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31. 发明授权

US3946032A Acetal derivatives of 6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-carboxaldehyde 失效
标题翻译： 6-苯基-4H-s-三唑并[8,3,3-a {9 {8 1,4 {9苯并二氮杂-1-甲醛
公开(公告)号：US3946032A
公开(公告)日：1976-03-23
申请号：US406060
申请日：1973-10-12
申请人： Hans Allgeier , Andre Gagneux
发明人： Hans Allgeier , Andre Gagneux
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： Compounds of the class of acetals of 6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-carboxaldehyde and the 5-oxides and pharmaceutically acceptable acid addition salts thereof have valuable pharmacological properties, in particular anticonvulsant effectiveness. Further, they show central depressant and muscle-relaxing activity and are active ingredients for therapeutic preparations. Specific embodiments are 6-phenyl-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-carboxaldehyde-diethylacetal, 6-(o-chlorophenyl)-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-carboxaldehyde-diethylacetal and 6-(o-fluorophenyl-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-carboxaldehyde-diethylacetal.
摘要翻译： 6-苯基-4H-3-三唑并[4,3-a] [1,4]苯并二氮杂-1-甲醛的缩醛类化合物及其5-氧化物和药学上可接受的酸加成盐具有有价值的药理学性质，特别是抗惊厥效果。此外，它们显示中枢抑制剂和肌肉松弛活性，并且是治疗制剂的活性成分。具体实施方案是6-苯基-8-氯-4H-三唑并[4,3-a] [1,4]苯并二氮杂1-甲醛二乙基缩醛，6-（邻氯苯基）-8-氯-4H - 三唑并[4,3-a] [1,4]苯并二氮杂-1-甲醛 - 二乙基缩醛和6-（邻 - 氟苯基-8-氯-4H-三唑并[4,3-a] 4]苯并二氮杂-1-c芳樟醛 - 二乙基缩醛。

32. 发明申请

US20110294818A1 1H-QUINAZOLINE-2,4-DIONES 失效
标题翻译： 1H-喹唑啉-2,4-二酮
公开(公告)号：US20110294818A1
公开(公告)日：2011-12-01
申请号：US13192816
申请日：2011-07-28
申请人： Hans Allgeier , Yves Auberson , David Carcache , Philipp Floersheim , Christel Guibourdenche , Wolfgang Froestl , Jörg Kallen , Manuel Koller , Henri Mattes , Joachim Nozulak , David Orain , Johanne Renaud
发明人： Hans Allgeier , Yves Auberson , David Carcache , Philipp Floersheim , Christel Guibourdenche , Wolfgang Froestl , Jörg Kallen , Manuel Koller , Henri Mattes , Joachim Nozulak , David Orain , Johanne Renaud
IPC分类号： A61K31/517 , C07D403/10 , C07D405/10 , C07D401/10 , C07C229/66 , C07C229/64 , C07D307/16 , C07D309/12 , C07C265/12 , C07D231/12 , C07D249/06 , C07D207/337 , C07C205/57 , C07D237/08 , A61P25/08 , A61P25/18 , C07D239/96
CPC分类号： C07D239/96 , C07C207/00 , C07C229/56 , C07C229/64 , C07C229/66 , C07C255/18 , C07C265/12 , C07C271/58 , C07D207/337 , C07D231/12 , C07D237/08 , C07D239/26 , C07D241/12 , C07D249/06 , C07D263/32 , C07D307/16 , C07D307/54 , C07D309/12 , C07D401/04 , C07D403/04 , C07D405/04 , C07D413/04
摘要： The present invention relates to 1H-Quinazoline-2,4-diones of formula (I) wherein R1 and R2 are as defined in the specification, their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them. Further, intermediates for the manufacture of compounds of formula (I) are and combinations comprising compounds of formula (I) are disclosed.
摘要翻译：本发明涉及式（I）的1H-喹唑啉-2,4-二酮，其中R 1和R 2如说明书中所定义，其制备，作为药物的用途，以及含有它们的药物组合物。此外，公开了用于制备式（I）化合物的中间体和包含式（I）化合物的组合。

33. 发明授权

US08012988B2 N-(2,4-dioxo-6-(tetrahydrofuran-2-yl)-7-(trifluoromethyl)-1,4-dihydro-2H-quinazolin-3-yl)methanesulfonamide 失效
标题翻译： N-（2,4-二氧代-6-（四氢呋喃-2-基）-7-（三氟甲基）-1,4-二氢-2H-喹唑啉-3-基）甲磺酰胺
公开(公告)号：US08012988B2
公开(公告)日：2011-09-06
申请号：US12569402
申请日：2009-09-29
申请人： Hans Allgeier , Yves Auberson , David Carcache , Philipp Floersheim , Christel Guibourdenche , Wolfgang Froestl , Jörg Kallen , Manuel Koller , Henri Mattes , Joachim Nozulak , David Orain , Johanne Renaud
发明人： Hans Allgeier , Yves Auberson , David Carcache , Philipp Floersheim , Christel Guibourdenche , Wolfgang Froestl , Jörg Kallen , Manuel Koller , Henri Mattes , Joachim Nozulak , David Orain , Johanne Renaud
IPC分类号： A61K31/517
CPC分类号： C07D239/96 , C07C207/00 , C07C229/56 , C07C229/64 , C07C229/66 , C07C255/18 , C07C265/12 , C07C271/58 , C07D207/337 , C07D231/12 , C07D237/08 , C07D239/26 , C07D241/12 , C07D249/06 , C07D263/32 , C07D307/16 , C07D307/54 , C07D309/12 , C07D401/04 , C07D403/04 , C07D405/04 , C07D413/04
摘要： The present invention relates to 1H-Quinazoline-2,4-diones of formula (I) wherein R1 and R2 are as defined in the specification, their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them. Further, intermediates for the manufacture of compounds of formula (I) are and combinations comprising compounds of formula (I) are disclosed.
摘要翻译：本发明涉及式（I）的1H-喹唑啉-2,4-二酮，其中R 1和R 2如说明书中所定义，其制备，作为药物的用途，以及含有它们的药物组合物。此外，公开了用于制备式（I）化合物的中间体和包含式（I）化合物的组合。

34. 发明授权

US5051413A Unsaturated amino acids 失效
标题翻译：不饱和氨基酸
公开(公告)号：US5051413A
公开(公告)日：1991-09-24
申请号：US452995
申请日：1989-12-18
申请人： Christof Angst , Derek E. Brundish , John G. Dingwall , Graham E. Fagg , Hans Allgeier , Guido Bold , Rudolf Duthaler , Roland Heckendorn , Antonio Togni
发明人： Christof Angst , Derek E. Brundish , John G. Dingwall , Graham E. Fagg , Hans Allgeier , Guido Bold , Rudolf Duthaler , Roland Heckendorn , Antonio Togni
IPC分类号： C07F9/30 , C07F9/32 , C07F9/38 , C07F9/40 , C07F9/48
CPC分类号： C07F9/4825 , C07F9/302 , C07F9/3217 , C07F9/3826 , C07F9/4015
摘要： The invention relates to unsaturated amino acids of the formula I ##STR1## in which R.sup.1 represents hydroxy or etherified hydroxy, R.sup.2 represents hydrogen, alkyl, hydroxy or etherified hydroxy, R.sup.3 represents hydrogen, alkyl, haloalkyl, hydroxyalkyl, lower alkoxyalkyl, arylalkyl, lower alkenyl, halogen or aryl, R.sup.4 represents hydrogen, alkyl or aryl, R.sup.5 represents hydrogen or alkyl, R.sup.6 represents carboxy or esterified or amidated carboxy, R.sup.7 represents amino or amino substituted by alkyl or acyl, A represents unsubstituted or alkyl-substituted .alpha.,.omega.-alkylene having from 1 to 3 carbon atoms or represents a bond, and B represents methylene or a bond, with the proviso that A is other than a bond when B represents a bond, and salts thereof. They can be manufactured, for example, in accordance with the Michaelis-Arbuzov reaction and can be used as pharmacologically active substances.
摘要翻译：本发明涉及式I（I）的不饱和氨基酸，其中R 1表示羟基或醚化羟基，R 2表示氢，烷基，羟基或醚化羟基，R 3表示氢，烷基，卤代烷基，羟基烷基，低级烷氧基烷基，芳基烷基，低级烯基，卤素或芳基，R 4表示氢，烷基或芳基，R 5表示氢或烷基，R 6表示羧基或酯化或酰胺化羧基，R 7表示氨基或被烷基或酰基取代的氨基，A表示未取代或烷基取代具有1至3个碳原子的α，ω-亚烷基或表示键，并且B表示亚甲基或键，条件是当B表示键时A不是键，以及其盐。它们可以例如根据Michaelis-Arbuzov反应制造，并且可以用作药理活性物质。

35. 发明授权

US4178378A Etherified triazolobenzodiazepine derivatives 失效
标题翻译：醚化三唑并苯并二氮杂衍生物
公开(公告)号：US4178378A
公开(公告)日：1979-12-11
申请号：US833421
申请日：1977-09-15
申请人： Hans Allgeier , Andre Gagneux
发明人： Hans Allgeier , Andre Gagneux
IPC分类号： A61K31/53 , A61K31/55 , A61P25/08 , A61P25/20 , C07D317/22 , C07D487/04 , A61K31/62
CPC分类号： C07D487/04 , C07C243/00 , C07D317/22
摘要： Etherified diazepine derivatives of the formula ##STR1## in which R.sub.1 represents hydrogen or alkyl having up to 3 carbon atoms, R.sub.2 and R.sub.3 independently of one another each represent hydrogen or alkyl having up to 7 carbon atoms, or represent the partial formula R.sub.4 --(OCH.sub.2 --CH.sub.2).sub.m, in which R.sub.4 represents hydrogen or alkyl having up to 7 carbon atoms and m represents the number 1 to 3, A.sub.1 represents alkylidene or alkylene having up to 3 carbon atoms, A.sub.2, depending on the meaning of n, represents alkylene or alkanetriyl having up to 5 carbon atoms, no carbon atom in the radical A.sub.2 being bonded to more than one oxygen atom, n represents the number 0 or 1, Ph represents substituted or unsubstituted 1,2-phenylene and Ar represents an aromatic radical, and their addition salts are manufactured according to methods known per se. They are useful in the treatment of states of epilepsy, stress and agitation.
摘要翻译：其中R 1表示氢或具有至多3个碳原子的烷基的式（I）的醚化二氮杂衍生物，R 2和R 3彼此独立地表示氢或具有至多7个碳原子的烷基，或表示部分式 R 4 - （OCH 2 -CH 2）m，其中R 4表示氢或具有至多7个碳原子的烷基，m表示数1至3，A 1表示亚烷基或具有至多3个碳原子的亚烷基，取决于 n表示具有至多5个碳原子的亚烷基或烷三三基，基团A2中的碳原子不连接至多于一个氧原子，n表示数字0或1，Ph表示取代或未取代的1,2-亚苯基，Ar表示芳族基团，并且它们的加成盐按照本身已知的方法制备。它们可用于治疗癫痫，压力和激动的状态。

36. 发明授权

US08299085B2 Quinazoline derivatives 失效
标题翻译：喹唑啉衍生物
公开(公告)号：US08299085B2
公开(公告)日：2012-10-30
申请号：US11572007
申请日：2005-07-26
申请人： Hans Allgeier , Wolfgang Froestl , Manuel Koller , Henri Mattes , Joachim Nozulak , Silvio Ofner , David Orain , Vittorio Rasetti , Johanne Renaud , Nicolas Soldermann , Philipp Floersheim
发明人： Hans Allgeier , Wolfgang Froestl , Manuel Koller , Henri Mattes , Joachim Nozulak , Silvio Ofner , David Orain , Vittorio Rasetti , Johanne Renaud , Nicolas Soldermann , Philipp Floersheim
IPC分类号： A01N43/54 , A61K31/517
CPC分类号： C07D409/12 , C07D239/96 , C07D401/12 , C07D403/04
摘要： The present invention relates to 1H-Quinazoline-2,4-dione derivatives of formula(I) wherein the substituents are defined as in the specification, their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them.
摘要翻译：本发明涉及式（I）的1H-喹唑啉-2,4-二酮衍生物，其中取代基如说明书中所定义，它们的制备，它们作为药物的用途以及含有它们的药物组合物。

37. 发明申请

US20080153836A1 1H-Quinazoline-2,4-Diones 失效
标题翻译： 1H-喹唑啉-2,4-二酮
公开(公告)号：US20080153836A1
公开(公告)日：2008-06-26
申请号：US11911040
申请日：2006-04-10
申请人： Hans Allgeier , Yves Auberson , David Carcache , Philipp Floersheim , Christel Guibourdenche , Wolfgang Froestl , Jorg Kallen , Manuel Koller , Henri Mattes , Joachim Nozulak , David Orain , Johanne Renaud
发明人： Hans Allgeier , Yves Auberson , David Carcache , Philipp Floersheim , Christel Guibourdenche , Wolfgang Froestl , Jorg Kallen , Manuel Koller , Henri Mattes , Joachim Nozulak , David Orain , Johanne Renaud
IPC分类号： A61K31/501 , C07D239/72 , A61K31/517 , A61P25/00 , C07D237/06
CPC分类号： C07D239/96 , C07C207/00 , C07C229/56 , C07C229/64 , C07C229/66 , C07C255/18 , C07C265/12 , C07C271/58 , C07D207/337 , C07D231/12 , C07D237/08 , C07D239/26 , C07D241/12 , C07D249/06 , C07D263/32 , C07D307/16 , C07D307/54 , C07D309/12 , C07D401/04 , C07D403/04 , C07D405/04 , C07D413/04
摘要： The present invention relates to 1H-Quinazoline-2,4-diones of formula (I) wherein R1 and R2 are as defined in the specification, their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them. Further, intermediates for the manufacture of compounds of formula (I) are and combinations comprising compounds of formula (I) are disclosed.
摘要翻译：本发明涉及式（I）的1H-喹唑啉-2,4-二酮，其中R 1和R 2如本说明书中所定义，它们的制备，它们的用作药物，以及含有它们的药物组合物。此外，公开了用于制备式（I）化合物的中间体和包含式（I）化合物的组合。

38. 发明申请

US20050014407A1 Plug connector position control for checking the complete and proper execution of an electrical plug connection between a plug connector and a mating connector 审中-公开
标题翻译：插头连接器位置控制，用于检查插头连接器和配对连接器之间电插头连接的完整和正确执行
公开(公告)号：US20050014407A1
公开(公告)日：2005-01-20
申请号：US10746410
申请日：2003-12-23
申请人： Martin Saur , Achim Puettner , Michael Schoenfeld , Andreas Simmel , Sabine Allgeier , Mohammed Lamdiziz , Markus Todesco , Hans Allgeier
发明人： Martin Saur , Achim Puettner , Michael Schoenfeld , Andreas Simmel , Sabine Allgeier , Mohammed Lamdiziz , Markus Todesco , Hans Allgeier
IPC分类号： H01R13/703 , H01R13/64 , H01R13/641 , H01R29/00
CPC分类号： H01R13/641
摘要： A plug connector position control element for checking the complete and proper execution of an electrical plug connection between a plug having a locking mechanism and a mating connector, which is constantly demonstrable at a remote location, as to whether the electrical plug connection is properly plugged in. A triggering element actuates a sensor element depending upon a properly executed plug connection.
摘要翻译：一种插头连接器位置控制元件，用于检查在具有锁定机构的插头和在远程位置处不间断地显示的匹配连接器之间的电插头连接的完整和适当的执行，以确定电插头连接是否正确插入根据正确执行的插头连接，触发元件致动传感器元件。

39. 发明授权

US06117873A Substituted aminoalkane phosphonic acids 有权
标题翻译：取代的氨基烷烃膦酸
公开(公告)号：US06117873A
公开(公告)日：2000-09-12
申请号：US297010
申请日：1999-04-23
申请人： Pierre Acklin , Hans Allgeier , Yves Auberson , Silvio Ofner , Siem Jacob Veenstra
发明人： Pierre Acklin , Hans Allgeier , Yves Auberson , Silvio Ofner , Siem Jacob Veenstra
IPC分类号： A61K31/675 , A61P9/00 , A61P25/00 , A61P25/08 , A61P43/00 , C07F9/6509 , A61K31/495 , C07F9/02
CPC分类号： C07F9/650994
摘要： Compounds of the formula I ##STR1## in which R.sub.1 is hydroxyl or an aliphatic, araliphatic or aromatic radical,X is a divalent aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, araliphatic, heteroarylaliphatic or aromatic radical,R.sub.2 is hydrogen or an aliphatic or araliphatic radical, alk is lower alkylidene andR.sub.3, R.sub.4 and R.sub.5 independently of one another are hydrogen, lower alkyl, halogen, trifluoromethyl, cyano or nitro,and their salts can be used for the treatment of pathological conditions which respond to blockage of excitatory amino acid receptors, and for the production of pharmaceutical preparations.
摘要翻译： PCT No.PCT / EP97 / 05843 Sec。 371日期1999年4月23日第 102（e）1999年4月23日PCT PCT 1997年10月22日PCT公布。第WO98 / 17672号PCT公告日期：1998年4月30日，其中R 1为羟基或脂族，芳脂族或芳族基团的式I化合物，X为二价脂族，脂环族，脂环族 - 脂族，芳脂族，杂芳基脂族或芳族基团，R2为氢或脂族或芳族芳脂肪族基团，烷基是亚烷基，R3，R4和R5彼此独立地是氢，低级烷基，卤素，三氟甲基，氰基或硝基，并且它们的盐可用于治疗响应兴奋性氨基酸阻断的病理状况酸受体和用于制备药物制剂。

40. 发明授权

US5633379A 3-heteroaliphatyl- and 3-hetero(aryl)aliphatyl-2(1H)-quinolone derivatives 失效
标题翻译： 3-杂芳基和3-杂芳基芳基-2（1H） - 喹诺酮衍生物
公开(公告)号：US5633379A
公开(公告)日：1997-05-27
申请号：US456358
申请日：1995-06-01
申请人： Hans Allgeier
发明人： Hans Allgeier
IPC分类号： A61K31/47 , A61P9/00 , A61P9/10 , A61P25/00 , A61P25/04 , A61P25/20 , A61P25/28 , C07D215/22 , C07D215/36 , C07D401/12 , C07D405/12 , C07D409/12 , C07D215/20 , C07D215/227
CPC分类号： C07D215/22 , C07D215/36 , C07D401/12 , C07D405/12 , C07D409/12
摘要： 3-Heteroaliphatyl- and 3-hetero(aryl)aliphatyl-2(1H)quinolone derivatives of formula I ##STR1## wherein the radicals R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently of the others hydrogen, an aliphatic hydrocarbon radical, free or etherified hydroxy, mercapto or etherified and/or oxidised mercapto, unsubstituted or aliphaticaliy substituted amino, nitro, free or esterified or amidated carboxy, cyano, free or amidated sulfamoyl, halogen or trifluoromethyl, X is oxy or optionally oxidised thio, A is a divalent aliphatic radical and R.sub.5 is an optionally partially hydrogenated aryl or heteroaryl radical that is unsubstituted or substituted by aliphatic or araliphatic hydrocarbon radicals, by free or etherified hydroxy, by mercapto or etherified and/or oxidised mercapto, by unsubstituted or aliphatically substituted amino, by aliphatic acyl, by free or esterified or amidated carboxy, by cyano, by free or amidated sulfamoyl, by halogen and/or by trifluoromethyl; free or etherified hydroxymethyl; cyano; or free or esterified or amidated carboxy, and tautomers and/or salts thereof, have antagonistic properties with respect to excitatory amino acids and can be used for the treatment of pathological conditions that are responsive to glycine-antagonistic blocking of NMDA-sensitive receptors.
摘要翻译：其中基团R 1，R 2，R 3和R 4各自独立地为氢，脂族烃基（C 1 -C 6）烷基，游离或醚化的羟基，巯基或醚化的和/或氧化的巯基，未取代的或脂族取代的氨基，硝基，游离或酯化或酰胺化的羧基，氰基，游离或酰胺化的氨磺酰基，卤素或三氟甲基，X是氧或任选被氧化的硫代， R5是任选部分氢化的芳基或杂芳基，其未被取代或被脂肪族或芳脂族烃基取代，被游离的或醚化的羟基，被巯基或醚化和/或氧化的巯基取代，被未取代的或脂族取代的氨基由脂族酰基，游离或酯化或酰胺化的羧基，氰基，游离或酰胺基氨磺酰基，卤素和/或三氟甲基取代; 游离的或醚化的羟甲基; 氰基; 或游离的或酯化的或酰胺化的羧基及其互变异构体和/或其盐对兴奋性氨基酸具有拮抗作用，并且可用于治疗对甘氨酸拮抗性阻断NMDA敏感性受体有反应的病理状况。

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