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31. 发明授权

US07529584B2 Pacing method 有权
标题翻译：起搏方式
公开(公告)号：US07529584B2
公开(公告)日：2009-05-05
申请号：US10782420
申请日：2004-02-19
申请人： Timothy G. Laske , Paul A. Iaizzo
发明人： Timothy G. Laske , Paul A. Iaizzo
IPC分类号： A61N1/362
CPC分类号： A61N1/056 , A61N1/0573
摘要： A method for delivering physiological pacing includes selecting an electrode implant site within an interventricular septal zone, which is in proximity to the bundle of His where pacing stimulation results in a rhythm breaking out at an intrinsic location, and wherein a ratio of sensed P-wave amplitude to sensed R-wave amplitude is less than approximately 0.5 and a pacing threshold is less than or equal to approximately 1.5 volts.
摘要翻译：用于递送生理起搏的方法包括选择室间隔区内的电极植入部位，所述间隔隔膜区域靠近His束，其中起搏刺激导致在固有位置处破裂的节律，并且其中感测的P波的比率幅度到感测的R波幅度小于约0.5，起搏阈值小于或等于约1.5伏。

32. 发明授权

US07251532B2 Medical lead fixation 有权
标题翻译：医用铅固定
公开(公告)号：US07251532B2
公开(公告)日：2007-07-31
申请号：US10688229
申请日：2003-10-17
申请人： Douglas N. Hess , Nicolaas M. Lokhoff , Michael A. Ruff , Richard D. Sandstrom , Timothy G. Laske
发明人： Douglas N. Hess , Nicolaas M. Lokhoff , Michael A. Ruff , Richard D. Sandstrom , Timothy G. Laske
IPC分类号： A61N1/05
CPC分类号： A61N1/0575 , A61N1/0565
摘要： A distal tip coupled to a body of an implantable medical device includes a canted passageway extending distally from a lumen of the body and an opening terminating the passageway and positioned in proximity to a distal end of the distal tip; a helical fixation element coupled to an elongated member extending within the lumen of the body is adapted to deflect along the canted passageway of the distal tip. The elongated member is adapted to move the helical member through the passageway of the distal tip and out from the opening and to rotate the helical element thereby affixing the helical element into an implant site.
摘要翻译：联接到可植入医疗装置的主体的远侧末端包括从主体的内腔向远端延伸的倾斜通道和终止该通道并且定位在远侧末端的远端附近的开口; 耦合到在主体的内腔内延伸的细长构件的螺旋固定元件适于沿着远端尖端的倾斜通道偏转。细长构件适于将螺旋构件移动通过远侧尖端的通道并从开口移出并旋转螺旋元件，从而将螺旋元件固定到植入位置。

33. 发明授权

US06868291B1 Arrangement for implanting an endocardial cardiac lead 有权
标题翻译：用于植入心内膜心脏铅的装置
公开(公告)号：US06868291B1
公开(公告)日：2005-03-15
申请号：US09699865
申请日：2000-10-30
申请人： Matthew D. Bonner , Timothy G. Laske
发明人： Matthew D. Bonner , Timothy G. Laske
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61M25/0043 , A61M25/01 , A61N2001/0578
摘要： An arrangement for introducing and implanting the electrode(s) of an endocardial implantable cardiac lead at a cardiac implantation site within a heart chamber or vessel. An elongated guide body formed of flexible material and extending between a guide body proximal end and a guide body distal end is advanced transvenously to position the guide body distal end in relation to the cardiac implantation site. Guide body tracking means is coupled with the lead distal end for receiving and slidingly engaging the guide body to allow the cardiac lead to be advanced along the guide body until the electrode is positioned at the cardiac implantation site. Pusher means formed of an elongated pusher body of flexible material extends between a pusher body proximal end and a pusher body distal end and has a cardiac lead engaging means for engaging the cardiac lead at or adjacent the distal lead end. The pusher body has sufficient column strength to be advanced alongside the guide body and lead body with the cardiac lead engaging means engaging and slidingly advancing the guide body tracking means and the cardiac lead distally along the guide body to thereby allow the cardiac lead to be advanced along the guide body until the electrode is positioned at the cardiac implantation site. The lead body is released from the lead engaging means and fixed, if the lead includes a fixation mechanism. The pusher means is retracted by retraction of the pusher body.
摘要翻译：用于在心室或血管内的心脏植入部位处引入和植入心内可植入心脏引线的电极的装置。由柔性材料形成并在引导体近端和引导体远端之间延伸的细长引导体相对于心脏植入部位传递推进以引导体远端。引导体跟踪装置与引线远端联接，用于接收和滑动地接合引导体，以允许心脏引导沿引导体前进，直到电极定位在心脏植入部位。由细长的柔性材料推动器构成的推动器装置在推动器本体近端和推动器主体远端之间延伸，并且具有心脏引线接合装置，用于在远侧引线端处或与其相邻的心脏引线接合。推动器主体具有足够的柱强度，以使引导体和引线体沿着引导体接合装置前进，引导体跟踪装置和心引导件沿引导体向远侧滑动，从而允许心导线前进沿着引导体直到电极位于心脏植入部位。如果引线包括固定机构，则引线体从引线接合装置释放并固定。推动器装置通过推动器主体的缩回缩回。

34. 发明授权

US06671550B2 System and method for determining location and tissue contact of an implantable medical device within a body 有权
公开(公告)号：US06671550B2
公开(公告)日：2003-12-30
申请号：US09953485
申请日：2001-09-14
申请人： Paul A. Iaizzo , Timothy G. Laske
发明人： Paul A. Iaizzo , Timothy G. Laske
IPC分类号： A61N1362
CPC分类号： A61B5/06 , A61B8/0833 , A61N1/056
摘要： The current invention provides an improved system for monitoring status of an IMD within a body. The system includes a device such as a lead, guidewire, stylet, catheter, or other IMD carrying a device such as a microphone for detecting acoustic signals in the body. The IMD is coupled to an amplifier device which generates an audible signal that may be utilized to determine status associated with the IMD, including location and tissue-contact data. A processing circuit may further be provided to aid in the analysis of the acoustic data.

35. 发明授权

US6038463A Medical electrical lead 失效
标题翻译：医用电线
公开(公告)号：US6038463A
公开(公告)日：2000-03-14
申请号：US938238
申请日：1997-09-26
申请人： Timothy G. Laske , Jon M. Ocel
发明人： Timothy G. Laske , Jon M. Ocel
IPC分类号： A61N1/05 , A61B5/042
CPC分类号： A61N1/056 , A61N1/0565 , A61N2001/058
摘要： An implantable electrical lead of the type having a rigid, insulative electrode head carrying an advanceable helical electrode. The electrode head is mounted to an elongated insulative lead body less rigid than said electrode head and which carries an extensible conductor coupled to the helical electrode and an inextensible conductor mechanically coupled to the proximal end of the lead. A second electrode is mounted to said lead body adjacent the electrode head and is coupled to the inextensible conductor. The inextensible electrical conductor is mechanically coupled to the electrode head such that poximally directed traction forces applied to the proximal end of the lead body are applied to the head by the inextensible conductor and not by the second electrode.
摘要翻译：该类型的可植入电引线具有承载可前进螺旋电极的刚性绝缘电极头。电极头安装到比所述电极头刚性较小的细长绝缘引线体，并且其具有耦合到螺旋电极的可延伸导体和机械耦合到引线的近端的不可伸展的导体。第二电极安装到邻近电极头的所述引线体上，并且连接到不可伸展的导体。不可伸展的电导体机械耦合到电极头，使得施加到引线主体的近端的近似引导的牵引力通过不可伸展的导体而不是由第二电极施加到头部。

36. 发明授权

US5843141A Medical lead connector system 失效
标题翻译：医用铅连接器系统
公开(公告)号：US5843141A
公开(公告)日：1998-12-01
申请号：US846008
申请日：1997-04-25
申请人： Thomas C. Bischoff , Bonner D. Bonner , Timothy G. Laske , Andrew J. Ries , John L. Sommer
发明人： Thomas C. Bischoff , Bonner D. Bonner , Timothy G. Laske , Andrew J. Ries , John L. Sommer
IPC分类号： A61N1/05 , A61N1/375 , H01R13/52 , A61N1/372
CPC分类号： H01R13/5224 , A61N1/3752
摘要： An implantable medical device system including an implantable electronic device having multiple electrical connectors and an associated electrical lead also having a corresponding set of electrical connectors which engage with the connectors on the device. The lead has a connector assembly mounted to its proximal end, including the lead's electrical connectors and a mechanical connector. The device has a connector block with a bore extending therethrough sized to receive the connector assembly of the lead. A pulling tool is provided for pulling the lead connector assembly proximally in the bore of said connector block from a first position in which the lead's connector assembly is not fully inserted in the connector block to a second position in which said connector assembly is fully inserted in the connector block, the pulling tool being provided with a mechanical connector which engages with mechanical connector on the lead's connector assembly.
摘要翻译：一种可植入式医疗装置系统，其包括具有多个电连接器的可植入电子装置和相关联的电引线，该电引线还具有与装置上的连接器接合的对应的一组电连接器。引线具有安装到其近端的连接器组件，包括引线的电连接器和机械连接器。该装置具有连接器块，其具有延伸穿过其中的孔，其尺寸适于接纳引线的连接器组件。提供一种牵引工具，用于将导线连接器组件向近侧拉动在所述连接器块的孔中，从第一位置将导线的连接器组件未完全插入连接器块中的第二位置到第二位置，在第二位置，所述连接器组件完全插入连接器块，拉动工具设置有机械连接器，其与引线的连接器组件上的机械连接器接合。

37. 发明授权

US5578068A Medical electrical lead with radially asymmetric tip 失效
标题翻译：医用电线带径向不对称尖端
公开(公告)号：US5578068A
公开(公告)日：1996-11-26
申请号：US437460
申请日：1995-05-08
申请人： Timothy G. Laske , Gioi T. Tran
发明人： Timothy G. Laske , Gioi T. Tran
IPC分类号： A61N1/05
CPC分类号： A61N1/0565 , A61N1/056
摘要： A medical electrical lead with an elongated lead body containing an elongated conductor and carrying a tip electrode mounted to and extending the distal tip of the lead body, coupled to the conductor. The distal tip of the lead body includes flange portions extending radially outward from a point immediately adjacent to the electrode and flat portions extending longitudinally and proximally from the electrode. The flange portions and flat portions alternate around the circumference of the lead body tip.
摘要翻译：一种具有细长引线体的医用电引线，其包含细长的导体，并且携带安装到引线主体的远端并延伸并连接到导体的尖端电极。引线主体的远端包括从紧邻电极的点径向向外延伸的凸缘部分和从电极纵向和近端延伸的平坦部分。凸缘部分和平坦部分围绕引线主体末端的圆周交替。

38. 发明授权

US09468754B2 Leads for selective sensing and virtual electrodes 有权
标题翻译：引领选择性感应和虚拟电极
公开(公告)号：US09468754B2
公开(公告)日：2016-10-18
申请号：US12474645
申请日：2009-05-29
申请人： Gonzalo Martinez , Timothy G. Laske , Mark T. Marshall
发明人： Gonzalo Martinez , Timothy G. Laske , Mark T. Marshall
IPC分类号： A61N1/05
CPC分类号： A61N1/0563 , A61B5/042 , A61N1/0534 , A61N1/0541 , A61N1/056
摘要： Selective sensing implantable medical leads include pulsing and sensing portions and pulsing and not sensing portion. Leads and electrodes may be used in defibrillation and as integrated bipolar defibrillation electrodes. An entire electrode can pass charge while a valve metal or valve metal oxide portion of the electrode prevents the entire electrode from sensing, effectively rejecting unwanted signals. Differential conduction pathways, due to the valve metal and/or oxides thereof, cause the portions of the electrodes to conduct differently when used anodically and cathodically. Complex intracardiac electrical gradient can be formed along with a number of virtual electrodes within the tissue. Reentrant loops can thereby be pinned following defibrillation shock.
摘要翻译：选择性感测可植入医疗引线包括脉冲和感测部分以及脉冲和不感测部分。引线和电极可用于除颤和作为集成的双极除颤电极。整个电极可以通过电荷，同时电极的阀金属或阀金属氧化物部分防止整个电极感测，有效地排除不需要的信号。由于阀门金属和/或其氧化物导致的差动传导路径导致当阳极和阴极使用时，电极的部分不同地传导。可以与组织内的多个虚拟电极一起形成复杂的心内电梯度。因此，除颤休克后可以固定可重入环。

39. 发明授权

US09320871B2 Systems and methods for variable injection flow 有权
公开(公告)号：US09320871B2
公开(公告)日：2016-04-26
申请号：US13409875
申请日：2012-03-01
申请人： Regina E. Groves , Jean-Pierre Lalonde , Timothy G. Laske , Claudia Lueckge , Dan Wittenberger , Ramin Sabbaghe-Kermani , Mahmoud Kabir-Seraj
发明人： Regina E. Groves , Jean-Pierre Lalonde , Timothy G. Laske , Claudia Lueckge , Dan Wittenberger , Ramin Sabbaghe-Kermani , Mahmoud Kabir-Seraj
IPC分类号： A61B18/02 , A61M25/00 , A61M39/28 , A61M39/22 , A61M25/01 , A61B18/00
CPC分类号： A61B18/02 , A61B18/0218 , A61B2018/00023 , A61B2018/00095 , A61B2018/00101 , A61B2018/00202 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268 , A61M25/0029 , A61M25/007 , A61M39/22 , A61M39/28 , A61M2025/0025 , A61M2025/0079 , A61M2025/0175 , Y10T137/0318
摘要： Systems and methods for controllably variable fluid flow are disclosed that provide the ability to modify the effective cross-sectional area of the fluid delivery conduit available for fluid flow. Accordingly, selective control of these configurations allows fluid flow to be regulated as desired while the fluid delivery pressure remains the same. Additional configurations provided herein allow for the selective manipulation of a footprint or therapeutic pattern achievable with the medical device during a single procedure, negating the need for the removal and insertion of multiple devices to achieve the same variations in treatment geometry or characteristics.

40. 发明授权

US08685077B2 Delivery systems and methods of implantation for prosthetic heart valves 有权
标题翻译：用于假体心脏瓣膜的输送系统和植入方法
公开(公告)号：US08685077B2
公开(公告)日：2014-04-01
申请号：US13420101
申请日：2012-03-14
申请人： Timothy G. Laske , Timothy R. Ryan , Carolyn C. Majkrzak , Eliot Bloom , Charles Tabor
发明人： Timothy G. Laske , Timothy R. Ryan , Carolyn C. Majkrzak , Eliot Bloom , Charles Tabor
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2403 , A61F2/2412 , A61F2/243 , A61F2/2436 , A61F2/82 , A61F2002/9505 , A61F2002/9511 , A61F2250/0098
摘要： A delivery system with sequential release mechanism and method of delivering and deploying an implantable stented device into a body lumen including a tabular body, a plurality of activation members extending from the distal end of the tubular body, and a plurality of disks. Each disk includes a proximal and distal surface, at least one stent engagement element attached to the distal surface of the disk and at least one aperture. At least one activation member attaches to the proximal surface of a first disk and at least one activation member passes through an aperture of the first disk and attaches to the proximal surface of a second disk. At least one stent engagement element attached to the distal surface of the first disk passes through an aperture of the second disk. Axially movement of the activation members causes sequential release of the stent engagement elements from a stented device.
摘要翻译：具有顺序释放机构的递送系统和将可植入支架装置递送和展开到体腔内的方法，该体腔包括片状体，从管状体的远端延伸的多个致动构件和多个盘。每个盘包括近端和远端表面，至少一个支架接合元件附接到盘的远端表面和至少一个孔。至少一个激活构件附接到第一盘的近侧表面，并且至少一个激活构件穿过第一盘的孔并附接到第二盘的近侧表面。附接到第一盘的远端表面的至少一个支架接合元件通过第二盘的孔。致动构件的轴向移动导致支架接合元件从支架装置的顺序释放。

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