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31. 发明申请

US20060240086A1 Adhesive patch 审中-公开
标题翻译：胶贴
公开(公告)号：US20060240086A1
公开(公告)日：2006-10-26
申请号：US10566350
申请日：2004-07-30
申请人： Tetsuro Tateishi , Satoshi Amano , Sachiko Honma , Naruhito Higo
发明人： Tetsuro Tateishi , Satoshi Amano , Sachiko Honma , Naruhito Higo
IPC分类号： A61K9/70 , A61F13/00
CPC分类号： A61K9/7061 , A61K31/138
摘要： An adhesive patch which includes a pressure-sensitive adhesive layer comprising a composition which comprises: bisoprolol and/or a pharmaceutically acceptable salt thereof; and an acrylic polymer obtained by copolymerizing a (meth)acrylic ester with a carboxylated (meth)acrylic acid. The adhesive patch is stable and excellent in penetration through the skin.
摘要翻译：一种粘合贴剂，其包括压敏粘合剂层，其包含组合物，其包含：比索洛尔和/或其药学上可接受的盐; 和通过使（甲基）丙烯酸酯与羧化的（甲基）丙烯酸共聚得到的丙烯酸类聚合物。粘合贴剂稳定且穿透皮肤优异。

32. 发明申请

US20060110433A1 Adhesive patch 审中-公开
标题翻译：胶贴
公开(公告)号：US20060110433A1
公开(公告)日：2006-05-25
申请号：US10526065
申请日：2003-08-07
申请人： Takaaki Terahara , Kazunosuke Aida , Arata Toshimitsu , Naruhito Higo
发明人： Takaaki Terahara , Kazunosuke Aida , Arata Toshimitsu , Naruhito Higo
IPC分类号： A61K31/48 , A61F13/02 , A61L15/16
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7076 , A61K31/48
摘要： A patch comprising a backing layer and an adhesive layer disposed on the backing layer and compounded with an adhesive base agent and pergolide and/or a pharmaceutically acceptable salt thereof, wherein the adhesive base agent comprises an acrylic polymer including no substantial carboxyl group and hydroxyl group and having self-adhesion properties and a rubber polymer, and the weight ratio of the content of the acrylic polymer to the content of the rubber polymer is from 1:1 to 1:9.
摘要翻译：一种贴剂，其包括背衬层和设置在背衬层上并与粘合剂基剂和高氯代内酯和/或其药学上可接受的盐复合的粘合剂层，其中所述粘合剂基剂包含不含实质性羧基和羟基的丙烯酸聚合物并且具有自粘性和橡胶聚合物，并且丙烯酸类聚合物的含量与橡胶聚合物的含量的重量比为1:1至1:9。

33. 发明授权

US07034083B2 Pressure-sensitive adhesive and patch employing the same 有权
标题翻译：压敏粘合剂和使用其的贴剂
公开(公告)号：US07034083B2
公开(公告)日：2006-04-25
申请号：US10502474
申请日：2003-01-24
申请人： Takashi Yasukochi , Toshiro Yamaguchi , Tetsuro Tateishi , Naruhito Higo
发明人： Takashi Yasukochi , Toshiro Yamaguchi , Tetsuro Tateishi , Naruhito Higo
IPC分类号： C08F8/00
CPC分类号： A61K9/7061
摘要： An adhesive which comprises aqueous and nonaqueous polymers suitable for holding an lipophilic drug, etc., and has tackiness and cohesiveness which are sufficient for the plaster of a patch; and a patch employing the adhesive. The adhesive contains a polymer which comprises one or more kinds of acrylic or methacrylic monomer units, at least one kind of the monomer units having a hydroxy group, and which has been crosslinked with a boron compound.
摘要翻译：一种粘合剂，其包含适于保持亲脂性药物的水性和非水性聚合物等，并且具有足够的贴剂粘贴性和粘性; 和使用粘合剂的贴剂。粘合剂含有包含一种或多种丙烯酸或甲基丙烯酸单体单元，至少一种具有羟基的单体单元并且已经与硼化合物交联的聚合物。

34. 发明申请

US20060013865A1 Transdermal patch for external use comprising fentanyl 有权
标题翻译：用于外用的透皮贴片，包括芬太尼
公开(公告)号：US20060013865A1
公开(公告)日：2006-01-19
申请号：US10531433
申请日：2003-10-17
申请人： Takeshi Ito , Tetsuro Tateishi , Naruhito Higo
发明人： Takeshi Ito , Tetsuro Tateishi , Naruhito Higo
IPC分类号： A61K31/445 , A61K9/70
CPC分类号： A61K9/7053 , A61K31/4468
摘要： A transdermal patch for external use having a backing layer and a pressure-sensitive adhesive layer formed on one surface of the backing layer, which contains polyisobutylene, a mineral oil and fentanyl employed as the active ingredient in the pressure-sensitive adhesive layer and in which the contents of polyisobutylene and fentanyl in the pressure-sensitive adhesive layer respectively range from 75.2 to 94.2% by mass and 1 to 6% by mass while the content of the mineral oil is from 0.25 to 0.05 parts by mass based on polyisobutylene. This patch can be easily produced, has a long-lasting effect and is excellent in adhesion to the skin and tolerability against movement to the body parts.
摘要翻译：一种用于外用的透皮贴剂，其具有背衬层和形成在背衬层的一个表面上的压敏粘合剂层，该背衬层包含聚异丁烯，在压敏粘合剂层中用作活性成分的矿物油和芬太尼，其中粘合剂层中聚异丁烯和芬太尼的含量分别为75.2〜94.2质量％和1〜6质量％，相对于聚异丁烯，矿物油的含量为0.25〜0.05质量份。该贴剂可以容易地制造，具有持久的效果，并且对皮肤的粘附性和对身体部位的运动的耐受性都优异。

35. 发明申请

US20050175676A1 Patch 有权
标题翻译：补丁
公开(公告)号：US20050175676A1
公开(公告)日：2005-08-11
申请号：US10517468
申请日：2003-06-06
申请人： Tatsuaki Suzuki , Tetsuro Tateishi , Naruhito Higo
发明人： Tatsuaki Suzuki , Tetsuro Tateishi , Naruhito Higo
IPC分类号： A61K9/70 , A61K31/4468 , A61K47/32 , A61K47/34 , A61P25/02 , A61P25/04 , A61K47/30
CPC分类号： A61K9/7053 , A61K9/7076 , A61K31/4468 , Y10T428/2852 , Y10T428/2883
摘要： The present invention relates to a patch which is free from any migration of a drug into a substrate and has favorable anchoring properties between the substrate and a adhesive layer, in which the drug-containing adhesive layer firmly adheres onto the substrate and which gives no adhesive residue when applied to the skin and then peeled off. Namely, a patch comprising a substrate made of a polyester-based film and a drug-containing adhesive layer laminated thereon wherein the surface roughness of the polyester-based film surface in the side in contact with the adhesive layer is from 0.05 to 0.8 μmRa is provided.
摘要翻译：本发明涉及一种贴剂，其不会将药物迁移到基质中，并且在基材和粘合剂层之间具有良好的锚固性能，其中含药物的粘合剂层牢固地粘附到基底上并且不产生粘合剂残留物施用于皮肤后剥离。即，将由聚酯类薄膜构成的基材和层叠有药物的粘合剂层的贴剂，其中与粘合剂层接触的一侧的聚酯类薄膜表面的表面粗糙度为0.05〜0.8μmRa为提供。

36. 发明授权

US06654635B1 Iontophoresis device 失效
标题翻译：离子渗透装置
公开(公告)号：US06654635B1
公开(公告)日：2003-11-25
申请号：US09622050
申请日：2000-08-24
申请人： Nobuhiro Koga , Hiroyuki Maeda , Mitsuru Kuribayashi , Naruhito Higo
发明人： Nobuhiro Koga , Hiroyuki Maeda , Mitsuru Kuribayashi , Naruhito Higo
IPC分类号： A61N130
CPC分类号： A61N1/303
摘要： An iontophoresis device, which can ensure the long-term stability of drugs and which can be easily assembled when used, is provided. A donor electrode-printed portion (6) is placed on one side of a backing layer (4), and a reference electrode-printed portion (7) is placed on the other side. Both printed parts are connected to a current generating part (Ia) through a connector (Id). A drug support film (14) is joined to a drug-dissolving portion (11), and a cup-like shaped protective cover (12), which covers the drug support film (14), is removed before the device is used. The exposed drug support film (14) is attached to the skin of a user, and the device is driven by turning on a power supply of the current-generating portion (Ia).
摘要翻译：一种离子电渗疗法装置，其可以确保药物的长期稳定性，并且在使用时可以容易地组装。供体电极印刷部分（6）放置在背衬层（4）的一侧上，另一侧放置参考电极印刷部分（7）。两个印刷部分通过连接器（Id）连接到电流产生部分（Ia）。将药物保护膜（14）与药物溶解部（11）接合，在使用该装置之前，除去覆盖药物保护膜（14）的杯状保护罩（12）。暴露的药物支撑膜（14）附接到使用者的皮肤，并且通过接通电流产生部分（1a）的电源来驱动该装置。

37. 发明授权

US06643544B1 Iontophoresis device 失效
标题翻译：离子渗透装置
公开(公告)号：US06643544B1
公开(公告)日：2003-11-04
申请号：US09958602
申请日：2001-10-12
申请人： Hirotoshi Adachi , Kazuya Katagai , Naruhito Higo
发明人： Hirotoshi Adachi , Kazuya Katagai , Naruhito Higo
IPC分类号： A61N130
CPC分类号： A61N1/30
摘要： The present invention provides an iontophoresis device and an energization method whereby a prostaglandin can be effectively and continuously administered via a skin or mucosa. The iontophoresis device comprises the first electrode structure (31); the second electrode structure (32); and a power supply (33) electrically connected between the first and the second electrode structures (31), (32). At least one of the first and the second electrode structures contains a prostaglandin and also stabilizing means for inhibiting hydrolysis of the prostaglandin during storage. The power supply (33) is equipped with constant current supplying means and, when both electrode structures contain a prostaglandin, also polarity inverting means. Output current from the power supply may allow the prostaglandin to be delivered to a skin or mucosa.
摘要翻译：本发明提供了一种离子电渗疗法装置和通电方法，其中前列腺素可通过皮肤或粘膜有效且连续地施用。离子电渗装置包括第一电极结构（31）; 第二电极结构（32）; 和电连接在第一和第二电极结构（31），（32）之间的电源（33）。第一和第二电极结构中的至少一个包含前列腺素以及用于在储存期间抑制前列腺素水解的稳定手段。电源（33）配备有恒流供给装置，并且当两个电极结构都包含前列腺素时，还具有极性反转装置。来自电源的输出电流可允许将前列腺素输送至皮肤或粘膜。

38. 发明授权

US06564092B1 Transdermal or transmucosal drug delivery device 有权
标题翻译：透皮或透粘膜给药装置
公开(公告)号：US06564092B1
公开(公告)日：2003-05-13
申请号：US09445451
申请日：2000-03-27
申请人： Katsuhiro Nakamura , Kazuya Katagai , Kazutaka Inoue , Naruhito Higo
发明人： Katsuhiro Nakamura , Kazuya Katagai , Kazutaka Inoue , Naruhito Higo
IPC分类号： A61N130
CPC分类号： A61N1/0432 , A61N1/0436 , A61N1/325
摘要： A transdermal or transmucosal drug delivery device excellent in terms of drug permeability and skin irritability and capable of reducing power consumption, is disclosed. An output control circuit (4) of an energization pattern controller (1) supplies a combined energization of pulse depolarized type energization and at least one of direct current type energization and pulse energization between an anode-side device (5) and a cathode-side device (6) of iontophoresis. The details of combination of energization in the output control circuit (4) is determined based on external setting of the energization pattern controller (1) or internal storage information.
摘要翻译：公开了透皮或透粘膜药物递送装置，其在药物渗透性和皮肤刺激性方面优异并且能够降低功耗。通电图案控制器（1）的输出控制电路（4）在阳极侧装置（5）和阴极侧（5）之间提供脉冲去极化型通电的组合通电和直流型通电和脉冲通电中的至少一个离子电渗法的装置（6）。输出控制电路（4）中的通电组合的细节基于通电图案控制器（1）的外部设定或内部存储信息来确定。

39. 发明授权

US5733900A Percutaneous administration base composition and percutaneous administration medicinal composition comprising said base composition and medicine 失效
标题翻译：经皮给药基础组合物和包含所述基础组合物和药物的经皮给药药物组合物
公开(公告)号：US5733900A
公开(公告)日：1998-03-31
申请号：US702449
申请日：1996-09-26
申请人： Naruhito Higo , Ken-ichi Komori
发明人： Naruhito Higo , Ken-ichi Komori
IPC分类号： A61K9/00 , A61K47/00 , A61K47/10 , A61K47/12 , A61K47/26 , A61K31/045 , A61K31/19 , A61K31/22 , A61K31/34
CPC分类号： A61K9/0014 , A61K47/10 , A61K47/12 , A61K47/26
摘要： A percutaneous administration base composition is disclosed comprising an absorption promoter, a moisture-retaining agent, water, an irritation-lessening agent, a lower alcohol and an organic acid wherein a medicine is optionally contained in the base composition.
摘要翻译： PCT No.PCT / JP95 / 00774 Sec。 371日期1996年9月26日 102（e）1996年9月26日PCT PCT 1995年4月19日PCT公布。公开号WO95 / 28914 PCT 日期1995年11月2日公开了一种经皮给药基础组合物，其包含吸收促进剂，保湿剂，水，刺激性减轻剂，低级醇和有机酸，其中药物任选地包含在基础组合物中。

40. 再颁专利

USRE45936E1 Pressure-sensitive adhesive and patch employing the same 有权
公开(公告)号：USRE45936E1
公开(公告)日：2016-03-22
申请号：US12108934
申请日：2008-04-24
申请人： Takashi Yasukochi , Toshiro Yamaguchi , Tetsuro Tateishi , Naruhito Higo
发明人： Takashi Yasukochi , Toshiro Yamaguchi , Tetsuro Tateishi , Naruhito Higo
IPC分类号： C08F8/00 , A61K9/70 , A61K47/04 , A61K47/32 , C09J4/00 , C09J11/04
CPC分类号： A61K9/7061 , A61K9/7069
摘要： An adhesive which comprises aqueous and nonaqueous polymers suitable for holding an lipophilic drug, etc., and has tackiness and cohesiveness which are sufficient for the plaster of a patch; and a patch employing the adhesive. The adhesive contains a polymer which comprises one or more kinds of acrylic or methacrylic monomer units, at least one kind of the monomer units having a hydroxy group, and which has been crosslinked with a boron compound.

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