模块（110）和透镜组件（120），以便接收从准直模块（110）输出的准直光，其中从中间模块（130）输出的至少一些光照射在透镜组件（120）上。

39. 发明授权

US08323221B2 Tissue temperature indicating element for ultrasound therapy 有权
标题翻译：用于超声治疗的组织温度指示元件
公开(公告)号：US08323221B2
公开(公告)日：2012-12-04
申请号：US12742016
申请日：2008-11-11
申请人： Christopher S. Hall , Ralph Kurt
发明人： Christopher S. Hall , Ralph Kurt
IPC分类号： A61H1/00
CPC分类号： A61N7/02 , A61B2017/00084 , C09K19/38 , C09K19/408 , C09K19/52 , G01K11/16 , G01K11/165
摘要： The present invention relates to a hydrogel-containing temperature indicating element for use in ultrasound therapy. The temperature indicating element of the present invention and the therapeutic device and method making use of the same enable in some embodiments an automated adaptation of the power output as a function of the tissue temperature, avoiding therefore overheating or burning of the skin.
摘要翻译：本发明涉及一种用于超声治疗的含水凝胶温度指示元件。本发明的温度指示元件和使用其的治疗装置和方法在一些实施例中能够根据组织温度自动调整功率输出，从而避免皮肤过热或燃烧。

40. 发明授权

US08244078B2 Hydrogel based sensor probe for detecting an environmental state 失效
标题翻译：用于检测环境状态的基于水凝胶的传感器探头
公开(公告)号：US08244078B2
公开(公告)日：2012-08-14
申请号：US12600881
申请日：2008-05-22
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Szabolcs Deladi , Ralph Kurt , Jan Frederik Suijver
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Szabolcs Deladi , Ralph Kurt , Jan Frederik Suijver
IPC分类号： G02B6/00
CPC分类号： G01N21/7703 , A61B5/0084 , A61B5/14539 , G01N2021/772 , G01N2021/7723 , G01N2021/773 , G01N2021/7779
摘要： A sensor probe for detecting an environmental state within a bodily lumen includes an elongated body having an optical guide with an outcoupling surface, which is part of an end surface of the elongated body, facing a reflective surface of an overhanging part. The sensor probe further includes a photodetector which detects a property of light which is composed of light in the optical guide that is reflected from the outcoupling surface of the optical guide and of light in the optical guide that is reflected from the overhanging part. The sensor probe also includes a hydrogel material having a property that changes when getting into contact with an environmental material and/or when detecting an environmental change. The hydrogel material is provided between the end surface of the elongated body and the overhanging part.
摘要翻译：用于检测身体腔内的环境状态的传感器探针包括细长体，其具有带有外耦合表面的光导，所述光耦合器是细长体的端表面的一部分，面向突出部分的反射表面。传感器探头还包括光电检测器，其检测由光导中的光构成的光的特性，所述光从光导的输出耦合表面反射，以及从突出部反射的光导中的光。传感器探头还包括具有在与环境材料接触和/或当检测到环境变化时变化的性质的水凝胶材料。水凝胶材料设置在细长体的端面与突出部之间。

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