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31. 发明申请

US20120208752A1 CELL PROLIFERATION-PROMOTING PEPTIDE AND USE THEREOF 有权
标题翻译：细胞增殖促进肽及其用途
公开(公告)号：US20120208752A1
公开(公告)日：2012-08-16
申请号：US13503220
申请日：2010-10-28
申请人： Tetsuhiko Yoshida , Nahoko Kobayashi , Mikio Niwa , Chikara Shinohara , Masatoki Watanabe , Ken-ichiro Hata
发明人： Tetsuhiko Yoshida , Nahoko Kobayashi , Mikio Niwa , Chikara Shinohara , Masatoki Watanabe , Ken-ichiro Hata
IPC分类号： A61K38/18 , C12P1/00 , C12N5/071 , A61K38/10 , A61K38/08 , A61P17/02 , A61P25/00 , A61P35/00 , A61P27/02 , A61P25/14 , A61P25/16 , A61P17/00 , C12N5/02 , A61P25/28
CPC分类号： C12N5/0662 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/001 , C07K14/475 , C07K2319/10 , C07K2319/21 , C07K2319/23 , C12N5/0018 , C12N2501/998
摘要： A cell proliferation promoter includes, as an active ingredient, an artificially synthesized peptide that includes (A) an amino acid sequence constituting a membrane-permeable peptide and (B) an amino acid sequence selected from SEQ ID NOs: 19 to 103 or an amino acid sequence formed by substituting, deleting and/or adding one or several amino acid residues in the selected amino acid sequence.
摘要翻译：细胞增殖促进剂包括作为活性成分的人造合成肽，其包含（A）构成膜可渗透肽的氨基酸序列和（B）选自SEQ ID NO：19至103的氨基酸序列或氨基酸通过在所选择的氨基酸序列中取代，缺失和/或添加一个或几个氨基酸残基形成的酸序列。

32. 发明申请

US20120149053A1 CARRIER PEPTIDE FRAGMENT AND USE THEREOF 审中-公开
标题翻译：载体蛋白片段及其用途
公开(公告)号：US20120149053A1
公开(公告)日：2012-06-14
申请号：US13386585
申请日：2010-07-28
申请人： Tetsuhiko Yoshida , Nahoko Kobayashi , Mikio Niwa , Kenichi Tanaka
发明人： Tetsuhiko Yoshida , Nahoko Kobayashi , Mikio Niwa , Kenichi Tanaka
IPC分类号： C12Q1/02 , C12N15/85 , C07K9/00 , C07K19/00 , C12N5/071 , C07K7/08
CPC分类号： G01N33/5005 , A61K31/7088 , A61K47/64 , A61K47/645 , C07K7/06 , C07K7/08 , C07K14/001 , C07K2319/00
摘要： A method for transferring a foreign substance includes the steps of: preparing a construct for transferring a foreign substance that contains a carrier peptide fragment including any amino acid sequence selected from SEQ ID Nos. 1, 2, 3, 4, 5, and 6, or an amino acid sequence formed by the substitution, deletion, and/or addition (insertion) of 1, 2, or 3 amino acid residues in the amino acid sequence of the selected sequence identification number, and a foreign substance of interest that is bonded to the N-terminus and/or C-terminus of the carrier peptide fragment; supplying the construct for transferring a foreign substance to a test sample that contains a target eukaryotic cell; and incubating the test sample that has been supplied with the construct for transferring a foreign substance to thereby transfer the construct into the eukaryotic cell in the test sample.
摘要翻译：用于转移异物的方法包括以下步骤：制备用于转移含有载体肽片段的异物的构建体，所述载体肽片段包括选自SEQ ID NO：1,2,3,4,5和6的任何氨基酸序列，或通过选择的序列鉴定号的氨基酸序列中1,2或3个氨基酸残基的取代，缺失和/或添加（插入）形成的氨基酸序列，以及被结合的目的异物到载体肽片段的N末端和/或C末端; 提供用于将异物转移到含有目标真核细胞的测试样品的构建体; 并将已经提供的用于转移异物的构建物的测试样品孵育，从而将构建体转移到测试样品中的真核细胞中。

33. 发明申请

US20120122225A1 CARRIER PEPTIDE FRAGMENT AND USE THEREOF 有权
标题翻译：载体蛋白片段及其用途
公开(公告)号：US20120122225A1
公开(公告)日：2012-05-17
申请号：US13386582
申请日：2010-07-28
申请人： Nahoko Kobayashi , Tetsuhiko Yoshida , Mikio Niwa , Kenichi Tanaka
发明人： Nahoko Kobayashi , Tetsuhiko Yoshida , Mikio Niwa , Kenichi Tanaka
IPC分类号： C12N15/85 , C12N5/071 , C07K17/10 , C07K17/00 , C07K19/00
CPC分类号： A61K31/366 , A61K31/22 , A61K31/397 , A61K31/40 , A61K45/06 , A61K47/64 , C07K7/06 , A61K2300/00
摘要： The method for transferring a foreign substance provided by the present invention includes the steps of: preparing a construct for transferring a foreign substance that contains a carrier peptide fragment including either the amino acid sequence WRRQARFK (SEQ ID NO. 1) or any amino acid sequence formed by the substitution, deletion, and/or addition (insertion) of 1, 2, or 3 amino acid residues in the amino acid sequence, and a foreign substance of interest that is bonded to the N-terminus and/or C-terminus of the carrier peptide fragment; supplying the construct for transferring a foreign substance to a test sample that contains a target eukaryotic cell; and incubating the test sample that has been supplied with the construct for transferring a foreign substance to thereby transfer the construct into the eukaryotic cell in the test sample.
摘要翻译：由本发明提供的转移异物的方法包括以下步骤：制备含有包含氨基酸序列WRRQARFK（SEQ ID NO.1）或任何氨基酸序列的载体肽片段的异物转移构建体通过氨基酸序列中1,2或3个氨基酸残基的取代，缺失和/或添加（插入）形成，以及与N末端和/或C末端键合的目的异物的载体肽片段; 提供用于将异物转移到含有目标真核细胞的测试样品的构建体; 并将已经提供的用于转移异物的构建物的测试样品孵育，从而将构建体转移到测试样品中的真核细胞中。

34. 发明申请

US20120035112A1 NEURONAL DIFFERENTIATION-INDUCING PEPTIDE AND USE THEREOF 有权
标题翻译：神经元差异诱导肽及其用途
公开(公告)号：US20120035112A1
公开(公告)日：2012-02-09
申请号：US13258788
申请日：2010-04-12
申请人： Tetsuhiko Yoshida , Nahoko Kobayashi
发明人： Tetsuhiko Yoshida , Nahoko Kobayashi
IPC分类号： A61K38/16 , A61P25/28 , C12N5/00 , A61P25/00 , C07K14/435 , C07K7/08
CPC分类号： C07K14/4756 , A61K38/00
摘要： A neuronal differentiation inducer provided by the present invention contains an artificially synthesized peptide which includes an amino acid sequence constituting a signal peptide in amyloid precursor protein (APP), or a partial sequence of the amino acid sequence constituting this signal peptide.
摘要翻译：本发明提供的神经元分化诱导剂含有人造合成的肽，其包含构成该淀粉状蛋白前体蛋白（APP）中的信号肽的氨基酸序列或构成该信号肽的氨基酸序列的部分序列。

35. 发明授权

US07964556B1 Antimicrobial peptides and use thereof 有权
标题翻译：抗微生物肽及其用途
公开(公告)号：US07964556B1
公开(公告)日：2011-06-21
申请号：US11761869
申请日：2007-06-12
申请人： Nahoko Kobayashi , Tetsuhiko Yoshida
发明人： Nahoko Kobayashi , Tetsuhiko Yoshida
IPC分类号： A61K38/00 , A61K38/04 , A61K51/00
CPC分类号： A61K38/10 , A61K38/08 , C07K7/06 , C07K7/08
摘要： Antimicrobial agent including an artificially synthesized antimicrobial peptide that does not occur naturally is provided by present invention. The peptide included in the antimicrobial agent includes 1 unit, 2 units or more units of sequence(s) or sequence(s) with partial modification, the sequence(s) composed of at least 6 contiguous amino acid residues selected from any one of amino acid sequences: (a) KVQIINKK; (b) SVQIVYKP; (c) QVEVKSEK; (d) KKVAVVRT; (e) KKVAIIRT; (f) KKPTSAK, and the total number of amino acid residues included in 1 unit, 2 units or more units of sequence(s) is 30% or more of the total number of amino acid residues constituting the peptide chain.
摘要翻译：本发明提供了包含天然不发生的人工合成的抗微生物肽的抗微生物剂。包含在抗微生物剂中的肽包括具有部分修饰的1个单元，2个单元或更多个单元的序列或序列，所述序列由至少6个连续氨基酸残基组成，所述连续氨基酸残基选自氨基酸序列：（a）KVQIINKK; （b）SVQIVYKP; （c）QVEVKSEK; （d）KKVAVVRT; （e）KKVAIIRT; （f）KKPTSAK，1单位，2单位或多个单位序列中包含的氨基酸残基总数为构成肽链的氨基酸残基总数的30％以上。

36. 发明授权

US07899254B2 Method and device for restoring degraded information 有权
标题翻译：恢复退化信息的方法和设备
公开(公告)号：US07899254B2
公开(公告)日：2011-03-01
申请号：US11665011
申请日：2005-10-13
申请人： Mitsuo Eguchi , Tetsuhiko Yoshida
发明人： Mitsuo Eguchi , Tetsuhiko Yoshida
IPC分类号： G06K9/46
CPC分类号： G06T5/003 , G06T5/10 , G06T2207/20056
摘要： The present invention provides a technology which precisely restores a distribution of original information by carrying out an iterative calculation based on a distribution of degraded information and a transfer function including a phase characteristic of a transfer system. A method according to the present invention restores the original information using the degraded information and the transfer function in the frequency space. The method according to the present invention considers a distribution of the degraded information and a distribution of the original information as distributions of probability density functions, and considers the transfer function as a probability density function of a conditional probability. The most probable distribution of the original information according to the distribution of the degraded information is acquired by the iterative calculation by means of relational equations based on the Bayes' theorem relating to the probability density functions.
摘要翻译：本发明提供一种通过基于劣化信息的分布和包括传送系统的相位特性的传递函数进行迭代计算来精确地恢复原始信息分布的技术。根据本发明的方法使用退化信息和频率空间中的传递函数来恢复原始信息。根据本发明的方法考虑了劣化信息的分布和原始信息的分布作为概率密度函数的分布，并将传递函数视为条件概率的概率密度函数。通过基于与概率密度函数有关的贝叶斯定理的关系方程进行迭代计算，获取根据劣化信息分布的原始信息的最可能分布。

37. 发明申请

US20100297758A1 ARTIFICIAL PEPTIDE AND USE THEREOF 审中-公开
标题翻译：人造肽及其用途
公开(公告)号：US20100297758A1
公开(公告)日：2010-11-25
申请号：US12864147
申请日：2009-01-23
申请人： Tetsuhiko Yoshida , Nahoko Kobayashi , Junichi Masuda
发明人： Tetsuhiko Yoshida , Nahoko Kobayashi , Junichi Masuda
IPC分类号： C12N5/071 , C07K14/00
CPC分类号： C07K7/08 , C07K2319/09 , C12N15/625
摘要： The present invention provides a method of transporting a peptide motif of interest into a nucleus of a eukaryotic cell from outside the cell, including: synthesizing a peptide chain having an amino acid sequence constituting the peptide motif of interest at an N-terminal end or a C-terminal end of a cell membrane-permeable nucleolar localization signal sequence defined by the amino acid sequence KKRTLRKNDRKKR (SEQ ID NO: 1); adding the synthesized peptide to a culture medium which includes the eukaryotic cell or a tissue containing the eukaryotic cell; and culturing the eukaryotic cell to which the synthesized peptide is added, or the tissue containing the cell.
摘要翻译：本发明提供了一种将感兴趣的肽基序转运到细胞外的真核细胞核中的方法，其包括：在N末端或者N末端合成具有构成目标肽基序的氨基酸序列的肽链由氨基酸序列KKRTLRKNDRKKR（SEQ ID NO：1）定义的细胞膜可渗透的核仁定位信号序列的C末端; 将合成的肽加入到包含真核细胞的培养基或含有真核细胞的组织中; 培养加入合成肽的真核细胞或含有细胞的组织。

38. 发明授权

US07615534B2 Antimicrobial peptides and use thereof 有权
标题翻译：抗微生物肽及其用途
公开(公告)号：US07615534B2
公开(公告)日：2009-11-10
申请号：US11247376
申请日：2005-10-11
申请人： Tetsuhiko Yoshida , Yoshinao Yamada , Nahoko Kobayashi , Hiroki Kourai
发明人： Tetsuhiko Yoshida , Yoshinao Yamada , Nahoko Kobayashi , Hiroki Kourai
IPC分类号： A61K38/10
CPC分类号： C07K14/005 , A61K38/00 , C12N2740/16122
摘要： Artificially synthesized antimicrobial peptide that does not occur naturally is provided by the present invention. The antimicrobial peptide includes one unit, two units or more units of amino acid sequence composed of the following 8 amino acid residues: (R or Q)-(L or F or I)—I—K-(L or F or I or V)-L-Y-Q; and/or, modified sequence composed of said sequence with partial modification.
摘要翻译：人造合成的天然不发生的抗微生物肽由本发明提供。抗微生物肽包括由以下8个氨基酸残基组成的一个单元，两个单元或更多个氨基酸序列单元：（R或Q） - （L或F或I）-IK-（L或F或I或V） -LYQ; 和/或由所述序列组成的经部分修饰的修饰序列。

39. 发明申请

US20090270334A1 NEURONAL DIFFERENTIATION INHIBITOR PEPTIDE AND USE THEREOF 有权
标题翻译：神经元差异抑制肽及其用途
公开(公告)号：US20090270334A1
公开(公告)日：2009-10-29
申请号：US12088974
申请日：2006-10-03
申请人： Tetsuhiko Yoshida , Nahoko Kobayashi , Hiroshi Kanno
发明人： Tetsuhiko Yoshida , Nahoko Kobayashi , Hiroshi Kanno
IPC分类号： A61K38/10 , C07K2/00 , C07K7/08 , C07K1/00 , A61K38/02 , A61P25/00
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4705
摘要： Disclosed is a neuronal differentiation inhibitor which comprises at least one peptide capable of inhibiting or controlling the neuronal differentiation of at least one cell capable of being differentiated into a neuronal cell. The peptide is an artificially synthesized peptide which comprises a BC-box derived amino acid sequence comprising at least 10 contiguous amino acid residues selected from an amino acid sequence constituting the BC-box of at least one protein belonging to the elongin A family or comprises an amino acid sequence having a partial modification in the BC-box derived amino acid sequence.
摘要翻译：公开了一种神经元分化抑制剂，其包含至少一种能够抑制或控制能够分化成神经元细胞的至少一种细胞的神经元分化的肽。肽是人工合成的肽，其包含BC-盒衍生的氨基酸序列，其包含至少10个连续氨基酸残基，其选自构成所述至少一种属于所述延伸蛋白A家族的蛋白质的BC盒的氨基酸序列，或包含在BC盒衍生的氨基酸序列中具有部分修饰的氨基酸序列。

40. 发明授权

US07482328B2 Antimicrobial polypeptide and utilization thereof 有权
标题翻译：抗菌多肽及其利用
公开(公告)号：US07482328B2
公开(公告)日：2009-01-27
申请号：US10512299
申请日：2003-04-24
申请人： Tetsuhiko Yoshida , Masayoshi Kume , Yoshinao Yamada , Yoko Matsuda , Hiroki Kourai
发明人： Tetsuhiko Yoshida , Masayoshi Kume , Yoshinao Yamada , Yoko Matsuda , Hiroki Kourai
IPC分类号： A61K38/10 , A61K38/16
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08 , C07K14/001 , Y02A50/481
摘要： The present invention provides an artificially synthesized antimicrobial polypeptide that does not occur in nature and an antimicrobial agent comprising this polypeptide as the main component. This polypeptide contains in its peptide chain one or more types of nuclear localization signal sequences (NLSs) and/or one or more units of sequences prepared by partially modifying the NLS(s). The one or more units of NLSs and/or modified NLSs contain at least 5 amino acid residues in total and amount to 30% or more of the total amino acid residues constituting the peptide chain.
摘要翻译：本发明提供了人造合成的抗微生物多肽，其在天然中不发生，并且包含该多肽作为主要成分的抗微生物剂。该多肽在其肽链中含有一种或多种类型的核定位信号序列（NLS）和/或通过部分修饰NLS制备的一个或多个序列单元。 NLS和/或修饰的NLS的一个或多个单元总共含有至少5个氨基酸残基，并且占构成肽链的总氨基酸残基的30％或更多。

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