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31. 发明授权

US08293888B2 Sialic acid derivatives 有权
标题翻译：唾液酸衍生物
公开(公告)号：US08293888B2
公开(公告)日：2012-10-23
申请号：US12987878
申请日：2011-01-10
申请人： Sanjay Jain , Ioannis Papaioannou , Smita Thobhani
发明人： Sanjay Jain , Ioannis Papaioannou , Smita Thobhani
IPC分类号： C07H1/00 , C07K14/00
CPC分类号： C07H15/26 , A61K38/27 , A61K47/61 , C07H1/00 , C08B37/00 , C08B37/0006 , Y02A50/473
摘要： An amine or hydrazide derivative of a sialic acid unit, e.g. in a polysaccharide, is reacted with a bifunctional reagent at least one of the functionalities of which is an ester of N-hydroxy succinimide, to form an amide or hydrazide product. The product has a useful functionality, which allows it to be conjugated, for instance to proteins, drugs, drug delivery systems or the like. The process is of particular utility for derivatising amine groups introduced in sialic acid terminal groups of polysialic acids.
摘要翻译：唾液酸单元的胺或酰肼衍生物，例如在多糖中与双功能试剂反应，其功能中的至少一个是N-羟基琥珀酰亚胺的酯，以形成酰胺或酰肼产物。该产品具有有用的功能，其允许其结合，例如结合蛋白质，药物，药物递送系统等。该方法特别适用于衍生聚唾液酸唾液酸端基引入的胺基。

32. 发明授权

US07925683B2 Methods and apparatus for content-aware data de-duplication 有权
标题翻译：用于内容感知数据重复数据删除的方法和装置
公开(公告)号：US07925683B2
公开(公告)日：2011-04-12
申请号：US12642023
申请日：2009-12-18
申请人： Sanjay Jain , Puneesh Chaudhry
发明人： Sanjay Jain , Puneesh Chaudhry
IPC分类号： G06F17/30 , G06F13/00 , G06F13/28
CPC分类号： G06F3/0641 , G06F3/0608 , G06F3/067 , G06F17/30156 , Y10S707/968 , Y10S707/969 , Y10S707/97 , Y10S707/971 , Y10S707/972 , Y10S707/973 , Y10S707/974
摘要： The systems and methods partition digital data units in a content aware fashion without relying on any ancestry information, which enables one to find duplicate chunks in unrelated units of digital data even across millions of documents spread across thousands of computer systems.
摘要翻译：系统和方法以内容感知方式分割数字数据单元，而不依赖于任何祖先信息，这使得能够在数千个数字数据的无关单元中找到重复的块，甚至跨数千个计算机系统传播的数百万个文档。

33. 发明申请

US20100022443A1 DERIVATISATION OF ERYTHROPOIETIN (EPO) 有权
标题翻译：红细胞生成素（EPO）的衍生物
公开(公告)号：US20100022443A1
公开(公告)日：2010-01-28
申请号：US12375008
申请日：2007-07-25
申请人： Sanjay Jain , Peter Laing , Gregory Gregoriadis , Norbert Oskar Rumpf
发明人： Sanjay Jain , Peter Laing , Gregory Gregoriadis , Norbert Oskar Rumpf
IPC分类号： A61K38/16 , C07K17/10
CPC分类号： A61K47/61 , A61K38/00 , A61K38/1816 , A61K38/193 , A61K38/465 , C07K14/505 , C07K14/52 , C07K14/535 , C07K14/575 , C12N9/22 , C12Y301/21001 , Y02A50/473
摘要： The present invention relates to a compound which is a polysaccharide derivative of EPO, or of an EPO like protein, wherein the polysaccharide is anionic and comprises between 2 and 200 saccharide units. The present invention also relates to pharmaceutical compositions comprising the novel compounds, and methods for making the novel compounds.
摘要翻译：本发明涉及作为EPO的多糖衍生物或EPO样蛋白质的化合物，其中所述多糖是阴离子型的，并且包含2至200个糖单元。本发明还涉及包含新化合物的药物组合物和制备新化合物的方法。

34. 发明授权

US07623468B2 Programmable packet parsing processor 有权
公开(公告)号：US07623468B2
公开(公告)日：2009-11-24
申请号：US10927290
申请日：2004-08-25
申请人： Rina Panigrahy , Jackie Liu , Daniel Yu-Kwong Ng , Sanjay Jain , Nagaraj A. Bagepalli , Abhijit Patra
发明人： Rina Panigrahy , Jackie Liu , Daniel Yu-Kwong Ng , Sanjay Jain , Nagaraj A. Bagepalli , Abhijit Patra
IPC分类号： H04L12/56
CPC分类号： H04L63/0254 , H04L63/1408 , H04L69/22
摘要： The present invention provides a packet processing device and method. A parsing processor provides instruction-driven content inspection of network packets at 10-Gbps and above with a parsing engine that executes parsing instructions. A flow state unit maintains statefulness of packet flows to allow content inspection across several related network packets. A state-graph unit traces state-graph nodes to keyword indications and/or parsing instructions. The parsing instructions can be derived from a high-level application to emulate user-friendly parsing logic. The parsing processor sends parsed packets to a network processor unit for further processing.

35. 发明申请

US20090118509A1 PREPARATION OF [2-METHYL-5-PHENYL-3-(PIPERAZIN-1-YLMETHYL)] PYRROLE DERIVATIVES 审中-公开
公开(公告)号：US20090118509A1
公开(公告)日：2009-05-07
申请号：US11911272
申请日：2006-04-05
申请人： Sudershan Kumar Arora , Neelima Sinha , Sanjay Jain , Ram Shankar Upadhayaya , Om Dutt Tyagi , Vasanth Nalam , Yogendra Kumar Chauhan
发明人： Sudershan Kumar Arora , Neelima Sinha , Sanjay Jain , Ram Shankar Upadhayaya , Om Dutt Tyagi , Vasanth Nalam , Yogendra Kumar Chauhan
IPC分类号： C07D401/14
CPC分类号： C07D207/50 , C07D207/335 , C07D401/04 , C07D401/12
摘要： A process for the preparation of compounds of Formula I and their pharmaceutically acceptable acid addition salt wherein, R1 is phenyl or substituted phenyl R2 is selected from a group consisting of phenyl which is unsubstituted or substituted with 1 or 2 substituents, each independently selected from Cl, F, or pyridine, or naphthalene, or NHCOR4 wherein R4 is aryl, unsubstituted or substituted heteroaryl, unsubstituted or substituted heterocyclyl. R3 is selected from a group of formula wherein R5 is phenyl which is unsubstituted or substituted with 1 or 2 substituents each independently selected from the group consisting of halogen, C1-C4 alkyl, C1-C4 alkoxy, nitro, amino, haloalkyl, haloalkoxy etc.; unsubstituted or substituted benzyl; unsubstituted or substituted heteroaryl; unsubstituted or substituted heteroaroyl; unsubstituted or substituted diphenylmethyl, n=0-2 and X═—NCH3, CH2, S, SO, or SO2 Such that when R2 is phenyl, which is unsubstituted or substituted with 1 or 2 substituents, each independently selected from Cl, F; R5 is not C1-C4 alkyl, or X is not —NCH3, CH2, S, SO, or SO2, when n=1, or X is not —CH2 when n=0; comprising the steps of (a) reacting compound of Formula II with a chlorinating agent in the presence or absence of catalytic amount of N,N-dimethylformamide to yield the compound of Formula III, (b) reacting the compound of Formula III with a compound of Formula R1H (R1 is as defined above), in presence of a Lewis acid to obtain the compound of Formula IV, (c) reacting the compound of Formula IV with a compound of Formula R2NH2 (R2 is as defined above) in presence of catalytic amounts of an aryl or alkyl sulphonic acid in an organic solvent to obtain the compound of Formula V, (d) reacting the compound of Formula V with various secondary amines of the Formula R3H (R3 is as defined above) in the presence of formaldehyde and acetic acid in acetonitrile followed by crystallization yield the compound of Formula I, (e) purifying the compound of Formula I by crystallization, (f) converting the purified compound of Formula I to a pharmaceutically acceptable acid addition salt.

36. 发明授权

US07469827B2 Vehicle information systems and methods 有权
标题翻译：车辆信息系统和方法
公开(公告)号：US07469827B2
公开(公告)日：2008-12-30
申请号：US11281843
申请日：2005-11-17
申请人： Lalitesh Katragadda , Sanjay Jain
发明人： Lalitesh Katragadda , Sanjay Jain
IPC分类号： G07B15/02
CPC分类号： G08G1/123
摘要： In some of the embodiments described herein, a vehicle information system may be used to generate route map information, schedule information, estimated time of arrival information, or the like based upon location information received from passenger-carried or cargo-carried wireless devices, such as passengers' cellular phones. In such circumstances, a remote device (e.g., a display device at a vehicle station, a network-connected personal computer, or a cellular phone of a person who might board a mass transit vehicle) may access the route map information, schedule information, and other information related to one or more mass transit vehicles.
摘要翻译：在本文描述的一些实施例中，可以使用车辆信息系统来基于从乘客携带或携带货物的无线设备接收的位置信息来生成路线图信息，时间表信息，估计到达时间信息等，作为乘客的手机。在这种情况下，远程设备（例如，车辆站的显示设备，网络连接的个人计算机或可能登上公共交通车辆的人的移动电话）可以访问路线图信息，时间表信息，以及与一个或多个集体运输车辆相关的其他信息。

37. 发明申请

US20080262209A1 Activated Sialic Acid Derivatives for Protein Derivatisation and Conjugation 有权
标题翻译：用于蛋白质衍生和缀合的活性唾液酸衍生物
公开(公告)号：US20080262209A1
公开(公告)日：2008-10-23
申请号：US11816823
申请日：2006-02-16
申请人： Sanjay Jain , Ioannis Papaioannou , Smita Thobhani
发明人： Sanjay Jain , Ioannis Papaioannou , Smita Thobhani
IPC分类号： C08B37/00 , C07H15/26
CPC分类号： A61K47/4823 , A61K38/27 , A61K47/61 , C07H5/06 , C07H15/26 , C07K17/10 , C08B37/0006 , C08H1/02 , C12N9/96 , C12P19/44
摘要： Derivatives of PSAs are synthesised, in which a reducing and/or non-reducing end terminal sialic acid unit is transformed into a N-hydroxysuccinimide (NHS) group. The derivatives may be reacted with substrates, for instance substrates containing amine or hydrazine groups, to form non-cross-linked/crosslinked polysialylated compounds. The substrates may, for instance, be therapeutically useful drugs, peptides or proteins or drug delivery systems.
摘要翻译：合成PSA的衍生物，其中将还原和/或非还原末端唾液酸单元转化为N-羟基琥珀酰亚胺（NHS）基团。衍生物可以与底物反应，例如含有胺或肼基团的底物，以形成非交联/交联的聚唾液酸化化合物。底物可以是例如治疗上有用的药物，肽或蛋白质或药物递送系统。

38. 发明申请

US20080242676A1 PYRROLE DERIVATIVES AS ANTIMYCOBACTERIAL COMPOUNDS 失效
标题翻译：吡咯衍生物作为抗微生物化合物
公开(公告)号：US20080242676A1
公开(公告)日：2008-10-02
申请号：US12137170
申请日：2008-06-11
申请人： Sudershan Kumar Arora , Neelima Sinha , Sanjay Jain , Ram Shankar Upadhayaya , Gourhari Jana , Shankar Ajay , Rakesh Kumar Sinha
发明人： Sudershan Kumar Arora , Neelima Sinha , Sanjay Jain , Ram Shankar Upadhayaya , Gourhari Jana , Shankar Ajay , Rakesh Kumar Sinha
IPC分类号： A61K31/496 , C07D403/02 , C12N1/00 , C12N1/20 , A61P31/04
CPC分类号： C07D207/335 , C07D207/32 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D405/14 , C07D417/06
摘要： Novel pyrrole derivatives of formula (I) and their pharmaceutically acceptable acid addition salts having superior antimycobacterial activity against clinically sensitive as well as resistant strains of Mycobacterium tuberculosis as well as having lesser toxicity compared to known compounds. The use of the novel compounds of formula (I) for treatment of latent tuberculosis including Multi Drug Resistant Tuberculosis (MDR TB). The methods for preparation of the novel compounds, pharmaceutical compositions containing the novel compounds and method of treating MDR TB by administration of compounds of formula (I).
摘要翻译：式（I）的新型吡咯衍生物及其药学上可接受的酸加成盐对临床敏感性以及抗结核分枝杆菌菌株具有优异的抗分枝杆菌活性，并且与已知化合物相比具有较小的毒性。使用式（I）的新化合物用于治疗潜在结核病，包括多药耐药性结核病（MDR TB）。制备新化合物的方法，含有新化合物的药物组合物和通过施用式（I）化合物治疗MDR TB的方法。

39. 发明申请

US20070282096A1 Sialic Acid Derivatives 有权
标题翻译：唾液酸衍生物
公开(公告)号：US20070282096A1
公开(公告)日：2007-12-06
申请号：US11660128
申请日：2005-08-12
申请人： Sanjay Jain , Ioannis Papaioannou , Smita Thobhani
发明人： Sanjay Jain , Ioannis Papaioannou , Smita Thobhani
IPC分类号： C07H15/26 , C07H1/00
CPC分类号： C07H15/26 , A61K38/27 , A61K47/61 , C07H1/00 , C08B37/00 , C08B37/0006 , Y02A50/473
摘要： An amine or hydrazide derivative of a sialic acid unit, e.g. in a polysaccharide, is reacted with a bifunctional reagent at least one of the functionalities of which is an ester of N-hydroxy succinimide, to form an amide or hydrazide product. The product has a useful functionality, which allows it to be conjugated, for instance to proteins, drugs, drug delivery systems or the like. The process is of particular utility for derivatising amine groups introduced in sialic acid terminal groups of polysialic acids.
摘要翻译：唾液酸单元的胺或酰肼衍生物，例如在多糖中与双功能试剂反应，其功能中的至少一个是N-羟基琥珀酰亚胺的酯，以形成酰胺或酰肼产物。该产品具有有用的功能，其允许其结合，例如结合蛋白质，药物，药物递送系统等。该方法特别适用于衍生聚唾液酸唾液酸端基引入的胺基。

40. 发明申请

US20070220796A1 Alternative Design Thermal Wristband Business Form 有权
标题翻译：替代设计热带手表业务形式
公开(公告)号：US20070220796A1
公开(公告)日：2007-09-27
申请号：US11754812
申请日：2007-05-29
申请人： James Riley , Sanjay Jain , Mark Greer
发明人： James Riley , Sanjay Jain , Mark Greer
IPC分类号： A44C5/00
CPC分类号： G09F3/005 , B42D15/00 , B42P2241/22
摘要： A business form particularly adapted for generalized use, although it may be used in a medical or hospital environment includes a roll or continuous construction of a plurality of wristbands, with each wristband being separately formed in a panel comprised of an underlying continuous carrier of a laminating material with a series of face stock patches placed therealong. Each wristband is provided with a face stock imaging area die cut into each face stock patch and a laminating portion die cut into the underlying carrier of laminating material, with the two die cut portions being adhered to each other to form a matrix for ready separation from its panel. The laminating portion has a first area for receiving the face stock portion and a second similarly sized and shaped area for fold over lamination of the first area and face stock portion, along with a pair of straps extending to the opposing sides thereof.
摘要翻译：特别适用于广泛使用的商业形式虽然可以用于医疗或医院环境中，但是包括多个腕带的卷或连续结构，每个腕带分别形成在由层叠的下层连续载体构成的面板中材料与一系列的面部补丁放在一起。每个腕带设置有切割成每个面部贴片的面部成像区域，以及切割成层压材料的下面的载体的层压部分模具，其中两个模切部分彼此粘合以形成用于从其面板。层压部分具有用于接收面部存储部分的第一区域和用于第一区域和面部存储部分的层叠的第二相似大小和形状的区域，以及延伸到其相对侧的一对带束。

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