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31. 发明授权

US07744621B2 Inflatable occlusion devices, methods, and systems 有权
标题翻译：充气闭塞装置，方法和系统
公开(公告)号：US07744621B2
公开(公告)日：2010-06-29
申请号：US11294998
申请日：2005-12-06
申请人： Ram H. Paul , Jacob A. Flagle , Brian C. Case
发明人： Ram H. Paul , Jacob A. Flagle , Brian C. Case
IPC分类号： A61M29/00
CPC分类号： A61L29/005 , A61B17/12109 , A61B17/12136 , A61B17/1219 , A61B2017/1205
摘要： Described are devices, methods and systems useful for achieving occlusion of vascular vessels. Percutaneous procedures can be used to occlude and obliterate the greater saphenous vein, for example in the treatment of varicose vein condition caused by venous reflux. Certain embodiments encompass the deployment and filling of an inflatable occlusion device via a percutaneous procedure, so as to occlude or obliterate a portion of a vascular vessel.
摘要翻译：描述了用于实现血管血管阻塞的装置，方法和系统。经皮手术可用于闭塞和闭塞较大的隐静脉，例如用于治疗由静脉回流引起的静脉曲张病变。某些实施方案包括经由经皮程序展开和填充可充气闭塞装置，从而封闭或消除血管容器的一部分。

32. 发明授权

US07717930B2 Valvulotome with a cutting edge 有权
标题翻译：瓣切开术带有切削刃
公开(公告)号：US07717930B2
公开(公告)日：2010-05-18
申请号：US11070130
申请日：2005-02-28
申请人： Ram H. Paul, Jr. , Brian C. Case , Jacob A. Flagle
发明人： Ram H. Paul, Jr. , Brian C. Case , Jacob A. Flagle
IPC分类号： A61B17/22
CPC分类号： A61B17/3207 , A61B17/320725 , A61B2017/22097
摘要： Valvulotome devices comprising a cutting edge are provided. Some valvulotome devices incisably engage a venous valve leaflet within a body vessel while at least a portion of the cutting edge is oriented substantially parallel to the longitudinal axis of the valvulotome device. Valvulotome devices are preferably configured to slidably engage a venous valve leaflet upon translation of the valvulotome device along the longitudinal axis of a body vessel. A valvulotome device can further comprise one or more valvulotome arms of variable lengths and dimensions. In some embodiments, the valvulotome device can be self expanding. Embodiments of the invention also provide delivery systems comprising a valvulotome device. The present invention also provides for methods of using a valvulotome device. Kits comprising a valvulotome device are also provided.
摘要翻译：提供包括切削刃的瓣膜切开装置。一些瓣膜切开装置可切割地与身体血管内的静脉瓣膜接合，同时切割边缘的至少一部分基本上平行于瓣膜切开装置的纵向轴线定向。瓣膜切开装置优选地构造成在沿着身体血管的纵向轴线平移瓣膜切开装置时可滑动地接合静脉瓣膜瓣。瓣膜切开装置还可以包括一个或多个可变长度和尺寸的瓣膜切开臂。在一些实施例中，瓣膜切开装置可以是自膨胀的。本发明的实施例还提供包括瓣膜切开装置的输送系统。本发明还提供了使用瓣膜切开装置的方法。还提供了包括瓣膜切开装置的套件。

33. 发明授权

US07686844B2 Prosthetic valve for implantation in a body vessel 有权
标题翻译：用于植入体内的假体瓣膜
公开(公告)号：US07686844B2
公开(公告)日：2010-03-30
申请号：US10903907
申请日：2004-07-30
申请人： Brian C. Case , Thomas A. Osborne , Jacob A. Flagle , Fred T. Parker
发明人： Brian C. Case , Thomas A. Osborne , Jacob A. Flagle , Fred T. Parker
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2230/0067 , A61F2230/0078 , A61F2230/008 , A61F2250/0063
摘要： Prosthetic valves for implantation in a body vessel are provided. Prosthetic valves according to the invention comprise first and second frame members and a graft member at least partially disposed between the first and second frame members. The graft member forms a valve that permits fluid flow through the body vessel in a first direction and substantially prevents fluid flow through the body vessel in a second, opposite direction.
摘要翻译：提供用于植入体内的假体瓣膜。根据本发明的假体瓣膜包括第一和第二框架构件以及至少部分地设置在第一和第二框架构件之间的移植构件。移植物构件形成允许流体沿第一方向流过身体容器的阀，并且基本上防止流体沿第二相反方向流过身体血管。

34. 发明授权

US07670366B2 Intraluminal support device with graft 有权
标题翻译：腔内支持装置与移植物
公开(公告)号：US07670366B2
公开(公告)日：2010-03-02
申请号：US10820918
申请日：2004-04-08
申请人： Brian C. Case , Jacob A. Flagle , Ram H. Paul , Andrew K. Hoffa , Michael L. Garrison , Joseph F. Obermiller
发明人： Brian C. Case , Jacob A. Flagle , Ram H. Paul , Andrew K. Hoffa , Michael L. Garrison , Joseph F. Obermiller
IPC分类号： A61F2/06
CPC分类号： A61F2/2475 , A61F2/2418 , A61F2/848 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/0026 , A61F2230/0054 , A61F2230/0095
摘要： Implantable medical devices comprising a support frame and a graft member attached to the support frame. The support frame can define one or more structural features that substantially prevent migration of the graft member along the support frame.
摘要翻译：可植入医疗装置，其包括支撑框架和附接到支撑框架的移植物构件。支撑框架可以限定一个或多个结构特征，其基本上防止移植构件沿着支撑框架的移动。

35. 发明授权

US07563276B2 Intraluminal medical device with cannula for controlled retrograde flow 有权
标题翻译：管腔内医疗器械带套管用于控制逆行流
公开(公告)号：US07563276B2
公开(公告)日：2009-07-21
申请号：US11260981
申请日：2005-10-28
申请人： Thomas A. Osborne , Charles W. Agnew , Brian C. Case
发明人： Thomas A. Osborne , Charles W. Agnew , Brian C. Case
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0016 , A61F2220/0058 , A61F2220/0075 , A61F2230/0026 , A61F2230/0067 , A61F2230/0095
摘要： Prosthetic valves for regulating fluid flow through a body vessel are described. The valves include a valve member that includes at least a portion that is capable of moving to selectively permit and substantially prevent fluid flow through the body vessel, either alone or with one or more additional valve members. A cannula is associated with the valve and permits a controlled amount of fluid flow through the valve, such as retrograde flow while the valve member substantially prevents fluid flow through the body vessel.
摘要翻译：描述了用于调节通过身体血管的流体流动的假体瓣膜。阀包括阀构件，该阀构件包括至少一部分，其能够移动以选择性地允许和基本上防止流体流过身体容器，单独地或与一个或多个附加的阀构件。套管与阀相关联并且允许受控量的流体流过阀，例如逆流，同时阀构件基本上防止流体流过身体血管。

36. 发明申请

US20090177275A1 SENSING DELIVERY SYSTEM FOR INTRALUMINAL MEDICAL DEVICES 审中-公开
标题翻译：感染输送系统用于内科医疗器械
公开(公告)号：US20090177275A1
公开(公告)日：2009-07-09
申请号：US12406678
申请日：2009-03-18
申请人： Brian C. Case
发明人： Brian C. Case
IPC分类号： A61F2/24 , A61B5/05
CPC分类号： A61B5/1076 , A61B5/0215 , A61B2090/3784 , A61F2/2412 , A61F2/2436 , A61F2/2475 , A61F2/95 , A61F2002/011
摘要： Delivery systems and methods of treatment are described. The delivery systems facilitate visualization, monitoring, or sensing of body vessel parameters, blood parameters, or an intraluminal medical device included in the delivery system prior to, during, or after deployment in a body vessel. A sensing apparatus associated with the delivery systems provide information relating to the body vessel and/or fluid within the body vessel that can be used for verification of placement, confirmation of intraluminal medical device function, and/or determination of the need for additional delivery steps, among other purposes. The information can also be used for verification of initial vessel sizing information.
摘要翻译：描述了递送系统和治疗方法。递送系统便于在部署在体内血管之前，期间或之后的体内血管参数，血液参数或包括在输送系统中的管腔内医疗装置的可视化，监测或感测。与输送系统相关联的感测装置提供与身体容器和/或身体容器内的流体相关的信息，其可用于验证放置，确认管腔内医疗装置的功能和/或确定需要额外的输送步骤，其他目的。该信息也可用于验证初始容器尺寸信息。

37. 发明授权

US07524332B2 Vascular valve with removable support component 有权
标题翻译：具有可拆卸支撑部件的血管瓣
公开(公告)号：US07524332B2
公开(公告)日：2009-04-28
申请号：US10549437
申请日：2004-03-17
申请人： Thomas A. Osborne , Brian C. Case , David R. Lessard , Neal E. Fearnot
发明人： Thomas A. Osborne , Brian C. Case , David R. Lessard , Neal E. Fearnot
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2427 , A61F2/243 , A61F2/2475 , A61F2220/0016 , A61F2220/005 , A61F2220/0075 , A61F2230/0026 , A61F2230/0095
摘要： Described are vascular valve devices having valve elements formed of flexible material and at least one removable frame element. Also described are methods for using such devices in the vascular system and in particular in the venous system to treat venous insufficiency.
摘要翻译：描述了具有由柔性材料形成的阀元件和至少一个可拆卸框架元件的血管瓣膜装置。还描述了在血管系统中，特别是在静脉系统中使用这种装置来治疗静脉功能不全的方法。

38. 发明申请

US20090048669A1 METHODS AND SYSTEMS FOR MODIFYING VASCULAR VALVES 有权
标题翻译：用于修补血管的方法和系统
公开(公告)号：US20090048669A1
公开(公告)日：2009-02-19
申请号：US12257720
申请日：2008-10-24
申请人： Jacob A. Flagle , Brian C. Case
发明人： Jacob A. Flagle , Brian C. Case
IPC分类号： A61F2/28 , A61B19/00
CPC分类号： A61B17/00234 , A61B17/00491 , A61B17/064 , A61B17/122 , A61B18/1492 , A61B2017/00783 , A61F2/06 , A61F2/2475 , Y10S623/904
摘要： Described are methods and systems for modifying vascular valves in order to reduce retrograde blood flow through the valves. Preferred methods include connecting vascular valve leaflets with at least one remodelable material, such that the valve leaflets become fused by the ingrowth of the patient's native tissue. Preferred remodelable materials include collagenous extracellular matrix material, such as small intestine submucosa.
摘要翻译：描述了用于修改血管瓣膜以减少通过瓣膜的逆行血流量的方法和系统。优选的方法包括将血管瓣叶与至少一种可重塑材料连接，使得瓣膜小叶由于患者的天然组织的向内生长而变得熔化。优选的可重塑材料包括胶原细胞外基质材料，例如小肠粘膜下层。

39. 发明授权

US07449027B2 Modifying fluid flow in a body vessel lumen to promote intraluminal flow-sensitive processes 有权
标题翻译：修改体内血管腔内的流体流动，以促进腔内流感敏感过程
公开(公告)号：US07449027B2
公开(公告)日：2008-11-11
申请号：US11093401
申请日：2005-03-29
申请人： James B. Hunt , Brian C. Case
发明人： James B. Hunt , Brian C. Case
IPC分类号： A61F2/06
CPC分类号： A61F2/2403 , A61B17/12022 , A61B17/12036 , A61B17/1204 , A61B17/12109 , A61B17/12131 , A61B50/30 , A61B2017/00783 , A61F2/2412 , A61F2/2475 , A61F2002/068 , A61F2250/006 , Y10S623/903
摘要： The present invention, in one embodiment, provides an implantable intraluminal fluid flow control system comprising an interface and a flow-modifying device positioned at a flow-modifying effective distance from the interface within the lumen of a body vessel. In one embodiment, the invention relates to maintaining, regulating or varying the fluid flow within a body vessel to preserve, promote, alter or enhance remodeling of tissue at the interface. Remodeling can include the resorption and replacement of implanted remodelable material with autologous tissue. The interface can comprise remodelable material such as small intestine submucosa. In one embodiment, one or more interfaces are positioned at flow-modifying effective distances from one or more flow-modifying devices. Related medical devices, kits and methods of treatment are also provided in some embodiments.
摘要翻译：本发明在一个实施例中提供了一种植入式管腔内流体流动控制系统，其包括界面和流动修改装置，所述界面和流动修改装置以与主体容器的内腔内的界面有效距离的流动修改方式定位。在一个实施方案中，本发明涉及维持，调节或改变体内容器内的流体流动以保持，促进，改变或增强组织在界面处的重塑。重塑可以包括用自体组织吸收和替换植入的可重塑材料。界面可以包括可重塑的材料，例如小肠粘膜下层。在一个实施例中，一个或多个接口被定位成与一个或多个流量修改设备的流动修改有效距离。在一些实施例中也提供了相关的医疗装置，套件和治疗方法。

40. 发明授权

US07442206B2 Methods and systems for modifying vascular valves 有权
标题翻译：改变血管瓣膜的方法和系统
公开(公告)号：US07442206B2
公开(公告)日：2008-10-28
申请号：US11260360
申请日：2005-10-27
申请人： Jacob A. Flagle , Brian C. Case
发明人： Jacob A. Flagle , Brian C. Case
IPC分类号： A61F2/24
CPC分类号： A61B17/00234 , A61B17/00491 , A61B17/064 , A61B17/122 , A61B18/1492 , A61B2017/00783 , A61F2/06 , A61F2/2475 , Y10S623/904
摘要： Described are methods and systems for modifying vascular valves in order to reduce retrograde blood flow through the valves. Preferred methods include connecting vascular valve leaflets with at least one remodelable material, such that the valve leaflets become fused by the ingrowth of the patient's native tissue. Preferred remodelable materials include collagenous extracellular matrix material, such as small intestine submucosa.
摘要翻译：描述了用于修改血管瓣膜以减少通过瓣膜的逆行血流量的方法和系统。优选的方法包括将血管瓣叶与至少一种可重塑材料连接，使得瓣膜小叶通过患者的天然组织的向内生长而变得熔化。优选的可重塑材料包括胶原细胞外基质材料，例如小肠粘膜下层。

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