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1. 发明授权

US08673846B2 Cell proliferation-promoting peptide and use thereof 有权
标题翻译：细胞增殖促进肽及其用途
公开(公告)号：US08673846B2
公开(公告)日：2014-03-18
申请号：US13503220
申请日：2010-10-28
申请人： Tetsuhiko Yoshida , Nahoko Kobayashi , Mikio Niwa , Chikara Shinohara , Masatoki Watanabe , Ken-ichiro Hata
发明人： Tetsuhiko Yoshida , Nahoko Kobayashi , Mikio Niwa , Chikara Shinohara , Masatoki Watanabe , Ken-ichiro Hata
IPC分类号： A61K38/02 , A61K38/18 , C12N5/02
CPC分类号： C12N5/0662 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/001 , C07K14/475 , C07K2319/10 , C07K2319/21 , C07K2319/23 , C12N5/0018 , C12N2501/998
摘要： A cell proliferation promoter includes, as an active ingredient, an artificially synthesized peptide that includes (A) an amino acid sequence constituting a membrane-permeable peptide and (B) an amino acid sequence selected from SEQ ID NOs: 19 to 103 or an amino acid sequence formed by substituting, deleting and/or adding one or several amino acid residues in the selected amino acid sequence.
摘要翻译：细胞增殖促进剂包括作为活性成分的人造合成肽，其包含（A）构成膜可渗透肽的氨基酸序列和（B）选自SEQ ID NO：19至103的氨基酸序列或氨基酸通过在所选择的氨基酸序列中取代，缺失和/或添加一个或几个氨基酸残基形成的酸序列。

2. 发明申请

US20120208752A1 CELL PROLIFERATION-PROMOTING PEPTIDE AND USE THEREOF 有权
标题翻译：细胞增殖促进肽及其用途
公开(公告)号：US20120208752A1
公开(公告)日：2012-08-16
申请号：US13503220
申请日：2010-10-28
申请人： Tetsuhiko Yoshida , Nahoko Kobayashi , Mikio Niwa , Chikara Shinohara , Masatoki Watanabe , Ken-ichiro Hata
发明人： Tetsuhiko Yoshida , Nahoko Kobayashi , Mikio Niwa , Chikara Shinohara , Masatoki Watanabe , Ken-ichiro Hata
IPC分类号： A61K38/18 , C12P1/00 , C12N5/071 , A61K38/10 , A61K38/08 , A61P17/02 , A61P25/00 , A61P35/00 , A61P27/02 , A61P25/14 , A61P25/16 , A61P17/00 , C12N5/02 , A61P25/28
CPC分类号： C12N5/0662 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/001 , C07K14/475 , C07K2319/10 , C07K2319/21 , C07K2319/23 , C12N5/0018 , C12N2501/998
摘要： A cell proliferation promoter includes, as an active ingredient, an artificially synthesized peptide that includes (A) an amino acid sequence constituting a membrane-permeable peptide and (B) an amino acid sequence selected from SEQ ID NOs: 19 to 103 or an amino acid sequence formed by substituting, deleting and/or adding one or several amino acid residues in the selected amino acid sequence.
摘要翻译：细胞增殖促进剂包括作为活性成分的人造合成肽，其包含（A）构成膜可渗透肽的氨基酸序列和（B）选自SEQ ID NO：19至103的氨基酸序列或氨基酸通过在所选择的氨基酸序列中取代，缺失和/或添加一个或几个氨基酸残基形成的酸序列。

3. 发明授权

US08603967B2 Carrier peptide fragment and use thereof 有权
标题翻译：载体肽片段及其用途
公开(公告)号：US08603967B2
公开(公告)日：2013-12-10
申请号：US13386539
申请日：2010-07-28
申请人： Tetsuhiko Yoshida , Nahoko Kobayashi , Mikio Niwa
发明人： Tetsuhiko Yoshida , Nahoko Kobayashi , Mikio Niwa
IPC分类号： A61K38/04 , C07K7/00
CPC分类号： C07K7/08 , A61K47/6455 , C07K2319/10 , C12N2710/14143
摘要： A method for transferring a foreign substance includes the steps of: preparing a construct for transferring a foreign substance that contains a carrier peptide fragment including either the amino acid sequence KKRTLRKNDRKKR (SEQ ID NO. 1) or an amino acid sequence formed by the substitution, deletion, and/or addition (insertion) of 1, 2, or 3 amino acid residues in the amino acid sequence, and a foreign substance of interest that is bonded to the N-terminus and/or C-terminus of the carrier peptide fragment; supplying the construct for transferring a foreign substance to a test sample that contains a target eukaryotic cell; and incubating the test sample that has been supplied with the construct for transferring a foreign substance to thereby transfer the construct into the eukaryotic cell in the test sample.
摘要翻译：用于转移异物的方法包括以下步骤：制备用于转移含有包含氨基酸序列KKRTLRKNDRKKR（SEQ ID NO.1）或由该取代形成的氨基酸序列的载体肽片段的异物的构建体，缺失和/或添加（插入）氨基酸序列中的1,2或3个氨基酸残基，以及与载体肽片段的N末端和/或C末端键合的目标异源 ; 提供用于将异物转移到含有目标真核细胞的测试样品的构建体; 并将已经提供的用于转移异物的构建物的测试样品孵育，从而将构建体转移到测试样品中的真核细胞中。

4. 发明授权

US08673845B2 Carrier peptide fragment and use thereof 有权
标题翻译：载体肽片段及其用途
公开(公告)号：US08673845B2
公开(公告)日：2014-03-18
申请号：US13386582
申请日：2010-07-28
申请人： Nahoko Kobayashi , Tetsuhiko Yoshida , Mikio Niwa , Kenichi Tanaka
发明人： Nahoko Kobayashi , Tetsuhiko Yoshida , Mikio Niwa , Kenichi Tanaka
IPC分类号： A61K38/02 , A61K38/18 , C12N5/02
CPC分类号： A61K31/366 , A61K31/22 , A61K31/397 , A61K31/40 , A61K45/06 , A61K47/64 , C07K7/06 , A61K2300/00
摘要： The method for transferring a foreign substance provided by the present invention includes the steps of: preparing a construct for transferring a foreign substance that contains a carrier peptide fragment including either the amino acid sequence WRRQARFK (SEQ ID NO. 1) or any amino acid sequence formed by the substitution, deletion, and/or addition (insertion) of 1, 2, or 3 amino acid residues in the amino acid sequence, and a foreign substance of interest that is bonded to the N-terminus and/or C-terminus of the carrier peptide fragment; supplying the construct for transferring a foreign substance to a test sample that contains a target eukaryotic cell; and incubating the test sample that has been supplied with the construct for transferring a foreign substance to thereby transfer the construct into the eukaryotic cell in the test sample.
摘要翻译：由本发明提供的转移异物的方法包括以下步骤：制备含有包含氨基酸序列WRRQARFK（SEQ ID NO.1）或任何氨基酸序列的载体肽片段的异物转移构建体通过氨基酸序列中1,2或3个氨基酸残基的取代，缺失和/或添加（插入）形成，以及与N末端和/或C末端键合的目的异物的载体肽片段; 提供用于将异物转移到含有目标真核细胞的测试样品的构建体; 并将已经提供的用于转移异物的构建物的测试样品孵育，从而将构建体转移到测试样品中的真核细胞中。

5. 发明申请

US20120122210A1 CARRIER PEPTIDE FRAGMENT AND USE THEREOF 有权
标题翻译：载体蛋白片段及其用途
公开(公告)号：US20120122210A1
公开(公告)日：2012-05-17
申请号：US13386539
申请日：2010-07-28
申请人： Tetsuhiko Yoshida , Nahoko Kobayashi , Mikio Niwa
发明人： Tetsuhiko Yoshida , Nahoko Kobayashi , Mikio Niwa
IPC分类号： C12N5/071 , C07K14/00 , C12N5/02
CPC分类号： C07K7/08 , A61K47/6455 , C07K2319/10 , C12N2710/14143
摘要： A method for transferring a foreign substance includes the steps of: preparing a construct for transferring a foreign substance that contains a carrier peptide fragment including either the amino acid sequence KKRTLRKNDRKKR (SEQ ID NO. 1) or an amino acid sequence formed by the substitution, deletion, and/or addition (insertion) of 1, 2, or 3 amino acid residues in the amino acid sequence, and a foreign substance of interest that is bonded to the N-terminus and/or C-terminus of the carrier peptide fragment; supplying the construct for transferring a foreign substance to a test sample that contains a target eukaryotic cell; and incubating the test sample that has been supplied with the construct for transferring a foreign substance to thereby transfer the construct into the eukaryotic cell in the test sample.
摘要翻译：用于转移异物的方法包括以下步骤：制备用于转移含有包含氨基酸序列KKRTLRKNDRKKR（SEQ ID NO.1）或由该取代形成的氨基酸序列的载体肽片段的异物的构建体，缺失和/或添加（插入）氨基酸序列中的1,2或3个氨基酸残基，以及与载体肽片段的N末端和/或C末端键合的目标异源 ; 提供用于将异物转移到含有目标真核细胞的测试样品的构建体; 并将已经提供的用于转移异物的构建物的测试样品孵育，从而将构建体转移到测试样品中的真核细胞中。

6. 发明授权

US09365618B2 Synthetic peptide that induces expression of TNF receptor 2 and use thereof 有权
标题翻译：诱导TNF受体2表达的合成肽及其用途
公开(公告)号：US09365618B2
公开(公告)日：2016-06-14
申请号：US14114010
申请日：2012-04-17
申请人： Nahoko Kobayashi , Tetsuhiko Yoshida , Mikio Niwa
发明人： Nahoko Kobayashi , Tetsuhiko Yoshida , Mikio Niwa
IPC分类号： C07K7/08 , C07K7/06 , C07K14/715 , C07K14/47 , A61K35/12 , A61K38/10 , A61K35/28 , A61K35/26
CPC分类号： C07K7/08 , A61K35/26 , A61K35/28 , A61K38/10 , A61K2035/126 , C07K7/06 , C07K14/4705 , C07K14/7151 , C07K2319/09
摘要： This invention provides a TNFR2 expression-inducing composition including as an active ingredient a peptide having TNFR2 expression-inducing activity, and a method for producing cells that express TNFR2 selectively by use of the composition. The cell production method provided by this invention includes: culturing at least one species of cells capable of expressing TNF receptor 2, and supplying the cells with a synthetic peptide consisting of a nuclear localization signal sequence (NLS) or a nucleolar localization signal sequence (NoLS) to enhance TNFR2 expression in the cells.
摘要翻译：本发明提供一种TNFR2表达诱导组合物，其包含作为活性成分的具有TNFR2表达诱导活性的肽，以及通过使用该组合物选择性地生成表达TNFR2的细胞的方法。本发明提供的细胞制备方法包括：培养能够表达TNF受体2的至少一种细胞，向细胞提供由核定位信号序列（NLS）或核仁定位信号序列（NoLS）组成的合成肽）以增强细胞中TNFR2的表达。

7. 发明申请

US20140051647A1 SYNTHETIC PEPTIDE THAT INDUCES EXPRESSION OF TNF RECEPTOR 2 AND USE THEREOF 有权
标题翻译：诱导TNF受体2表达的合成肽及其用途
公开(公告)号：US20140051647A1
公开(公告)日：2014-02-20
申请号：US14114010
申请日：2012-04-17
申请人： Nahoko Kobayashi , Tetsuhiko Yoshida , Mikio Niwa
发明人： Nahoko Kobayashi , Tetsuhiko Yoshida , Mikio Niwa
IPC分类号： C07K7/08 , C07K7/06
CPC分类号： C07K7/08 , A61K35/26 , A61K35/28 , A61K38/10 , A61K2035/126 , C07K7/06 , C07K14/4705 , C07K14/7151 , C07K2319/09
摘要： This invention provides a TNFR2 expression-inducing composition including as an active ingredient a peptide having TNFR2 expression-inducing activity, and a method for producing cells that express TNFR2 selectively by use of the composition. The cell production method provided by this invention includes: culturing at least one species of cells capable of expressing TNF receptor 2, and supplying the cells with a synthetic peptide consisting of a nuclear localization signal sequence (NLS) or a nucleolar localization signal sequence (NoLS) to enhance TNFR2 expression in the cells.
摘要翻译：本发明提供一种TNFR2表达诱导组合物，其包含作为活性成分的具有TNFR2表达诱导活性的肽，以及通过使用该组合物选择性地生成表达TNFR2的细胞的方法。本发明提供的细胞制备方法包括：培养能够表达TNF受体2的至少一种细胞，向细胞提供由核定位信号序列（NLS）或核仁定位信号序列（NoLS）组成的合成肽）以增强细胞中TNFR2的表达。

8. 发明申请

US20120149053A1 CARRIER PEPTIDE FRAGMENT AND USE THEREOF 审中-公开
标题翻译：载体蛋白片段及其用途
公开(公告)号：US20120149053A1
公开(公告)日：2012-06-14
申请号：US13386585
申请日：2010-07-28
申请人： Tetsuhiko Yoshida , Nahoko Kobayashi , Mikio Niwa , Kenichi Tanaka
发明人： Tetsuhiko Yoshida , Nahoko Kobayashi , Mikio Niwa , Kenichi Tanaka
IPC分类号： C12Q1/02 , C12N15/85 , C07K9/00 , C07K19/00 , C12N5/071 , C07K7/08
CPC分类号： G01N33/5005 , A61K31/7088 , A61K47/64 , A61K47/645 , C07K7/06 , C07K7/08 , C07K14/001 , C07K2319/00
摘要： A method for transferring a foreign substance includes the steps of: preparing a construct for transferring a foreign substance that contains a carrier peptide fragment including any amino acid sequence selected from SEQ ID Nos. 1, 2, 3, 4, 5, and 6, or an amino acid sequence formed by the substitution, deletion, and/or addition (insertion) of 1, 2, or 3 amino acid residues in the amino acid sequence of the selected sequence identification number, and a foreign substance of interest that is bonded to the N-terminus and/or C-terminus of the carrier peptide fragment; supplying the construct for transferring a foreign substance to a test sample that contains a target eukaryotic cell; and incubating the test sample that has been supplied with the construct for transferring a foreign substance to thereby transfer the construct into the eukaryotic cell in the test sample.
摘要翻译：用于转移异物的方法包括以下步骤：制备用于转移含有载体肽片段的异物的构建体，所述载体肽片段包括选自SEQ ID NO：1,2,3,4,5和6的任何氨基酸序列，或通过选择的序列鉴定号的氨基酸序列中1,2或3个氨基酸残基的取代，缺失和/或添加（插入）形成的氨基酸序列，以及被结合的目的异物到载体肽片段的N末端和/或C末端; 提供用于将异物转移到含有目标真核细胞的测试样品的构建体; 并将已经提供的用于转移异物的构建物的测试样品孵育，从而将构建体转移到测试样品中的真核细胞中。

9. 发明申请

US20120122225A1 CARRIER PEPTIDE FRAGMENT AND USE THEREOF 有权
标题翻译：载体蛋白片段及其用途
公开(公告)号：US20120122225A1
公开(公告)日：2012-05-17
申请号：US13386582
申请日：2010-07-28
申请人： Nahoko Kobayashi , Tetsuhiko Yoshida , Mikio Niwa , Kenichi Tanaka
发明人： Nahoko Kobayashi , Tetsuhiko Yoshida , Mikio Niwa , Kenichi Tanaka
IPC分类号： C12N15/85 , C12N5/071 , C07K17/10 , C07K17/00 , C07K19/00
CPC分类号： A61K31/366 , A61K31/22 , A61K31/397 , A61K31/40 , A61K45/06 , A61K47/64 , C07K7/06 , A61K2300/00
摘要： The method for transferring a foreign substance provided by the present invention includes the steps of: preparing a construct for transferring a foreign substance that contains a carrier peptide fragment including either the amino acid sequence WRRQARFK (SEQ ID NO. 1) or any amino acid sequence formed by the substitution, deletion, and/or addition (insertion) of 1, 2, or 3 amino acid residues in the amino acid sequence, and a foreign substance of interest that is bonded to the N-terminus and/or C-terminus of the carrier peptide fragment; supplying the construct for transferring a foreign substance to a test sample that contains a target eukaryotic cell; and incubating the test sample that has been supplied with the construct for transferring a foreign substance to thereby transfer the construct into the eukaryotic cell in the test sample.
摘要翻译：由本发明提供的转移异物的方法包括以下步骤：制备含有包含氨基酸序列WRRQARFK（SEQ ID NO.1）或任何氨基酸序列的载体肽片段的异物转移构建体通过氨基酸序列中1,2或3个氨基酸残基的取代，缺失和/或添加（插入）形成，以及与N末端和/或C末端键合的目的异物的载体肽片段; 提供用于将异物转移到含有目标真核细胞的测试样品的构建体; 并将已经提供的用于转移异物的构建物的测试样品孵育，从而将构建体转移到测试样品中的真核细胞中。

10. 发明申请

US20090253618A1 NEURONAL DIFFERENTIATION-INDUCING PEPTIDE AND USE THEREOF 审中-公开
标题翻译：神经元差异诱导肽及其用途
公开(公告)号：US20090253618A1
公开(公告)日：2009-10-08
申请号：US11996207
申请日：2006-07-20
申请人： Hiroshi Kanno , Tetsuhiko Yoshida , Nahoko Kobayashi
发明人： Hiroshi Kanno , Tetsuhiko Yoshida , Nahoko Kobayashi
IPC分类号： A61K38/16 , C12N5/08 , C07K14/00
CPC分类号： C07K14/4703 , A61K38/00
摘要： A neuronal differentiation inducer comprising at least one peptide which can induce the differentiation of at least one cell into a neurocyte. The peptide is an artificially synthesized peptide comprising an amino acid sequence derived from a BC-box of at least one protein belonging to the SOCS protein family or an amino acid sequence having a partial modification in the BC-box-derived amino acid sequence, wherein the BC-box-derived amino acid sequence is composed of at least 10 contiguous amino acid residues selected in the amino acid sequence constituting the BC-box.
摘要翻译：一种神经元分化诱导剂，其包含至少一种能诱导至少一种细胞分化为神经细胞的肽。肽是人造合成的肽，其包含衍生自属于SOCS蛋白家族的至少一种蛋白质的BC盒的氨基酸序列或在BC-盒衍生的氨基酸序列中具有部分修饰的氨基酸序列，其中 BC盒衍生的氨基酸序列由在构成BC盒的氨基酸序列中选择的至少10个连续氨基酸残基组成。

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