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1. 发明授权

US09675554B1 Method of forming liposomes 有权
公开(公告)号：US09675554B1
公开(公告)日：2017-06-13
申请号：US09719795
申请日：1999-06-16
申请人： Gregory Gregoriadis , Brahim Zadi , Pramukh N Jayasekera
发明人： Gregory Gregoriadis , Brahim Zadi , Pramukh N Jayasekera
IPC分类号： A61K9/127
CPC分类号： A61K9/127 , A61K9/1271 , A61K9/1278
摘要： Compositions of reagents are formed by forming empty liposomes, mixing the thus-formed liposomes with a sugar solution and a regent, then drying the mixture. The compositions will generally contain less than 10% w/v sucrose. Using this procedure small liposomes are formed with high entrapment efficiency. The process is useful in the production of pharmaceuticals.

2. 发明申请

US20130058994A1 LIPOSOMES CONTAINING OLIGOPEPTIDE FRAGMENTS OF MYELIN BASIC PROTEIN, A PHARMACEUTICAL COMPOSITION AND A METHOD FOR TREATMENT OF MULTIPLE SCLEROSIS 审中-公开
标题翻译：含有髓氨酸蛋白酶的寡肽片段的药物，药物组合物和治疗多发性硬化症的方法
公开(公告)号：US20130058994A1
公开(公告)日：2013-03-07
申请号：US13444788
申请日：2012-04-11
申请人： Alexander Gabivov , Alexey Belogurov , Natalia Ponomarenko , Ivan Smirnov , Andrew Bacon , Gregory Gregoriadis
发明人： Alexander Gabivov , Alexey Belogurov , Natalia Ponomarenko , Ivan Smirnov , Andrew Bacon , Gregory Gregoriadis
IPC分类号： C07K17/00 , A61K38/16 , C07K19/00 , A61K9/127 , A61P25/00 , A61K38/02 , C07K17/10 , B82Y5/00
CPC分类号： A61K9/127 , A61K9/0019 , A61K38/10 , A61K38/16 , A61K38/1709
摘要： The present invention provides compositions and methods for the treatment of multiple sclerosis. Among others, the invention provides compositions of immunodominant peptides of myelin basic protein encapsulated in mannosylated liposomes. In a specific embodiment, the compositions comprise mylein basic protein (MBP) peptides MBP(46-62), MBP(124-139), and MBP(147-170).
摘要翻译：本发明提供了用于治疗多发性硬化症的组合物和方法。其中，本发明提供了包封在甘露糖基化脂质体中的髓鞘碱性蛋白的免疫显性肽的组合物。在一个具体实施方案中，组合物包含mylein碱性蛋白（MBP）肽MBP（46-62），MBP（124-139）和MBP（147-170）。

3. 发明申请

US20120121690A1 METHOD TO ENHANCE AN IMMUNE RESPONSE OF NUCLEIC ACID VACCINATION 有权
标题翻译：增强核酸疫苗免疫应答的方法
公开(公告)号：US20120121690A1
公开(公告)日：2012-05-17
申请号：US13292778
申请日：2011-11-09
申请人： Andrew David BACON , Peter Laing , Gregory GREGORIADIS , Wilson Romero CAPARROS-WANDERLEY
发明人： Andrew David BACON , Peter Laing , Gregory GREGORIADIS , Wilson Romero CAPARROS-WANDERLEY
IPC分类号： A61K9/127 , A61P37/02 , A61K39/02 , A61K39/00 , A61K39/12
CPC分类号： A61K9/1277 , A61K39/00 , A61K39/12 , A61K39/145 , A61K39/292 , A61K39/39 , A61K2039/5252 , A61K2039/53 , A61K2039/55555 , A61K2039/70 , C07H21/04 , C12N7/00 , C12N2730/10134 , C12N2760/16134
摘要： A composition comprising liposomes associated with a nucleic acid operatively encoding an antigenic protein and with an assistor protein, wherein the assistor protein shares at least one epitope with the antigenic protein, and wherein the nucleic acid and said assistor protein are associated with the same liposomes is described. The composition provides an improved immune response compared to mixtures of liposomes some of which are associated with the nucleic acid and some of which are associated with the assistor protein.
摘要翻译：一种组合物，其包含与可操作地编码抗原性蛋白质和蛋白质蛋白质的核酸相关联的脂质体，其中所述组合物蛋白质与所述抗原蛋白质共享至少一个表位，并且其中所述核酸和所述组合物蛋白质与相同的脂质体相关联描述。与脂质体的混合物相比，组合物提供了改善的免疫应答，其中一些与核酸相关，并且其中一些与核苷酸蛋白质相关。

4. 发明申请

US20110159130A1 REDUCTION OF ENDOTOXIN IN POLYSIALIC ACIDS 审中-公开
标题翻译：减少多糖中的内毒素
公开(公告)号：US20110159130A1
公开(公告)日：2011-06-30
申请号：US12528763
申请日：2008-02-28
申请人： Sanjay Jain , Peter Laing , Gregory Gregoriadis
发明人： Sanjay Jain , Peter Laing , Gregory Gregoriadis
IPC分类号： A61K35/74 , C07K14/00 , C12P21/06
CPC分类号： C08B37/0006 , B01D15/363 , C08B37/0003
摘要： The present invention relates to process for reducing the endotoxin content of a sample of fermentation broth containing polysialic acid and endotoxin comprising the sequential steps: (i) adding to the sample a base having a pKa of at least 12 to form a basic solution having a pH of at least 12, incubating the solution for a pre-determined time at a pre-determined temperature; and (ii) recovery of PSA, suitably by (iii) passing the sample through an anion-exchange column whereby polysialic acid is absorbed on the ion exchange resin; (iv) washing the column with one washing buffer, whereby polysialic acid remains absorbed on the ion exchange resin; and (v) eluting the polysialic acid from the column using an elution buffer to provide a product solution of polysialic acid having reduced endotoxin content.
摘要翻译：本发明涉及降低含有唾液酸和内毒素的发酵肉汤样品的内毒素含量的方法，其包括以下顺序步骤：（i）向样品中加入pKa至少为12的碱，以形成具有 pH至少为12，在预定温度下将溶液温育预定时间; 和（ii）PSA的回收，适当地通过（iii）使样品通过阴离子交换柱，由此唾液酸被吸收在离子交换树脂上; （iv）用一个洗涤缓冲液洗涤该柱，由此聚唾液酸保持吸收在离子交换树脂上; 和（v）使用洗脱缓冲液从柱洗脱聚唾液酸以提供具有降低的内毒素含量的聚唾液酸的产物溶液。

5. 发明申请

US20080317838A1 Liposomal Vaccine Compositions Comprising a Polysaccharide Antigen and a Protein Adjuvant 失效
标题翻译：包含多糖抗原和蛋白质佐剂的脂质体疫苗组合物
公开(公告)号：US20080317838A1
公开(公告)日：2008-12-25
申请号：US12088672
申请日：2006-09-29
申请人： Andrew David Bacon , Gregory Gregoriadis , Peter Laing
发明人： Andrew David Bacon , Gregory Gregoriadis , Peter Laing
IPC分类号： A61K9/127 , A61K39/02 , A61P31/04
CPC分类号： A61K9/127 , A61K9/1272 , A61K39/02 , A61K39/092 , A61K39/39 , A61K2039/55544 , A61K2039/55555
摘要： A liposomal composition, preferably a vaccine, comprising liposomes formed of liposome forming compounds, containing coentrapped polysaccharide antigen and T-cell dependent protein carrier, such as tetanus toxoid or diphtheria toxin modified to render it non-toxic. The invention is of use in the production of vaccines against Haemophilus influenzae, Streptococcus pneumoniae or Neisseria meningitidis.
摘要翻译：脂质体组合物，优选疫苗，其包含由形成脂质体的化合物形成的脂质体，其含有包被的多糖抗原和T细胞依赖性蛋白质载体，例如经过修饰的破伤风类毒素或白喉毒素，使其无毒。本发明可用于生产针对流感嗜血杆菌，肺炎链球菌或脑膜炎奈瑟氏球菌的疫苗。

6. 发明申请

US20080286353A1 CATIONIC LIPOSOMES CONTAINING IMMUNE RESPONSE GENERATING MOIETIES 有权
标题翻译：含有免疫应答产生动力的阳离子脂质体
公开(公告)号：US20080286353A1
公开(公告)日：2008-11-20
申请号：US12101107
申请日：2008-04-10
申请人： Gregory GREGORIADIS
发明人： Gregory GREGORIADIS
IPC分类号： A61K9/127 , A61K31/70 , A61K39/00 , A61P37/00
CPC分类号： C12N15/88 , A61K9/1272 , A61K48/00 , Y10S977/803 , Y10S977/904 , Y10S977/907 , Y10S977/917 , Y10S977/918
摘要： Cationic liposomes with entrapped polynucleotide in the intravesicular space are described. The liposomes include cationic components such as cationic lipids such as DOTAP. Preferably the method of forming liposomes uses the dehydration-rehydration method in the presence of the polynucleotide. The polynucleotide preferably operatively encodes an antigen capable of eliciting a desired immune response, that is, is a gene vaccine.
摘要翻译：描述了在囊内空间内具有夹带多核苷酸的阳离子脂质体。脂质体包括阳离子组分如阳离子脂质如DOTAP。优选地，形成脂质体的方法在多核苷酸的存在下使用脱水 - 再水化方法。多核苷酸优选有效地编码能够引发所需免疫应答的抗原，即基因疫苗。

7. 发明授权

US09795683B2 Glycopolysialylation of non-blood coagulation proteins 有权
公开(公告)号：US09795683B2
公开(公告)日：2017-10-24
申请号：US12843284
申请日：2010-07-26
申请人： Sanjay Jain , Gregory Gregoriadis , Archana Dwivedi , Srijit Nath , Juergen Siekmann , Stefan Haider , Hanspeter Rottensteiner , Peter Turecek
发明人： Sanjay Jain , Gregory Gregoriadis , Archana Dwivedi , Srijit Nath , Juergen Siekmann , Stefan Haider , Hanspeter Rottensteiner , Peter Turecek
IPC分类号： A61K9/127 , A61K47/48
CPC分类号： A61K47/6455 , A61K47/60 , A61K47/61 , A61K47/65
摘要： A water soluble polymer, in particular polysialic acid (PSA) or a modified PSA (mPSA), is conjugated to an oxidized carbohydrate moiety of a glycoprotein other than a blood coagulation protein or to a ganglioside or drug delivery system by contacting the oxidized carbohydrate moiety with the water soluble polymer, wherein said water soluble polymer contains an aminooxy group and an oxime linkage is formed between the oxidized carbohydrate moiety and the aminooxy group on the water soluble polymer or wherein said water soluble polymer contains a hydrazide group and a hydrazone linkage is formed between the oxidized carbohydrate moiety and the hydrazide group on the water soluble polymer. Conjugates of aminooxy- or hydrazide-water soluble polymer, such as PSA and mPSA, are thus obtained in which the PSA or mPSA is attached via a carbohydrate moiety.

8. 发明授权

US08828405B2 Method to enhance an immune response of nucleic acid vaccination 有权
标题翻译：增强核酸疫苗免疫应答的方法
公开(公告)号：US08828405B2
公开(公告)日：2014-09-09
申请号：US13292778
申请日：2011-11-09
申请人： Andrew David Bacon , Peter Laing , Gregory Gregoriadis , Wilson Romero Caparros-Wanderley
发明人： Andrew David Bacon , Peter Laing , Gregory Gregoriadis , Wilson Romero Caparros-Wanderley
IPC分类号： A61K39/00 , A61K39/12 , A61K39/02 , A61K9/127 , A61K39/145 , C12N7/00
CPC分类号： A61K9/1277 , A61K39/00 , A61K39/12 , A61K39/145 , A61K39/292 , A61K39/39 , A61K2039/5252 , A61K2039/53 , A61K2039/55555 , A61K2039/70 , C07H21/04 , C12N7/00 , C12N2730/10134 , C12N2760/16134
摘要： A composition comprising liposomes associated with a nucleic acid operatively encoding an antigenic protein and with an assistor protein, wherein the assistor protein shares at least one epitope with the antigenic protein, and wherein the nucleic acid and said assistor protein are associated with the same liposomes is described. The composition provides an improved immune response compared to mixtures of liposomes some of which are associated with the nucleic acid and some of which are associated with the assistor protein.
摘要翻译：一种组合物，其包含与可操作地编码抗原性蛋白质和蛋白质蛋白质的核酸相关联的脂质体，其中所述组合物蛋白质与所述抗原蛋白质共享至少一个表位，并且其中所述核酸和所述组合物蛋白质与相同的脂质体相关联描述。与脂质体的混合物相比，组合物提供了改善的免疫应答，其中一些与核酸相关，并且其中一些与核苷酸蛋白质相关。

9. 发明授权

US08653255B2 Sialic acid derivatives for protein derivatisation and conjugation 有权
标题翻译：用于蛋白质衍生化和缀合的唾液酸衍生物
公开(公告)号：US08653255B2
公开(公告)日：2014-02-18
申请号：US12897523
申请日：2010-10-04
申请人： Sanjay Jain , Peter Laing , Gregory Gregoriadis , Dale Howard Hreczuk-Hirst , Ioannis Papaioannou
发明人： Sanjay Jain , Peter Laing , Gregory Gregoriadis , Dale Howard Hreczuk-Hirst , Ioannis Papaioannou
IPC分类号： A61K31/702 , A61K31/726 , C07H5/06
CPC分类号： A61K47/4823 , A61K31/702 , A61K31/726 , A61K38/27 , A61K38/28 , A61K39/44 , A61K47/61 , A61K47/6807 , C07H3/06 , C07H5/06 , C07H15/04 , C07K17/12 , C08B37/00 , C08B37/0006 , C08B37/006 , C08B37/0063
摘要： Derivatives are synthesized of starting materials, usually polysaccharides, having sialic acid at the reducing terminal end, in which the reducing terminal unit is transformed into an aldehyde group. Where the polysaccharide has a sialic acid unit at the non-reducing end it may be passivated, for instance by converting into hydroxyl-substituted moiety. The derivatives may be reacted with substrates, for instance containing amine or hydrazine groups, to form non-cross-linked polysialylated compounds. The substrates may, for instance, be therapeutically useful drugs peptides or proteins or drug delivery systems.
摘要翻译：衍生物由还原性末端具有唾液酸的原料（通常为多糖）合成，其中还原末端单元转化为醛基。当多糖在非还原末端具有唾液酸单元时，其可以被钝化，例如通过转化成羟基取代的部分。衍生物可以与底物反应，例如含有胺或肼基团，以形成非交联的聚唾液酸化化合物。底物可以例如是治疗上有用的药物肽或蛋白质或药物递送系统。

10. 发明授权

US08299026B2 Derivatisation of erythropoietin (EPO) 有权
标题翻译：促红细胞生成素（EPO）的衍生化
公开(公告)号：US08299026B2
公开(公告)日：2012-10-30
申请号：US12375008
申请日：2007-07-25
申请人： Sanjay Jain , Peter Laing , Gregory Gregoriadis , Norbert Oskar Rumpf
发明人： Sanjay Jain , Peter Laing , Gregory Gregoriadis , Norbert Oskar Rumpf
IPC分类号： A61K38/18 , C07K14/00 , C07K1/00
CPC分类号： A61K47/61 , A61K38/00 , A61K38/1816 , A61K38/193 , A61K38/465 , C07K14/505 , C07K14/52 , C07K14/535 , C07K14/575 , C12N9/22 , C12Y301/21001 , Y02A50/473
摘要： The present invention relates to a compound which is a polysaccharide derivative of EPO, or of an EPO like protein, wherein the polysaccharide is anionic and comprises between 2 and 200 saccharide units. The present invention also relates to pharmaceutical compositions comprising the novel compounds, and methods for making the novel compounds.
摘要翻译：本发明涉及作为EPO的多糖衍生物或EPO样蛋白质的化合物，其中所述多糖是阴离子型的，并且包含2至200个糖单元。本发明还涉及包含新化合物的药物组合物和制备新化合物的方法。

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