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31. 发明授权

US5643773A Preparation of elongated seamless capsules containing a coaxial rod and biological material 失效
标题翻译：制备包含同轴杆和生物材料的细长无缝胶囊
公开(公告)号：US5643773A
公开(公告)日：1997-07-01
申请号：US430786
申请日：1995-04-27
申请人： Patrick Aebischer , John F. Mills , Lars Wahlberg , Edward J. Doherty , Patrick A. Tresco
发明人： Patrick Aebischer , John F. Mills , Lars Wahlberg , Edward J. Doherty , Patrick A. Tresco
IPC分类号： A61F2/02 , A61J3/07 , A61K9/00 , A61K9/48 , A61K9/50 , A61K35/12 , A61K35/22 , A61K35/30 , A61M31/00 , B01J13/02 , B01J13/04 , C12N5/00 , C12N5/071 , C12N5/0793 , C12N11/04 , C12N11/08
CPC分类号： A61K9/0092 , A61F2/022 , A61J3/07 , A61K35/22 , A61K35/30 , A61K9/0024 , A61K9/0085 , A61K9/4816 , A61K9/4833 , A61K9/5089 , A61M31/002 , B01J13/02 , B01J13/04 , C12N11/04 , C12N11/08 , C12N5/0012 , C12N5/0614 , C12N5/0619 , A61M2210/0687 , A61M2210/0693 , C12N2533/30 , Y10S530/817
摘要： Elongated seamless capsules containing biological material are prepared by a method in which a coagulant, which includes a cell suspension or other biological material, and a polymeric casting solution are extruded through a common extrusion port having at least two concentric bores, such that the coagulant is extruded through an inner bore and the polymeric casting solution is extruded through an outer bore. Extrusion of the coagulant is initiated subsequent to initiating delivery of the casting solution to form a capsule having a curved and smooth leading edge shape. Delivery of the coagulant is then shut off, and extrusion of the casting solution is terminated either immediately or after some predetermined time. This procedure can be modified to form in the capsule a coaxial rod that is connected to one end but not the other end of the capsule. This is accomplished by drawing casting solution into the inner bore after initiating extrusion of the casting solution through the outer bore, and then initiating delivery of the coagulant through the inner bore so as to coagulate the casting solution therein and form a rod, and ejecting the rod from the inner bore by pressure of the coagulant. Delivery of the coagulant and casting solution are then terminated as described above.
摘要翻译：包含生物材料的细长无缝胶囊是通过一种方法制备的，其中包括细胞悬浮液或其它生物材料的凝结剂和聚合物浇铸溶液通过具有至少两个同心孔的共同挤出口挤出，使得凝结剂为通过内孔挤出，并且聚合物浇铸溶液通过外孔挤出。在引发浇铸溶液的输送之后开始凝结剂的挤出，以形成具有弯曲且光滑的前缘形状的胶囊。然后关闭凝结剂的输送，并且立即或在一些预定时间之后终止浇注溶液的挤出。该过程可以被修改以在胶囊中形成连接到胶囊的一端而不是另一端的同轴杆。这是通过将铸造溶液通过外孔开始挤出之后将铸造溶液吸入内孔中，然后通过内孔引发凝结剂的输送，从而将铸造溶液凝结在其中并形成杆通过凝结剂的压力从内孔中取出杆。然后如上所述终止凝结剂和浇铸溶液的输送。

32. 发明授权

US5011472A Implantable delivery system for biological factors 失效
标题翻译：生物因子植入式输送系统
公开(公告)号：US5011472A
公开(公告)日：1991-04-30
申请号：US240939
申请日：1988-10-06
申请人： Patrick Aebischer , Pierre M. Galletti , George Panol , Luigi Miracoli
发明人： Patrick Aebischer , Pierre M. Galletti , George Panol , Luigi Miracoli
IPC分类号： A61F2/02 , A61M5/142
CPC分类号： A61M5/14276 , A61F2/022 , A61M2205/3523
摘要： Devices and methods are disclosed to provide hybrid, modular systems for the constitutive delivery of appropriate dosages of active factor to a subject and, in some instances, to specific anatomical regions of the subject. The systems include a cell reservoir containing living cells capable of secreting an active agent, which is preferably adapted for implantation within the body of the subject and further includes at least one semipermeable membrane, whereby the transplanted cells can be nourished by nutrients transported across the membrane while at the same time protected from immunological, bacterial, and viral assault. The systems further include a pumping means, which can be implantable or extracorporeal, for drawing a body fluid from the subject into the cell reservoir and for actively transporting the secreted biological factors from the cell reservoir to a selected region of the subject.
摘要翻译：公开了装置和方法以提供混合模块化系统，用于将主动因子的合适剂量的组成型递送给受试者，并且在某些情况下提供给对象的特定解剖区域。该系统包括含有能够分泌活性剂的活细胞的细胞储库，其优选适于植入受试者的身体内并且还包括至少一种半透膜，由此可以通过跨膜运送的营养物滋养移植的细胞同时保护免受免疫，细菌和病毒攻击。所述系统还包括可植入或体外的抽吸装置，用于将体液从受试者吸入细胞储存器中并用于将分泌的生物因子从细胞储存器积极输送到受试者的选定区域。

33. 发明授权

US4877029A Semipermeable nerve guidance channels 失效
标题翻译：半透明神经引导通道
公开(公告)号：US4877029A
公开(公告)日：1989-10-31
申请号：US32489
申请日：1987-03-30
申请人： Robert F. Valentini , Patrick Aebischer , Pierre M. Galletti
发明人： Robert F. Valentini , Patrick Aebischer , Pierre M. Galletti
IPC分类号： A61B17/00 , A61B17/11 , A61B19/00 , A61F2/00 , A61L27/26
CPC分类号： A61B17/1128 , A61L27/26 , A61B17/00491 , A61B2017/00004 , A61F2002/30235 , A61F2230/0069 , A61L2430/32
摘要： Medical devices employing semipermeable materials, such as acrylic copolymers, polyurethane isocyanate, and other biocompatible semipermeable polymers, are disclosed for use as guidance channels in regenerating nerves. The devices can be formed by tubular semipermeable conduits adapted to receive the ends of a severed or damaged nerve. The tubular conduits define lumens through which axons can regenerate to restore motor and/or sensory functions. The guidance materials are chosen such that they are capable of allowing the diffusion of nutrients and other metabolites to the regenerating nerve site while excluding fibroblasts and other scar-forming cells. In particular, tubular channels which have a smooth inner surface and longitudinally oriented trabeculae result in significantly larger regenerated nerve cables and higher numbers of regenerated myelinated axons.

34. 发明授权

US6156572A Bioartificial extracellular matrix containing hydrogel matrix derivatized with cell adhesive peptide fragment 有权
标题翻译：生物人造细胞外基质含有细胞粘附肽片段衍生的水凝胶基质
公开(公告)号：US6156572A
公开(公告)日：2000-12-05
申请号：US160654
申请日：1998-09-25
申请人： Ravi Bellamkonda , John P. Ranieri , Patrick Aebischer
发明人： Ravi Bellamkonda , John P. Ranieri , Patrick Aebischer
IPC分类号： A61L27/00 , A61K38/00 , A61L27/20 , A61L27/22 , A61L27/38 , A61L27/52 , A61L31/00 , A61L31/04 , C07K7/06 , C07K7/08 , C07K14/78 , C12N5/00 , C07K17/02 , C07K17/10 , C12N11/10
CPC分类号： A61L27/3839 , A61L27/20 , A61L27/227 , A61L27/52 , A61L31/005 , A61L31/047 , C07K14/78 , A61K38/00 , A61L2430/32 , Y10S530/812 , Y10S530/813
摘要： A bioartificial extracellular matrix for use in tissue regeneration or replacement is provided by derivatizing a three-dimensional hydrogel matrix with a cell adhesive extracellular matrix protein or cell adhesive peptide fragment of the protein. Preferably, derivatizing is by covalent immobilization of a cell adhesive peptide fragment having the amino acid sequence, ArgGlyAsp, TyrIleGlySerArg or IleLysValAlaVal. Cartilage or tendon can be regenerated by implanting a matrix containing an adhesive peptide fragment that favors chondrocyte invasion. The matrix can be pre-seeded with cells, and tissue can be reconstituted in vitro and then implanted. A cell-seeded matrix can be encapsulated in a semi-permeable membrane to form a bioartificial organ. An agarose hydrogel matrix having an agarose concentration of 0.5-1.25% (w/v) and an average pore radius between 120 nm and 290 nm is preferred. A nerve guidance channel for use in regenerating severed nerve is prepared containing a tubular semi-permeable membrane having openings adapted to receive ends of a severed nerve, and an inner lumen containing the hydrogel matrix having a bound cell adhesive peptide fragment through which the nerve can regenerate.
摘要翻译：通过用蛋白质的细胞粘附细胞外基质蛋白或细胞粘附肽片段衍生三维水凝胶基质来提供用于组织再生或替代的生物人造细胞外基质。优选地，衍生化是通过共价固定具有氨基酸序列ArgGlyAsp，TyrIleGlySerArg或IleLysValAlaVal的细胞粘附性肽片段。可以通过植入含有有利于软骨细胞侵入的粘合肽片段的基质来再生软骨或肌腱。基质可以用细胞预种子，组织可以在体外重建然后植入。细胞接种的基质可以包封在半透膜中以形成生物人造器官。具有琼脂糖浓度为0.5-1.25％（w / v）且平均孔半径在120nm与290nm之间的琼脂糖水凝胶基质是优选的。制备用于再生切断的神经的神经引导通道，其包含具有适于接收切断的神经的端部的开口的管状半透膜，以及含有具有结合的细胞粘附肽片段的水凝胶基质的内腔，神经可穿过该片段再生。

35. 发明授权

US5418154A Method of preparing elongated seamless capsules containing biological material 失效
标题翻译：制备含有生物材料的细长无缝胶囊的方法
公开(公告)号：US5418154A
公开(公告)日：1995-05-23
申请号：US997770
申请日：1992-12-24
申请人： Patrick Aebischer , John F. Mills , Lars Wahlberg , Edward J. Doherty , Patrick A. Tresco
发明人： Patrick Aebischer , John F. Mills , Lars Wahlberg , Edward J. Doherty , Patrick A. Tresco
IPC分类号： A61F2/02 , A61J3/07 , A61K9/00 , A61K9/48 , A61K9/50 , A61K35/12 , A61K35/22 , A61K35/30 , A61M31/00 , B01J13/02 , B01J13/04 , C12N5/00 , C12N5/071 , C12N5/0793 , C12N11/04 , C12N11/08
CPC分类号： A61K9/0092 , A61F2/022 , A61J3/07 , A61K35/22 , A61K35/30 , A61K9/0024 , A61K9/0085 , A61K9/4816 , A61K9/4833 , A61K9/5089 , A61M31/002 , B01J13/02 , B01J13/04 , C12N11/04 , C12N11/08 , C12N5/0012 , C12N5/0614 , C12N5/0619 , A61M2210/0687 , A61M2210/0693 , C12N2533/30 , Y10S530/817
摘要： Elongated seamless capsules containing biological material are prepared by a method in which a coagulant, which includes a cell suspension or other biologically active factor, and a polymeric casting solution are extruded through a common extrusion port having at least two concentric bores, such that the coagulant is extruded through the inner bore and the polymeric casting solution is extruded through the outer bore. The method involves initiating extrusion of the coagulant subsequent to initiating delivery of the casting solution through the respective bores to form a capsule having a curved and smooth leading edge shape. Delivery of the coagulant is then shut off, and extrusion of the casting solution is terminated either immediately or after some predetermined time.
摘要翻译：包含生物材料的细长无缝胶囊通过以下方法制备，其中包括细胞悬浮液或其它生物活性因子的凝结剂和聚合物浇铸溶液通过具有至少两个同心孔的共同挤出口挤出，使得凝结剂通过内孔挤出，并且聚合物浇铸溶液通过外孔挤出。该方法包括在引发浇铸溶液通过相应的孔之后引发凝结剂的挤出，以形成具有弯曲且光滑的前缘形状的胶囊。然后关闭凝结剂的输送，并且立即或在一些预定时间之后终止浇注溶液的挤出。

36. 发明授权

US5092871A Electrically-charged nerve guidance channels 失效
标题翻译：电荷神经引导通道
公开(公告)号：US5092871A
公开(公告)日：1992-03-03
申请号：US600021
申请日：1990-11-30
申请人： Patrick Aebischer , Paolo Dario , Angelo Sabatini , Robert F. Valentini
发明人： Patrick Aebischer , Paolo Dario , Angelo Sabatini , Robert F. Valentini
IPC分类号： A61B17/00 , A61B17/11 , A61F2/00 , A61L31/04 , A61L31/14
CPC分类号： A61L31/14 , A61B17/1128 , A61L31/04 , A61L31/048 , A61B17/00491 , A61B2017/00004 , A61F2002/30235 , A61F2230/0069 , A61L2430/32 , Y10S623/92 , Y10S977/908
摘要： A medical device is disclosed for use in regenerating a severed nerve, including a tubular, biocompatible, electrically-charged membrane or guidance channel, having openings adapted to receive the ends of the severed nerve and defining a lumen through which the nerve can regenerate. The electrically-charged membrane can further include a polymeric electret material that is electrically poled. A method for repairing a severed nerve is also disclosed and includes placing severed nerve ends in proximity to each other within the lumen of the guidance channel of the present invention and securing the nerve ends to the device.
摘要翻译：公开了用于再生切断的神经的医疗装置，其包括管状的，生物相容的，带电荷的膜或引导通道，其具有适于接收切断的神经的端部并限定神经可再生的内腔的开口。带电膜可以进一步包括电极化的聚合物驻极体材料。还公开了修复切断的神经的方法，并且包括在本发明的引导通道的内腔内彼此靠近地设置切断的神经末端并将神经末端固定到该装置。

37. 发明授权

US5030225A Electrically-charged nerve guidance channels 失效
标题翻译：电荷神经引导通道
公开(公告)号：US5030225A
公开(公告)日：1991-07-09
申请号：US621081
申请日：1990-11-30
申请人： Patrick Aebischer , Robert F. Valentini
发明人： Patrick Aebischer , Robert F. Valentini
IPC分类号： A61B17/00 , A61B17/11 , A61F2/00 , A61L31/04 , A61L31/14
CPC分类号： A61L31/14 , A61B17/1128 , A61L31/04 , A61L31/048 , A61N1/0556 , A61N1/36103 , A61B17/00491 , A61B2017/00004 , A61F2002/30235 , A61F2230/0069 , A61L2430/32 , Y10S977/908
摘要： A medical device is disclosed for use in regenerating a severed nerve. The device includes an implantable, tubular, electrically-charged membrane having openings adapted to receive the ends of the severed nerve and a lumen having a diameter ranging from about 0.5 millimeters to about 2.0 centimeters to permit regeneration of the nerve therethrough. The membrane is fabricated such that an electric charge is exhibited at the inner membrane surface to stimulate regeneration by axonal sprouting and process extension. Also disclosed are methods for repairing a severed nerve and for preparing a medical device for use in regeneration of a severed nerve.
摘要翻译：公开了用于再生切断的神经的医疗装置。该装置包括可植入的，管状带电的膜，其具有适于接纳切断的神经的端部的开口和具有约0.5毫米至约2.0厘米的直径的内腔，以允许神经通过其再生。制造膜，使得在内膜表面显示电荷，以通过轴突发芽和加工延伸来刺激再生。还公开了修复切断的神经和用于制备用于再次切断的神经的医疗装置的方法。

38. 发明授权

US5011486A Composite nerve guidance channels 失效
标题翻译：复合神经引导通道
公开(公告)号：US5011486A
公开(公告)日：1991-04-30
申请号：US273236
申请日：1988-11-18
申请人： Patrick Aebischer , Anastassios N. Salessiotis
发明人： Patrick Aebischer , Anastassios N. Salessiotis
IPC分类号： A61L31/04 , A61L31/10 , A61L31/14 , A61L31/16
CPC分类号： A61L31/16 , A61L31/047 , A61L31/048 , A61L31/10 , A61L31/146 , A61L2300/252 , A61L2300/412 , A61L2300/414 , A61L2430/32
摘要： Medical devices and methods employing biocompatible polymers and nerve growth-enhancing active factors are disclosed for use as guidance channels for regenerating nerves. The devices are formed from a porous, tubular membrane containing active factor incorporated within the membrane and having openings adapted to receive the ends of the severed nerve. In one aspect of the invention, the membrane has an impermeable, outer membrane surface and a porous, inner membrane surface through which the active factor can diffuse and which defines the boundary of a lumen through which said nerve may regenerate. Methods for fabricating such devices are also disclosed.
摘要翻译：公开了使用生物相容性聚合物和神经生长增强活性因子的医疗装置和方法用作神经再生的引导通道。该装置由多孔的管状膜形成，该多孔的管状膜含有并入膜内的活性因子并且具有适于接收切断的神经的末端的开口。在本发明的一个方面，所述膜具有不可透过的外膜表面和多孔的内膜表面，所述活性因子可通过所述内膜表面扩散并限定所述神经可再生的内腔的边界。还公开了制造这种装置的方法。

39. 发明申请

US20110106062A1 System and Method For In Vivo Delivery of Antibodies and Fragments Thereof 审中-公开
标题翻译：用于体内递送抗体及其片段的系统和方法
公开(公告)号：US20110106062A1
公开(公告)日：2011-05-05
申请号：US12940090
申请日：2010-11-05
申请人： Osiris Marroquin , Patrick Aebischer , Maurizio Molinari , Nicolas Bouche
发明人： Osiris Marroquin , Patrick Aebischer , Maurizio Molinari , Nicolas Bouche
IPC分类号： A61M37/00
CPC分类号： A61M5/14276 , A61K9/0024 , A61K9/0085 , A61K9/0092
摘要： The present invention is directed to devices and methods for in situ delivering an antibody or a fragment thereof to a host. In particular, the invention relates to devices and methods for in situ delivering an antibody or a fragment thereof to patient suffering for a neurodegenerative disorder or other diseases treated by antibody administration.
摘要翻译：本发明涉及将抗体或其片段原位递送至宿主的装置和方法。特别地，本发明涉及将抗体或其片段原位递送给患有神经退行性疾病或通过抗体给药治疗的其它疾病的患者的装置和方法。

40. 发明授权

US6027721A Device and method for encapsulated gene therapy 失效
标题翻译：封装基因治疗的装置和方法
公开(公告)号：US6027721A
公开(公告)日：2000-02-22
申请号：US650726
申请日：1996-05-20
申请人： Joseph P. Hammang , Patrick Aebischer
发明人： Joseph P. Hammang , Patrick Aebischer
IPC分类号： A61K9/48 , A61K48/00 , C12N15/85 , C12N15/00
CPC分类号： A61K48/00
摘要： Methods and devices are provided for gene therapy using encapsulated packaging cell lines to deliver viral particles carrying at least one heterologous gene encoding at least one biologically active molecule.
摘要翻译：提供了使用包封的包装细胞系进行基因治疗的方法和装置，以递送携带至少一种编码至少一种生物活性分子的异源基因的病毒颗粒。

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