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31. 发明申请

US20060105440A1 Method of producing polyhydroxyalkanoate 审中-公开
标题翻译：聚羟基链烷酸酯的制备方法
公开(公告)号：US20060105440A1
公开(公告)日：2006-05-18
申请号：US11237686
申请日：2005-09-29
申请人： Koichi Kinoshita , Yoshifumi Yanagida , Fumio Osakada , Yasuyoshi Ueda
发明人： Koichi Kinoshita , Yoshifumi Yanagida , Fumio Osakada , Yasuyoshi Ueda
IPC分类号： C12P7/62
CPC分类号： C12P7/62 , C08G63/89
摘要： The present invention has its object to provide a method of producing PHA by extracting, separating, and purifying PHA from biomass containing PHA having an weight average molecular weight of more than 2,000,000, by which smooth stirring can be carried out during extraction and filterability of a residue becomes good to thereby efficiently produce PHA with good operability. In the present invention, PHA is extracted, separated, and purified from biomass by a method of producing polyhydroxyalkanoate by extracting and isolating polyhydroxyalkanoate by using an aprotic organic solvent from biomass containing polyhydroxyalkanoate having a weight average molecular weight of more than 2,000,000, which comprises decreasing the weight average molecular weight of the polyhydroxyalkanoate through any one of the following treatments: (a) the biomass is heated at 40 to 500° C. before addition of the aprotic organic solvent; (b) the biomass is heated at 40 to 500° C. before addition of the aprotic organic solvent, and is further heated at 40 to 200° C. in the aprotic organic solvent; (c) the biomass is heated at 40 to 500° C. before addition of the aprotic organic solvent, and is further heated at 40 to 200° C. in the aprotic organic solvent in the presence of water and/or an alcohol; (d) the biomass is not heated before addition of the aprotic organic solvent, but is heated at 40 to 200° C. in the aprotic organic solvent; and (e) the biomass is not heated before addition of the aprotic organic solvent, but is heated at 40 to 200° C. in the aprotic organic solvent in the presence of water and/or an alcohol.
摘要翻译：本发明的目的是提供一种通过从重均分子量大于2,000,000的PHA的生物质中提取，分离和纯化PHA来生产PHA的方法，通过该方法可以在提取过程中进行平稳的搅拌和过滤性残留物变得良好，从而有效地产生具有良好可操作性的PHA。在本发明中，通过使用含有重均分子量大于2,000,000的聚羟基链烷酸酯的生物质的非质子有机溶剂提取和分离聚羟基链烷酸酯的方法，从生物质中提取，分离和纯化PHA，其包括降低通过以下任何一种处理，聚羟基链烷酸酯的重均分子量：（a）在加入非质子有机溶剂之前，将生物质在40-500℃下加热; （b）在加入非质子有机溶剂之前将生物质在40-500℃加热，并在非质子有机溶剂中在40〜200℃下进一步加热; （c）在加入非质子有机溶剂之前将生物质加热至40-500℃，并在水和/或醇存在下，在非质子有机溶剂中在40〜200℃下进一步加热; （d）在加入非质子有机溶剂之前，不加热生物质，但在非质子有机溶剂中在40〜200℃下加热生物质; 和（e）生物质在加入非质子有机溶剂之前不被加热，但在水和/或醇的存在下，在非质子传递的有机溶剂中在40-200℃下加热。

32. 发明授权

US06204393B1 Method for crystallizing maleic acid salt of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-L-proline 失效
标题翻译： N-（1（S） - 乙氧基羰基-3-苯基丙基）-L-丙氨酰-L-脯氨酸的马来酸盐结晶方法
公开(公告)号：US06204393B1
公开(公告)日：2001-03-20
申请号：US09508801
申请日：2000-03-17
申请人： Koichi Kinoshita , Tadashi Moroshima , Yoshifumi Yanagida , Yoshihide Fuse , Yasuyoshi Ueda
发明人： Koichi Kinoshita , Tadashi Moroshima , Yoshifumi Yanagida , Yoshihide Fuse , Yasuyoshi Ueda
IPC分类号： C07K5062
CPC分类号： C07K5/06026
摘要： A process for simply and easily crystallizing a maleate salt of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-L-proline (enalapril) having a high quality out of an aqueous liquid, which comprises mixing an aqueous liquid having a pH of not less than 4 and containing N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-L-proline, maleic acid and a base with an amount of an acid sufficient to convert substantially all the base into a neutral salt.
摘要翻译：一种从水性液体中简单且容易地结晶出具有高质量的N-（1（S） - 乙氧基羰基-3-苯基丙基）-L-丙氨酰-L-脯氨酸（依那普利）的马来酸盐的方法，其包括将含有不少于4的pH并含有N-（1（S） - 乙氧基羰基-3-苯基丙基）-L-丙氨酰-L-脯氨酸，马来酸和碱的量的水溶液，其含量足以基本上转化所有的碱都成为中性盐。

33. 发明授权

US09388109B2 Reduced coenzyme Q10 crystal having excellent stability 有权
标题翻译：还原型辅酶Q10晶体具有优异的稳定性
公开(公告)号：US09388109B2
公开(公告)日：2016-07-12
申请号：US14129003
申请日：2012-06-21
申请人： Hideo Kawachi , Shiro Kitamura , Yasuyoshi Ueda
发明人： Hideo Kawachi , Shiro Kitamura , Yasuyoshi Ueda
IPC分类号： A61K31/12 , C07C49/577 , A23L2/52 , A23K1/16 , A23L1/30 , A61K8/34 , A61Q19/00 , C07C45/81 , C07C41/40 , C07C41/46 , C07C43/23
CPC分类号： C07C49/577 , A23K20/111 , A23L2/52 , A23L33/10 , A23V2002/00 , A61K8/347 , A61K9/28 , A61K31/122 , A61Q19/00 , C07C41/40 , C07C41/46 , C07C43/23 , C07C45/81
摘要： With respect to reduced coenzyme Q10, there has been no report about the presence of crystal polymorphism, and it has been considered that a conventionally obtained crystal form is only one form. The present invention relates to a reduced coenzyme Q10 crystal having an endothermic peak indicating melting at 54±2° C. during temperature rise at a rate of 5° C./min by differential scanning calorimetry (DSC), and/or to a reduced coenzyme Q10 crystal showing characteristic peaks at diffraction angles (2θ±0.2°) of 11.5°, 18.2°, 19.3°, 22.3°, 23.0° and 33.3° by powder X-ray (Cu—Kα) diffraction. The crystal form is a novel reduced coenzyme Q10 crystal which has a higher melting point and a lower solubility in a solvent, and is more excellent in stability than the conventionally known reduced coenzyme Q10 crystal.
摘要翻译：关于还原型辅酶Q10，没有关于晶体多晶型的存在的报道，已经认为常规获得的晶体形式仅是一种形式。本发明涉及在通过差示扫描量热法（DSC）以5℃/ min的速率升温的温度升高期间具有指示在54±2℃熔化的吸热峰的还原型辅酶Q10晶体和/或还原型辅酶Q10晶体通过粉末X射线（Cu-Kα）衍射，辅助Q10晶体在衍射角（2θ;±0.2°）为11.5°，18.2°，19.3°，22.3°，23.0°和33.3°处显示出特征峰。晶体形式是在溶剂中具有较高熔点和较低溶解度的新型还原型辅酶Q10晶体，其稳定性优于常规已知的还原型辅酶Q10晶体。

34. 发明授权

US09315839B2 Processes for producing coenzyme Q10 有权
标题翻译：生产辅酶Q10的方法
公开(公告)号：US09315839B2
公开(公告)日：2016-04-19
申请号：US13020500
申请日：2011-02-03
申请人： Kazuyoshi Yajima , Takahisa Kato , Akihisa Kanda , Shiro Kitamura , Yasuyoshi Ueda
发明人： Kazuyoshi Yajima , Takahisa Kato , Akihisa Kanda , Shiro Kitamura , Yasuyoshi Ueda
IPC分类号： C12P7/66 , C12P7/22
CPC分类号： C12P7/66 , C12P7/22
摘要： The present invention relates to a process for producing reduced coenzyme Q10 which comprises obtaining microbial cells containing reduced coenzyme Q10 at a ratio of not less than 70 mole % among the entire coenzymes Q10, optionally disrupting the cells and recovering thus produced reduced coenzyme Q10. The present invention also relates to a process for producing oxidized coenzyme Q10 which comprises either recovering oxidized coenzyme Q10 after oxidizing the above-mentioned microbial cells or disrupted product thereof, or recovering reduced coenzyme Q10 from the above-mentioned microbial cells or disrupted product thereof to oxidize thus-obtained reduced coenzyme Q10 thereafter. According to the processes of the present invention, reduced coenzyme Q10 and oxidized coenzyme Q10 can be produced simply on the industrial scale.
摘要翻译：本发明涉及一种还原型辅酶Q10的制备方法，其包括在整个辅酶Q10中获得含有还原型辅酶Q10比例不小于70摩尔％的微生物细胞，任选地破坏细胞并回收所生成的还原型辅酶Q10。本发明还涉及氧化型辅酶Q10的制造方法，该方法包括在氧化上述微生物细胞或其破坏的产物后回收氧化型辅酶Q10，或将还原型辅酶Q10从上述微生物细胞或其破坏性产物回收至此后氧化由此得到的还原型辅酶Q10。根据本发明的方法，可以简单地在工业规模上制备还原型辅酶Q10和氧化型辅酶Q10。

35. 发明授权

US08067217B2 Method for preserving reduced coenzyme Q10 有权
标题翻译：保留还原型辅酶Q10的方法
公开(公告)号：US08067217B2
公开(公告)日：2011-11-29
申请号：US11315161
申请日：2005-12-23
申请人： Takahiro Ueda , Tadao Ono , Shiro Kitamura , Yasuyoshi Ueda
发明人： Takahiro Ueda , Tadao Ono , Shiro Kitamura , Yasuyoshi Ueda
IPC分类号： C12N9/98
CPC分类号： A61K9/4816
摘要： The present invention has its object to provide a method for stably preserving a capsule containing reduced coenzyme Q10, which is useful as foods, functional nutritive foods, specific health foods, nutritional supplements, nutrients, animal drugs, drinks, feeds, cosmetics, medicines, remedies, preventive drugs, etc. The present invention relates to a method for preserving reduced coenzyme Q10 which comprises producing or obtaining a capsule containing reduced coenzyme Q10, and controlling environment surrounding the capsule to a relative humidity of not less than 0% but not more than 60%. According to this method, reduced coenzyme Q10 can be preserved stably, without requiring huge cost and labor, or special equipment.
摘要翻译：本发明的目的是提供一种用于稳定保存含有还原型辅酶Q10的胶囊的方法，所述还原型辅酶Q10可用作食品，功能营养食品，特定保健食品，营养补充剂，营养物质，动物药物，饮料，饲料，化妆品，药物，补救剂，预防药物等。本发明涉及一种保存还原型辅酶Q10的方法，其包括制备或获得含有还原型辅酶Q10的胶囊，并且将胶囊周围的环境控制在相对湿度不小于0％但不超过超过60％。根据该方法，可以稳定地保持还原型辅酶Q10，而不需要巨大的成本和劳动力，或特殊设备。

36. 发明申请

US20110263906A1 METHOD OF PRODUCING REDUCED COENZYME Q10 CRYSTALS WITH EXCELLENT HANDLING PROPERTIES 有权
标题翻译：生产具有优异处理性能的还原型COYZYME Q10水晶的方法
公开(公告)号：US20110263906A1
公开(公告)日：2011-10-27
申请号：US13176479
申请日：2011-07-05
申请人： Takahiro Ueda , Shiro Kitamura , Yasuyoshi Ueda
发明人： Takahiro Ueda , Shiro Kitamura , Yasuyoshi Ueda
IPC分类号： C07C41/40
CPC分类号： C07C41/40 , C07C43/23
摘要： The present invention provides a method of producing reduced coenzyme Q10 crystals suitable for commercial scale production thereof.According to a method of the present invention of producing a reduced coenzyme Q10 crystal which comprises a crystallization of reduced coenzyme Q10 in a solution of alcohols and/or ketones, reduced coenzyme Q10 crystal excellent in slurry properties and crystalline properties maybe obtained. Moreover, an isolation process including a crystal separation or the whole process including the isolation process maybe minimized and simplified. Thus, highly pure reduced coenzyme Q10 may be obtained in a high yield.
摘要翻译：本发明提供了适合于商业规模生产的还原型辅酶Q10晶体的制造方法。根据本发明的制备还原型辅酶Q10晶体的方法，所述还原型辅酶Q10晶体包括在醇和/或酮溶液中结晶还原型辅酶Q10，可得到浆料性能和结晶性能优异的还原型辅酶Q10晶体。此外，包括晶体分离的分离过程或包括隔离过程的整个过程可以被最小化和简化。因此，可以高产率获得高纯度还原型辅酶Q10。

37. 发明授权

US07897169B2 Ubiquinol-enriched fat-containing foods 有权
标题翻译：富含蛋白质的富含脂肪的食物
公开(公告)号：US07897169B2
公开(公告)日：2011-03-01
申请号：US10501669
申请日：2003-01-20
申请人： Yasuyoshi Ueda , Shiro Kitamura , Tadayoshi Shiraishi , Masayuki Abe , Takeshi Kawashima , Toshinori Ikehara
发明人： Yasuyoshi Ueda , Shiro Kitamura , Tadayoshi Shiraishi , Masayuki Abe , Takeshi Kawashima , Toshinori Ikehara
IPC分类号： A61K47/00
CPC分类号： A23G9/32 , A21D2/14 , A23C11/04 , A23C19/082 , A23D7/0056 , A23D7/015 , A23D9/007 , A23F3/163 , A23F5/243 , A23L7/111 , A23L7/122 , A23L7/13 , A23L7/165 , A23L9/12 , A23L9/22 , A23L19/03 , A23L19/14 , A23L23/00 , A23L27/60 , A23L33/10 , A23P20/11 , A23P30/40 , A23V2002/00 , C11B5/0092 , A23V2250/314
摘要： To provide a food which suitably supply ubiquinol, a substance indispensable to the living body but is liable to be decreased and fall short of the requirements, through ingestion in the same ways as the ordinary foods in daily living. A ubiquinol-enriched oil/fat-containing food.
摘要翻译：提供适当地提供泛醌的食物，其通过以与日常生活中的普通食物相同的方式摄取，这是生物体不可缺少但易于降低并且不符合要求的物质。富含ubiquinol的含油/脂肪的食物。

38. 发明授权

US07524975B2 Peroxisome proliferator activated receptor ligand and process for producing the same 失效
标题翻译：过氧化物酶体增殖物激活受体配体及其制备方法
公开(公告)号：US07524975B2
公开(公告)日：2009-04-28
申请号：US10490641
申请日：2002-10-11
申请人： Tatsumasa Mae , Misuzu Tsukagawa , Mikio Kitahara , Kaku Nakagawa , Shiro Kitamura , Yasuyoshi Ueda , Minpei Kuroda , Yoshihiro Mimaki , Yutaka Sashida
发明人： Tatsumasa Mae , Misuzu Tsukagawa , Mikio Kitahara , Kaku Nakagawa , Shiro Kitamura , Yasuyoshi Ueda , Minpei Kuroda , Yoshihiro Mimaki , Yutaka Sashida
IPC分类号： C07D311/00
CPC分类号： C07D311/06 , A23K20/111 , A23K20/121 , A23K50/00 , A23K50/40 , A23L33/10 , A23L33/105 , A61K31/12 , A61K31/353 , A61K31/37 , A61K36/484 , A61K2300/00
摘要： The present invention easily and efficiently provides a peroxisome proliferator-activated receptor ligand, and a composition for amelioration of insulin resistance or for prevention and/or amelioration of the insulin resistance syndrome containing the same, as an active ingredient. The present invention relates to a peroxisome proliferator-activated receptor ligand which comprises a prenylflavonoid, a chalcone derivative exclusive of prenylflavonoids, a flavonol derivative exclusive of prenylflavonoids, and a salt, a glycoside and/or an esterified substance thereof acceptable as a pharmaceutical preparation or a food or a beverage; a composition containing the above ligand; a plant-derived extract containing the above ligand; and a process for producing the above extract.
摘要翻译：本发明容易且有效地提供过氧化物酶体增殖物激活受体配体，以及用于改善胰岛素抵抗或用于预防和/或改善含有它们的胰岛素抵抗综合征作为活性成分的组合物。本发明涉及一种过氧化物酶体增殖物激活受体配体，其包含异戊烯基类黄酮，不含异戊烯基黄酮的查耳酮衍生物，不含异戊烯基黄酮的黄酮醇衍生物，以及作为药物制剂可接受的盐，糖苷和/或其酯化物质，食物或饮料; 含有上述配体的组合物; 含有上述配体的植物来源的提取物; 以及生产上述提取物的方法。

39. 发明授权

US07393668B2 Method of collecting highly pure polyhydroxyalkanoate from microbial cells 有权
标题翻译：从微生物细胞中收集高纯度聚羟基链烷酸酯的方法
公开(公告)号：US07393668B2
公开(公告)日：2008-07-01
申请号：US10541389
申请日：2004-01-20
申请人： Yoshifumi Yanagita , Noriko Ogawa , Yasuyoshi Ueda , Fumio Osakada , Keiji Matsumoto
发明人： Yoshifumi Yanagita , Noriko Ogawa , Yasuyoshi Ueda , Fumio Osakada , Keiji Matsumoto
IPC分类号： C12P7/62 , C12N9/00
CPC分类号： C12P7/625
摘要： The present invention has an object to provide a method for separating and purifying a PHA without causing a serious decrease of the molecular weight to obtain a highly pure PHA in a high yield, which comprises efficiently removing cell components other than PHA particles from a cultured PHA-containing microbial cell. Another object of the present invention is to provide a method for obtaining an agglomerate of PHA particles.The method for recovering a PHA according to the present invention is a method which comprises efficiently disrupting a cell to recover the PHA by carrying out a physical disruption treatment and an alkali addition at low temperature for an aqueous suspension of the PHA-containing microbial cell, and then treating the PHA with an enzyme and/or a surfactant. Moreover, the particle diameter of the PHA may be enlarged by suspending the PHA in a hydrophilic solvent and/or water, and stirring at a temperature equal to or below the boiling point of said suspension, to agglomerate said PHA.
摘要翻译：本发明的目的是提供一种分离纯化PHA的方法，而不会导致分子量的严重降低以获得高产率的高纯度PHA，其包括从培养的PHA有效除去PHA颗粒以外的细胞成分含微生物细胞。本发明的另一个目的是提供一种获得PHA颗粒附聚物的方法。根据本发明的回收PHA的方法是通过对含PHA的微生物细胞的水性悬浮液进行物理破坏处理和低温碱添加来有效地破坏细胞以回收PHA的方法，然后用酶和/或表面活性剂处理PHA。此外，通过将PHA悬浮在亲水溶剂和/或水中并在等于或低于所述悬浮液沸点的温度下搅拌以使所述PHA聚集，可以扩大PHA的粒径。

40. 发明申请

US20070161825A1 Method of producing reduced coenzyme Q10 as oily product 有权
公开(公告)号：US20070161825A1
公开(公告)日：2007-07-12
申请号：US11716828
申请日：2007-03-12
申请人： Takahiro Ueda , Shiro Kitamura , Yasuyoshi Ueda
发明人： Takahiro Ueda , Shiro Kitamura , Yasuyoshi Ueda
IPC分类号： C07C43/20
CPC分类号： C07C41/26 , C07C41/34 , C07C43/23
摘要： The present invention provides a method for obtaining reduced coenzyme Q10 which is useful as an ingredient in foods, functional nutritive foods, specific health foods, nutritional supplements, nutrients, drinks, feeds, cosmetics, medicines, remedies, preventive drugs, etc. suited for a commercial scale production in high quality and efficiently. The high-quality oily reduced coenzyme Q10 which has low viscosity and thereby easily handled may be produced by separating an aqueous phase from the reaction mixture obtainable by oily reacting oxidized coenzyme Q10 with a reducing agent in water, or by distilling off an coexisting organic solvent at or above the melting temperature of reduced coenzyme Q10 in concentrating the organic phase containing reduced coenzyme Q10. Moreover, a solution or slurry of reduced coenzyme Q10 may be obtained by adding a desired solvent to the obtained oily product, or a solid of reduced coenzyme Q10 may be produced by contacting the oily product with a seed crystal.

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