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31. 发明授权

US08470529B2 Methine-substituted cyanine dye compounds 有权
公开(公告)号：US08470529B2
公开(公告)日：2013-06-25
申请号：US12851030
申请日：2010-08-05
申请人： Jason Dallwig , David Hagen , Ching-Ying Cheung , Gerald Thomas , Stephen Yue
发明人： Jason Dallwig , David Hagen , Ching-Ying Cheung , Gerald Thomas , Stephen Yue
IPC分类号： A61K31/4709 , C07D215/12 , C12Q1/68
CPC分类号： C09B23/164 , C07D277/64 , C07D417/06 , C09B23/0008 , C09B23/04 , C09B23/06 , C09B23/107 , C12Q1/6806 , C12Q1/6876 , C12Q2600/16 , G01N33/5308 , Y10T436/143333
摘要： Cyanine dye compounds having a substituted methine moiety that are nucleic acid stains, particularly for fluorescent staining of RNA, including compounds having the formula where R1 is a C1-C6 alkyl, sulfoalkyl, carboxyalkyl or C1-C6 alkoxy; each R2 is independently selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy, fused benzo, trifluoromethyl, amino, sulfo, carboxy and halogen, that is optionally further substituted; at least one of R3, R4, and R5 is an alkyl, aryl, heteroaryl, cyclic, or heterocyclic moiety that is optionally substituted by alkyl, amino, aminoalkyl, carboxy, nitro, or halogen; and the remaining R3, R4 or R5 are hydrogen; X is S, O, or Se; and D is a substituted or unsubstituted pyridinium, quinolinium or benzazolium moiety.

32. 发明授权

US08436170B2 Xanthene dyes comprising a sulfonamide group 有权
公开(公告)号：US08436170B2
公开(公告)日：2013-05-07
申请号：US12699778
申请日：2010-02-03
申请人： Fei Mao , Wai-Yee Leung , Ching-Ying Cheung
发明人： Fei Mao , Wai-Yee Leung , Ching-Ying Cheung
IPC分类号： C07D405/14 , C07D405/12 , C07D491/22 , C07D491/147 , C07D311/88
CPC分类号： G01N33/57484 , C07D311/88 , C07D405/12 , C07D405/14 , C07D491/147 , C07D491/22 , C07K1/13 , C09B11/24 , G01N33/582
摘要： The present invention relates to fluorescent dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions.

33. 发明授权

US08252932B2 Modified carbocyanine dyes and their conjugates 有权
标题翻译：改性碳菁染料及其共轭物
公开(公告)号：US08252932B2
公开(公告)日：2012-08-28
申请号：US12906304
申请日：2010-10-18
申请人： Wai-Yee Leung , Ching-Ying Cheung , Stephen Yue
发明人： Wai-Yee Leung , Ching-Ying Cheung , Stephen Yue
IPC分类号： C07D215/00
CPC分类号： G01N1/30 , A61K41/0057 , C07C66/02 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/16 , C07D209/18 , C07D209/24 , C07D209/54 , C07D209/60 , C07D209/96 , C07D401/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D417/06 , C07D417/14 , C07D471/04 , C07D498/04 , C07K1/13 , C09B23/02 , C09B23/06 , C09B23/083 , C09B23/107 , C12Q1/6825 , C40B70/00 , G01N31/22 , G01N33/533 , G01N33/535 , G01N33/58 , G01N33/581 , G01N33/582 , G01N2001/302 , Y10T436/143333
摘要： Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.
摘要翻译：描述了结合通过反应性基团或共轭物质在3位被取代的吲哚环部分的化学活性碳菁染料及其用途。通过该位置的共轭导致光谱性质均匀地优于光谱相似的染料的缀合物，其中附着在不同的位置。本发明包括具有一个或多个苯并氮的衍生化合物。

34. 发明申请

US20110097735A1 FLUORESCENT PYRENE COMPOUNDS 有权
标题翻译：荧光紫胶化合物
公开(公告)号：US20110097735A1
公开(公告)日：2011-04-28
申请号：US12607915
申请日：2009-10-28
申请人： Fei Mao , Wai-Yee Leung , Ching-Ying Cheung
发明人： Fei Mao , Wai-Yee Leung , Ching-Ying Cheung
IPC分类号： G01N33/53 , C07K5/10 , C07K16/18 , C07K1/107 , C07C245/24 , C07H21/00 , C08B37/00 , C07D401/12 , C07D207/46
CPC分类号： C07C309/47 , C07C2603/50 , C07D207/46 , C07D401/12 , C07K1/13 , C08H1/00 , G01N33/533 , G01N33/57484 , G01N2333/475
摘要： The present invention relates to fluorescent pyrene dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions.
摘要翻译：本发明一般涉及荧光芘染料。本发明提供了广泛的荧光染料和含有该荧光染料的试剂盒，其可用于标记各种生物分子，细胞和微生物。本发明还提供使用荧光染料进行研究，开发鉴定，环境研究，诊断，预后和/或治疗疾病的各种方法。

35. 发明授权

US07927830B2 Modified carbocyanine dyes and their conjugates 有权
标题翻译：改性碳菁染料及其共轭物
公开(公告)号：US07927830B2
公开(公告)日：2011-04-19
申请号：US12129671
申请日：2008-05-29
申请人： Ching-Ying Cheung , Stephen Yue , Wai-Yee Leung
发明人： Ching-Ying Cheung , Stephen Yue , Wai-Yee Leung
IPC分类号： G01N1/30 , G01N33/68 , G01N33/53
CPC分类号： G01N1/30 , A61K41/0057 , C07C66/02 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/16 , C07D209/18 , C07D209/24 , C07D209/54 , C07D209/60 , C07D209/96 , C07D401/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D417/06 , C07D417/14 , C07D471/04 , C07D498/04 , C07K1/13 , C09B23/02 , C09B23/06 , C09B23/083 , C09B23/107 , C12Q1/6825 , C40B70/00 , G01N31/22 , G01N33/533 , G01N33/535 , G01N33/58 , G01N33/581 , G01N33/582 , G01N2001/302 , Y10T436/143333
摘要： Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.
摘要翻译：描述了结合通过反应性基团或共轭物质在3位被取代的吲哚环部分的化学活性碳菁染料及其用途。通过该位置的共轭导致光谱性质均匀地优于光谱相似的染料的缀合物，其中附着在不同的位置。本发明包括具有一个或多个苯并氮的衍生物化合物。

36. 发明授权

US07888136B2 Unsymmetrical cyanine dimer compounds and their application 有权
标题翻译：不对称花青二聚体化合物及其应用
公开(公告)号：US07888136B2
公开(公告)日：2011-02-15
申请号：US12099020
申请日：2008-04-07
申请人： Stephen Yue , Ching-Ying Cheung
发明人： Stephen Yue , Ching-Ying Cheung
IPC分类号： G01N33/53 , B01L3/00 , C12Q1/68 , C07H19/04
CPC分类号： C12Q1/6816 , Y10S436/80 , C12Q2563/173
摘要： Embodiments of the present invention provide methods and nucleic acid reporter molecules for the detection of nucleic acid in a sample. The nucleic acid reporter molecule comprises two unsymmetrical cyanine monomer moieties, which may be the same or different, that are covalently attached by a linker comprising at least one aromatic, heteroaromatic, cyclic or heterocyclic moiety comprising 3-20 non-hydrogen atoms selected from the group consisting of O, N, S, P and C. The linker may be rigid, relatively flexible or some degree thereof. The unsymmetrical cyanine monomer moieties comprise a substituted or unsubstituted benzazolium moiety and a substituted or unsubstituted pyridinium or quinolinium moiety that is connected by a methine bridge that is monomethine, trimethine or pentamethine. The linkers form the cyanine dimer compounds by attaching to the pyridinium or quinolinium moiety of the monomer moieties. The present nucleic acid reporter molecules find utility in forming a nucleic acid-reporter molecule complex and detecting the nucleic acid. In particular, present nucleic acid reporter molecules with a rigid linker and monomer moieties with a monomethine bridge find utility in detecting RNA in the presence of DNA.
摘要翻译：本发明的实施方案提供了用于检测样品中核酸的方法和核酸报告分子。核酸报告分子包含两个不对称的花青单体部分，其可以相同或不同，其通过包含至少一个芳族，杂芳族，环状或杂环部分的连接体共价连接，该部分包含3-20个非氢原子，所述非氢原子选自由O，N，S，P和C组成的组。接头可以是刚性的，相对柔性的或其某种程度的。不对称花青单体部分包含取代或未取代的苯并唑鎓部分和通过单甲基，三甲基或五甲氧基的次甲基桥连接的取代或未取代的吡啶鎓或喹啉鎓部分。连接体通过连接到单体部分的吡啶鎓或喹啉鎓部分而形成花青二聚体化合物。本发明的核酸报告分子可用于形成核酸 - 报道分子复合物并检测核酸。特别地，具有刚性连接体和具有单甲基桥的单体部分的本发明的核酸报告分子在DNA存在下可用于检测RNA。

37. 发明申请

US20090035810A1 MODIFIED CARBOCYANINE DYES AND THEIR CONJUGATES 有权
标题翻译：改性卡波胺染料及其结合
公开(公告)号：US20090035810A1
公开(公告)日：2009-02-05
申请号：US12129671
申请日：2008-05-29
申请人： Wai-Yee Leung , Ching-Ying Cheung , Stephen Yue
发明人： Wai-Yee Leung , Ching-Ying Cheung , Stephen Yue
IPC分类号： G01N1/30 , G01N33/68 , G01N33/53 , C07K1/107 , C07H1/00 , C07D209/04 , C07D209/56
CPC分类号： G01N1/30 , A61K41/0057 , C07C66/02 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/16 , C07D209/18 , C07D209/24 , C07D209/54 , C07D209/60 , C07D209/96 , C07D401/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D417/06 , C07D417/14 , C07D471/04 , C07D498/04 , C07K1/13 , C09B23/02 , C09B23/06 , C09B23/083 , C09B23/107 , C12Q1/6825 , C40B70/00 , G01N31/22 , G01N33/533 , G01N33/535 , G01N33/58 , G01N33/581 , G01N33/582 , G01N2001/302 , Y10T436/143333
摘要： Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.
摘要翻译：描述了结合通过反应性基团或共轭物质在3位被取代的吲哚环部分的化学活性碳菁染料及其用途。通过该位置的共轭导致光谱性质均匀地优于光谱相似的染料的缀合物，其中附着在不同的位置。本发明包括具有一个或多个苯并氮的衍生化合物。

38. 发明申请

US20080039630A1 CYANINE COMPOUNDS AND THEIR APPLICATION AS QUENCHING COMPOUNDS 审中-公开
标题翻译：氰胺化合物及其作为化学化合物的应用
公开(公告)号：US20080039630A1
公开(公告)日：2008-02-14
申请号：US11782244
申请日：2007-07-24
申请人： Rosaria Haugland , Ching-Ying Cheung , Stephen Yue
发明人： Rosaria Haugland , Ching-Ying Cheung , Stephen Yue
IPC分类号： C07D401/10 , C07D209/18 , C07D403/10 , C07D403/14 , C07D417/10
CPC分类号： C12Q1/6876 , C07D209/12 , C07D209/14 , C07D209/24 , C07D401/04 , C09B23/12
摘要： The present invention provides methods and non-fluorescent carbocyanine quencher compounds having the general formula: Wherein the A moiety is a substituted pyridinium, unsubstituted pyridinium, substituted quinolinium, unsubstituted quinolinium, substituted benzazolium, unsubstituted benzazolium, substituted indolinium, or substituted indolinium. The invention further provides luminescent donor molecule-quencher pairs and luminescent donor molecule-quencher-luminescent acceptor molecule conjugates wherein the quencher is a cyanine compound of the present invention. The energy transfer pairs are used to detect an analyte of interest in a sample.
摘要翻译：本发明提供了具有以下通式的方法和非荧光碳花青猝灭剂：其中A部分是取代的吡啶鎓，未取代的吡啶鎓，取代的喹啉鎓，未取代的喹啉鎓，取代的苯并唑鎓，未取代的苯并咪唑鎓，取代的吲哚鎓或取代的吲哚啉鎓。本发明还提供了发光供体分子猝灭剂对和发光供体分子 - 猝灭剂 - 发光受体分子缀合物，其中猝灭剂是本发明的花青化合物。能量转移对用于检测样品中感兴趣的分析物。

39. 发明申请

US20060099638A1 Modified carbocyanine dyes and their conjugates 有权
公开(公告)号：US20060099638A1
公开(公告)日：2006-05-11
申请号：US11313890
申请日：2005-12-20
申请人： Wai-Yee Leung , Ching-Ying Cheung , Stephen Yue
发明人： Wai-Yee Leung , Ching-Ying Cheung , Stephen Yue
IPC分类号： C12Q1/68 , G01N33/53 , G01N1/30 , C07D471/02
CPC分类号： G01N1/30 , A61K41/0057 , C07C66/02 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/16 , C07D209/18 , C07D209/24 , C07D209/54 , C07D209/60 , C07D209/96 , C07D401/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D417/06 , C07D417/14 , C07D471/04 , C07D498/04 , C07K1/13 , C09B23/02 , C09B23/06 , C09B23/083 , C09B23/107 , C12Q1/6825 , C40B70/00 , G01N31/22 , G01N33/533 , G01N33/535 , G01N33/58 , G01N33/581 , G01N33/582 , G01N2001/302 , Y10T436/143333
摘要： Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.

40. 发明申请

US20060004188A1 Intermediates and the synthesis of modified carbocyanine dyes and their conjugates 有权
公开(公告)号：US20060004188A1
公开(公告)日：2006-01-05
申请号：US11150596
申请日：2005-06-10
申请人： Wai-Yee Leung , Ching-Ying Cheung , Stephen Yue
发明人： Wai-Yee Leung , Ching-Ying Cheung , Stephen Yue
IPC分类号： A61K39/395 , C07K16/46 , C07K14/47 , C07D487/02 , C07D471/02 , C07D403/02
CPC分类号： G01N1/30 , A61K41/0057 , C07C66/02 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/16 , C07D209/18 , C07D209/24 , C07D209/54 , C07D209/60 , C07D209/96 , C07D401/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D417/06 , C07D417/14 , C07D471/04 , C07D498/04 , C07K1/13 , C09B23/02 , C09B23/06 , C09B23/083 , C09B23/107 , C12Q1/6825 , C40B70/00 , G01N31/22 , G01N33/533 , G01N33/535 , G01N33/58 , G01N33/581 , G01N33/582 , G01N2001/302 , Y10T436/143333
摘要： Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein attachment is at a different position. The invention includes derivative compounds having one or more benzo nitrogens.

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