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31. 发明授权

US5683403A Implantable lead suture sleeve 失效
标题翻译：可植入铅缝合套管
公开(公告)号：US5683403A
公开(公告)日：1997-11-04
申请号：US630920
申请日：1996-04-05
申请人： John M. Adams , Clifton A. Alferness
发明人： John M. Adams , Clifton A. Alferness
IPC分类号： A61B17/08 , A61M25/02 , A61N1/05
CPC分类号： A61B17/08 , A61M25/02 , A61N1/05 , A61M2025/0253
摘要： A suture sleeve fixes an implanted cardiac device lead to body tissue beneath the skin of a patient. The suture sleeve includes a base, and suture holes permitting the suture sleeve to be suture to the body tissue. A flexible strap member extends from the base for encircling the lead and includes at least one ratchet tooth. A pawl within the base lockingly engages the flexible strap ratchet tooth after the strap is wrapped about the lead.
摘要翻译：缝合套筒将植入的心脏装置导向患者皮肤下方的身体组织。缝合套筒包括基部，并且允许缝线套管缝合到身体组织的缝合孔。弹性带构件从基座延伸以环绕引线并且包括至少一个棘齿。在扎带围绕导线缠绕之后，基座内的棘爪锁定地接合柔性带棘轮齿。

32. 发明授权

US5490862A Atrial defibrillator having patient activated modality 失效
标题翻译：心房除颤器具有患者激活的形态
公开(公告)号：US5490862A
公开(公告)日：1996-02-13
申请号：US306665
申请日：1994-09-15
申请人： John M. Adams , Clifton A. Alferness
发明人： John M. Adams , Clifton A. Alferness
IPC分类号： A61N1/05 , A61N1/39
CPC分类号： A61N1/056 , A61N1/0563 , A61N1/3918 , A61N1/3956 , A61N1/3962 , A61N1/395 , A61N1/3987 , A61N2001/0585
摘要： An atrial defibrillator implantable beneath the skin of a patient includes an intervention sequencer for performing an intervention sequence. The intervention sequencer includes an atrial fibrillation detector for determining if atrial fibrillation is present in a patient's heart and a cardiovertor for applying cardioverting electrical energy to the atria of the patient's heart if the atrial fibrillation detector determines that atrial fibrillation is present. A sequence initiating stage includes a receiver for receiving a sequence command generated from external to the patient. The sequence initiating stage causes the intervention sequencer to perform the intervention sequence upon receipt of a sequence command.
摘要翻译：植入患者皮肤下方的房颤除颤器包括用于执行干预顺序的干预序列发生器。干预测序仪包括心房颤动检测器，用于确定心房颤动是否存在于患者的心脏中;以及心律转换器，如果心房颤动检测器确定存在心房颤动，则将心脏转复电能施加到患者心脏的心房。序列发起阶段包括用于接收从患者外部产生的序列命令的接收器。序列发起阶段使得干预序列器在接收到序列命令时执行干预序列。

33. 发明授权

US5403354A Defibrillator and method utilizing three channel sensing 失效
标题翻译：除颤器和利用三通道感测的方法
公开(公告)号：US5403354A
公开(公告)日：1995-04-04
申请号：US297145
申请日：1994-08-29
申请人： John M. Adams , Clifton A. Alferness
发明人： John M. Adams , Clifton A. Alferness
IPC分类号： A61N1/05 , A61N1/39
CPC分类号： A61N1/3918 , A61N1/056 , A61N1/0563 , A61N1/3956 , A61N1/3962 , A61N1/395 , A61N1/3987 , A61N2001/0585
摘要： An implantable atrial defibrillator provides a pulse of defibrillating electrical energy to the atria of the heart in synchronism with sensed R waves in response to non-coincident sensing of an R wave at first and second areas of the heart. The defibrillating pulse is provided after a predetermined number of consecutive R waves are non-coincidently sensed to assure reliable synchronization. The atrial defibrillator is also operational in a marker mode wherein a number of synchronization marker pulses are delivered to the heart for detection on an externally generated electrocardiogram. The atrial fibrillation detector of the defibrillator is normally disabled and is activated when the sensed ventricular activity indicates a probability of atrial fibrillation to conserve a depletable power source. An endocardial lead is also described which ensures that the delivered atrial defibrillating electrical energy is substantially confined to the atria of the heart.
摘要翻译：可植入心房除颤器响应于在心脏的第一和第二区域处的R波的不一致的感测，与感测到的R波同步地向心脏的心房提供除颤电脉冲。在不一致地感测到预定数量的连续R波之后提供除颤脉冲，以确保可靠的同步。心房除颤器还可以在标记模式中操作，其中多个同步标记脉冲被传送到心脏以便在外部产生的心电图上进行检测。除颤器的心房颤动检测器通常被禁用，并且当感测到的心室活动指示心房颤动的概率以节省可消耗的电源时被激活。还描述了一种心内膜导联，其确保输送的心房除颤电能基本上限于心脏的心房。

34. 发明授权

US5348021A Apparatus and method for reliably detecting a depolarization activation wave of the heart and atrial defibrillator utilizing same 失效
标题翻译：利用其可靠地检测心脏和心房除颤器的去极化激活波的装置和方法
公开(公告)号：US5348021A
公开(公告)日：1994-09-20
申请号：US861184
申请日：1992-03-31
申请人： John M. Adams , Clifton A. Alferness , Kenneth R. Infinger
发明人： John M. Adams , Clifton A. Alferness , Kenneth R. Infinger
IPC分类号： A61N1/39 , A61B5/046
CPC分类号： A61N1/3956 , A61N1/395 , A61N1/3987
摘要： An atrial defibrillator reliably detects a depolarization activation wave of the heart and delivers cardioverting electrical energy to the atria of the heart in synchronism with a detected depolarization activation wave. The atrial defibrillator includes a first sensor for producing a first electrical output having a duration substantially equal to the duration of the depolarization activation wave sensed between a first pair of spaced apart locations of the heart. The atrial defibrillator further includes a second sensor for producing a second electrical output having a duration substantially equal to the duration of the depolarization activation wave sensed between a second pair of spaced apart locations of the heart. The spacing between the second pair of locations is greater than the spacing between the first pair of locations. A microprocessor is responsive to the first and second electrical outputs for providing an indication signal indicating the occurrence of the depolarization activation wave when the second electrical output is longer in duration than the first electrical output. A pulse generator coupled to the microprocessor applies electrical cardioverting energy to the atria of the heart in response to the indication signal.
摘要翻译：心房除颤器可靠地检测心脏的去极化激活波，并且与检测到的去极化激活波同步地将心电转移到心脏的心房。心房除颤器包括用于产生第一电输出的第一传感器，其具有基本上等于在心脏的第一对间隔位置之间感测到的去极化激活波的持续时间的持续时间。心房除颤器还包括第二传感器，用于产生第二电输出，该第二电输出的持续时间基本上等于在心脏的第二对间隔位置之间感测的去极化激活波的持续时间。第二对位置之间的间隔大于第一对位置之间的间隔。当第二电输出的持续时间比第一电输出更长时，微处理器响应于第一和第二电输出，用于提供指示去极化激活波的发生的指示信号。耦合到微处理器的脉冲发生器响应于指示信号将心脏转换能量施加到心脏的心房。

35. 发明授权

US5304139A Improved lead configuration for an atrial defibrillator 失效
标题翻译：改善心房除颤器的引导配置
公开(公告)号：US5304139A
公开(公告)日：1994-04-19
申请号：US924109
申请日：1992-08-03
申请人： John M. Adams , Clifton A. Alferness
发明人： John M. Adams , Clifton A. Alferness
IPC分类号： A61N1/05 , A61N1/39
CPC分类号： A61N1/3918 , A61N1/056 , A61N1/0563 , A61N1/3956 , A61N1/3962 , A61N1/395 , A61N1/3987 , A61N2001/0585
摘要： An implantable atrial defibrillator provides a pulse of defibrillating electrical energy to the atria of the heart in synchronism with sensed R waves in response to non-coincident sensing of an R wave at first and second areas of the heart. The defibrillating pulse is provided after a predetermined number of consecutive R waves are non-coincidently sensed to assure reliable synchronization. The atrial defibrillator is also operational in a marker mode wherein a number of synchronization marker pulses are delivered to the heart for detection on an externally generated electrocardiogram. The atrial fibrillation detector of the defibrillator is normally disabled and is activated when the sensed ventricular activity indicates a probability of atrial fibrillation to conserve a depletable power source. An endocardial lead is also described which ensures that the delivered atrial defibrillating electrical energy is substantially confined to the atria of the heart.
摘要翻译：可植入心房除颤器响应于在心脏的第一和第二区域处的R波的不一致的感测，与感测到的R波同步地向心脏的心房提供除颤电脉冲。在不一致地感测到预定数量的连续R波之后提供除颤脉冲，以确保可靠的同步。心房除颤器还可以在标记模式中操作，其中多个同步标记脉冲被传送到心脏以便在外部产生的心电图上进行检测。除颤器的心房颤动检测器通常被禁用，并且当感测到的心室活动指示心房颤动的概率以节省可消耗的电源时被激活。还描述了一种心内膜导联，其确保输送的心房除颤电能基本上限于心脏的心房。

36. 发明授权

US5158079A Implantable device for preventing tachyarrhythmias 失效
标题翻译：用于防止TACHYARRHYTHMIAS的可植入装置
公开(公告)号：US5158079A
公开(公告)日：1992-10-27
申请号：US660541
申请日：1991-02-25
申请人： John M. Adams , Clifton A. Alferness
发明人： John M. Adams , Clifton A. Alferness
IPC分类号： A61N1/365 , A61N1/362
CPC分类号： A61N1/3622
摘要： An implantable device prevents tachyarrhythmias of a human heart which has arrhythmogenic tissue such as a myocardial infarction site. The device includes a plurality of electrodes configured for electrical contact with the heart and for placement in proximity to the arrhythmogenic tissue and a sensor including a single sensing electrode for sensing electrical activations of one chamber of the heart. A pulse generator coupled to the plurality of electrodes and responsive to the sensor provides the plurality of electrodes with an electrical pulse during each sensed electrical activation.
摘要翻译：可植入装置可以预防心律失常的心律失常，心律失常会导致心律失常的组织，如心肌梗死部位。该装置包括多个电极，其被配置为与心脏电接触并用于放置在致心律失常组织附近;以及传感器，其包括用于感测心脏一个腔室的电激活的单个感测电极。耦合到多个电极并响应于传感器的脉冲发生器在每个感测的电激活期间为多个电极提供电脉冲。

37. 发明申请

US20120330328A1 TISSUE FIXATION DEVICES AND A TRANSORAL ENDOSCOPIC GASTROESOPHAGEAL FLAP VALVE RESTORATION DEVICE AND ASSEMBLY USING SAME 审中-公开
标题翻译：组织固定装置和转移性内镜胃气道瓣瓣恢复装置及其组装
公开(公告)号：US20120330328A1
公开(公告)日：2012-12-27
申请号：US13604276
申请日：2012-09-05
申请人： Steve G. BAKER , Brett J. Carter , Stefan J.M. Kraemer , Clifton A. Alferness , John M. Adams
发明人： Steve G. BAKER , Brett J. Carter , Stefan J.M. Kraemer , Clifton A. Alferness , John M. Adams
IPC分类号： A61B17/03
CPC分类号： A61B17/0401 , A61B17/0469 , A61B17/064 , A61B17/068 , A61B2017/00827 , A61B2017/0409 , A61B2017/0414 , A61B2017/0419
摘要： Tissue fasteners carried on a tissue piercing deployment wire fasten tissue layers of a mammalian body together. The fasteners include a first member, a second member, and a connecting member extending between the first and second members. The first and second members are substantially parallel to each other. The fasteners may be deployed in limited spaces and in various applications including the restoration of a gastroesophageal flap valve.
摘要翻译：携带在组织穿刺部署线上的组织紧固件将哺乳动物身体的组织层紧固在一起。紧固件包括第一构件，第二构件和在第一构件和第二构件之间延伸的连接构件。第一和第二构件基本上彼此平行。紧固件可以在有限的空间和各种应用中部署，包括恢复胃食管瓣阀。

38. 发明申请

US20080097324A1 Disposable infusion device with linear peristaltic pump 有权
标题翻译：一次性输液装置，带有线性蠕动泵
公开(公告)号：US20080097324A1
公开(公告)日：2008-04-24
申请号：US11516456
申请日：2006-09-06
申请人： John M. Adams , Clifton A. Alferness , Daniel Hawkins
发明人： John M. Adams , Clifton A. Alferness , Daniel Hawkins
IPC分类号： A61M1/00
CPC分类号： A61M5/14248 , A61M5/152
摘要： A wearable infusion device delivers a liquid medicant, such as insulin, to a patient. The infusion device comprises a base that contacts a patient's skin and a reservoir arranged to contain a liquid medicant to be delivered beneath a patient's skin. The reservoir has an outlet through which the medicant flows. The infusion device further includes a flexible conduit communicating with the outlet of the reservoir and a pump that causes the medicant to flow down the conduit.
摘要翻译：可佩戴的输注装置将诸如胰岛素的液体药物递送给患者。输注装置包括接触患者皮肤的基部和布置成容纳要在患者皮肤下方递送的液体药物的储存器。储存器具有药物流过的出口。输液装置还包括与储存器的出口连通的柔性导管和使得药物沿管道流下的泵。

39. 发明授权

US07270676B2 Mitral valve therapy device, system and method 有权
标题翻译：二尖瓣治疗装置，系统及方法
公开(公告)号：US07270676B2
公开(公告)日：2007-09-18
申请号：US10925570
申请日：2004-08-24
申请人： Clifton A. Alferness , John M. Adams , John Melmoth Power
发明人： Clifton A. Alferness , John M. Adams , John Melmoth Power
IPC分类号： A61F2/24
CPC分类号： A61F2/2451 , Y10S623/904
摘要： An assembly and method for effecting the condition of a mitral valve annulus of a heart includes a guide wire configured to be fed into the coronary sinus of the heart, and a mitral valve annulus therapy device configured to be slidingly received on the guide wire and advanced into the coronary sinus of the heart on the guide wire. A guide tube may further be employed for guiding the device into the coronary sinus. An introducer which may be employed for pushing the device into or pulling device out of the heart has a mechanism for releasably locking to the device. This enables substitution of the device if needed. Also, the crossover point of the circumflex artery and coronary sinus may be determined and avoided when the device is deployed.
摘要翻译：用于实现心脏二尖瓣环的状态的组件和方法包括：构造成供给到心脏的冠状窦内的导线，以及构造成滑动地容纳在导丝上并提前的二尖瓣环空间治疗装置进入导丝的心脏冠状窦。还可以使用导管来将装置引导到冠状窦中。可以用于将装置推入或拉出装置离开心脏的导引器具有用于可释放地锁定到装置的机构。如果需要，这可以替代设备。此外，当部署装置时，可以确定并避免回旋动脉和冠状窦的交叉点。

40. 发明授权

US07179282B2 Device and method for modifying the shape of a body organ 有权
公开(公告)号：US07179282B2
公开(公告)日：2007-02-20
申请号：US10429171
申请日：2003-05-02
申请人： Clifton A. Alferness , John M. Adams , Mark L. Mathis , David G. Reuter , Cruz Beeson , Leonard Kowalsky
发明人： Clifton A. Alferness , John M. Adams , Mark L. Mathis , David G. Reuter , Cruz Beeson , Leonard Kowalsky
IPC分类号： A61F2/06 , A61B19/00 , A61M29/00
CPC分类号： A61F2/2451 , A61F2250/001 , A61F2250/0059
摘要： An intravascular support device includes a support or reshaper wire, a proximal anchor and a distal anchor. The support wire engages a vessel wall to change the shape of tissue adjacent the vessel in which the intravascular support is placed. The anchors and support wire are designed such that the vessel in which the support is placed remains open and can be accessed by other devices if necessary. The device provides a minimal metal surface area to blood flowing within the vessel to limit the creation of thrombosis. The anchors can be locked in place to secure the support within the vessel.

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