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31. 发明授权

US5741943A Hydroformylation processes employing indicator ligands 失效
标题翻译：使用指示剂配体的加氢甲酰化方法
公开(公告)号：US5741943A
公开(公告)日：1998-04-21
申请号：US756500
申请日：1996-11-26
申请人： David Robert Bryant , Tak Wai Leung
发明人： David Robert Bryant , Tak Wai Leung
IPC分类号： C07B61/00 , B01J19/18 , B01J27/18 , B01J31/02 , B01J31/18 , B01J31/22 , B01J31/40 , B01J38/74 , C07C45/49 , C07C45/50 , C07C47/02 , C07C51/00 , C07C51/255 , C07C51/265 , C07C51/42 , C07C51/43 , C07C63/00 , C07C63/15 , C07C63/26 , C07F9/02 , C07F9/141 , C07F9/145 , C07F9/50 , C07F9/6571 , C07F9/6574 , C07F15/00 , F04D25/08 , F04D29/28
CPC分类号： C07F9/65746 , B01J19/18 , B01J31/0237 , B01J31/0259 , B01J31/0267 , B01J31/1805 , B01J31/185 , B01J31/4023 , B01J31/4046 , B01J31/4053 , B01J31/4061 , B01J38/74 , C07C45/49 , C07C45/50 , C07C45/505 , C07F9/025 , C07F9/145 , B01J2219/00083 , B01J2219/00103 , B01J2231/32 , B01J2231/321 , B01J2231/52 , B01J2531/822 , B01J2531/96 , B01J31/20 , Y02P20/582 , Y02P20/584
摘要： This invention relates to a hydroformylation process which comprises reacting one or more olefinic unsaturated compounds with carbon monoxide and hydrogen in the presence of a metal-organopolyphosphite ligand complex catalyst and optionally free organopolyphosphite ligand, and an amount of a sterically hindered organophosphorus ligand different from the organopolyphosphite ligand of said metal-organopolyphosphite ligand complex catalyst, to produce one or more aldehydes. The sterically hindered organophosphorus ligands are useful as indicators of organopolyphosphite ligand depletion in said hydroformylation process.
摘要翻译：本发明涉及加氢甲酰化方法，其包括在金属 - 有机多亚磷酸酯配位体配位体催化剂和任选的游离有机多亚磷酸酯配体存在下使一种或多种烯属不饱和化合物与一氧化碳和氢反应，和一定量的空间位阻有机磷配体不同于所述金属 - 有机多亚磷酸酯配体配合物催化剂的有机多亚磷酸酯配体，以产生一种或多种醛。空间位阻有机磷配体可用作所述加氢甲酰化方法中有机多亚磷酸酯配体消耗的指标。

32. 发明授权

US5681473A Membrane separation process 失效
标题翻译：膜分离过程
公开(公告)号：US5681473A
公开(公告)日：1997-10-28
申请号：US430790
申请日：1995-05-05
申请人： Jay Fingeret Miller , David Robert Bryant , Kenneth Look Hoy , Nancy Ellen Kinkade , Rachel Hilda Zanapalidou
发明人： Jay Fingeret Miller , David Robert Bryant , Kenneth Look Hoy , Nancy Ellen Kinkade , Rachel Hilda Zanapalidou
IPC分类号： B01D61/02 , B01D69/02 , B01J31/24 , B01J31/40 , B01J37/00 , B01J38/00 , C07C45/50 , C07C45/78 , C07C47/02 , B01D61/00
CPC分类号： B01J31/185 , B01D61/02 , B01D61/025 , B01D61/027 , B01J31/4046 , B01J31/4061 , B01J37/009 , B01J38/00 , C07C45/50 , C07C45/505 , C07C45/786 , B01J2231/321 , B01J2531/822 , Y02P20/582 , Y02P20/584
摘要： This invention relates to membrane separation of organic solubilized rhodium-organophosphite complex catalyst and free organophosphite ligand from a homogeneous non-aqueous hydroformylation reaction mixture, said mixture also containing, in addition to said catalyst and free ligand, aldehyde product and an organic solvent.
摘要翻译：本发明涉及有机溶解的铑 - 有机亚磷酸酯配合物催化剂和游离的有机亚磷酸酯配体从均相非水羰基化反应混合物中分离，所述混合物除了所述催化剂和游离配体外，还含有醛产物和有机溶剂。

33. 发明授权

US06303830B1 Metal-ligand complex catalyzed processes 有权
标题翻译：金属 - 配体络合物催化方法
公开(公告)号：US06303830B1
公开(公告)日：2001-10-16
申请号：US09526638
申请日：2000-03-15
申请人： John Nicholas Argyropoulos , Jeffrey Scott Kanel , Michael Leo Tulchinsky , David James Miller , Donald Lee Morrison , Paul Foley , David Robert Bryant
发明人： John Nicholas Argyropoulos , Jeffrey Scott Kanel , Michael Leo Tulchinsky , David James Miller , Donald Lee Morrison , Paul Foley , David Robert Bryant
IPC分类号： C07C4550
CPC分类号： C07B63/00 , C07C67/58 , Y02P20/582 , C07C69/716
摘要： This invention relates to a process for separating one or more organophosphorus ligand degradation products, one or more reaction byproducts and one or more formylester products from a reaction product fluid comprising one or more unreacted unsaturated ester reactants, a metal-organophosphorus ligand complex catalyst, optionally free organophosphorus ligand, said one or more organophosphorus ligand degradation products, said one or more reaction byproducts, said one or more products, a polar solvent and a nonpolar solvent by phase separation wherein(i) the selectivity of the polar phase for the organophosphorus ligand with respect to the one or more products is expressed by a partition coefficient ratio Ef1 which is a value greater than about 2.5, (ii) the selectivity of the polar phase for the organophosphorus ligand with respect to the one or more organophosphorus ligand degradation products is expressed by a partition coefficient ratio Ef2 which is a value greater than about 2.5, and (iii) the selectivity of the polar phase for the organophosphorus ligand with respect to the one or more reaction byproducts is expressed by a partition coefficient ratio Ef3 which is a value greater than about 2.5.
摘要翻译：本发明涉及一种从包含一种或多种未反应的不饱和酯反应物，金属 - 有机磷配位体配合物催化剂，任选的一种或多种反应产物流体的反应产物流体中分离一种或多种有机磷配体降解产物，一种或多种反应副产物和一种或多种甲酰酯产物的方法所述一种或多种有机磷配体降解产物，所述一种或多种反应副产物，所述一种或多种产物，极性溶剂和非极性溶剂通过相分离，其中（i）极性相对于有机磷配体的选择性对于一种或多种产物，由分配系数比Ef1表示，该分配系数比Ef1大于约2.5，（ii）极性相对于一种或多种有机磷配体降解产物的有机磷配体的选择性为由大于约2.5的值的分配系数比Ef2表示，a d（iii）极性相对于一种或多种反应副产物的有机磷配体的选择性由分配系数比Ef3表示，该分配系数比Ef3是大于约2.5的值。

34. 发明授权

US06300496B1 Processes for producing epsilon caprolactams 失效
标题翻译：生产ε己内酰胺的方法
公开(公告)号：US06300496B1
公开(公告)日：2001-10-09
申请号：US09413572
申请日：1999-10-06
申请人： Kurt Damar Olson , Thomas Carl Eisenschmid , David Robert Bryant , Arthur Roy Doumaux, Jr.
发明人： Kurt Damar Olson , Thomas Carl Eisenschmid , David Robert Bryant , Arthur Roy Doumaux, Jr.
IPC分类号： C07D20108
CPC分类号： C07D201/08 , Y02P20/582
摘要： This invention relates in part to processes for producing one or more substituted or unsubstituted epsilon caprolactams, e.g., epsilon caprolactam, which comprise (a) converting one or more substituted or unsubstituted hydroxyaldehydes, e.g., 6-hydroxyhexanal, optionally in the presence of a catalyst or a catalyst and promoter, to one or more substituted or unsubstituted hydroxyamides, e.g. 6-hydroxycaproamide, and/or one or more substituted or unsubstituted epsilon caprolactam precursors, e.g., 6-aminocaproamide, epsilon caprolactone, epsilon caprolactone oligomers and esters of 6-hydroxycaproic acid and mixtures thereof, and (b) converting said one or more substituted or unsubstituted hydroxyamides and/or said one or more substituted or unsubstituted epsilon caprolactam precursors, optionally in the presence of a catalyst or a catalyst and promoter, to said one or more substituted or unsubstituted epsilon caprolactams; wherein the amount of byproducts resulting from reduction and/or reductive amination of said one or more substituted or unsubstituted hydroxyaldehydes, e.g., 1,6-hexanediol, aminohexanol, and the like, is no greater than about 10 weight percent, preferably no greater than about 5 weight percent, and more preferably no greater than about 1 weight percent, of the total of said one or more substituted or unsubstituted hydroxyamides and/or one or more substituted or unsubstituted epsilon caprolactam precursors. This invention also relates in part to reaction mixtures containing one or more substituted or unsubstituted epsilon caprolactams as principal product(s) of reaction.
摘要翻译：本发明部分地涉及用于制备一种或多种取代或未取代的ε-己内酰胺（例如ε-己内酰胺）的方法，其包括（a）任选在催化剂存在下，将一种或多种取代或未取代的羟基醛例如6-羟基己醛转化或催化剂和促进剂，与一种或多种取代或未取代的羟基酰胺，例如， 6-羟基己酰胺和/或一种或多种取代或未取代的ε-己内酰胺前体，例如6-氨基己酰胺，ε-己内酯，ε-己内酯低聚物和6-羟基己酸的酯及其混合物，和（b）将所述一种或多种取代的或所述一种或多种取代或未取代的ε-己内酰胺前体，任选在催化剂或催化剂和促进剂存在下，与所述一种或多种取代或未取代的ε己内酰胺反应; 其中所述一种或多种取代或未取代的羟基醛（例如1,6-己二醇，氨基己醇等）的还原和/或还原胺化产生的副产物的量不大于约10重量％，优选不大于所述一个或多个取代或未取代的羟基酰胺和/或一个或多个取代或未取代的ε-己内酰胺前体的总量的约5重量％，更优选不大于约1重量％。本发明还部分涉及含有一种或多种取代或未取代的ε-己内酰胺作为主要反应产物的反应混合物。

35. 发明授权

US5932772A Separation processes 失效
标题翻译：分离过程
公开(公告)号：US5932772A
公开(公告)日：1999-08-03
申请号：US17457
申请日：1998-02-02
申请人： John N. Argyropoulos , David Robert Bryant , Donald Lee Morrison , Kenneth Elwood Stockman , Anthony George Abatjoglou
发明人： John N. Argyropoulos , David Robert Bryant , Donald Lee Morrison , Kenneth Elwood Stockman , Anthony George Abatjoglou
IPC分类号： B01J31/18 , B01J31/40 , C07B63/00 , C07C45/50 , C07C45/80 , C07C49/92 , C07C51/373 , C07C51/48 , C07C59/147 , C07F9/02 , C07F9/50 , C07F9/655 , C07F9/6574
CPC分类号： B01J31/0267 , B01J31/0259 , B01J31/185 , B01J31/24 , B01J31/2404 , B01J31/2457 , B01J31/2495 , B01J31/4015 , B01J31/4046 , B01J31/4053 , C07C45/50 , C07C45/80 , C07C51/48 , C07F9/025 , B01J2231/32 , B01J2231/321 , B01J2231/52 , B01J2231/641 , B01J2531/822 , B01J31/2208 , Y02P20/582 , Y02P20/584
摘要： This invention relates to a process for separating one or more products from a reaction product fluid comprising a metal-organophosphorus ligand complex catalyst, optionally free organophosphorus ligand, a polar solvent and said one or more products, wherein said process comprises (1) mixing said reaction product fluid with a nonpolar solvent to obtain by phase separation a polar phase comprising said metal-organophosphorus ligand complex catalyst, optionally free organophosphorus ligand and said polar solvent and a nonpolar phase comprising said one or more products and nonpolar solvent, and (2) recovering said nonpolar phase from said polar phase; wherein said organophosphorus ligand has a partition coefficient between the polar solvent and the nonpolar solvent of greater than about 10, and said one or more products have a partition coefficient between the nonpolar solvent and the polar solvent of greater than about 0.5.
摘要翻译：本发明涉及从包含金属 - 有机磷配体配合物催化剂，任选的游离有机磷配体，极性溶剂和所述一种或多种产物的反应产物流体中分离一种或多种产物的方法，其中所述方法包括（1）将所述反应产物流体与非极性溶剂通过相分离获得包含所述金属 - 有机磷配体配合物催化剂的极性相，任选的游离有机磷配体和所述极性溶剂和包含所述一种或多种产物和非极性溶剂的非极性相，和（2）从所述极性相中回收所述非极性相; 其中所述有机磷配体具有大于约10的极性溶剂和非极性溶剂之间的分配系数，并且所述一种或多种产物在非极性溶剂和极性溶剂之间具有大于约0.5的分配系数。

36. 发明授权

US5892127A Processes for producing 1,6-hexanedials and derivatives 失效
标题翻译：生产1,6-己二醛和衍生物的方法
公开(公告)号：US5892127A
公开(公告)日：1999-04-06
申请号：US842665
申请日：1997-04-15
申请人： Diane Lee Packett , John Robert Briggs , David Robert Bryant , Ailene Gardner Phillips
发明人： Diane Lee Packett , John Robert Briggs , David Robert Bryant , Ailene Gardner Phillips
IPC分类号： C07C29/16 , C07C45/49 , C07C45/50 , C07C47/12 , C07C47/21
CPC分类号： C07C29/16 , C07C45/49 , C07C45/50 , C07C47/12 , C07C47/21 , Y02P20/582
摘要： This invention relates in part to processes for selectively producing one or more substituted or unsubstituted 1,6-hexanedials, e.g., adipaldehyde, which comprise: (a) subjecting one or more substituted or unsubstituted alkadienes, e.g., butadiene, or a mixture comprising one or more substituted or unsubstituted alkadienes to hydroformylation in the presence of a hydroformylation catalyst, e.g., a metal-organophosphorus ligand complex catalyst, and at an alkadiene partial pressure and/or a carbon monoxide partial pressure sufficient to selectively produce one or more substituted or unsubstituted pentenals or a reaction mixture comprising one or more substituted or unsubstituted pentenals; and (b) subjecting said one or more substituted or unsubstituted pentenals or said reaction mixture comprising one or more substituted or unsubstituted pentenals to hydroformylation in the presence of a hydroformylation catalyst, e.g., a metal-organophosphorus ligand complex catalyst, to selectively produce said one or more substituted or unsubstituted 1,6-hexanedials. The substituted or unsubstituted 1,6-hexanedials produced by the processes of this invention can undergo further reaction(s) to afford desired derivatives thereof, e.g., epsilon caprolactone. This invention also relates in part to reaction mixtures containing one or more substituted or unsubstituted 1,6-hexanedials as principal product(s) of reaction.
摘要翻译：本发明部分地涉及选择性地生产一种或多种取代或未取代的1,6-己二醛例如己二醛的方法，所述方法包括：（a）使一种或多种取代或未取代的二烯烃如丁二烯或包含一种或更多的取代或未取代的链烯二醇在加氢甲酰化催化剂（例如金属 - 有机磷配体配合物催化剂）存在下加氢甲酰化，并且在烯二烯分压和/或一氧化碳分压下，足以选择性地产生一个或多个取代或未取代的戊烯醛或包含一种或多种取代或未取代的戊烯醛的反应混合物; 和（b）在加氢甲酰化催化剂（例如金属 - 有机磷配体配合物催化剂）的存在下，将所述一种或多种取代或未取代的戊烯醛或包含一种或多种取代或未取代的戊烯醛的反应混合物进行加氢甲酰化，以选择性地生产所述一种或更多取代或未取代的1,6-己二醛。通过本发明的方法制备的取代或未取代的1,6-己二醛可进一步反应以提供其所需的衍生物，例如ε己内酯。本发明还部分涉及含有一个或多个取代或未取代的1,6-己二醛作为主要反应产物的反应混合物。

37. 发明授权

US5821389A Processes for producing hydroxyaldehydes 失效
标题翻译：羟基醛生产工艺
公开(公告)号：US5821389A
公开(公告)日：1998-10-13
申请号：US843339
申请日：1997-04-15
申请人： John Robert Briggs , Diane Lee Packett , David Robert Bryant , Ailene Gardner Phillips , David James Schreck , Kurt Damar Olson , Erik Bruce Tjaden , Anil Sakharam Guram , Thomas Carl Eisenschmid , Elaine Susan Brigham
发明人： John Robert Briggs , Diane Lee Packett , David Robert Bryant , Ailene Gardner Phillips , David James Schreck , Kurt Damar Olson , Erik Bruce Tjaden , Anil Sakharam Guram , Thomas Carl Eisenschmid , Elaine Susan Brigham
IPC分类号： C07C29/16 , C07C45/49 , C07C45/50 , C07C45/68 , C07C47/19 , C07F9/6574
CPC分类号： C07F9/65744 , C07C29/16 , C07C45/49 , C07C45/50 , C07C45/68 , C07C47/19 , C07B2200/09 , Y02P20/582
摘要： This invention relates in part to processes for producing one or more substituted or unsubstituted hydroxyaldehydes, e.g., 6-hydroxyhexanals, which comprise subjecting one or more substituted or unsubstituted alkadienes, e.g., butadiene, to reductive hydroformylation in the presence of a reductive hydroformylation catalyst, e.g., a metal-organophosphorus ligand complex catalyst, and hydroformylation in the presence of a hydroformylation catalyst, e.g., a metal-organophosphorus ligand complex catalyst, to produce one or more substituted or unsubstituted hydroxyaldehydes. The substituted and unsubstituted hydroxyaldehydes produced by the processes of this invention can undergo further reaction(s) to afford desired derivatives thereof, e.g., epsilon caprolactone. This invention also relates in part to reaction mixtures containing one or more substituted or unsubstituted hydroxyaldehydes as principal product(s) of reaction.
摘要翻译：本发明部分地涉及用于制备一种或多种取代或未取代的羟基醛（例如6-羟基己醛）的方法，其包括使一种或多种取代或未取代的二烯烃例如丁二烯在还原加氢甲酰化催化剂存在下还原加氢甲酰化，例如金属 - 有机磷配体络合物催化剂，以及在加氢甲酰化催化剂例如金属 - 有机磷配体配合物催化剂的存在下加氢甲酰化，以产生一种或多种取代或未取代的羟基醛。通过本发明的方法制备的取代和未取代的羟基醛可以进一步反应以提供其所需的衍生物，例如ε己内酯。本发明还部分涉及含有一种或多种取代或未取代的羟基醛作为主要反应产物的反应混合物。

38. 发明授权

US07196230B2 Phosoxophite ligands and use thereof in carbonylation processes 有权
标题翻译： Phosoxophite配体及其在羰基化过程中的应用
公开(公告)号：US07196230B2
公开(公告)日：2007-03-27
申请号：US10504247
申请日：2003-03-04
申请人： Wei-Jun Peng , David Robert Bryant
发明人： Wei-Jun Peng , David Robert Bryant
IPC分类号： C07F9/02
CPC分类号： C07F15/008 , C07C45/49 , C07C45/50 , C07C67/293 , C07C67/347 , C07F9/65742 , C07F9/65744 , C07F9/65746 , C07C47/19 , C07C47/228 , C07C69/003 , C07C69/716 , C07C69/14
摘要： A novel organophosphorus composition and synthesis thereof, the composition being characterized by one phosphite moiety, one phosoxophite moiety, and a plurality of sterically bulky substituents. The novel composition finds utility as a ligand in Group VIII transition metal phosoxophite complex catalysts and complex catalyst precursors that are used in carbonylation processes, preferably, hydroformylation processes. Additionally, there is disclosed a novel method of preparing a phosphoromonochloridite composition that finds utility as a precursor to the novel phosoxophite composition.
摘要翻译：一种新颖的有机磷组合物及其合成，该组合物的特征在于一个亚磷酸酯部分，一个亚磷酸酯部分和多个空间庞大的取代基。该新型组合物可用作第VIII族过渡金属磷酸盐络合物催化剂和复合催化剂前体中的配体，其用于羰基化方法，优选加氢甲酰化方法。此外，公开了一种制备可用作新型磷酸盐组合物的前体的一氯代氯酸盐组合物的新方法。

39. 发明授权

US06362367B1 Preparation of organic acids 失效
公开(公告)号：US06362367B1
公开(公告)日：2002-03-26
申请号：US09063675
申请日：1998-04-21
申请人： John Braithwaite , David Robert Bryant , David James Miller , John Earl Logsdon
发明人： John Braithwaite , David Robert Bryant , David James Miller , John Earl Logsdon
IPC分类号： C07C5121
摘要： This invention relates to a process for producing one or more organic acids in high purity which process comprises (i) oxidizing in a liquid oxidation reactor one or more organic liquids with essentially pure oxygen or oxygen-enriched air containing at least about 50% oxygen, at a temperature sufficiently stable to prevent cycling of reaction rate, to produce a crude reaction product fluid, and (ii) refining said crude reaction product fluid to give said one or more organic acids in high purity. The oxidation temperature is preferably controlled to within about ±3° C. of a target temperature. The organic acids described herein is useful in a variety of applications, such as intermediates in the manufacture of chemical compounds, pharmaceutical manufacture and the like.

40. 发明授权

US06252121B1 Metal-ligand complex catalyzed processes 有权
标题翻译：金属 - 配体络合物催化方法
公开(公告)号：US06252121B1
公开(公告)日：2001-06-26
申请号：US09361907
申请日：1999-07-27
申请人： John Nicholas Argyropoulos , David Robert Bryant , Michael Leo Tulchinsky , Jeffrey Scott Kanel , Paul Foley , Barry Brent Fish
发明人： John Nicholas Argyropoulos , David Robert Bryant , Michael Leo Tulchinsky , Jeffrey Scott Kanel , Paul Foley , Barry Brent Fish
IPC分类号： C07C4550
CPC分类号： C07B63/00 , B33Y40/00 , B33Y70/00 , C07B2200/09 , C07C29/141 , C07C45/49 , C07C45/50 , C07C45/78 , C07C45/80 , C07C47/32 , C07C209/26 , C07C253/30 , C07C2601/14 , Y02P20/582 , C07C47/347 , C07C47/36 , C07C31/276
摘要： This invention relates to a process for separating one or more cyclic products from a reaction product fluid comprising one or more cyclic reactants, a metal-organophosphorus ligand complex catalyst, optionally free organophosphorus ligand, a non-polar solvent and said one or more cyclic products, wherein said process comprises: (1) reacting said one or more cyclic reactants in the presence of said metal-organophosphorus ligand complex catalyst, optionally free organophosphorus ligand and non-polar solvent to form a multiphase reaction product fluid; and (2) separating said multiphase reaction product fluid to obtain a non-polar phase comprising said one or more cyclic reactants, metal-organophosphorus ligand complex catalyst, optionally free organophosphorus ligand and non-polar solvent and a polar phase comprising said one or more cyclic products.
摘要翻译：本发明涉及从包含一种或多种环状反应物，金属 - 有机磷配位体配合物催化剂，任选的游离有机磷配体，非极性溶剂和所述一种或多种环状产物的反应产物流体中分离一种或多种环状产物的方法其中所述方法包括：（1）在所述金属 - 有机磷配体配合物催化剂，任选的游离有机磷配体和非极性溶剂的存在下使所述一种或多种环状反应物反应以形成多相反应产物流体; 和（2）分离所述多相反应产物流体以获得包含所述一种或多种环状反应物，金属 - 有机磷配体络合物催化剂，任选的游离有机磷配体和非极性溶剂的非极性相和包含所述一种或多种循环产品。

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