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31. 发明授权

US4758193A Color cathode ray tube having improved internal magnetic shield 失效
标题翻译：彩色阴极射线管具有改进的内部磁屏蔽
公开(公告)号：US4758193A
公开(公告)日：1988-07-19
申请号：US58085
申请日：1987-06-04
申请人： Richard I. Brown
发明人： Richard I. Brown
IPC分类号： H01J29/06
CPC分类号： H01J29/06
摘要： Internal magnetic shield for color television picture tube has a pair of slot-shaped openings, facing each other above and below the Z axis, and an oblong-shaped aperture surrounding the Z axis, having a length-to-width ratio of about 1.7 to 2.1.
摘要翻译：用于彩色电视显像管的内部磁屏蔽具有一对在Z轴上方和下方彼此相对的槽形开口，以及围绕Z轴的长圆形孔，其长宽比为约1.7至 2.1。

32. 发明授权

US4680025A Blood component collection systems and methods 失效
标题翻译：血液成分收集系统和方法
公开(公告)号：US4680025A
公开(公告)日：1987-07-14
申请号：US833530
申请日：1984-11-27
申请人： Robert J. Kruger , Richard I. Brown
发明人： Robert J. Kruger , Richard I. Brown
IPC分类号： A61M1/36 , A61M37/00
CPC分类号： A61M1/3693 , A61M1/3696 , A61M2202/0415 , A61M2202/0427 , A61M2209/06
摘要： A blood component collection system and method each utilizes centrifugation to first separate whole blood into red blood cells and platelet-rich plasma. Noncentrifugal separation is then utilized to further separate the platelet-rich plasma into platelet concentrate and plasma which is virtually free of platelets. The system and method are applicable for use in association with both batch and continuous flow procedures.
摘要翻译：血液成分收集系统和方法各自利用离心法首先将全血分离成红细胞和富血小板血浆。然后使用非离心分离来进一步将富含血小板的血浆分离成实质上不含血小板的血小板浓缩物和血浆。该系统和方法适用于与批次和连续流程相关联的使用。

33. 发明授权

US07001321B1 Carrier for holding a flexible fluid processing container 失效
标题翻译：用于保持柔性流体处理容器的载体
公开(公告)号：US07001321B1
公开(公告)日：2006-02-21
申请号：US09050614
申请日：1998-03-30
申请人： Richard I. Brown , Ying-Cheng Lo
发明人： Richard I. Brown , Ying-Cheng Lo
IPC分类号： B04B7/12
CPC分类号： B04B5/0442 , B04B5/0428 , B04B2005/045 , B04B2005/0492
摘要： A fluid processing assembly can be easily inserted into and removed from a rotatable centrifuge channel. The processing assembly comprises a processing container and a carrier. The processing container has flexibility and, in use, occupies the channel to receive fluids for separation in the centrifugal field. The carrier retains the processing container outside the channel in a flexed condition conforming to the channel. The carrier resists deformation of the processing container during its insertion into or removal from the channel.
摘要翻译：流体处理组件可以容易地插入到可旋转的离心机通道中并从旋转离心机通道中移除。处理组件包括处理容器和载体。处理容器具有柔性，并且在使用中占据通道以接收在离心场中分离的流体。承运人将处理容器保持在通道外，处于符合通道的弯曲状态。载体抵抗处理容器在其插入或从通道移除时的变形。

34. 发明授权

US06354291B1 Diving regulator with valved mouthpiece 失效
标题翻译：潜水调节器带阀口
公开(公告)号：US06354291B1
公开(公告)日：2002-03-12
申请号：US09612164
申请日：2000-07-08
申请人： Richard I. Brown , David S. Brown
发明人： Richard I. Brown , David S. Brown
IPC分类号： B63C1102
CPC分类号： B63C11/2227 , B63C11/186
摘要： A second stage diving regulator of the type used by scuba divers is provided. The regulator comprises a regulator housing and a mouthpiece. The regulator housing includes an inhalation chamber having a port, and a demand valve that releases air to the port in response to inhalation through the port. The mouthpiece comprises a unitary housing attachable to the regulator housing and includes a one-way exhalation pathway, thus obviating the need for an exhalation pathway in the regulator housing itself. Inhalation no-return valves can be additionally incorporated into the fluid pathway from the regulator housing to the diver to prevent fluids from flowing into the regulator housing through the mouthpiece. Saliva and exhaled air with its attendant moistures and pathogenic entities can thus be prevented from entering the regulator housing. The mouthpiece can be made easily detachable and can be sanitized between uses, making it particularly well suited for rental and instructional purposes. The disclosed invention keeps the interior spaces of the regulator clean and dry even when the regulator is not in place in the diver's mouth, thus extending regulator life and preventing a dangerous and irritating free-flow condition from occurring due to icing when used in cold water. The mouthpiece can be variously constructed to differentiate common-use mouthpieces from those owned individually.
摘要翻译：提供了潜水员使用的第二级潜水调节器。调节器包括调节器外壳和接口。调节器壳体包括具有端口的吸入室和响应于通过端口的吸入而将空气释放到端口的需求阀。吸嘴包括可连接到调节器壳体的单一壳体，并且包括单向呼气路径，从而避免了调节器壳体本身中的呼出路径的需要。吸入式止回阀可以额外地结合到从调节器壳体到潜水员的流体通道中，以防止流体通过接口管流入调节器壳体。因此可以防止唾液和呼出的空气及其伴随的湿润和致病实体进入调节器壳体。喉舌可以很容易地拆卸，并且可以在使用之间进行消毒，使其特别适用于出租和教学目的。所公开的发明保持调节器的内部空间即使在调节器不在潜水员的嘴中就位时也能够清洁和干燥，从而延长了调节器的使用寿命，并且防止在冷水中使用时由于结冰而产生危险和刺激性的自由流动状况。喉舌可以进行各种不同的构造，以将通用口气与单独使用的吸嘴区分开来。

35. 发明授权

US06228017B1 Compact enhanced yield blood processing systems 失效
标题翻译：紧密增强产量血液处理系统
公开(公告)号：US06228017B1
公开(公告)日：2001-05-08
申请号：US08856096
申请日：1997-05-14
申请人： Richard I. Brown
发明人： Richard I. Brown
IPC分类号： B01D2126
CPC分类号： B04B13/00 , A61M1/025 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3603 , A61M1/3693 , A61M1/3696 , A61M2202/0427 , A61M2205/331 , A61M2205/3344 , A61M2205/3351 , A61M2205/3355 , A61M2205/3393 , B01D17/0217 , B01D21/0003 , B01D21/2405 , B01D21/245 , B01D21/26 , B01D21/262 , B01D21/32 , B01D21/34 , B01D2221/10 , B04B5/0442 , B04B7/08 , B04B2005/045 , A61M2202/0071
摘要： A chamber for use in a rotating field to separate blood components. An inlet port near one end of the chamber introduces blood into the chamber for flow circumferentially about the rotational axis toward the opposite end of the chamber for separation into at least one blood component. At least one outlet port is juxtaposed next to the inlet port near the one end of the chamber for conveying one separated blood component from the channel. The chamber directs the one separated blood component to a collection region near the opposite end of the chamber. An enclosed interior collection passage within the channel leads from the collection region and directs the one collected component to the outlet port for transport from the chamber.
摘要翻译：用于旋转场中用于分离血液成分的室。靠近腔室一端的入口将血液引入腔室，用于围绕旋转轴线周向地朝向腔室的相对端流动，以分离成至少一个血液成分。至少一个出口端口靠近腔室一端的入口邻近并排，用于从通道传送一个分开的血液成分。腔室将一个分离的血液成分引导到靠近腔室相对端的收集区域。通道内的封闭内部收集通道从收集区域引出，并将一个收集的部件引导到出口，以便从腔室运输。

36. 发明授权

US6071421A Systems and methods for obtaining a platelet suspension having a reduced number of leukocytes 失效
标题翻译：用于获得白细胞数目减少的血小板悬浮液的系统和方法
公开(公告)号：US6071421A
公开(公告)日：2000-06-06
申请号：US977305
申请日：1997-11-25
申请人： Richard I. Brown
发明人： Richard I. Brown
IPC分类号： A61M1/02 , A61M1/30 , A61M1/36 , B01D17/02 , B01D21/24 , B01D21/26 , B04B5/04 , B04B7/08 , B04B13/00 , B01D36/00 , B01D37/00 , A61M1/38
CPC分类号： A61M1/3672 , A61M1/0218 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3603 , A61M1/3624 , A61M1/3693 , A61M1/3696 , B01D17/0217 , B01D21/2405 , B01D21/245 , B01D21/262 , B01D21/34 , B04B13/00 , B04B5/0442 , B04B7/08 , A61M1/025 , A61M1/30 , A61M2202/0427 , A61M2205/331 , A61M2205/3344 , A61M2205/3351 , A61M2205/3355 , A61M2205/3393 , B01D2221/08 , B01D2221/10 , B04B2005/045
摘要： Systems and methods obtain a platelet suspension with reduced number of leukocytes by centrifugally separating whole blood into red blood cells, a suspension of platelets, and an intermediate layer comprising leukocytes. The systems and methods convey the suspension of platelets from the centrifugal separation chamber to a filter, while maintaining the intermediate layer containing leukocytes inside the centrifugal separation chamber. The systems and methods filter remaining leukocytes from the platelet suspension in the filter.
摘要翻译：系统和方法通过将全血离心分离成红细胞，血小板悬浮液和包含白细胞的中间层，获得白细胞数目减少的血小板悬浮液。系统和方法将血小板从离心分离室的悬浮液输送到过滤器，同时将含有白细胞的中间层保持在离心分离室内。系统和方法从过滤器中的血小板悬浮液中过滤剩余的白细胞。

37. 发明授权

US5849203A Methods of accumulating separated blood components in a rotating chamber for collection 失效
标题翻译：在旋转室内积聚分离的血液成分的方法用于收集
公开(公告)号：US5849203A
公开(公告)日：1998-12-15
申请号：US943750
申请日：1997-10-03
申请人： Richard I. Brown , Sidney Smith , David E. Cerny , John T. Foley
发明人： Richard I. Brown , Sidney Smith , David E. Cerny , John T. Foley
IPC分类号： A61M1/02 , A61M1/30 , A61M1/36 , B01D17/02 , B01D21/24 , B01D21/26 , B04B5/04 , B04B13/00 , A61M1/38
CPC分类号： B01D17/0217 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3603 , A61M1/3693 , A61M1/3696 , B01D21/2405 , B01D21/2472 , B01D21/262 , B01D21/34 , B04B13/00 , B04B5/0442 , A61M1/025 , A61M1/30 , A61M2202/0439 , A61M2205/331 , A61M2205/3344 , A61M2205/3351 , A61M2205/3355 , A61M2205/3393 , B01D2221/10 , B04B2005/045
摘要： Methods of separating selected blood components separate blood by centrifugation in a rotating chamber into a first separated blood component, a residual blood fluid, and an interface between the first separated blood component and the residual blood fluid. The methods withdraw the first separated blood component out of the rotating chamber through a first outlet port, and withdraw the residual blood fluid out of the rotating chamber through a second outlet port. During the separation step, the methods accumulate a second separated blood component in the interface without withdrawal from the rotating chamber by controlling the position of the interface within the rotating chamber at a location spaced away from flow communication with both the first and second outlet ports. The methods terminate the withdrawing steps either when a desired volume of the second separated blood component has accumulated in the location or after a selected time period, and shift the location of the interface within the rotating chamber into flow communication with one of the first and second outlet ports. The methods withdraw the second separated blood component from the rotating chamber through the one outlet port.
摘要翻译：分离选择的血液成分的方法通过在旋转室中离心分离成第一分离的血液成分，残留血液流体和第一分离的血液成分与残留血液之间的界面来分离血液。所述方法通过第一出口将第一分离的血液成分从旋转腔中取出，并通过第二出口将剩余的血液流出旋转腔。在分离步骤期间，该方法通过在与第一和第二出口两端的流动连通间隔开的位置处控制旋转室内的界面的位置，从而在界面中积聚第二分离的血液成分，而不会从旋转腔中退出。当所述第二分离的血液成分的期望体积积聚在所述位置或选定的时间段之后，所述方法终止所述抽出步骤，并且使所述旋转室内的界面的位置与所述第一和第二出口端口该方法通过一个出口将第二分离的血液成分从旋转腔中取出。

38. 发明授权

US5730883A Blood processing systems and methods using apparent hematocrit as a process control parameter 失效
标题翻译：血液处理系统和方法使用明显的血细胞比容作为过程控制参数
公开(公告)号：US5730883A
公开(公告)日：1998-03-24
申请号：US473316
申请日：1995-06-07
申请人： Richard I. Brown
发明人： Richard I. Brown
IPC分类号： A61K35/14 , A61M1/02 , A61M1/30 , A61M1/36 , B01D17/02 , B01D17/038 , B01D17/12 , B01D21/24 , B01D21/26 , B04B5/04 , B04B7/08 , B04B13/00
CPC分类号： A61M1/3696 , A61M1/0209 , A61M1/0218 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3603 , A61M1/3624 , A61M1/3672 , A61M1/3693 , A61M1/385 , B01D17/0217 , B01D21/34 , B04B13/00 , B04B5/0442 , B04B7/08 , A61M1/025 , A61M2202/0415 , A61M2202/0427 , A61M2205/331 , A61M2205/3344 , A61M2205/3351 , A61M2205/3355 , A61M2205/3393 , B01D21/2405 , B01D21/245 , B01D21/262 , B01D2221/10
摘要： Blood processing systems and methods separate whole blood into red blood cells and a plasma constituent within a rotating centrifugal separation device. The systems and methods convey whole blood into the separation device through an inlet path including a pump operable at a prescribed rate. The systems and methods remove plasma constituent from the separation device through an outlet path including a pump operable at a prescribed rate. The systems and methods derive a value H.sub.b representing an apparent hematocrit of whole blood entering the separation device, where: ##EQU1## and where H.sub.rbc is a value relating to hematocrit of red blood cells in the separation device. The systems and methods generate outputs and control commands based, at least in part, upon H.sub.b.
摘要翻译：血液处理系统和方法将全血分离成红细胞和旋转离心分离装置内的等离子体成分。系统和方法通过包括可以规定速率操作的泵的入口路径将全血输送到分离装置中。系统和方法通过包括以规定速率操作的泵的出口路径从分离装置中除去等离子体成分。系统和方法得出表示进入分离装置的全血的明显血细胞比容的值Hb，其中：＆lt; IMAGE＆gt;其中Hrbc是与分离装置中的红细胞的血细胞比容有关的值。系统和方法至少部分地基于Hb生成输出和控制命令。

39. 发明授权

US5427695A Systems and methods for on line collecting and resuspending cellular-rich blood products like platelet concentrate 失效
标题翻译：在线收集和重悬细胞富集血液制品如血小板浓缩物的系统和方法
公开(公告)号：US5427695A
公开(公告)日：1995-06-27
申请号：US97293
申请日：1993-07-26
申请人： Richard I. Brown
发明人： Richard I. Brown
IPC分类号： A61M1/02 , A61K35/14 , A61M1/36 , B01D21/26 , B04B5/00 , B04B5/04
CPC分类号： B04B5/0442 , A61M1/3693 , A61M1/3696 , B01D21/262 , B01D21/302 , A61M2202/0427 , B01D2221/08 , B01D2221/10 , B04B2005/045
摘要： Systems and methods resuspend cellular-rich concentrates of blood by rocking the separation chamber to create variable agitation forces within the separation chamber. The systems and methods also add resuspension fluids to aid the resuspension.
摘要翻译：系统和方法通过摇动分离室来重新悬浮富含细胞的血液浓缩物，以在分离室内产生可变的搅动力。系统和方法还加入重悬浮液以辅助再悬浮。

40. 发明授权

US4530691A Centrifuge with movable mandrel 失效
标题翻译：用可移动心轴离心
公开(公告)号：US4530691A
公开(公告)日：1985-07-23
申请号：US560880
申请日：1983-12-13
申请人： Richard I. Brown
发明人： Richard I. Brown
IPC分类号： B04B5/00 , B04B5/04 , B04B7/12 , B04B1/06
CPC分类号： B04B5/0442
摘要： There is disclosed herein a liquid processing apparatus for use in centrifugal apheresis in which whole blood is received from a donor, separated into therapeutic components and selectively collected. The apparatus includes a processing chamber support system for cooperating in controlling the volume of a variable-volume blood processing chamber during apheresis. The support system is constructed to spin about a spin axis and is substantially symmetric about said axis.The elements of the support system include a chamber cover for receiving a variable-volume chamber. A mandrel is provided for engaging the variable-volume chamber and applying a conforming force to the chamber by urging the chamber toward the cover and thereby causing the chamber to conform to the shape of the cover. Thus the chamber is positioned between the cover and mandrel during apheresis, and the cover and mandrel cooperate in controlling the volume and shape of the chamber.The apparatus and chamber define an annular blood volume having a blood sedimentation surface and a cylindrical plasma volume having a cylindrical blood/plasma interface. The area of the blood sedimentation surface is greater than the interface area so as to maximize blood cell separation while minimizing platelet separation during the red blood cell separation and collection.
摘要翻译：本文公开了一种用于离心取样的液体处理装置，其中从供体接收全血，分离成治疗成分并选择性收集。该装置包括一个处理室支撑系统，用于在分离过程中协调控制可变体积血液处理室的体积。支撑系统构造成围绕旋转轴旋转并且基本上围绕所述轴对称。支撑系统的元件包括用于容纳可变容积室的室盖。提供了一个心轴，用于接合可变体积腔室，并通过将腔室推向盖子并由此使腔室符合盖子的形状，向腔室施加适应力。因此，在分离过程期间，室被定位在盖和心轴之间，并且盖和心轴协调控制腔的体积和形状。该装置和室限定具有血液沉降表面的环形血液体积和具有圆柱形血液/血浆界面的圆柱形血浆体积。血液沉淀表面的面积大于界面面积，从而最大化血液细胞分离，同时使血细胞分离和收集期间的血小板分离最小化。

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