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    • 33. 发明授权
    • .omega.-(N-acylamino)alkylphosphoryl ethanolamines, pharmaceutical
compositions containing them, and their uses
    • {107-(N-酰基氨基)烷基磷酰基乙醇胺,含有它们的药物组合物及其用途
    • US3985875A
    • 1976-10-12
    • US537601
    • 1974-12-30
    • Kouji HayashiMasahisa HashimotoKiyoshi NakamuraMasanao ShimizuNaonobu HatanoKunihiko Takeyama
    • Kouji HayashiMasahisa HashimotoKiyoshi NakamuraMasanao ShimizuNaonobu HatanoKunihiko Takeyama
    • C07F9/09A01N9/36
    • C07F9/091Y02P20/55Y10S530/86
    • New .omega.-(N-acylamino)alkylphosphoryl ethanolamines and their pharmaceutically acceptable acid addition salts have superior renin-inhibitory activities, antihypertensive activities and cholesterol-lowering activities. The .omega.-(N-acylamino)alkylphosphoryl ethanolamines are prepared by (1) reacting an .omega.-(N-acylamino) alkanol with a 2-(N-substituted amino)ethyl phosphate or its derivative, hydrolyzing the resulting product or splitting off the phosphoric acid-protective group of the resulting product thereby to form an .omega.-(N-acylamino) alkyl 2-(N-substituted amino) ethyl phosphate, and splitting off the amino-protective groups of the resulting phosphate, or (2) reacting an .omega.-(N-acylamino) alkanol with a phosphorus oxyhalide, reacting the resulting .omega.-(N-acylamino)alkyl dichlorophosphate with a 2-(N-substituted amino) ethanol, hydrolyzing the reaction product to form an .omega.-(N-acylamino) alkyl 2-(N-substituted)ethyl phosphate, and splitting off the amino-protective groups of said phosphate.
    • 新的ω-(N-酰基氨基)烷基磷酰基乙醇胺及其药学上可接受的酸加成盐具有优异的肾素抑制活性,降压活性和降胆固醇活性。 ω-(N-酰氨基)烷基磷酰基乙醇胺通过以下步骤制备:(1)使ω-(N-酰氨基)链烷醇与2-(N-取代氨基)乙基磷酸酯或其衍生物反应,水解得到的产物或将 得到产物的磷酸保护基,从而形成2-(N-取代氨基)乙基磷酸的ω-(N-酰基氨基)烷基酯,并分离得到的磷酸酯的氨基保护基,或(2)使 将具有卤代磷酸酯的ω-(N-酰基氨基)链烷醇与所得的ω-(N-酰基氨基)烷基二氯磷酸酯与2-(N-取代的氨基)乙醇反应,水解反应产物以形成ω-(N- 酰基氨基)烷基2-(N-取代)乙基磷酸酯,并分离出所述磷酸酯的氨基保护基团。
    • 34. 发明授权
    • Method for controlling mold clamping device
    • 用于控制夹紧装置的方法
    • US08244397B2
    • 2012-08-14
    • US12392784
    • 2009-02-25
    • Takashi HakodaIsamu KomamuraHaruo OkadaKiyoshi Nakamura
    • Takashi HakodaIsamu KomamuraHaruo OkadaKiyoshi Nakamura
    • B29C45/03
    • B29C45/82B29C45/76B29C2945/76083B29C2945/7611B29C2945/76227B29C2945/76387B29C2945/76575B29C2945/76595B29C2945/76705B29C2945/76866
    • A predetermined speed control pattern B is sct. In a mold clamping process, in a mold closing section Zm, mold closing control is performed at a mold closing speed Vm, and based on a current mold closing speed Vd and a current mold closing position Xd, which are both detected, a deceleration starting position Xmc of the deceleration section Zmd, where the current mold closing speed Vd becomes a zero (O) at a virtual stop position Xc, is sequentially forecasted at each predetermined time interval by calculation. Upon reaching the deceleration starting position Xmc the deceleration section Zmd is started, and in the deceleration section Zmd, based on the detected current mold closing position Xd, a speed command value Dm corresponding to the speed control pattern B is obtained sequentially by calculation, and according to the speed command value Dm deceleration control is performed. Upon reaching a mold clamping-transition speed Vc, a predetermined mold clamping processing is performed via a low-pressure low-speed section Zc.
    • 预定的速度控制模式B是sct。 在合模过程中,在模具闭合部分Zm中,以模具闭合速度Vm执行模具闭合控制,并且基于当前的模具闭合速度Vd和当前的模具闭合位置Xd,两者都被检测到减速开始 在虚拟停止位置Xc处的当前模具关闭速度Vd变为零(O)的减速部分Zmd的位置Xmc通过计算在每个预定时间间隔被顺序预测。 在到达减速开始位置Xmc时,减速部分Zmd开始,在减速部分Zmd中,根据检测到的当前模具关闭位置Xd,通过计算顺序地获得与速度控制模式B相对应的速度指令值Dm, 根据速度指令值Dm进行减速控制。 在达到模具夹紧转变速度Vc时,通过低压低速部分Zc执行预定的模具夹紧处理。
    • 35. 发明授权
    • Method for controlling mold clamping device
    • 用于控制夹紧装置的方法
    • US08239058B2
    • 2012-08-07
    • US12392799
    • 2009-02-25
    • Takashi HakodaIsamu KomamuraHaruo OkadaKiyoshi Nakamura
    • Takashi HakodaIsamu KomamuraHaruo OkadaKiyoshi Nakamura
    • B29C45/03
    • B29C45/82B29C45/80B29C2945/76083B29C2945/7611B29C2945/76227B29C2945/76394B29C2945/76575B29C2945/76595B29C2945/76705B29C2945/76872
    • A predetermined speed control pattern A is set. In controlling mold opening, in the mold opening section Zm, mold opening control is performed at the mold opening speed Vm, and based on a current mold opening speed Vd and a current mold opening position Xd, which are both detected, a deceleration starting position Xmc of the deceleration section Zmd where a current mold opening speed Vd becomes a zero (O) at a virtual stop position Xso is sequentially forecasted at each predetermined time interval by calculation. Upon reaching the deceleration starting position Xmc the deceleration section Zmd is started, and in the deceleration section Zmd, based on the detected current mold opening position Xd, a speed command value Dm corresponding to the speed control pattern A is obtained sequentially by calculation, and according to the speed command value Dm deceleration control is performed. Upon reaching a last-transition speed Vc, a predetermined stop controlling processing is performed.
    • 设定预定速度控制模式A. 在控制开模时,在开模部Zm中,以开模速度Vm进行开模控制,并且根据检测到的当前的开模速度Vd和当前的开模位置Xd,设定减速开始位置 通过计算,在每个预定时间间隔顺序地预测在虚拟停止位置Xso处当前模具打开速度Vd变为零(O)的减速部分Zmd的Xmc。 到达减速开始位置Xmc时,减速部Zmd开始,在减速部Zmd中,根据检测到的当前开模位置Xd,通过计算顺序地获得与速度控制图案A对应的速度指令值Dm, 根据速度指令值Dm进行减速控制。 达到最后转变速度Vc时,执行预定的停止控制处理。
    • 40. 发明授权
    • Control system for electric vehicle
    • 电动汽车控制系统
    • US5847534A
    • 1998-12-08
    • US696660
    • 1996-08-14
    • Tokunosuke TanamachiKiyoshi Nakamura
    • Tokunosuke TanamachiKiyoshi Nakamura
    • B60L9/18B60L3/10H02P27/06H02P5/34
    • B60L3/10B60L2200/26B60L2220/12Y02T10/7258
    • The control system is constructed so that an inverter output frequency command is increased/decreased based on a frequency-to-time rate-of-change command, and the frequency-to-time rate-of-change command is controlled with a current control system. Further, it is also constructed so that the frequency-to-time rate-of-change command is adjusted and the current command is changed with a readhesion control system. The control system is capable of accelerating and decelerating the vehicle with a torque corresponding to an inverter output current command which is generated basically without using any rotational frequency of induction motor, and further capable of accelerating and decelerating the vehicle with a torque corresponding to a value near the limit adhesion between the wheel and the rail under a condition of occurrence of slip/skid.
    • 控制系统被构造成使得基于频率 - 时间变化率指令来增加/减少逆变器输出频率命令,并且利用电流控制来控制频率 - 时间变化率指令 系统。 此外,还构造为使得频率 - 时间变化率指令被调整,并且当前命令随着再附着控制系统而改变。 控制系统能够以基本上不使用感应电动机的任何转速来生成的逆变器输出电流指令的转矩加速和减速,并且还能够以对应于值的转矩来加速和减速车辆 在发生滑移/滑动的情况下靠近车轮和轨道之间的极限粘附。