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1. 发明授权

US5011472A Implantable delivery system for biological factors 失效
标题翻译：生物因子植入式输送系统
公开(公告)号：US5011472A
公开(公告)日：1991-04-30
申请号：US240939
申请日：1988-10-06
申请人： Patrick Aebischer , Pierre M. Galletti , George Panol , Luigi Miracoli
发明人： Patrick Aebischer , Pierre M. Galletti , George Panol , Luigi Miracoli
IPC分类号： A61F2/02 , A61M5/142
CPC分类号： A61M5/14276 , A61F2/022 , A61M2205/3523
摘要： Devices and methods are disclosed to provide hybrid, modular systems for the constitutive delivery of appropriate dosages of active factor to a subject and, in some instances, to specific anatomical regions of the subject. The systems include a cell reservoir containing living cells capable of secreting an active agent, which is preferably adapted for implantation within the body of the subject and further includes at least one semipermeable membrane, whereby the transplanted cells can be nourished by nutrients transported across the membrane while at the same time protected from immunological, bacterial, and viral assault. The systems further include a pumping means, which can be implantable or extracorporeal, for drawing a body fluid from the subject into the cell reservoir and for actively transporting the secreted biological factors from the cell reservoir to a selected region of the subject.
摘要翻译：公开了装置和方法以提供混合模块化系统，用于将主动因子的合适剂量的组成型递送给受试者，并且在某些情况下提供给对象的特定解剖区域。该系统包括含有能够分泌活性剂的活细胞的细胞储库，其优选适于植入受试者的身体内并且还包括至少一种半透膜，由此可以通过跨膜运送的营养物滋养移植的细胞同时保护免受免疫，细菌和病毒攻击。所述系统还包括可植入或体外的抽吸装置，用于将体液从受试者吸入细胞储存器中并用于将分泌的生物因子从细胞储存器积极输送到受试者的选定区域。

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