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31. 发明申请

US20080285823A1 Device for Imaging an Interior of a Turbid Medium 审中-公开
标题翻译：用于成像混浊介质内部的装置
公开(公告)号：US20080285823A1
公开(公告)日：2008-11-20
申请号：US12094641
申请日：2006-11-13
申请人： Levinus Pieter Bakker , Michael Cornelis Van Beek , Martinus Bernardus Van Der Mark
发明人： Levinus Pieter Bakker , Michael Cornelis Van Beek , Martinus Bernardus Van Der Mark
IPC分类号： G06K9/00
CPC分类号： G01N21/4795 , A61B5/0091 , G01N21/6456 , G01N2021/1787 , G01N2021/6421
摘要： The invention relates to a device (1) for imaging an interior of a turbid medium (25). The device (1) may be used to accommodate a turbid medium (25) inside a measurement volume (20) and irradiate the turbid medium (25) with light from a light source (5), after which light emanating from the measurement volume (20) is detected and used to determine an image of the interior of the turbid medium (25). The device (1) is adapted such that additional means are introduced for irradiating the turbid medium (25) with light causing fluorescent emission in a contrast agent present in the turbid medium (25), for detecting the fluorescent emission in at least two spectral regions, and for calculating an image reconstruction for the at least two spectral regions detected. By detecting the fluorescent emission spectroscopically, that is as a function of wavelength, information can be obtained from which the concentration of a predetermined component present inside the turbid medium can be determined.
摘要翻译：本发明涉及一种用于对浑浊介质（25）的内部进行成像的装置（1）。装置（1）可以用于容纳测量体积（20）内部的混浊介质（25），并用来自光源（5）的光照射混浊介质（25），之后从测量体积 20）被检测并用于确定混浊介质（25）内部的图像。装置（1）适于使得附加装置被引入以用在浑浊介质（25）中存在的造影剂中引起荧光发射的光照射混浊介质，用于检测至少两个光谱区域中的荧光发射并且用于计算所检测的所述至少两个光谱区域的图像重建。通过检测荧光发射光谱，即作为波长的函数，可以获得可以确定存在于混浊介质内的预定成分的浓度的信息。

32. 发明授权

US11422308B2 Tip reflection reduction for shape-sensing optical fiber 有权
公开(公告)号：US11422308B2
公开(公告)日：2022-08-23
申请号：US13981933
申请日：2012-01-24
申请人： Martinus Bernardus Van Der Mark , Raymond Chan , Robert Manzke , Gert Wim 'T Hooft
发明人： Martinus Bernardus Van Der Mark , Raymond Chan , Robert Manzke , Gert Wim 'T Hooft
IPC分类号： G02B6/24 , A61B5/06 , G02B6/26 , A61B1/00 , A61B34/20
摘要： A reflection reduction device includes an optical fiber (104) configured for optical sensing and having an end portion. A tip portion (102) is coupled to the end portion. The tip portion includes a length dimension (d) and is index matched to the optical fiber. The tip portion is further configured to include an absorption length to absorb and scatter light within the length dimension, and a surface (S) opposite the end portion is configured to reduce back reflections.

33. 发明授权

US09050425B2 Magnetic coupling for aerosol generating apparatus 有权
标题翻译：用于气溶胶发生装置的磁耦合
公开(公告)号：US09050425B2
公开(公告)日：2015-06-09
申请号：US13521292
申请日：2010-12-08
申请人： Martinus Bernardus Van Der Mark
发明人： Martinus Bernardus Van Der Mark
IPC分类号： A61M11/00 , A61M15/00 , B05B17/06 , B05B17/00 , B65D83/14 , A61M16/00
CPC分类号： A61M15/001 , A61M11/00 , A61M11/005 , A61M15/00 , A61M15/0001 , A61M15/0005 , A61M15/0021 , A61M15/0085 , A61M2016/0021 , A61M2205/0272 , A61M2205/12 , A61M2205/14 , A61M2205/502 , A61M2205/52 , A61M2205/581 , A61M2205/8206 , B05B17/06 , B05B17/0607 , B05B17/0646 , B65D83/75 , B65D83/752
摘要： An apparatus (e.g., nebulizer) for aerosol delivery of a substance (e.g., a drug to a patient) has a mouthpiece (36); a chamber (34) holding a substance; a flexible membrane (38) having a plurality of apertures; and a vibrator (20) for vibrating the flexible membrane to form a flow of aerosol droplets of the substance that are ejected through the apertures and to the mouthpiece. The vibrator may be a piezoelectric element. A magnetic member (54) is provided on the flexible membrane and is configured to magnetically couple the flexible membrane to the vibrator. The magnetic member allows replacement of the membrane, without wasting the piezoelectric element.
摘要翻译：用于气溶胶递送物质（例如，药物到患者）的装置（例如雾化器）具有口件（36）; 容纳物质的室（34）; 具有多个孔的柔性膜（38）; 以及振动器（20），用于振动所述柔性膜以形成通过所述孔和所述口件喷射的物质的气溶胶液滴流。振动器可以是压电元件。磁性构件（54）设置在柔性膜上，并且构造成将柔性膜磁耦合到振动器。磁性部件允许更换膜，而不浪费压电元件。

34. 发明授权

US09050424B2 Magnetic coupling for aerosol generating apparatus 有权
标题翻译：用于气溶胶发生装置的磁耦合
公开(公告)号：US09050424B2
公开(公告)日：2015-06-09
申请号：US13521283
申请日：2010-12-08
申请人： Martinus Bernardus Van Der Mark
发明人： Martinus Bernardus Van Der Mark
IPC分类号： A61M11/00 , A61M15/00 , B05B17/06 , B05B17/00 , B65D83/14
CPC分类号： A61M15/001 , A61M11/00 , A61M11/005 , A61M15/00 , A61M15/0001 , A61M15/0005 , A61M15/0021 , A61M15/0085 , A61M2205/0272 , A61M2205/502 , A61M2205/52 , A61M2205/8206 , B05B17/06 , B05B17/0607 , B05B17/0646 , B65D83/75 , B65D83/752
摘要： An apparatus (e.g., nebulizer) for aerosol delivery of a substance (e.g., a drug to a patient) has a mouthpiece (36); a chamber (34) holding a substance; a flexible membrane (38) having a plurality of apertures; and a vibrator (44) for vibrating the flexible membrane to form a flow of aerosol droplets of the substance that are ejected through the apertures and to the mouthpiece. The vibrator may be a piezoelectric element. A magnetic member (54) is provided on the flexible membrane and is configured to magnetically couple the flexible membrane to the vibrator. The magnetic member allows replacement of the membrane, without wasting the piezoelectric element.
摘要翻译：用于气溶胶递送物质（例如，药物到患者）的装置（例如雾化器）具有口件（36）; 容纳物质的室（34）; 具有多个孔的柔性膜（38）; 以及振动器（44），用于振动所述柔性膜以形成所述物质的气溶胶液滴的流动通过所述孔和所述口件喷射。振动器可以是压电元件。磁性构件（54）设置在柔性膜上，并且构造成将柔性膜磁耦合到振动器。磁性部件允许更换膜，而不浪费压电元件。

35. 发明申请

US20140073912A1 TIP REFLECTION REDUCTION FOR SHAPE-SENSING OPTICAL FIBER 审中-公开
标题翻译：用于形状感光光纤的提示反射减少
公开(公告)号：US20140073912A1
公开(公告)日：2014-03-13
申请号：US13981933
申请日：2012-01-24
申请人： Martinus Bernardus Van Der Mark , Raymond Chan , Robert Manzke , Gert Wim 'T Hooft
发明人： Martinus Bernardus Van Der Mark , Raymond Chan , Robert Manzke , Gert Wim 'T Hooft
IPC分类号： G02B6/24 , A61B5/06
CPC分类号： G02B6/24 , A61B1/0017 , A61B5/065 , A61B34/20 , A61B2034/2061 , A61B2562/0266 , G02B6/243 , G02B6/262
摘要： A reflection reduction device includes an optical fiber (104) configured for optical sensing and having an end portion. A tip portion (102) is coupled to the end portion. The tip portion includes a length dimension (d) and is index matched to the optical fiber. The tip portion is further configured to include an absorption length to absorb and scatter light within the length dimension, and a surface (S) opposite the end portion is configured to reduce back reflections.
摘要翻译：反射减少装置包括被配置用于光学感测并具有端部的光纤（104）。尖端部分（102）联接到端部。尖端部分包括长度尺寸（d）并且与光纤的折射率匹配。尖端部分还被构造成包括吸收长度以吸收和散射长度尺寸内的光，并且与端部相对的表面（S）被配置为减少反射反射。

36. 发明申请

US20120285446A1 MAGNETIC COUPLING FOR AEROSOL GENERATING APPARATUS 有权
标题翻译：航空发动机的磁耦合
公开(公告)号：US20120285446A1
公开(公告)日：2012-11-15
申请号：US13521292
申请日：2010-12-08
申请人： Martinus Bernardus Van Der Mark
发明人： Martinus Bernardus Van Der Mark
IPC分类号： A61M11/00
CPC分类号： A61M15/001 , A61M11/00 , A61M11/005 , A61M15/00 , A61M15/0001 , A61M15/0005 , A61M15/0021 , A61M15/0085 , A61M2016/0021 , A61M2205/0272 , A61M2205/12 , A61M2205/14 , A61M2205/502 , A61M2205/52 , A61M2205/581 , A61M2205/8206 , B05B17/06 , B05B17/0607 , B05B17/0646 , B65D83/75 , B65D83/752
摘要： An apparatus (e.g., nebulizer) for aerosol delivery of a substance (e.g., a drug to a patient) has a mouthpiece (36); a chamber (34) holding a substance; a flexible membrane (38) having a plurality of apertures; and a vibrator (20) for vibrating the flexible membrane to form a flow of aerosol droplets of the substance that are ejected through the apertures and to the mouthpiece. The vibrator may be a piezoelectric element. A magnetic member (54) is provided on the flexible membrane and is configured to magnetically couple the flexible membrane to the vibrator. The magnetic member allows replacement of the membrane, without wasting the piezoelectric element.
摘要翻译：用于气溶胶递送物质（例如，药物到患者）的装置（例如雾化器）具有口件（36）; 容纳物质的室（34）; 具有多个孔的柔性膜（38）; 以及振动器（20），用于振动所述柔性膜以形成通过所述孔和所述口件喷射的物质的气溶胶液滴流。振动器可以是压电元件。磁性构件（54）设置在柔性膜上，并且构造成将柔性膜磁耦合到振动器。磁性部件允许更换膜，而不浪费压电元件。

37. 发明申请

US20110270093A1 OPTICAL EXAMINATION DEVICE ADAPTED TO BE AT LEAST PARTIALLY INSERTED INTO A TURBID MEDIUM 审中-公开
标题翻译：光学检查装置适用于至少部分插入涡轮介质
公开(公告)号：US20110270093A1
公开(公告)日：2011-11-03
申请号：US13142485
申请日：2010-01-18
申请人： Adrien Emmanuel Desjardins , Martinus Bernardus Van Der Mark , Bernardus Hendrikus Wilhelmus Hendriks , Gert 'T Hooft
发明人： Adrien Emmanuel Desjardins , Martinus Bernardus Van Der Mark , Bernardus Hendrikus Wilhelmus Hendriks , Gert 'T Hooft
IPC分类号： A61B6/00 , H01L27/00 , G01J3/00 , H01J5/02 , G01J1/42
CPC分类号： A61B5/0075 , A61B5/0062 , A61B5/0084 , A61B5/6848
摘要： An optical examination device (10) adapted to be at least partially inserted into a turbid medium is provided. The optical examination device comprises a shaft portion (21) adapted to be inserted into the turbid medium, the shaft portion (21) comprising a tip portion (22) adapted to be the foremost portion during insertion into the turbid medium. At least one light source device adapted to emit abeam (11) of broad-band light is provided in the region of the tip portion (21). The beam (11) of broad-band light comprises different wavelength bands (2a, 2b, . . . , 2n) which are differently modulated. At least one photodetector (27a, 27b, 27c) for detecting broad-band light is provided in a region adapted to be inserted into the turbid medium of the shaft portion (21).
摘要翻译：提供了适于至少部分地插入混浊介质中的光学检查装置（10）。光学检查装置包括适于插入混浊介质的轴部分（21），该轴部分（21）包括在插入混浊介质期间适于最前部分的末端部分（22）。在尖端部分（21）的区域中设置适于发射宽带光的光束（11）的至少一个光源装置。宽带光束（11）包括不同调制的不同波长带（2a，2b，...，2n）。用于检测宽带光的至少一个光电检测器（27a，27b，27c）设置在适于插入到轴部（21）的混浊介质中的区域中。

38. 发明申请

US20110090499A1 METHOD AND DEVICE FOR OPTICALLY EXAMINING THE INTERIOR OF TURBID MEDIA 有权
标题翻译：用于光学检测涡轮介质内部的方法和装置
公开(公告)号：US20110090499A1
公开(公告)日：2011-04-21
申请号：US12997627
申请日：2009-06-12
申请人： Martinus Bernardus Van Der Mark
发明人： Martinus Bernardus Van Der Mark
IPC分类号： G01J3/447 , G01J3/28
CPC分类号： G01N21/4795 , A61B5/0059 , G01J3/02 , G01J3/0229 , G01J3/027 , G01J3/10 , G01J3/42 , G01N21/49
摘要： A method for optically examining the interior of turbid media is provided. The method comprises the steps: providing broad-band light (2); spatially separating a plurality of wavelength bands (2a, 2b, . . . , 2n) contained in the broad-band light; separately modulating the plurality of wavelength bands (2a, 2b, . . . , 2n); recombining the plurality of modulated wavelength bands to a beam (11) of spectrally encoded broad-band light; illuminating a turbid medium (8) with the beam (11) of spectrally encoded broad-band light; detecting light emanating from the turbid medium (8) with a detector (9) and demodulating the detected light with a demodulator (10) to provide spectroscopic information.
摘要翻译：提供了一种用于光学检查混浊介质内部的方法。该方法包括以下步骤：提供宽带光（2）; 空间上分离宽带光中包含的多个波长带（2a，2b，...，2n）; 分别调制多个波长带（2a，2b，...，2n）; 将所述多个调制波长带重新组合成光谱编码的宽带光的波束（11）; 用频谱编码的宽带光束（11）照射混浊介质（8）; 用检测器（9）检测从混浊介质（8）发出的光，并用解调器（10）解调检测到的光，以提供光谱信息。

39. 发明申请

US20090259130A1 OPTICAL TOMOGRAPHY MEASUREMENT USING AN ADAPTED BRIM FOR THE RECEIVING VOLUME 审中-公开
标题翻译：使用适配BRIM进行光学测量的接收体积
公开(公告)号：US20090259130A1
公开(公告)日：2009-10-15
申请号：US12439726
申请日：2007-09-05
申请人： Martinus Bernardus Van Der Mark , Willem Peter Van Der Brug , Tim Nielsen
发明人： Martinus Bernardus Van Der Mark , Willem Peter Van Der Brug , Tim Nielsen
IPC分类号： A61B6/00
CPC分类号： A61B5/415 , A61B5/0091 , A61B5/418 , A61B5/4312
摘要： The invention relates to a device for imaging an interior of a turbid medium comprising: a) a receiving volume for receiving at least a part of the turbid medium, with the receiving volume being bound by a boundary having an opening bound by a brim, b) a light source for irradiating the turbid medium, and c) a photodetector unit for detecting light emanating from the volume as a result of irradiating the turbid medium. The device is adapted such that the brim is arranged for optically coupling the light source to the turbid medium and the turbid medium to the photodetector unit. One embodiment of the invention relates to a device for imaging an interior of a female breast comprising a cup-like receptacle (20) for accommodating the breast. The receptacle (20) comprises a convex shaped brim (60) arranged for optically coupling the light source to the patient's (55) breast and the breast to the photodetector unit.
摘要翻译：本发明涉及一种用于对浑浊介质内部进行成像的装置，包括：a）用于接收混浊介质的至少一部分的接收体积，其中接收体积被具有边缘边界的边界限制，b ）用于照射混浊介质的光源，以及c）用于通过照射混浊介质来检测从体积发出的光的光电检测器单元。该装置适于使得边缘布置成将光源光学耦合到混浊介质和混浊介质到光电探测器单元。本发明的一个实施例涉及一种用于对女性乳房内部进行成像的装置，其包括用于容纳乳房的杯状容器（20）。插座（20）包括凸形的边缘（60），该凸缘布置用于将光源光学地耦合到患者的（55）乳房和乳房到光电检测器单元。

40. 发明申请

US20080309940A1 Method of, System For, and Medical Image Acquisition System For Imaging an Interior of a Turbid Medium Taking Into Account the Geometry of the Turbid Medium 审中-公开
公开(公告)号：US20080309940A1
公开(公告)日：2008-12-18
申请号：US12094698
申请日：2006-11-20
申请人： Martinus Bernardus Van Der Mark , Michael Cornelis Van Beek , Levinus Pieter Bakker
发明人： Martinus Bernardus Van Der Mark , Michael Cornelis Van Beek , Levinus Pieter Bakker
IPC分类号： G01N21/00
CPC分类号： G01N21/4795 , G01N2021/1787 , G01N2021/4766 , G01N2021/6439
摘要： The invention relates to a method of imaging an interior of a turbid medium (45) comprising the following steps: accommodation of the turbid medium (45) inside a receiving volume (20); coupling transmission input light (65) from a transmission light source into the receiving volume (12), with said transmission input light (65) being chosen such that it is capable of propagating through the turbid medium (45) and with at least a part of said transmission input light (65) passing through a matching medium (50) in the receiving volume (12), said matching medium (50) being chosen to reduce optical boundary effects at an interface between the turbid medium (45) and its surroundings; detection of transmission output light emanating from the receiving volume as a result of coupling transmission input light (65) from the transmission light source into the receiving volume (12) through use of a transmission photodetector unit. The invention also relates to a system for imaging an interior of a turbid medium (45) and a medical image acquisition system both using the method. According to the invention, the method, system for imaging an interior of a turbid medium (45), and medical image acquisition system are adapted such that data relating to the exterior of the turbid medium (45) can be obtained. This object is realized in that the method further comprises the following additional steps: coupling geometry input light (70, 75, 80) from a geometry light source into the receiving volume (12), with the receiving volume comprising the turbid medium (45), with the receiving volume (12) further comprising a geometry medium (60) for surrounding the turbid medium (45) during coupling of geometry input light (70, 75, 80) into the receiving volume (12), and with the combination of the geometry input light (70, 75, 80), the geometry medium (60), and the interface being chosen for creating a contrast between the turbid medium and its surroundings; —detection of the contrast between the turbid medium (45) and its surroundings; reconstructing an image of an interior of the turbid medium (45) using the detected contrast.

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