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31. 发明授权

US5725552A Percutaneous catheter directed intravascular occlusion devices 失效
标题翻译：经皮导管导管的血管内闭塞装置
公开(公告)号：US5725552A
公开(公告)日：1998-03-10
申请号：US647712
申请日：1996-05-14
申请人： Frank Kotula , Kurt Amplatz , Curtis Amplatz
发明人： Frank Kotula , Kurt Amplatz , Curtis Amplatz
IPC分类号： A61B17/12 , A61B17/00 , A61F2/00 , A61F2/01 , A61F2/90 , A61M25/00 , B21F45/00 , A61B17/08
CPC分类号： A61F2/90 , A61B17/0057 , A61B17/12022 , A61B17/12109 , A61B17/12122 , A61B17/12172 , A61B17/12177 , A61F2/01 , B21F45/00 , B21F45/008 , A61B2017/00526 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00615 , A61B2017/00867 , A61F2/95 , A61F2002/016 , A61F2002/018 , A61F2002/30093 , A61F2210/0019 , A61F2220/0041 , A61F2230/0006 , A61F2230/0069 , A61F2230/0078 , A61F2230/008 , A61F2240/001
摘要： The present invention provides a method of forming a medical device and medical devices which can be formed in accordance with the method. In one embodiment, the method includes the steps of a) providing a metal fabric formed of a plurality of strands formed of a metal which can be heat treated to substantially set a desired shape; b) deforming the metal fabric to generally conform to a surface of a molding element; c) heat treating the metal fabric in contact with the surface of the molding element to substantially set the shape of the fabric in its deformed state; and d) removing the metal fabric from contact with the molding element. The resulting metal fabric will define a medical device which can be collapsed for passage through a catheter or the like for deployment in a channel of a patient's body. Medical devices made in accordance with this method can have varying structures.
摘要翻译：本发明提供一种可以根据该方法形成的医疗装置和医疗装置的形成方法。在一个实施方案中，该方法包括以下步骤：a）提供由多个由金属形成的股线形成的金属织物，该金属纤维可被热处理以基本上设定所需形状; b）使金属织物变形以与模制元件的表面大致相符; c）对与模制元件的表面接触的金属织物进行热处理，以将织物的形状基本上设定在其变形状态; 以及d）去除金属织物与模制元件的接触。所得到的金属织物将限定医疗装置，其可以折叠以通过导管等，以便部署在患者身体的通道中。根据该方法制造的医疗装置可以具有不同的结构。

32. 发明授权

US5135516A Lubricious antithrombogenic catheters, guidewires and coatings 失效
标题翻译：润滑性抗生素导管，指南和涂层
公开(公告)号：US5135516A
公开(公告)日：1992-08-04
申请号：US451507
申请日：1989-12-15
申请人： Ronald Sahatjian , Kurt Amplatz
发明人： Ronald Sahatjian , Kurt Amplatz
IPC分类号： A61L33/00 , A61M25/00
CPC分类号： A61M25/0045 , A61L33/0023 , A61L33/0029 , A61M2025/0046
摘要： Method for rendering a preformed article lubricious and antithrombogenic and a device being the same. On the surface of the article a thin coating of a biologically compatible, lubricious, hydrophilic polymer including acid groups, is provided. On the coating, ammonium cation, and heparin are applied in the manner that heparin is bound by electrostatic attraction to the ammonium cation of the coating to permit time release of heparin. A buffer solution may be applied in a manner to act to enhance the lubriciousness of the coating.
摘要翻译：用于使预成型制品具有光滑和抗血栓形成的方法和与之相同的装置。在制品的表面上提供了包含酸基团的生物相容的，润滑的亲水性聚合物的薄涂层。在涂层上，铵盐阳离子和肝素以使肝素被静电吸引到涂层的铵阳离子结合以允许肝素释放的方式施用。缓冲溶液可以以提高涂层的光泽度的方式起作用。

33. 发明授权

US08163004B2 Stent graft for reinforcement of vascular abnormalities and associated method 有权
标题翻译：支架移植用于加强血管异常及相关方法
公开(公告)号：US08163004B2
公开(公告)日：2012-04-24
申请号：US12032938
申请日：2008-02-18
申请人： Kurt Amplatz , Robert Laine
发明人： Kurt Amplatz , Robert Laine
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61F2/90 , A61F2250/0037 , A61F2250/0039
摘要： A stent graft for reinforcement of a vascular abnormalities and an associated method are provided. According to one embodiment, the stent graft includes a flexible tubular structure comprising a proximal end and a distal end and having an expanded heat set configuration. The tubular structure is configured to be constrained to a smaller diameter than the expanded heat set configuration, and the tubular structure is heat set such that at least a portion of the proximal and/or distal ends is configured to fold over on itself when unconstrained.
摘要翻译：提供了用于增强血管异常的支架移植物和相关方法。根据一个实施例，支架移植物包括柔性管状结构，其包括近端和远端并具有膨胀的热定形构型。管状结构被配置为被限制到比膨胀的热定形构造更小的直径，并且管状结构被热定形，使得近端和/或远端的至少一部分被配置成在不受约束的情况下自身折叠。

34. 发明授权

US06402772B1 Alignment member for delivering a non-symmetrical device with a predefined orientation 有权
标题翻译：用于递送具有预定义取向的非对称装置的对准构件
公开(公告)号：US06402772B1
公开(公告)日：2002-06-11
申请号：US09981736
申请日：2001-10-17
申请人： Kurt Amplatz , Michael Afremov
发明人： Kurt Amplatz , Michael Afremov
IPC分类号： A61B1700
CPC分类号： A61B17/12022 , A61B17/12109 , A61B17/12172 , A61B2017/00455 , A61B2017/00592 , A61B2017/00606 , A61B2017/00623 , A61B2017/12095
摘要： A method for delivering an object within a patient, wherein the object is delivered in a preferred orientation relative to the delivery site of the patient. The delivery device has an alignment member that allows the object to be delivered intravascularly to the delivery site of the patient, wherein the object is delivered in a pre-determined orientation. The object may, for example, be non-symmetric or include a configuration that requires delivery to the site in only one suitable orientation relative to the delivery site. Such objects may be used, for example, to treat certain defects or injuries in vessels or organs within a patient's body.
摘要翻译：一种用于递送患者体内的物体的方法，其中所述物体相对于患者的递送部位以优选的方向递送。递送装置具有对准构件，其允许物体血管内输送到患者的输送部位，其中物体以预定方向递送。例如，该对象可以是非对称的，或者包括需要相对于递送部位仅以一个合适方向递送到该站点的配置。这样的物体可以用于例如治疗患者体内的血管或器官中的某些缺陷或损伤。

35. 发明授权

US5846261A Percutaneous catheter directed occlusion devices 失效
标题翻译：经皮导管导向闭塞装置
公开(公告)号：US5846261A
公开(公告)日：1998-12-08
申请号：US925935
申请日：1997-09-08
申请人： Frank Kotula , Kurt Amplatz
发明人： Frank Kotula , Kurt Amplatz
IPC分类号： A61B17/08 , A61B17/00 , A61B17/12 , A61F2/00 , A61F2/01 , A61F2/90
CPC分类号： A61B17/12122 , A61B17/0057 , A61B17/12022 , A61B17/12109 , A61B17/12172 , A61B17/12177 , A61F2/01 , B21F45/008 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00867 , A61F2/90 , A61F2002/016 , A61F2002/30093 , A61F2210/0019 , A61F2230/0006 , A61F2230/0065 , A61F2230/0069 , A61F2230/0071 , A61F2230/0078 , A61F2230/008
摘要： A collapsible medical device and associated methods for occluding an abnormal opening in, for example, a body organ, wherein the medical device is shaped from a heat treatable metal fabric. The metal fabric is formed from a plurality of metal strands and is heat treated within a mold in order to substantially set a desired shape of the device. The medical device includes a fastener for attaching to the end of a guide wire or delivery catheter, wherein the shape of the medical device is formed such that the fastener is attached to the metal fabric within a recess formed in the shape of the medical device. A medical device having a preselected shape is delivered through a catheter or the like for deployment in a desired channel or opening in a patient's body. The medical device may be shaped, for example, to occlude an ASD, PDA, or a VSD.
摘要翻译：一种可折叠的医疗装置和用于阻塞例如身体器官中的异常开口的相关方法，其中所述医疗装置由可热处理的金属织物成形。金属织物由多个金属线形成，并且在模具内进行热处理，以便基本上设定器件的期望形状。医疗装置包括用于附接到导丝或输送导管的端部的紧固件，其中医疗装置的形状形成为使得紧固件在形成为医疗装置形状的凹部内附接到金属织物。具有预选形状的医疗装置通过导管等传送，以展开在患者身体中的期望的通道或开口中。医疗装置可以被成形为例如遮挡ASD，PDA或VSD。

36. 发明授权

US4361899A Scanning x-ray system 失效
公开(公告)号：US4361899A
公开(公告)日：1982-11-30
申请号：US253182
申请日：1981-04-13
申请人： Kurt Amplatz
发明人： Kurt Amplatz
IPC分类号： A61B6/02 , A61B6/06 , G03B41/16
CPC分类号： A61B6/02 , A61B6/06 , A61B6/4464
摘要： An x-ray apparatus uses an x-ray tube which is pivoted about a pivot axis to provide scanning of an x-ray beam. The pivot axis passes essentially through the center of the focal spot on the target surface of the anode of the tube, is essentially perpendicular to the anode-cathode axis, and is essentially parallel to a film plane defined by the x-ray film. The scanning of the x-ray beam by pivoting the x-ray tube results in improved systems for standard radiography, linear tomography, and large-scale angiography. In standard radiography and large scale angiography systems, moving primary and secondary slots synchronized with the pivoting of the x-ray tube provide efficient removal of secondary radiation. In linear tomography systems, the object and film are moved synchronously with the pivoting of the x-ray tube, and primary and secondary slots which are stationary remove secondary radiation.

37. 发明申请

US20060253184A1 System for the controlled delivery of stents and grafts 审中-公开
标题翻译：用于支架和移植物受控输送的系统
公开(公告)号：US20060253184A1
公开(公告)日：2006-11-09
申请号：US11121386
申请日：2005-05-04
申请人： Kurt Amplatz
发明人： Kurt Amplatz
IPC分类号： A61F2/06
CPC分类号： A61F2/95
摘要： The present invention provides a delivery mechanism for percutaneously routing a stent or graft through the vascular system and procedures for addressing an aneurysm or an otherwise damaged vessel. The delivery system includes an outer tubular guide catheter 20, an inner tubular delivery (pusher) catheter 14 coaxially disposed and slidable relative to the outer guide catheter and an elongated flexible wire or cable 26 that is coaxially insertable through the lumen of the inner tubular catheter and that has a frusto-conical bead affixed at the distal end thereof which is sized to at least partially fit within the lumen of the inner pusher catheter when a proximally directed tension force is applied between the elongated flexible wire or cable 26 with respect to the pusher catheter 14. By inserting a compressed coil spring between a proximal end portion of the pusher catheter 14 and the proximal end portion of the cable 26, the requisite clamping force is maintained to secure the stent or graft to the distal end of the pusher catheter until the compression spring force is removed. With the stent or graft clamped to the distal end of the inner pusher catheter, it can be drawn within the lumen of the outer guide catheter for delivery therewith to the target site.
摘要翻译：本发明提供一种用于经皮穿透支架或移植物穿过血管系统的递送机制以及用于解决动脉瘤或另外受损的血管的程序。输送系统包括外部管状引导导管20，相对于外部引导导管同轴地设置和滑动的内部管状输送（推动器）导管14和可同轴插入穿过内部管状导管的内腔的细长柔性线或电缆26 并且其具有固定在其远端处的截头圆锥形珠，其尺寸设计成至少部分地配合在内部推动器导管的内腔内时，当在细长柔性线或电缆26之间相对于推动导管14.通过在推动器导管14的近端部分和电缆26的近端部分之间插入压缩的螺旋弹簧，维持必要的夹持力以将支架或移植物固定到推动导管的远端直到压缩弹簧力被去除。当将支架或移植物夹持到内部推动器导管的远端时，其可以在外导向导管的内腔中被拉伸以便与其一起输送到目标部位。

38. 发明授权

US06334864B1 Alignment member for delivering a non-symmetric device with a predefined orientation 有权
标题翻译：用于递送具有预定义取向的非对称装置的对准构件
公开(公告)号：US06334864B1
公开(公告)日：2002-01-01
申请号：US09572649
申请日：2000-05-17
申请人： Kurt Amplatz , Michael Afremov
发明人： Kurt Amplatz , Michael Afremov
IPC分类号： A61B1700
CPC分类号： A61B17/12022 , A61B17/12109 , A61B17/12172 , A61B2017/00455 , A61B2017/00592 , A61B2017/00606 , A61B2017/00623 , A61B2017/12095
摘要： A device and method for delivering an object within a patient, wherein the object is delivered in a preferred orientation relative to the delivery site of the patient. The delivery device has an alignment member that allows the object to be delivered intravascularly to the delivery site of the patient, wherein the object is delivered in a pre-determined orientation. The object may, for example, be non-symmetric or include a configuration that requires delivery to the site in only one suitable orientation relative to the delivery site. Such objects may be used, for example, to treat certain defects or injuries in vessels or organs within a patient's body.
摘要翻译：一种用于递送患者体内的物体的装置和方法，其中所述物体相对于患者的递送部位以优选的方向递送。递送装置具有对准构件，其允许物体血管内输送到患者的输送部位，其中物体以预定方向递送。例如，该对象可以是非对称的，或者包括需要相对于递送部位仅以一个合适方向递送到该站点的配置。这样的物体可以用于例如治疗患者体内的血管或器官中的某些缺陷或损伤。

39. 发明授权

US06210338B1 Sizing catheter for measuring cardiovascular structures 有权
标题翻译：用于测量心血管结构的尺寸导管
公开(公告)号：US06210338B1
公开(公告)日：2001-04-03
申请号：US09450240
申请日：1999-11-29
申请人： Michael Afremov , Kurt Amplatz
发明人： Michael Afremov , Kurt Amplatz
IPC分类号： A61B502
CPC分类号： A61B5/1076 , A61M25/10
摘要： A sizing catheter and method of measuring a preselected internal opening within a patient to provide a rapid and precise determination of first and second stretched diameters of the preselected internal opening. The sizing catheter includes a dilation balloon constructed of a thin expandable plastic, which is inflatable and is utilized to determine a size of the preselected opening. The dilation balloon is inflated to an inflation threshold wherein the dilation balloon deforms about the preselected opening and the size of the dilation balloon adjacent the preselected opening approximates the first stretched diameter of the preselected opening. The sizing catheter and method may be utilized to determine an appropriate sized device to be positioned within the preselected opening.
摘要翻译：尺寸导管和测量患者内的预选内部开口的方法，以快速和精确地确定预先选择的内部开口的第一和第二拉伸直径。定径导管包括由薄的可膨胀塑料构成的扩张气囊，其是可充气的并且用于确定预选开口的尺寸。膨胀气囊膨胀至充气阈值，其中扩张气囊围绕预选开口变形，并且与预选开口相邻的扩张球囊的尺寸近似于预选开口的第一拉伸直径。定径导管和方法可以用于确定要放置在预选开口内的合适尺寸的装置。

40. 发明授权

US5098393A Medical introducer and valve assembly 失效
标题翻译：医疗导引器和阀组件
公开(公告)号：US5098393A
公开(公告)日：1992-03-24
申请号：US200662
申请日：1988-05-31
申请人： Kurt Amplatz , Frank Kotula
发明人： Kurt Amplatz , Frank Kotula
IPC分类号： A61M25/06 , A61M39/06
CPC分类号： A61M25/0606 , A61M39/0606 , A61M2025/0687 , A61M2039/062 , A61M2039/0633 , A61M2039/0686
摘要： A medical catheter introducer and hemostasis valve assembly consists of a sheath having an elongated tube defining a conduit, a housing disposed at the proximal end of the sheath and further defining a conduit and an orifice, and a flexible elongated dilator sized for insertion through the hub and sheath conduit. The dilator has a tapered distal tip end and defines an axial conduit and an annular ridge having distally- and proximally-directed inclined surfaces. The sheath, when assembled with the dilator, has its distal end immediately adjacent the proximally-directed inclined surface of the ridge. A hemostasis valve for sealing the conduit is disposed in alignment with the conduit, and defines an aperture for passage of dilator and ridge therethrough in sealing engagement, into the conduit, and seals when the dilator is removed. The valve has a housing defining an orifice of a first diameter, and a valve element of a second diameter, greater than the first diameter. The valve is disposed within the orifice and is subject to externally-applied, radially directed forces that cause the valve to assume a dome-shape formation, with a convex surface disposed against the pressure of fluids within the body. As the introducer assembly is introduced into a body over a guidewire extending via a puncture opening into a vessel, the dilator and sheath flex to follow the guidewire, and the tapered end of the dilator and the distally-directed inclined surface of the ridge act to dilate the flesh about the opening to facilitate passage of the sheath. The introducer and valve may be used alone, or respectively with valves or introducers of other design. A base for attachment of the introducer to the patient is also described.
摘要翻译：医疗导管导引器和止血阀组件包括具有限定导管的细长管的护套，设置在护套的近端处并进一步限定导管和孔的壳体，以及尺寸适于插入穿过毂的柔性细长扩张器和鞘导管。扩张器具有锥形的远端尖端并且限定轴向导管和具有远侧和近侧定向的倾斜表面的环形脊。当与扩张器组装时，护套的远端紧邻脊的向近侧倾斜的表面。用于密封导管的止血阀设置成与管道对准，并且在密封接合时限定了用于使膨胀器和脊通过的孔，用于密封接合，并且当扩张器被移除时密封。阀具有限定第一直径的孔的壳体和大于第一直径的第二直径的阀元件。阀设置在孔内并且受到外部施加的径向力的作用，使得阀呈现穹顶形状，其中凸表面抵抗体内流体的压力设置。当导引器组件被引入到穿过穿刺孔延伸到血管中的导丝上的主体中时，扩张器和皮肤弯曲以跟随导丝，并且扩张器的锥形端和脊的远侧倾斜的表面作用到扩大围绕开口的肉体，以方便鞘的通过。导引器和阀可以单独使用，也可以分别用于其他设计的阀门或导引器。还描述了用于将导引器附接到患者的基部。

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