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1. 发明授权

US08019437B2 Lead fixation means 有权
标题翻译：铅固定方式
公开(公告)号：US08019437B2
公开(公告)日：2011-09-13
申请号：US10772989
申请日：2004-02-05
申请人： Paul A. Iaizzo , Timothy G. Laske
发明人： Paul A. Iaizzo , Timothy G. Laske
IPC分类号： A61N1/04
CPC分类号： A61N1/057 , A61B5/042 , A61B5/6882 , A61B2018/00273
摘要： A medical electrical lead includes a glue segment to adhere the lead to a treatment site. The glue segment, which may be disposed within a tip electrode of the lead, includes tissue adhesive which may encapsulated within a capsule.
摘要翻译：医用电引线包括将引线粘附到治疗部位的胶粘部分。可以设置在引线的尖端电极内的胶合部分包括可以封装在胶囊内的组织粘合剂。

2. 发明授权

US07045279B1 Isolated perfused heart preparation and method of use 有权
标题翻译：分离灌注心脏准备及使用方法
公开(公告)号：US07045279B1
公开(公告)日：2006-05-16
申请号：US09419271
申请日：1999-10-15
申请人： Timothy G. Laske , Paul A. Iaizzo , Mark A. Hjelle , Josée Morissette , Dale A. Wahlstrom
发明人： Timothy G. Laske , Paul A. Iaizzo , Mark A. Hjelle , Josée Morissette , Dale A. Wahlstrom
IPC分类号： C12N5/00
CPC分类号： A01N1/02 , A01N1/0247 , Y10T436/108331
摘要： An isolated heart preparation in which essentially normal pumping activity of all four chambers of the heart is preserved, allowing for the use of the preparation in conjunction with investigations of electrode leads, catheters, cardiac implants and other medical devices intended to be used in or on a beating heart. The preparation may also be employed to investigate heart functions, in the presence or absence of such medical devices. In order to allow for visualization of heart structures and devices located within the chambers of the heart, a clear perfusate such as a modified Krebs buffer solution with oxygenation is circulated through all four chambers of the heart and the coronary vasculature. The preparation and recordings of the preparation may be used in conjunction with the design, development and evaluation of devices for use in or on the heart, as well as for use as an investigational and teaching aid to assist physicians and students in understanding the operation of the heart.
摘要翻译：一种分离的心脏制剂，其中保留了心脏所有四个腔室的基本上正常的泵送活性，允许使用该制剂与电极引线，导管，心脏植入物和旨在用于或在其上使用的其它医疗装置一个跳动的心脏在存在或不存在这样的医疗装置的情况下，该制剂也可用于研究心脏功能。为了允许位于心脏腔室内的心脏结构和装置的可视化，清洁的灌注液（例如具有氧合作用的改良的克雷伯斯缓冲溶液）通过心脏和冠状动脉脉管系统的所有四个腔室循环。制剂的准备和记录可以与在心脏或心脏上使用的装置的设计，开发和评估结合使用，以及用作调查和教学辅助以帮助医师和学生理解操作心脏

3. 发明授权

US08332035B2 Pacing method 有权
标题翻译：起搏方式
公开(公告)号：US08332035B2
公开(公告)日：2012-12-11
申请号：US12435987
申请日：2009-05-05
申请人： Paul A. Iaizzo , Timothy G. Laske
发明人： Paul A. Iaizzo , Timothy G. Laske
IPC分类号： A61N1/362
CPC分类号： A61N1/056 , A61N1/0573
摘要： A method for delivering physiological pacing includes selecting an electrode implant site for sensing cardiac signals, which is in proximity to the heart's intrinsic conduction system, where pacing stimulation results in a rhythm breaking out at an intrinsic location, and selected in response to a ratio of sensed P-wave amplitude to sensed R-wave amplitude.
摘要翻译：用于递送生理起搏的方法包括选择用于感测心脏信号的电极植入部位，该心脏信号位于心脏的本征传导系统附近，其中起搏刺激导致在内在位置处的节律破裂，并且响应于感测到的P波幅度到感测到的R波幅度。

4. 发明申请

US20090276000A1 PACING METHOD 有权
标题翻译： PACING方法
公开(公告)号：US20090276000A1
公开(公告)日：2009-11-05
申请号：US12435987
申请日：2009-05-05
申请人： Paul A. Iaizzo , Timothy G. Laske
发明人： Paul A. Iaizzo , Timothy G. Laske
IPC分类号： A61N1/362
CPC分类号： A61N1/056 , A61N1/0573
摘要： A method for delivering physiological pacing includes selecting an electrode implant site for sensing cardiac signals, which is in proximity to the heart's intrinsic conduction system, where pacing stimulation results in a rhythm breaking out at an intrinsic location, and selected in response to a ratio of sensed P-wave amplitude to sensed R-wave amplitude.
摘要翻译：用于递送生理起搏的方法包括选择用于感测心脏信号的电极植入部位，该心脏信号位于心脏的本征传导系统附近，其中起搏刺激导致在内在位置处的节律破裂，并且响应于感测到的P波幅度到感测到的R波幅度。

5. 发明授权

US07529584B2 Pacing method 有权
标题翻译：起搏方式
公开(公告)号：US07529584B2
公开(公告)日：2009-05-05
申请号：US10782420
申请日：2004-02-19
申请人： Timothy G. Laske , Paul A. Iaizzo
发明人： Timothy G. Laske , Paul A. Iaizzo
IPC分类号： A61N1/362
CPC分类号： A61N1/056 , A61N1/0573
摘要： A method for delivering physiological pacing includes selecting an electrode implant site within an interventricular septal zone, which is in proximity to the bundle of His where pacing stimulation results in a rhythm breaking out at an intrinsic location, and wherein a ratio of sensed P-wave amplitude to sensed R-wave amplitude is less than approximately 0.5 and a pacing threshold is less than or equal to approximately 1.5 volts.
摘要翻译：用于递送生理起搏的方法包括选择室间隔区内的电极植入部位，所述间隔隔膜区域靠近His束，其中起搏刺激导致在固有位置处破裂的节律，并且其中感测的P波的比率幅度到感测的R波幅度小于约0.5，起搏阈值小于或等于约1.5伏。

6. 发明授权

US06671550B2 System and method for determining location and tissue contact of an implantable medical device within a body 有权
公开(公告)号：US06671550B2
公开(公告)日：2003-12-30
申请号：US09953485
申请日：2001-09-14
申请人： Paul A. Iaizzo , Timothy G. Laske
发明人： Paul A. Iaizzo , Timothy G. Laske
IPC分类号： A61N1362
CPC分类号： A61B5/06 , A61B8/0833 , A61N1/056
摘要： The current invention provides an improved system for monitoring status of an IMD within a body. The system includes a device such as a lead, guidewire, stylet, catheter, or other IMD carrying a device such as a microphone for detecting acoustic signals in the body. The IMD is coupled to an amplifier device which generates an audible signal that may be utilized to determine status associated with the IMD, including location and tissue-contact data. A processing circuit may further be provided to aid in the analysis of the acoustic data.

7. 发明授权

US06714806B2 System and method for determining tissue contact of an implantable medical device within a body 有权
标题翻译：用于确定体内可植入医疗装置的组织接触的系统和方法
公开(公告)号：US06714806B2
公开(公告)日：2004-03-30
申请号：US09952869
申请日：2001-09-14
申请人： Paul A. Iaizzo , Timothy G. Laske , Woohyek Choi
发明人： Paul A. Iaizzo , Timothy G. Laske , Woohyek Choi
IPC分类号： A61B504
CPC分类号： A61B5/053 , A61B5/05 , A61N1/056 , A61N1/0573
摘要： An improved system for monitoring the status of an IMD such as a medical electrical lead during an implant procedure is provided. The system includes a signal generator for supplying a first signal such as a constant current or voltage to the IMD. A resulting voltage or current signal is generated, respectively, and may be sensed as an indication of the impedance of a portion of the body that is proximal to one or more electrodes carried by the lead. This impedance indication is converted to an audible signal having a frequency that is proportional to the amplitude of the impedance indication. The pitch of the audible signal therefore rises when measured impedance increases, and drops as the impedance decreases. These pitch changes allow a user to determine positional information associated with the IMD, including the degree of lead tissue contact and extent of fixation of a device to tissue.
摘要翻译：提供了一种改进的系统，用于在植入过程期间监视诸如医疗电线之类的IMD的状态。该系统包括用于向IMD提供诸如恒定电流或电压的第一信号的信号发生器。分别产生所得到的电压或电流信号，并且可以将其感测为身体接近于由引线承载的一个或多个电极的部分的阻抗的指示。该阻抗指示被转换成具有与阻抗指示的幅度成比例的频率的可听信号。因此，当测量的阻抗增加时，听觉信号的音调会上升，并随着阻抗的降低而下降。这些间距变化允许用户确定与IMD相关联的位置信息，包括铅组织接触的程度和装置固定到组织的程度。

8. 发明授权

US09610423B2 Sleeve valve catheters 有权
公开(公告)号：US09610423B2
公开(公告)日：2017-04-04
申请号：US13486523
申请日：2012-06-01
申请人： Mary M. Morris , Timothy G. Laske , Kenneth T. Heruth , Michael R. Ujhelyi , Jesus W. Casas , David S. Olson
发明人： Mary M. Morris , Timothy G. Laske , Kenneth T. Heruth , Michael R. Ujhelyi , Jesus W. Casas , David S. Olson
IPC分类号： A61M1/00 , A61M25/00
CPC分类号： A61M25/0075
摘要： A catheter body includes an exit port over which a pressure responsive sleeve is formed that allows material to exit a lumen of the catheter body at a given pressure. In one embodiment, a surface of the sleeve is approximately flush with a surface of the catheter body.

9. 发明授权

US09352121B2 Systems and methods for variable injection flow 有权
公开(公告)号：US09352121B2
公开(公告)日：2016-05-31
申请号：US13409646
申请日：2012-03-01
申请人： Regina E. Groves , Jean-Pierre Lalonde , Timothy G. Laske , Claudia Lueckge , Dan Wittenberger , Ramin Sabbaghe-Kermani , Mahmoud Kabir-Seraj
发明人： Regina E. Groves , Jean-Pierre Lalonde , Timothy G. Laske , Claudia Lueckge , Dan Wittenberger , Ramin Sabbaghe-Kermani , Mahmoud Kabir-Seraj
IPC分类号： A61B18/02 , A61M25/00 , A61M39/28 , A61M39/22 , A61M25/01 , A61B18/00
CPC分类号： A61B18/02 , A61B18/0218 , A61B2018/00023 , A61B2018/00095 , A61B2018/00101 , A61B2018/00202 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61B2018/0268 , A61M25/0029 , A61M25/007 , A61M39/22 , A61M39/28 , A61M2025/0025 , A61M2025/0079 , A61M2025/0175 , Y10T137/0318
摘要： Systems and methods for controllably variable fluid flow are disclosed that provide the ability to modify the effective cross-sectional area of the fluid delivery conduit available for fluid flow. Accordingly, selective control of these configurations allows fluid flow to be regulated as desired while the fluid delivery pressure remains the same. Additional configurations provided herein allow for the selective manipulation of a footprint or therapeutic pattern achievable with the medical device during a single procedure, negating the need for the removal and insertion of multiple devices to achieve the same variations in treatment geometry or characteristics.

10. 发明授权

US09345528B2 Large area cryoablation catheter with multi-geometry tip ECG/CRYO mapping capabilities 有权
标题翻译：大面积冷冻消融导管具有多重几何尖端ECG / CRYO映射功能
公开(公告)号：US09345528B2
公开(公告)日：2016-05-24
申请号：US13360379
申请日：2012-01-27
申请人： Timothy G. Laske , Claudia Lueckge , Réal Ste-Marie
发明人： Timothy G. Laske , Claudia Lueckge , Réal Ste-Marie
IPC分类号： A61B18/04 , A61B18/02 , A61B18/14 , A61B17/32 , A61B18/18 , A61B18/00
CPC分类号： A61B18/02 , A61B17/320068 , A61B18/1492 , A61B18/1815 , A61B2018/00101 , A61B2018/00196 , A61B2018/00357 , A61B2018/00577 , A61B2018/00613 , A61B2018/0212 , A61B2018/0262 , A61B2018/1407 , A61B2090/0463 , F04C2270/041
摘要： A medical device including an ablation element. A thermally insulative sheath is included disposed within the ablation element. A fluid injection tube is disposed within a portion of the thermally insulative sheath. The ablation element passively transitions from a substantially linear geometric configuration to a substantially circular geometric configuration as the sheath is retracted proximally from a first position in which the sheath substantially encloses the fluid injection tube to a second position in which a portion of the fluid injection tube extends a distance away from the sheath.
摘要翻译：包括消融元件的医疗装置。包括设置在消融元件内的绝热护套。流体注入管设置在绝热护套的一部分内。当护套从第一位置向近侧缩回时，消融元件从基本线性的几何构型被无源地过渡到基本上圆形的几何构型，其中鞘基本上包围流体注入管到第二位置，在第二位置，一部分流体注入管距离护套延伸一段距离。

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